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1 eurogenesis by stabilising the bHLH protein, neurogenin.
2 expression during cell-fate specification by neurogenin.
3 riptional regulators of mammalian genes, the neurogenins.
4           The proneural transcription factor neurogenin 1 (neurog1) has been shown to be a key regula
5 ires the bHLH proneural transcription factor Neurogenin 1 (Neurog1).
6                            Here we show that neurogenin 1 (ngn1), a vertebrate proneural gene related
7 has been postulated that a proneural factor, neurogenin 1 (Ngn1), simultaneously activates the neurog
8 n of the proneural bHLH transcription factor neurogenin 1 (ngn1).
9 ession of the neuronal transcription factors neurogenin 1 and 2 to synchronize differentiation of ind
10                                              Neurogenin 1 and MASH1 activate PK2 transcription by bin
11 ripheral nervous system, the proneural genes neurogenin 1 and neurogenin 2 (Ngn1 and Ngn2), and Mash1
12 in is directly involved in the regulation of neurogenin 1 and possibly other proneural genes when neu
13   In the zebrafish, the transcription factor neurogenin 1 is essential for the generation of the sens
14  find that inactivation of the gene encoding neurogenin 1 leads to the development of over twice the
15 transcription factor Neurog1 (Ngn1, Neurod3, neurogenin 1) is involved in neuronal differentiation an
16 molog 1a) knockdown or neurons with neurog1 (neurogenin 1) knockdown, we showed that the remaining ce
17 he mouse otocyst epithelium, Tbx1 suppresses neurogenin 1-mediated neural fate determination and is r
18                                              Neurogenins 1 and 2 appear to control distinct sublineag
19          Proneural genes, including Pax6 and Neurogenin-1 and -2, were higher in preterm rabbit pups
20 geminal nerve fibers during development with neurogenin-1 knockout mice, during early postnatal devel
21 uronal identifies, but the potential role of Neurogenin 2 (Neurog2) remains unexplored.
22 main vertebrate proneural factors, Ascl1 and neurogenin 2 (Neurog2), induce different neuronal fates
23      Here we show that the proneural protein neurogenin 2 (Neurog2), which controls neurogenesis in t
24 system, the proneural genes neurogenin 1 and neurogenin 2 (Ngn1 and Ngn2), and Mash1 are required for
25           The proneural transcription factor Neurogenin 2 (Ngn2) acts as a master regulator of neuron
26                   Later the cultures express neurogenin 2 (Ngn2) and become neurogenic.
27  marked promoters of poised proneural genes [neurogenin 2 (Ngn2) and neurogenic differentiation 1 (Ne
28 und that two of these E-boxes are targets of Neurogenin 2 (Ngn2) and that this mechanism is important
29      The proneural factors Mash1 (Ascl1) and neurogenin 2 (Ngn2) are expressed during formation of th
30 amatergic neurons by transient expression of Neurogenin 2 (Ngn2) in pluripotent stem cells.
31                        The proneural protein neurogenin 2 (NGN2) is a key transcription factor in reg
32 orsomorphin) enable the transcription factor Neurogenin 2 (NGN2) to convert human fetal lung fibrobla
33              We found that the expression of neurogenin 2 (Ngn2), a basic helix-loop-helix transcript
34 conserved serine residues on the bHLH factor neurogenin 2 (Ngn2), S231 and S234, are phosphorylated d
35 ssion of the pro-neural transcription factor Neurogenin 2 (Ngn2), we generated disease-relevant, cort
36 IG2(S147A) prefers to form heterodimers with Neurogenin 2 or other bHLH partners, suggesting a molecu
37  and maturation by inducing the beta-catenin-neurogenin 2 pathway.
38 urons (iNs) were generated by overexpressing Neurogenin 2 using lentiviral vector to study neuronal g
39  differentiation gene Neurog2 (Ngn2, Math4A, neurogenin 2) as a direct target of PTF1-J.
40 ion and neuronal differentiation mediated by Neurogenin 2, a transcription factor expressed in adult
41 cells by expressing the transcription factor neurogenin-2 (NGN2).
42 PSC isogenic pairs were differentiated using Neurogenin-2 overexpression yielding populations of cort
43 pression in ESCs stably expressing ASCL-1 or neurogenin-2 promoters fused to luciferase reporter gene
44 Human embryonic stem cells with an inducible neurogenin-2 transgene were differentiated into glutamat
45 res by the genetically induced expression of neurogenin-2.
46 s, including Achate-scute-like 1 (Ascl1) and Neurogenin 3 (Neurog3) are widely expressed in hypothala
47 elopment, we detected only a single-phase of Neurogenin 3 (NEUROG3) expression and endocrine differen
48 level production of the transcription factor Neurogenin 3 (Neurog3) in Sox9(+) bipotent epithelial ce
49 ryonic development, the transcription factor neurogenin 3 (Neurog3) initiates the differentiation of
50                     The transcription factor Neurogenin 3 (Neurog3) is required for islet development
51 sin and immunostained for Musashi-1 (Msi-1), neurogenin 3 (NEUROG3), chromogranin A (CgA), serotonin,
52 tivate the proendocrine transcription factor neurogenin 3 (NEUROG3), exit the cell cycle, and differe
53 e EEC progenitor population, which expresses neurogenin 3 (neurog3).
54 ls expressing carboxypeptidase A1 (CPA1) and neurogenin 3 (NEUROG3).
55 induction of the endocrine progenitor factor neurogenin 3 (NEUROG3).
56 age is dependent on the transcription factor Neurogenin 3 (Neurog3, Ngn3).
57  Mice deficient for the transcription factor neurogenin 3 (ngn3) fail to develop endocrine cells in t
58    Moreover, we demonstrated upregulation of neurogenin 3 (NGN3) in both proliferating ducts and pree
59                                              Neurogenin 3 (NGN3) is the key transcription factor that
60 roliferating germ cells and colocalized with neurogenin 3 (Ngn3), a helix-loop-helix transcription fa
61 t protein (EGFP) inserted into one allele of neurogenin 3 (Ngn3), a marker for pancreatic endocrine p
62                                   Similarly, neurogenin 3 (Ngn3), a Math5 paralog expressed in pancre
63       We demonstrated that the expression of neurogenin 3 (ngn3), an islet- and neuron-specific basic
64 signaling and requires a threshold number of Neurogenin 3 (Ngn3)-expressing acinar cells.
65 alysis of e12.5-18.5 embryonic pancreas from neurogenin 3 (Ngn3)-null mice, a background that abrogat
66 3(zf/zf) mutant mice; however, the number of neurogenin 3 (Ngn3)-positive endocrine cell progenitors
67 ull allele of the bHLH transcription factor, neurogenin 3 (ngn3).
68 coding the proendocrine transcription factor neurogenin 3 (Ngn3).
69 ESIGN AND In order to separate the transient neurogenin 3 -expressing endocrine progenitor cells from
70                  Thus, our data suggest that Neurogenin 3 can redirect the differentiation of bipoten
71                         Severe deficiency of neurogenin 3 causes a rare novel subtype of permanent ne
72                           Loss of Lats1&2 in Neurogenin 3 expressing cells activated YAP1/TAZ transcr
73  to the nuclei in bipotent progenitor cells, Neurogenin 3 expressing endocrine progenitors completely
74 n of this model defines the narrow window of neurogenin 3 expression in islet progenitor cells and pe
75  the mouse villin promoter was used to drive Neurogenin 3 expression throughout the developing epithe
76 ult to distinguish cells actively expressing neurogenin 3 from differentiated cells that have stopped
77   We screened the coding region of the human neurogenin 3 gene (NEUROG3) for mutations in a group of
78 transcriptional activity of the bHLH protein neurogenin 3 in complex with the coactivators p300 or CB
79                                              Neurogenin 3 is a bHLH transcription factor that is expr
80                                              Neurogenin 3 is essential for enteroendocrine cell devel
81                                      Because neurogenin 3 is required for the development of beta-cel
82 ucted a library in which fetal pancreas from Neurogenin 3 null mice, which consists of only exocrine
83  proportion of smaller islets, and increased neurogenin 3 or insulin expression in cells adjacent to
84                                     Neurog3 (Neurogenin 3 or Ngn3) is both necessary and sufficient t
85                                              Neurogenin 3 plays a pivotal role in pancreatic endocrin
86 P1 requires both an intact Hippo pathway and Neurogenin 3 protein.
87 increased in the transgenics suggesting that Neurogenin 3 stimulated a program of terminal enteroendo
88 lation of native pancreatic cells expressing neurogenin 3, an established marker of islet progenitors
89           In addition, we determined whether neurogenin 3-expressing cells respond to abnormal Wnt si
90 slet progenitors leads to an increase in the neurogenin 3-expressing precursor cell population, which
91                                          The Neurogenin 3-expressing transgenics had decreased number
92  polymerized cytoskeleton strongly inhibited neurogenin 3-induced endocrine differentiation.
93 e cells expressing the transcription factor, neurogenin 3.
94  candidate islet progenitor cells expressing neurogenin 3.
95 ation of islet progenitor cells that express neurogenin 3.
96                                              Neurogenin-3 (NEUROG3) is a helix-loop-helix (HLH) trans
97                                              Neurogenin-3 (NEUROG3) is expressed in endocrine progeni
98  The neurogenic differentiation-1 (NEUROD1), neurogenin-3 (NEUROG3), and hepatic nuclear factor-1alph
99                                              Neurogenin-3 (Ngn-3) is required for pancreas developmen
100 1 and endocrine progenitors (EPs) expressing Neurogenin-3 (Ngn3).
101 ta-cell size, islet size, islet density, and neurogenin-3 expression were analyzed.
102 ween HNF3 and basic helix-loop-helix factors neurogenin-3 or NeuroD1 binding to adjacent sites played
103  gamma-secretase inhibitor dibenzazepine and neurogenin-3 overexpression induced goblet cell and ente
104         We enforced Pdx1 expression from the Neurogenin-3-expressing endocrine commitment point onwar
105                                              Neurogenins act via a cascade of downstream transcriptio
106 eover, the ability of p27(Xic1) to stabilise neurogenin and enhance neurogenesis localises to an N-te
107 erminal neural differentiation is induced by neurogenin and neuro D overexpression but not when only
108 t evolutionarily conserved core mediators of Neurogenin and NeuroD activities.
109 y neuronal differentiation at a step between neurogenin and neuroD activity.
110 transcriptional targets of the bHLH proteins Neurogenin and NeuroD and found that primary roles of th
111           We defined consensus sequences for Neurogenin and NeuroD binding and identified responsive
112  Taken together, these data demonstrate that Neurogenin and NeuroD preferentially recognize neurogene
113 can differentially inhibit the activities of neurogenin and neuroD, both neurogenic bHLH molecules an
114 also revealed a crucial control step between neurogenin and neuroD.
115 included targets of the transcription factor neurogenin and previously uncharacterized, evolutionaril
116 ogenesis in the olfactory system upstream of neurogenin and Xebf2.
117 st, misexpression of Olig2 alone derepresses Neurogenins and promotes motoneuron differentiation.
118 lix-loop-helix transcription factors such as Neurogenin are activators of neuronal gene expression.
119                                              Neurogenins are proneural transcription factors required
120 HES, Myc/USF, Hand, Mesp, Shout, p48, NeuroD/Neurogenin, Atonal and AS-C.
121 We show that Hes6 expression follows that of neurogenins but precedes that of the neuronal differenti
122                                     A single neurogenin gene, neurogenin1 (ngn1), is required for the
123               Overexpression of X-NGNR-1 (or NEUROGENIN) induces ectopic neurogenesis and ectopic exp
124  bHLH transcription factors achaete-scute or neurogenin, is located outside the central brain cords i
125 helix-loop-helix (bHLH) transcription factor Neurogenin/Math/atonal and Mash/achaete-scute family mem
126 computational approach to predict additional Neurogenin/NeuroD target genes involved in neurogenesis.
127                      Overexpression of mouse neurogenin ( Neurog) 2 alone or in combination with mous
128              All such neurons require either neurogenin (ngn) 1 or 2, two neuronal determination gene
129 embryos, NKL is induced by overexpression of Neurogenin (Ngn), arguing that NKL is downstream of the
130  neurogenesis, the bHLH transcription factor neurogenin (Ngn1) inhibits the differentiation of neural
131 and represses neuron formation by binding to Neurogenin (Ngn2) and blocking its function.
132 loop-helix (bHLH) transcription factors, the Neurogenins (NGNs) and MASH-1, respectively.
133                                          The NEUROGENINS (NGNs) are neural-specific basic helix-loop-
134 ver, neither XFD nor N17Ras inhibits noggin, neurogenin, or XBF2 induction of anterior neural markers
135                               Activating the neurogenin pathway in ferret progenitors promoted delami
136  is sufficient to induce phox2a-positive and neurogenin-positive cells.
137 h beta-catenin and Lef1 bind directly to the neurogenin promoter, and luciferase reporter assays demo
138 taposed to the expression domains of Xenopus Neurogenin related 1 and N-tubulin, markers of early neu
139 duces expression of the early proneural gene neurogenin-related 1 although not itself being induced b
140                        Expression of Xenopus NEUROGENIN-related-1 (X-NGNR-1) defines the three prospe
141     The related basic/helix-loop-helix genes neurogenin-related-1 and neuroD are not induced in respo
142                       In further contrast to neurogenin-related-1 and neuroD, high-level expression o
143                 Transcription factors in the Neurogenin, Runt, ETS, and LIM families control sequenti
144         In particular, studies on NeuroD and Neurogenin suggest a regulatory pathway, providing power
145 e revealed more cells coexpressing proneural neurogenin targets in human than in other species, sugge
146 l to express the basic helix-loop-helix gene neurogenin that is essential for the formation of neuron
147 stoma specimens, whereas NEUROD2 and NEUROD3/neurogenin were expressed in partly overlapping subsets
148 moted by proneural bHLH proteins such as the neurogenins, which act as potent transcriptional activat
149 scribe a novel, NeuroD-related bHLH protein, NEUROGENIN, whose expression precedes that of NeuroD in
150 is finding, XDmrt4 is sufficient to activate neurogenin, Xebf2, and neural cell adhesion molecule exp

 
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