ライフサイエンスコーパス: neuromedin

1 ors for the mammalian bombesin-like peptides neuromedin B (NMB) and gastrin-releasing peptide.

2 eptides, gastrin-releasing peptide (GRP) and neuromedin B (NMB) have been found in mammals.

3 o uncover the expression of the neuropeptide neuromedin B (NMB) in the trigeminal ganglia of mice.

4 Neuromedin B (NMB) is a mammalian member of the bombesin

5 Neuromedin B (NMB) is a member of the neuromedin family

6 ased by nasal sensory neurons, we found that neuromedin B (NMB) peptide is essential for signaling sn

7 opeptides gastrin-releasing peptide (GRP) or neuromedin B (NMB) produced a large membrane depolarizat

8 he gastrin-releasing peptide (GRP) receptor, neuromedin B (NMB) receptor, or BLP receptor subtype 3]

9 Neuromedin B (NMB) receptor-null and bombesin receptor s

10 gastrin-releasing peptide (GRP) receptor and neuromedin B (NMB) receptor.

11 Neuromedin B (NMB), a mammalian bombesin related peptide

12 highly expresses Vglut2 and the neuropeptide neuromedin B (Nmb), to investigate this question.

13 amounts of the receptor for the neuropeptide neuromedin B (NMB).

14 eptides [gastrin-releasing peptide (GRP) and neuromedin B (NMB)] are important in numerous biological

15 of mRNA for the three BLP receptor subtypes (neuromedin B [NMB]) receptor, gastrin-releasing peptide

16 atin M, we also detected increased levels of neuromedin B in fibroblasts of CNPG lesions compared wit

17 dization, we show here that a single marker, Neuromedin B mRNA (Nmb), identifies RTN neurons in roden

18 dentified with a single and specific marker, Neuromedin B mRNA (Nmb).

19 omedin B to Rat-1 cells transfected with the neuromedin B preferring receptor also activated p42(mapk

20 eptor number and receptor type (i.e., GRP or neuromedin B preferring).

21 pecifically to GRP-R (0.8 nmol/L) and to the neuromedin B receptor (NMB-R) (0.9 nmol/L), with no affi

22 hares high homology with bombesin receptors (neuromedin B receptor (NMB-R) and gastrin-releasing pept

23 gastrin-releasing peptide receptor (GRP-R), neuromedin B receptor (NMB-R), and bombesin receptor sub

24 trin-releasing peptide receptor (GRP-R), the neuromedin B receptor (NMB-R), and bombesin receptor sub

25 trin-releasing peptide receptor (GRP-R), the neuromedin B receptor (NMB-R), bombesin receptor subtype

26 , functions through a distinct receptor, the neuromedin B receptor (NMB-R), of which little is known

27 -releasing peptide receptor (GRP-R, or bb2), neuromedin B receptor (NMB-R, or bb1), and the bombesin

28 PD168368 was found to be a potent selective neuromedin B receptor (NMBR) antagonist.

29 electivity for GRPR over the closely related neuromedin B receptor (NMBR).

30 ma cells which possess native NMB-Rs and rat neuromedin B receptor (rNMR-R) transfected BALB 3T3 cell

31 gastrin-releasing peptide receptor (GRP-R), neuromedin B receptor, and bombesin receptor subtype 3.

32 de receptor, natriuretic peptide receptor A, neuromedin B receptor, and sst2A.

33 hat antagonists of gastrin-releasing peptide/neuromedin B receptors (BB/BB) PD168368 [(S)-a-methyl-a-

34 f CNPG lesions compared with AD and HC, with neuromedin B receptors detectable on some nerve endings.

35 Furthermore, addition of neuromedin B to Rat-1 cells transfected with the neurome

36 ignificant upregulation of 1080 genes (e.g., neuromedin B), and a significant downregulation of 518 g

37 r 15 (GDF15), angiopoietin-like 6 (Angptl6), neuromedin B, and nesfatin, linked to energy expenditure

38 ptides, including gastrin-releasing peptide, neuromedin B, neurotensin, gastrin, cholecystokinin and

39 ily, including gastrin-releasing peptide and neuromedin B, which are found in axons in the mediobasal

40 y conserved G-protein-coupled receptors: the neuromedin B-preferring, the gastrin-releasing peptide-p

41 tor 1F, natriuretic precursor peptide B, and neuromedin B.

42 in adulthood by the expression of Phox2b and neuromedin B.

43 eristic of the GRPr: bombesin > or = GRP > > neuromedin B.

44 esin(5-14) which has the sequence [Gln3,Arg6]neuromedin B.

45 ction in PHOX2B expression in chemosensitive neuromedin-B (NMB) expressing neurons in the RTN altered

46 dence suggests that bombesin-related peptide Neuromedin-B (Nmb) expression identifies chemoreceptor n

47 chymase (CMA1), tryptase (TPS1) and mastin, neuromedin-B (NMB), nerve growth factor (NGF), and leuko

48 N) that express the bombesin-related peptide Neuromedin-B are proposed to be important in this proces

49 NAs encoding bombesin receptor subtype 3 and neuromedin-B receptor (NMB-R), but not gastrin-releasing

50 or subtype (BRS)-1 (GRP receptor) and BRS-2 (neuromedin-B receptor), but the mRNA for GRP ligand was

51 by coupling a Boc-protected N(4)-chelator to neuromedin C (human GRP(18-27)), which, after (99m)Tc-la

52 In current clamp doses of 10 and 100 nM neuromedin C (NMC) were shown to increase basal firing r

53 atching induced by three peptides (bombesin, neuromedin-C, and [Leu(8)]phyllolitorin).

54 t (EC(50) = 5 nm) and specific in that other neuromedins did not induce a calcium flux in receptor-tr

55 Neuromedin B (NMB) is a member of the neuromedin family of neuropeptides with a high level of

56 ch/crop stretch after food ingestion and (2) Neuromedin/Hugin neurosecretory neurons in the ventral n

57 Tachykinin neuropeptides, including Neuromedin K (NK), Kassinin, and Substance P, have been

58 Expression of the gene encoding neurotensin/neuromedin N (NT/N) is mostly limited to the brain and s

59 ns of neurotensin, expression of neurotensin/neuromedin N (NT/N) mRNA, and numbers of neurotensin-imm

60 The peptides neurotensin (NT) and neuromedin N exert effects on neurons by means of a high

61 ticotropin-releasing hormone and neurotensin/neuromedin N significantly increase in a restricted regi

62 Neuromedin N was identified as a metabolite significantl

63 of over 1000 ligands tested, including other neuromedins (NmB, C, L, K, N), induced a calcium flux in

64 Expression of the neurotensin/neuromedin (NT/N) gene in preoptic area neurons is drama

65 e GRP::eGFP mouse, some of which express the neuromedin receptor 2 and likely belong to a cluster def

66 Here, we show in mice that neuromedin S (NMS) and vasoactive intestinal polypeptide

67 We found that expression of the neuropeptide neuromedin S (NMS) is robustly increased in VTA DA neuro

68 t of SCN neurons expressing the neuropeptide neuromedin S (NMS) plays an essential role in the genera

69 n of prolactin secretion diurnally, as their neuromedin S(+) inputs originate from neurons expressing

70 us with many synaptic afferents arising from neuromedin S(+) neurons of the suprachiasmatic nucleus.

71 tive intestinal peptide-expressing (VIP(+)), neuromedin S-expressing (NMS(+)) and gastrin-releasing p

72 for the GABA vesicular transporter Vgat from neuromedin-S (NMS)(+) neurons-a subset of neurons critic

73 Engineered Neuromedin U (LIMM102) had augmented efficacy in activat

74 ron (PSN) subset producing the neuropeptides neuromedin U (NMU) and calcitonin gene-related peptide b

75 Here, we report the identification of neuromedin U (NmU) as an extracellular biomarker in cell

76 nverse correlation between tumor RhoGDI2 and Neuromedin U (NMU) expression, suggesting that NMU might

77 revealed that IL-2, IL-4, IL-27, IL-10, and neuromedin U (NMU) increased IL-10 production in activat

78 Neuromedin U (NmU) is a 25 amino acid peptide prominentl

79 Here, we determined that the neuropeptide neuromedin U (NmU) is a c-Myb target gene.

80 Neuromedin U (NMU) is a highly conserved neuropeptide wi

81 Neuromedin U (NMU) is a neuropeptide enriched in the nuc

82 Neuromedin U (NmU) is a neuropeptide regulating diverse

83 Neuromedin U (NMU) is a neuropeptide with potent activit

84 n of type 2 innate lymphoid cells (ILC2s) by neuromedin U (NMU) is highly selective and key in contro

85 The effects of neuromedin U (NMU) on aqueous humor (AH) outflow were de

86 We found that the neuropeptide neuromedin U (Nmu) promotes hyperactivity and inhibits s

87 CGRP in concert with IL-33 and neuromedin U (NMU) supported IL-5 but constrained IL-13

88 Neuromedin U (NmU), a peptide affecting calcium transpor

89 e also modulate physical activity, including neuromedin U (NMU), a peptide found in the gut and brain

90 utionarily related to the vertebrate peptide neuromedin U (NMU), or are related to arginine vasopress

91 Neuromedin U (NmU), originally isolated from porcine spi

92 Neuromedin U (NMU), the ligand of NMUR1, activated ILC2s

93 ILC2s express NMUR1, a receptor for neuromedin U (NMU), which is a prominent cholinergic neu

94 neuronal termini expressing the neuropeptide neuromedin U (NMU), which stimulates type 2 (T2) cytokin

95 nergic neurons that express the neuropeptide neuromedin U (NMU).

96 the NAcSh (DRN -> NAcSh) is the neuropeptide neuromedin U (NMU).

97 to the NAcSh (DRN NAcSh) is the neuropeptide neuromedin U (NMU).

98 om insects (Drosophila and Anopheles) and to neuromedin U and ghrelin receptors from vertebrates.

99 haracterized in this report are activated by neuromedin U at nanomolar potency in heterologous expres

100 y to mediate central nervous system-specific neuromedin U effects.

101 enes, as well as the 3' partial locus of the Neuromedin U gene; sequence analysis also suggests the p

102 Binding sites for neuromedin U have been characterized in rat uterus, howe

103 Neuromedin U is a neuropeptide prominently expressed in

104 In addition, we show that whereas neuromedin U is expressed by monocytes and dendritic cel

105 Hugin neuropeptide, a neuromedin U ortholog, also regulates behavioral rhythms

106 namely pyrokinins, as well as the vertebrate neuromedin U peptide also induced a calcium response.

107 the generation of a mouse model based on the neuromedin U receptor 1 (Nmur1) promoter as a driver for

108 receptor 1-dependent, highlighting the ILC2-neuromedin U receptor 1 axis as a novel therapeutic targ

109 The renoprotective effects of LIMM102 were neuromedin U receptor 1-dependent, highlighting the ILC2

110 We found that rs2961757, located near neuromedin U receptor 2 (NMUR2) on chromosome 5, was gen

111 ese data, we conclude that NmU-R2 is a novel neuromedin U receptor subtype that is likely to mediate

112 Identification of neuromedin U receptor subtypes will greatly aid in the d

113 GPCRs from Drosophila that are homologous to neuromedin U receptors in vertebrates.

114 ted to the thyrotropin-releasing hormone and neuromedin U receptors.

115 ous expression systems and bind radiolabeled neuromedin U with high affinity.

116 ptide Y, corticotropin-releasing factor, and neuromedin U) and peripheral (eg, gastrin, histamine, ac

117 tential PanIN biomarker candidates including Neuromedin U, a circulating peptide hormone.

118 leasing Capa hormones, homologs of mammalian neuromedin U, which activate the Capa receptor (CapaR) i

119 peptide is highly related to neurotensin and neuromedin U, which are involved in blood pressure regul

120 S2, bone-morphogenetic protein 2A, MT1G, and neuromedin U, which showed frequent promoter hypermethyl

121 ion of perikarya and nerve fibers containing neuromedin U-like immunoreactivity in the brain of Rana

122 The distribution of neuromedin U-like immunoreactivity in the frog brain was

123 1) was identified as a specific receptor for neuromedin U.

124 obilize intracellular calcium in response to neuromedin U.

125 dentified as receptors for the neuropeptide, neuromedin U.