ライフサイエンスコーパス: neuron

1 by GA in the mouse central amygdala (CeA(GA) neurons).

2 can form functional connections with spinal neurons.

3 quencing of dorsal-lateral prefrontal cortex neurons.

4 ts of glucose-elevating parabrachial nucleus neurons.

5 between sensory neurons and non-target motor neurons.

6 insically attenuates apoptosis competence in neurons.

7 or optogenetics and calcium imaging of human neurons.

8 uding neural progenitor cells and developing neurons.

9 eases the response to noxious stimuli in ACC neurons.

10 ple intrinsic conductances in the individual neurons.

11 ity in Drosophila and cultured primary mouse neurons.

12 contains different subtypes of serotonergic neurons.

13 information across multiple days than other neurons.

14 d in nociceptive pathways, including sensory neurons.

15 level of overexpression could be toxic to DA neurons.

16 , information is distributed across multiple neurons.

17 ultimately cellular death of beta-endorphin neurons.

18 roteins mediating trans-synaptic contacts in neurons.

19 l manifolds formed by correlated patterns of neurons.

20 ynaptic deficits in cultured rat hippocampal neurons.

21 romechanical behaviors of cardiomyocytes and neurons.

22 what we previously reported in dentate gyrus neurons.

23 ated switch function in cultured hippocampal neurons.

24 aptic facilitation of excitatory hippocampal neurons.

25 ory, glutamatergic synapses on host cortical neurons.

26 GAP-43 is found in axonal extensions of most neurons.

27 atial resolution, on primary rat hippocampal neurons.

28 mpacts the development and function of human neurons.

29 identity as well as or better than amygdala neurons.

30 leading edge in growth cones of hippocampal neurons.

31 a combination of broadly and narrowly tuned neurons.

32 feedforward inhibition onto adult projection neurons.

33 l dendrites reproduces all features of these neurons.

34 ellular compared with magnocellular oxytocin neurons.

35 nd puff NMDAR currents in spinal dorsal horn neurons.

36 n vitro model of cellular injury on cortical neurons.

37 larly vulnerable to mutations of Mecp2 in PV neurons.

38 oral profile) within the same populations of neurons.

39 using either biophysically detailed or point neurons.

40 potentially reduce inhibitory input to these neurons.

41 s than those of Ocn-Cre(-) or adult born dDG neurons.

42 excitatory projections to abdominal premotor neurons.

43 drugs activate a shared ensemble of CeA(GA) neurons.

44 to splicing and activation of xbp-1 in these neurons.

45 nje cells, striatal neurons, and hippocampal neurons.

46 and IST1 localization in iPSC-derived human neurons.

47 riety of cellular systems, including primary neurons.

48 the promotion of cell motility in migrating neurons.

49 , little is known about their role in mature neurons.

50 gulator of dendritic arborization in sensory neurons.

51 homeostatic regulators in the fly's auditory neurons accelerated - or protected against - ARHL.

52 , suggesting several groups of PB-projecting neurons act downstream of P1 neurons to mediate nutritio

53 iscovered a distinct population of GABAergic neurons activated by GA in the mouse central amygdala (C

54 (2020) target neurons activated by ultrasonic pup vocalizations and di

55 f somatosensory cortex, have simply compared neurons' activities to the movement of the hand through

56 PI3K signaling in the modulation of NPY/AgRP neuron activity and maintenance of energy homeostasis, t

57 related and temporally offset PV GPe and STN neuron activity is generated in part by elevated striato

58 HEK-293 cells and murine cerebellar granule neurons, along with bioluminescence, calcium FLIPR, and

59 rom awake mice reveal changes of both single-neuron and population responses to USVs in TeA, improvin

60 ologically relevant sites, such as the motor neuron and the growth cone.

61 rvival of a subset of limb-innervating motor neurons and abnormal migration of V2a interneurons.

62 cytokines induce the expression of IFITM3 in neurons and astrocytes, which binds to gamma-secretase a

63 Pcdh-gammaC4 is expressed in both neurons and astrocytes.

64 rotease-9, increases branching of excitatory neurons and concomitantly attenuates the perineuronal ne

65 excitability in male versus female vHPC-NAc neurons and corresponding testosterone-dependent male re

66 pe mice enhanced the firing rate of cortical neurons and gamma oscillations, as well as improved cogn

67 h aspects of attention are processed by fSTS neurons and how or why these might depend on SC activity

68 d to cancer-derived mediators that sensitize neurons and is associated with increased neuronal densit

69 s promoted neurite outgrowth of diabetic DRG neurons and migration of Schwann cells challenged by hig

70 Imaging neurons and neural circuits over large volumes at high s

71 ation of molecular signaling between sensory neurons and non-target motor neurons.

72 ium influx is observed in both glutamatergic neurons and parvalbumin (PV) GABAergic interneurons of A

73 In CA1, both synaptic input to single neurons and population activity strongly tracked visual

74 pable of regenerating all classes of retinal neurons and restoring visual function.

75 family of circuit models with non-identical neurons and synapses underlying rhythmic behavior, we an

76 induced glutamate release onto magnocellular neurons and was sufficient to increase blood pressure.

77 as a mechanism to reduce tau burden in human neurons and, from a small-molecule screen, identify the

78 ARGluA1 in HEK293 cells and primary cortical neurons, and decreases AMPAR-mediated currents in the nu

79 ainst the nuclei of Purkinje cells, striatal neurons, and hippocampal neurons.

80 brain parenchyma including blood vessels and neurons, and in particular NPY and POMC neurons in the a

81 however, the proportions of rapidly adapting neurons, and of intermediately and slowly adapting neuro

82 ial role in preserving the survival of PV(+) neurons, and that inhibition of the impairment of NR2B/P

83 lts support the idea that Npas1(+)-Nkx2.1(+) neurons are a distinct GPe neuron subclass.

84 Thus, BLA excitatory neurons are a highly heterogenous collection of neurons

85 PeriLC(VGLUT2) neurons are a hub between hunger and thirst that specifi

86 mic agouti-related peptide (AgRP)-expressing neurons are acutely activated by caloric need, and this

87 Projection neurons are approximately twice as numerous as reported

88 ons in the primary visual cortex: inhibitory neurons are broadly tuned in vivo and show non-specific

89 that open chromatin regions in glutamatergic neurons are enriched for neuropsychiatric risk variants,

90 Genetically labeled mice established that L1 neurons are proprioceptors.

91 In vivo fiber photometry revealed that these neurons are selectively excited by the unconditioned sti

92 mediating functions of these glucose-sensing neurons are unclear.

93 In particular, late-born CUX1-positive neurons are widely dispersed throughout the GOF cortex.

94 c neuron, pC1d, and implicated aIPg and pC1d neurons as core nodes regulating female aggression.

95 neurons (PNs) and to a lesser degree layer 4 neurons, as well as inhibitory parvalbumin-expressing in

96 In contrast to neurons, astrocytes become less synchronized during non-

97 bust at 1 and at 3 months but reduced in TH+ neurons at 12 months and completely abolished in both TH

98 tes is based on the assumption that receptor neuron axons exclusively connect to a single glomerulus

99 scular diseases, such as regression of motor neuron axons, motor neuron death, and muscle degradation

100 ically or optogenetically onto identified VP neurons before and after applying dynorphin.

101 tion through the recruitment of second-order neurons boosts nociceptive encodings at intermediate int

102 refore, the details underlying how claustrum neurons broadcast information to cortical networks remai

103 nd completely abolished in both TH+ and SST+ neurons by 18 months.

104 posed to also contribute to toxin binding to neurons by interacting with lipid membranes (termed lipi

105 rotective to seeded aggregation within motor neurons by reducing (mislocalized) cytoplasmic TDP-43, T

106 g synaptic receptor trafficking in pyramidal neurons by SorCS2.

107 in C. elegans, sleep requires a sleep-active neuron called RIS.

108 In some pairs of retinal neurons, called paramorphic, one member responds to incr

109 Advancing understanding of neuron-cancer interactions will elucidate new therapeuti

110 nding that stimulation of VLPO glutamatergic neurons causes a strong increase in wakefulness.

111 concentrating-hormone (MCH) and orexin (ORX) neurons characteristics of the ARH and the LHA, respecti

112 In this issue of Neuron, Chung et al.

113 ory periods as well as an enhancement of the neurons' coding selectivity.

114 ss1(hrGFP) in prepubertal mice, ~30% of GHRH neurons coexpressed both reporter genes in adult females

115 onstructions of the basal arbor of pyramidal neurons collected across early postnatal development in

116 However, which neurons control the dynamics of cerebral arteries is not

117 In this issue of Neuron, Corkrum et al.

118 ily distinguished from amygdala activity, PL neurons could distinguish both valence and trial identit

119 dopamine 1 receptor-expressing medium spiny neurons (D1R-MSNs).

120 Different types of Drosophila dopaminergic neurons (DANs) reinforce memories of unique valence and

121 h as regression of motor neuron axons, motor neuron death, and muscle degradation and atrophy can als

122 ors strongly improved the selectivity of the neurons' delay activity, causing an increase in signal-t

123 replacement therapies that comprise dopamine neurons derived from human pluripotent stem cells, which

124 Brain glucose-sensing neurons detect glucose fluctuations and prevent severe h

125 of 14 Hz, and large field of view imaging of neurons, developing embryos, and centimeter-scale tissue

126 tion will help slow the progression of motor neuron disease, offering a novel treatment paradigm for

127 heimer's disease, Parkinson's disease, motor neuron diseases, or epilepsy.

128 -deficient mice, the distribution of corneal neurons displaying the three types of mechanically evoke

129 Inhibition of VTA-core-projecting neurons disrupted Pavlovian reward learning, and activat

130 ted by an evolutionary increase in principal neuron diversity.

131 n or acute optogenetic silencing of DR(Sert) neurons dramatically increased the latency of mice to ar

132 t HuR is expressed in postmitotic projection neurons during mouse brain development.

133 he in vivo dynamics of hunger-promoting AgRP neurons during the development of diet-induced obesity i

134 ding methods enable sampling of thousands of neurons during the performance of behavioral tasks, rais

135 preoptic area of the hypothalamus (POA(PAG) neurons) elicited USV production in the absence of socia

136 vivo calcium imaging revealed that T4 and T5 neurons encode the location and polarity of stationary e

137 We found that populations of neurons encoding choice outcomes, outcome prediction err

138 ferentially expressed genes in hiPSC-derived neurons, enriched in pathways including phosphoinositide

139 ircuitry and alterations in these inhibitory neurons, especially in the medial prefrontal cortex (mPF

140 Reduction of mPFC neuron excitability during the first 2 postnatal weeks c

141 Supporting this theory, many striatal neurons exhibit such graded changes without bursting nea

142 Here, we focus on how these 'cue-locked' neurons exhibited a variety of amplitude modulations fro

143 Neurons exhibited selectivity for stimulus rank during l

144 Unexpectedly, these prototypical pacemaker neurons express a rich set of immune-related genes media

145 rarely in microglia; instead, glutamatergic neurons express LepR, some of which project to a key pre

146 Immunostaining confirmed that NPY neurons express NPY, and we therefore hypothesized that

147 n the parvocellular PVN, and that PVN -> NAc neurons express VGLUT1, a marker of glutamatergic signal

148 However, lesion of VTA GABA neurons failed to disrupt this effect.

149 otic failure coincided with reduced dopamine neuron firing, which was not observed during antipsychot

150 nsity increasing from the summation of these neurons firing.

151 of calcium transients in GCaMP6s-expressing neurons for 920 nm two-photon and 1320 nm three-photon e

152 The lead agent protects neurons from death in vivo.

153 s of ~100 laser captured microdissected SNpc neurons from each tier from 7 healthy controls.

154 dulation of caspase 3 activation may benefit neurons from spine loss in diseases, at least, in those

155 eurons (cartwheel cell) and principal output neurons (fusiform cell) were compared before and after m

156 Indeed, between 7 and 24 weeks, adult-born neurons gained additional dendritic branches, formed a s

157 nding advances our knowledge of how ganglion neurons generate uncharacteristic electrical impulses du

158 association studies within subpopulations of neurons/glia for the brain data and granulocytes/T cells

159 Activation of EGFR signaling in the ALA neuron has previously been suggested to promote sleep in

160 vS1 inhibitory interneurons led to pyramidal neuron hyperactivity and increased stimulus sensitivity

161 critical role for Prdm12 in the anorexigenic neuron identity and suggest that it acts developmentally

162 idence that Syt2a localizes to synapses onto neurons implicated in social behavior in the ventral for

163 d virally in "indirect pathway" medium spiny neurons (iMSNs) in the ventral striatum of D2R knockout

164 lysis of AWC(ON), a well-described olfactory neuron in C. elegans, here we derive a general and broad

165 Moreover, pyramidal neurons in A25 had a heightened density of NMDARs, which

166 phic factor (BDNF)-induced pTRKB in cortical neurons in culture.

167 ularly recording and labeling single CA2/CA3 neurons in freely-moving mice, we explored whether and h

168 n response to repeated tones pyramidal (Pyr) neurons in male mouse auditory cortex (A1) exhibit facil

169 In contrast, CT neurons in mice were mostly located in Layer 6 across al

170 1,2,3,4 and erbB1,2,3,4 in PV and excitatory neurons in mouse visual cortex.

171 on in parvalbumin-expressing (PV) inhibitory neurons in mouse visual cortex.

172 The CT neurons in S1 synaptically excited S1-projecting thalamo

173 y excited S1-projecting thalamocortical (TC) neurons in subregions of both the ventral posterior late

174 learning analysis, we find that a subset of neurons in the ACC receives S1 inputs, and activation of

175 our electrophysiological studies showed that neurons in the adult nAc expressed functional KI GlyRs t

176 on suggested that a subpopulation of ERalpha neurons in the arcuate nucleus of female mice undergoes

177 activates prepronociceptin (PNOC)-expressing neurons in the arcuate nucleus of the hypothalamus (ARC)

178 and neurons, and in particular NPY and POMC neurons in the arcuate nucleus.

179 und that the activity of visually responsive neurons in the central brain was blocked by transient dF

180 depletion of the populations of upper layer neurons in the cortex.

181 show that dynamically growing somatosensory neurons in the Drosophila peripheral nervous system exhi

182 sitive for dopamine innervate reticulospinal neurons in the four reticular nuclei of lampreys.

183 vel functional mechanism for the preoptic DA neurons in the initiation of movement.

184 sulting responses resemble observations from neurons in the insect olfactory system.

185 hat serotonin 2c receptor (Htr2c)-expressing neurons in the lateral parabrachial nucleus (LPBN(Htr2c)

186 s innervated excitatory relay and inhibitory neurons in the MDmc that facilitate faithful transmissio

187 Activating PAG-projecting neurons in the preoptic area of the hypothalamus (POA(PA

188 involves the modulations of large groups of neurons in the primary motor cortex (M1).

189 xia on different subpopulations of GABAergic neurons in the striatum and to assess the outcome of dee

190 nd motor behaviors are coregulated by shared neurons in the substantia nigra pars reticulata (SNr).

191 ve coupling strengths between inferior olive neurons in the three conditions using a combination of a

192 Whenever the retinal image changes, some neurons in visual cortex increase their rate of firing w

193 plasticity and neuronal excitability of BLA neurons in vitro in the left and right amygdala of postn

194 Neurons in which GCase was inhibited by conduritol beta-

195 stinal polypeptide-expressing SCN (SCN(VIP)) neurons, including their molecular clock, in generating

196 ue discrimination activity of these thalamic neurons increased during learning, with the learned valu

197 In mice, Ecm29 knockout (KO) in neurons increases the density of NKCC1 protein in the AI

198 hat arise from these lamina terminalis AT1aR neurons induced glutamate release onto magnocellular neu

199 Here, we combine induced neurons (iNeurons) derived from embryonic stem cells wit

200 he lateral parabrachial nucleus (LPBN(Htr2c) neurons) inhibit sodium appetite.

201 About 50 bilateral pairs of neurons innervating all substructures of the central com

202 factors control the diversification of motor neurons into distinct neuronal subsets by ensuring the m

203 Ch and GABA based on the postsynaptic target neuron is reflected in VIP(+)/ChAT(+) interneuron pre-sy

204 ling the electrical properties of biological neurons is essential to determine their complement of io

205 The arousal potential of the C1 neurons is far greater than that of the RTN, however, co

206 ecifically, FGF21 signaling in glutamatergic neurons is necessary for protection against body weight

207 MEF2C hypofunction in neurons is presumed to underlie most of the symptoms of

208 d RET activation and prevented photoreceptor neuron loss in the retina.

209 compounds that reduce hyperexcitability and neuron loss, have anti-inflammatory properties, and are

210 earning, whereas Octbeta1R in the projection neurons mediates appetitive learning.

211 o cause toxicity by its interaction with the neuron membrane.

212 r genes, we observed that, while GHRH(tdTom) neurons minimally colocalize with Kiss1(hrGFP) in prepub

213 l (SN) and striatopallidal (SP) medium spiny neurons (MSNs) as playing a key role.

214 -cell patch-clamp recordings of medium spiny neurons (MSNs) in the NAc and determined the role of GSK

215 In this issue of Neuron, Newbold et al. build on this neuroplasticity wor

216 ergence of combinatorial inputs to principle neurons of associative brain regions is established duri

217 The chemosensory BAG neurons of C. elegans are striking exemplars of this.

218 Microbiota-induced expression of AHR in neurons of the distal gastrointestinal tract enables the

219 identify inputs to excitatory and inhibitory neurons of the intermediate and deep SC.

220 r head-fixed mice, monitored the activity of neurons of the lateral OFC using two-photon calcium imag

221 is a "hard-wired" property gated by specific neurons of the master clock to favor subsequent alertnes

222 The early-generated, largely transient neurons of the subplate play a key role in integrating s

223 t of amylin/calcitonin signaling in CTR-POMC neurons on energy metabolism and demonstrate the need fo

224 data suggest that Prdm8 regulates the motor neuron-OPC switch by controlling the level of Shh activi

225 In short, C1 neurons orchestrate cardiorespiratory and arousal respon

226 on-dependent modulation of olfactory sensory neuron (OSN) function in the Drosophila larva.

227 he involvement of another sexually dimorphic neuron, pC1d, and implicated aIPg and pC1d neurons as co

228 A transcriptome analysis of the neurons, performed at different times over 24 h, reveale

229 enetic interrogations demonstrate that these neurons play a pivotal role in the regulation of thirst

230 Primary mechanosensory neurons play an important role in converting mechanical

231 activation of excitatory layer 2/3 pyramidal neurons (PNs) and to a lesser degree layer 4 neurons, as

232 binatorial assemblies of molecularly defined neuron populations for grouped-ensemble coding of surviv

233 ng: Octbeta1R in the mushroom body alphabeta neurons processes aversive learning, whereas Octbeta1R i

234 and inhibition of cerebellar cortical output neurons, Purkinje cells, attenuated seizures.

235 Additional PB-projecting neurons regulated male sleep, suggesting several groups

236 cently, characterizing calcium signalling in neurons related to interactions with nanomaterials has b

237 These neurons reside in the pars intercerebralis (PI), a neuro

238 trophysiological study showed that more NAcC neurons responded more strongly to the incentive than th

239 that conditional knockout of Grp in sensory neurons results in attenuated non-histaminergic itch, wi

240 lar GABA transporter (VGAT) (MPOA(ESR1 VGAT) neurons) robustly promoted USV(+) mounting, and converte

241 For transplantation to be effective, grafted neurons should migrate to affected areas at a faster rat

242 y selected and cysteine modified epitopes of neuron specific enolase (NSE), as-synthesized gold nanop

243 inal environment and to induce expression of neuron-specific effector mechanisms.

244 s, selective chemogenetic activation of SubM neurons specifically projecting to VLO significantly inh

245 pas1(+)-Nkx2.1(+) neurons are a distinct GPe neuron subclass.

246 pecification of BMP target genes in efferent neuron subsets.

247 he H3K27ac histone modification, we identify neuron-subtype-specific regulatory elements that previou

248 of basal forebrain and striatal cholinergic neurons, suggesting that falls reflect disruption of the

249 pamine can upregulate VGluT2 in surviving DA neurons, suggesting the possibility of a role in cell su

250 yed increased poly(ADP-ribose) in cerebellar neurons, supporting poly(ADP-ribose) polymerase-1 upregu

251 specific miRNA expression using miRNA-guided neuron tags (mAGNET).

252 In this issue of Neuron, Tasaka et al.

253 tersectional optogenetic stimulation of MPOA neurons that express ESR1 and vesicular GABA transporter

254 mously acting nervous system, composed of 20 neurons that fall into 14 anatomically distinct types.

255 embedded through acoustically selective TeA neurons that help link the calls to a discriminative mat

256 induced pluripotent stem cell (iPSC)-derived neurons that model developing brains, we identified thou

257 ic increase in the spontaneous firing of BLA neurons that persisted (and in some units, increased fur

258 that a specific circuit in the brain [i.e., neurons that project from the central amygdala (CeA) to

259 Finally, we identify a novel group of CA1 neurons that robustly encode freeze behavior independent

260 rons are a highly heterogenous collection of neurons that spatially covary in molecular, cellular, an

261 To identify neurons that specifically increase blood glucose from am

262 Expression of xbp-1s in just two pairs of neurons that synthesize tyramine, the RIM and RIC intern

263 ENT In developing sensory systems, groups of neurons that will process information from similar senso

264 tent mechanism to elicit correlate firing of neurons that will process similar frequencies of sound.

265 eceptors to elicit coordinated excitation of neurons that will process similar frequencies of sound.S

266 enhancing the quality of a noisy hologram of neurons; the intensity distribution of the spatial frequ

267 However, P1 neurons themselves are not persistently active.

268 influence RNA metabolism and the capacity of neurons to adapt.

269 igh-fat diet attenuates the response of AgRP neurons to an array of nutritionally-relevant stimuli in

270 ocesses information perceived by two sensory neurons to control the induction of hydrogen peroxide de

271 e was known about how leptin acts in the NTS neurons to inhibit food intake.

272 vior through PAR(2) Exposure of pain-sensing neurons to Lgmn decreased the current required to genera

273 f PB-projecting neurons act downstream of P1 neurons to mediate nutritional modulation of the sleep-c

274 pMN progenitors switch from producing motor neurons to OPCs with distinct fates is poorly understood

275 distal gastrointestinal tract enables these neurons to respond to the luminal environment and to ind

276 4, and Rh7, are needed in gustatory receptor neurons to sense a plant-derived bitter compound, aristo

277 Primary mouse neurons transfected with CYLDM719V exhibited increased c

278 the parcel-specific neurite lengths of every neuron type from representative morphologic reconstructi

279 s to detail the progression of basal ganglia neuron type-specific pathology and the deficits stemming

280 ronment or their interactions with different neuron types.

281 This suggests that frontal pyramidal neurons use a different integration scheme compared with

282 In this issue of Neuron, van Veluw et al.

283 ar replacement approach in mouse hippocampal neurons, we show here that tamalin plays a critical role

284 erent genetic crosses were used, hundreds of neurons were electrophysiologically characterized, and >

285 The Ocn-Cre(+) dDG neurons were highly active in response to anxiogenic env

286 ophysiologically characterized, and >100,000 neurons were histologically- and/or anatomically-profile

287 We found that BD CA3 neurons were hyperexcitable only when they were derived

288 We find that splitter neurons were more likely to remain active and retained m

289 s, and of intermediately and slowly adapting neurons were significantly reduced.

290 essed during mid-gestation and in excitatory neurons, whereas neurodegenerative-disorder risk genes s

291 d by terminal endings of primary nociceptive neurons, which are organized into morphologically comple

292 lyze AL innervations of the various reported neurons, which demonstrated that all PNs innervating ven

293 system, including the brainstem parabrachial neurons, which promote arousal in response to elevated b

294 te TH-ir signals colocalized with EGFP(Vgat) neurons, which we validated by in situ hybridization for

295 Neurons with fbRFs are located in cortical layers that r

296 y dimensions associated with the activity of neurons with low centrality and displaying large ongoing

297 Here we show that in neurons with no history of activity whatsoever, synaptic

298 ral identity, resulting in the generation of neurons with the characteristics of dorsal NSCs in vivo.

299 s the gut-brain axis, is via spinal afferent neurons, with cell bodies in dorsal root ganglia (DRG).

300 t a broad regulation of motor behavior by DA neurons within multiple hypothalamic nuclei and elucidat