ライフサイエンスコーパス: neurokinin B

1 er activity of genes encoding kisspeptin and neurokinin B.

2 B > senktide > substance P = neurokinin A > neurokinin B.

3 s to concentrations of neurokinin A (10 nM), neurokinin B (0.1 microM), substance P (1 microM), neuro

4 nding sites for NHLH2 in the Kiss1 and Tac2 (neurokinin B) 5' regulatory regions.

5 NA and have elucidated the putative sites of neurokinin B action in the rat central nervous system.

6 te nucleus (ARC) that co-express kisspeptin, neurokinin B and dynorphin (KNDy cells) are essential fo

7 he Tac2 gene, which encodes the neuropeptide neurokinin B and its corresponding receptor neurokinin 3

8 ative feedback interactions mediated through neurokinin-B and dynorphin signaling respectively are co

9 cystokinin, pronociceptive Substance P (SP), Neurokinin B, and a late wave of somatostatin.

10 at release the neurotransmitters kisspeptin, neurokinin B, and dynorphin (KNDy neurons), and produce

11 the hypothalamus that coexpress kisspeptin, neurokinin B, and dynorphin (termed KNDy cells) which fo

12 eus, known as KNDy neurons for co-expressing neurokinin B, and dynorphin, drive pulsatile GnRH releas

13 viation based on coexpression of kisspeptin, neurokinin B, and dynorphin.

14 es for their natural ligands substance P and neurokinin B but also exhibited surprisingly high affini

15 arked alterations in hypothalamic kisspeptin/neurokinin B/dynorphin (KNDy) neurons, we hypothesized t

16 are also effects at the ARH to disrupt Kiss1/neurokinin B/dynorphin neuronal function through inhibit

17 Neurokinin B, encoded by the tachykinin3 gene, plays a c

18 trophy of neurons expressing substance P and neurokinin B gene transcripts in the infundibular (arcua

19 ing at the NK-3 receptor homolog was [MePhe7]neurokinin B > senktide > substance P = neurokinin A > n

20 hich includes substance P, neurokinin A, and neurokinin B, have three distinct receptors: NK-1, NK-2,

21 This cell line also bound [125I-MePhe7]neurokinin B; however, neurokinin B was an effective com

22 h similar rank orders of potency of [MePhe7] neurokinin B = neurokinin B = senktide > NKA = substance

23 We demonstrate that a "neuropeptide," neurokinin-B (NK-B), reversibly inhibits endothelial cel

24 hich encodes proneurokinin-B, a precursor of neurokinin-B (NK-B).

25 ses kisspeptin into the median eminence, and neurokinin B (NKB) and dynorphin onto neighboring Kiss1(

26 Neurokinin B (NKB) and its G-protein-coupled receptor, N

27 Patients with loss-of-function mutation in neurokinin B (NKB) and its receptor show hypogonadotropi

28 Human genetic studies have revealed that neurokinin B (NKB) and its receptor, neurokinin-3 recept

29 determine whether preprodynorphin (Dyn) and neurokinin B (NKB) are coexpressed in Kiss1 neurons in t

30 f neurons expressing the substance P (SP) or neurokinin B (NKB) genes in the human hypothalamus and b

31 The tachykinin neurokinin B (NKB) has been implicated in the hypertensi

32 Neurokinin B (NKB) is a hypothalamic neuropeptide bindin

33 Neurokinin B (NKB) is one member of an evolutionarily co

34 Kisspeptin (Kiss1) and neurokinin B (NKB) neurocircuits are essential for puber

35 Arcuate neurokinin B (NKB) neurons express estrogen receptor-alp

36 derable evidence suggests that dynorphin and neurokinin B (NKB) neurons in the hypothalamic arcuate n

37 mature peptide identical to the neuropeptide neurokinin B (NKB) of other mammalian species.

38 ction mutations in the genes encoding either neurokinin B (NKB) or its receptor, NK3 (NK3R), result i

39 Kisspeptin and neurokinin B (NKB) play a key role in several physiologi

40 procal plots of identical slope when [MePhe7]neurokinin B (NKB) was used as the other competition par

41 ior of Kiss1(ARH) neurons, expressing Kiss1, neurokinin B (NKB), and dynorphin (Dyn), varies througho

42 tergic 'KNDy' neurons co-express kisspeptin, neurokinin B (NKB), and dynorphin and exhibit a highly s

43 urokinin-3 receptor (NK3R), the receptor for neurokinin B (NKB), encoded by the Tac2 gene.

44 ng substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), that are encoded by the tac1 (SP and

45 conservation and physiological functions of neurokinin B (NKB), we identified tachykinin (tac) and t

46 micked by NK1 (substance P, 100 nm) and NK3 (neurokinin B [NKB], 100 nm) agonists.

47 called GPR54), neurokinin B (TAC3), and the neurokinin B receptor (TACR3) result in pubertal failure

48 mine D2 receptor (DRD2), hot flashes and the neurokinin B receptor (TACR3), cigarette smoking and rec

49 tance P receptor, neurokinin A receptor, and neurokinin B receptor).

50 orders of potency of [MePhe7] neurokinin B = neurokinin B = senktide > NKA = substance P.

51 Neurokinin B signalling is increased in menopausal women

52 thalamic neurons that produce kisspeptin and neurokinin B stimulate GnRH release.

53 promising advances in basic research of the neurokinin B/Tac2 pathway in both animals and humans, cl

54 in receptor (KISS1R, formerly called GPR54), neurokinin B (TAC3), and the neurokinin B receptor (TACR

55 so bound [125I-MePhe7]neurokinin B; however, neurokinin B was an effective competitor.

56 ncluding substance P (SP), neurokinin A, and neurokinin B, which are recognized for their roles in th

57 s include substance P (SP), neurokinin A and neurokinin B, which interact with three G-protein-couple