ライフサイエンスコーパス: neurogranin

1 ation (sTREM2), and synaptic markers (GAP43, neurogranin).

2 dent protein kinase II in knockout models of neurogranin.

3 ctive staining for the pyramidal cell marker neurogranin.

4 another widely used selective PKC substrate (neurogranin((28-43)) and was a good substrate for human

5 e generated transgenic mice that overexpress neurogranin (a calmodulin-binding protein that facilitat

6 decade, a range of fluid biomarkers such as neurogranin, alpha-synuclein, visinin-like protein 1 (VI

7 lack of morphine-induced phosphorylation of neurogranin and activation of CaMKII and CREB, and absen

8 ration of the apocalmodulin-binding proteins neurogranin and GAP-43, resulting in a low level of free

9 ncreased approximately 2-4 hr later, whereas neurogranin and gephyrin decreased during that time.

10 Correlations between neurogranin and neurodegeneration biomarkers, demographi

11 cium calmodulin-dependent protein kinase II, neurogranin, and activity-regulated cytoskeleton-associa

12 Male ICR mice were pretreated with neurogranin antisense or mismatch oligodeoxynucleotides

13 nal fluid levels of the postsynaptic protein neurogranin are increased in Alzheimer's disease, includ

14 They also implicate RC3/neurogranin as a downstream effector of PKC activity in

15 pport the hypothesis that phosphorylation of neurogranin at Ser-36 regulates its binding to CaM.

16 Neurogranin binds to the closed conformation of calmodul

17 additional proteins that might interact with neurogranin by screening brain cDNA libraries.

18 phasis on the interaction of calmodulin with neurogranin, calcineurin, and CaMKII.

19 Gln and Ser-36 --> Asp point mutants reduced neurogranin/CaM interactions.

20 Thus, neurogranin can provide a molecular link between enhance

21 Importantly, CSF neurogranin complements the collective ability of these

22 the form of rapidly dissociating calmodulin-neurogranin complexes.

23 otein, amyloid beta, phosphorylated tau, and neurogranin concentrations in cerebrospinal fluid.

24 Compared with NC, CSF neurogranin concentrations were increased in CJD (4.75 t

25 pTau(181):Abeta(42), CSF neurofilament, CSF neurogranin, CSF growth-associated protein 43, age, APOE

26 ted symptom onset for plasma pT217/T217, CSF neurogranin, CSF SNAP-25, CSF sTREM2, plasma GFAP, and p

27 The accuracy of neurogranin discriminating the three diagnostic groups w

28 P-25, 14-3-3 zeta/delta, beta-synuclein, and neurogranin exhibited the highest discriminatory accurac

29 Additionally, neurogranin expression in postmortem brain tissue was st

30 Antisense-pretreated mice showed decreased neurogranin expression, lack of morphine-induced phospho

31 5, independent of thyroid hormone-sensitive neurogranin expression.

32 At intermediate frequencies, neurogranin facilitates LTD, but limits LTP by precludin

33 y (NSE, BDNF, GFAP, S100beta, MCP1, VILIP-1, neurogranin); Factor 2 comprised markers related to vasc

34 Our results indicate that elevated neurogranin function within the PFC can enhance local pl

35 ophysin, PSD95, synapsin 1, synaptobrevin 1, neurogranin, GAP43 and synaptopodin (synaptic) were foun

36 ophysin, PSD95, synapsin 1, synaptobrevin 1, neurogranin, GAP43 and synaptopodin in brain tissues fro

37 Neurogranin has been suggested to serve as a common regu

38 rofilament, growth-associated protein 43 and neurogranin in Abeta(+) and phosphorylated tau(+) (A+T(1

39 An in-house immunoassay was used to analyse neurogranin in cerebrospinal fluid samples from a cohort

40 To elucidate the role of neurogranin in synaptic plasticity, we constructed a com

41 CaM is the major protein that interacts with neurogranin in vivo and support the hypothesis that phos

42 Our data illustrate that CaM binds to neurogranin in vivo and that CaM is the only neurogranin

43 e IQ domain are important for CaM binding to neurogranin in vivo.

44 At low spike frequencies, neurogranin inhibits the onset of LTD by limiting CaN ac

45 neurogranin in vivo and that CaM is the only neurogranin-interacting protein isolated from brain cDNA

46 However, it has not been established that neurogranin interacts with CaM in vivo.

47 Neurogranin is a neural-specific, calmodulin (CaM)-bindi

48 Neurogranin is a new biomarker of prion pathogenesis wit

49 Neurogranin is a postsynaptic neuronal protein that has

50 Neurogranin is a promising biomarker for AD because leve

51 Neurogranin is highly concentrated in dendritic spines.

52 se data demonstrate that cerebrospinal fluid neurogranin is increased already at the early clinical s

53 tsynaptic protein kinase (PKC) substrate RC3/neurogranin is increased in the maintenance phase of LTP

54 tested between baseline cerebrospinal fluid neurogranin levels and baseline and longitudinal cogniti

55 The CSF neurogranin levels correlated with brain atrophy (normal

56 The CSF neurogranin levels differentiated patients with early sy

57 addition, high baseline cerebrospinal fluid neurogranin levels in the mild cognitive impairment grou

58 ent group, high baseline cerebrospinal fluid neurogranin levels predicted cognitive decline as reflec

59 The CSF neurogranin levels predicted future cognitive impairment

60 CJD-MM1/MV1 cases displayed higher neurogranin levels than VV2 cases.

61 pairment group, elevated cerebrospinal fluid neurogranin levels were associated with accelerated dete

62 Consequently, we hypothesize that neurogranin may function to concentrate CaM at specific

63 While neurogranin might act as a calmodulin buffer, it does no

64 tic dysfunction/degeneration biomarkers like neurogranin (Ng) and synaptosomal-associated protein 25

65 Neurogranin (NG) binding of calmodulin (CaM) at its IQ d

66 In neurons, neurogranin (Ng) binds calmodulin (CaM), and its binding

67 Neurogranin (Ng) is a brain-specific postsynaptic calmod

68 Neurogranin (Ng) is a brain-specific, postsynaptically l

69 Neurogranin (Ng) is a member of the IQ motif class of ca

70 Neurogranin (Ng) is a neuron-specific protein kinase C-s

71 Neurogranin (Ng) is a postsynaptic IQ-motif containing p

72 Neurogranin (Ng) is a prominent protein kinase C (PKC) s

73 Reductions of neurogranin (Ng), a calcium-sensitive calmodulin-binding

74 sing both tools, we investigated the role of neurogranin (Ng), a major postsynaptic calmodulin (CaM)

75 Here, we report that neurogranin (Ng), a neuron-specific and postsynaptic pro

76 Neurogranin (Ng), a specific substrate of protein kinase

77 CaM-dependent protein kinase II (CaMKII) and neurogranin (Ng), as they both regulate CaM-dependent Ca

78 compare cerebrospinal fluid (CSF) levels of neurogranin (Ng), Beta-site amyloid-precursor-protein cl

79 wever, the role of the scaffolding molecule, neurogranin (Ng), in governing the dynamics of CaMKII is

80 erived transcripts, along with the mRNAs for neurogranin (NGN, a protein kinase C substrate) and the

81 Neurogranin (NGRN) seems to be a promising novel cerebro

82 e vicinity of transcription factor 4 (TCF4), neurogranin (NRGN) and an extended region covering the M

83 pts associated with ZFP804A, a SZ risk gene, neurogranin (NRGN), is one of ZFP804A targets.

84 gr1), small GTP binding protein Rac1 (Rac1), neurogranin (Nrgn), sodium channel beta4 subunit (Scn4b)

85 associated protein 43, GAP43), postsynaptic (neurogranin, NRGN) and axonal (neurofilament light chain

86 The CSF levels of the synaptic marker neurogranin offer diagnostic and prognostic utility for

87 y reveals dynamic regulatory roles played by neurogranin on synaptic plasticity, which provide mechan

88 Neurogranin overexpression in the PFC enhanced long-term

89 milar IQ motif in PEP-19 and neuromodulin or neurogranin, PEP-19 was not a substrate for protein kina

90 The sustained increase in RC3/neurogranin phosphorylation requires ongoing protein kin

91 LTP induction can reverse the increased RC3/neurogranin phosphorylation.

92 Taken together, these data suggest that neurogranin plays an essential role in acute opioid depe

93 In CJD, neurogranin positively correlated with tau (r=0.55, p<0.

94 Finally, at high spike frequencies, neurogranin promotes LTP by enhancing CaMKII autophospho

95 n, the microtubule-associated protein 2, and neurogranin (RC3) were evaluated for their ability to af

96 binding domains of neuromodulin (GAP-43) and neurogranin (RC3).

97 ted for their efficacies to modify rat brain neurogranin/RC3 (Ng) and neuromodulin/GAP-43 (Nm).

98 Neurogranin/RC3 (Ng), a postsynaptic neuronal protein ki

99 Neurogranin/RC3 is a neural-specific Ca(2+)-sensitive ca

100 spikes at various frequencies and show that neurogranin regulates synaptic plasticity along three mo

101 generation (N) included neurofilament light, neurogranin, SNAP-25, and NPTX2.

102 In the model, knockout of neurogranin strongly diminishes the LTP induced by a sin

103 e-associated genes (neuron-specific enolase, neurogranin), suggesting that EGR1 overexpression may co

104 ration biomarkers, such as CSF total tau and neurogranin, suggesting that CSF Lec-PF levels proximall

105 Neurogranin suppresses basal CaN activity, thus increasi

106 On the contrary, neurogranin synchronizes the opening of calmodulin's two

107 Moreover, it is noteworthy that neurogranin, the full-length protein of W-NG(28-43) and

108 Since CaM binds to neurogranin through the IQ domain, PKC phosphorylation a

109 ested the performance of cerebrospinal fluid neurogranin to predict cognitive decline and brain injur

110 CSF neurogranin, total tau, neurofilament light (NFL) and 14

111 cute opioid dependence, we directly targeted neurogranin using antisense oligodeoxynucleotides.

112 other biomarkers such as KLK-6, NCAM-1, and Neurogranin vary between brain region, while TDP-43 and

113 In brain tissue, neurogranin was detected in the cytoplasm, membrane and

114 Neurogranin was increased at early CJD disease stages an

115 Cerebrospinal fluid neurogranin was increased in patients with Alzheimer's d

116 levels of synaptotagmin, synaptophysin, and neurogranin were decreased years before dementia in pati

117 Abeta40, p-tau181, p-tau 217, total tau, and neurogranin were measured in Japanese participants (n =

118 tophysin, synaptopodin, synaptotagmin-2, and neurogranin were significantly lower in patients with FT

119 tion (synaptosomal-associated protein 25kDa, neurogranin) were measured in CSF obtained at presentati

120 of the cells were positive for both P2Y1 and neurogranin, whereas 16% were only P2Y1 positive.

121 substantially increased was RC3 (also called neurogranin), which encodes a calmodulin binding protein

122 ta42, Abeta40, and CSF MTBR-tau243, SNAP-25, neurogranin, YKL-40, sTREM2, and plasma eMTBR-tau243.