ライフサイエンスコーパス: neuron-specific

1 The effect is neuron specific.

2 cyclodextrin had no effect on transcripts of neuron-specific 24-hydroxylase, and its product 24(S)-hy

3 ssociative memories is elicited by inducible neuron-specific ablation of Nptn gene expression in adul

4 we generated and compared Schwann cell- and neuron-specific ablation of Perk in S63del nerves.

5 mice with pan-neuron-specific or cholinergic neuron-specific ablation of the cpeb2 gene.

6 Here we show that global and sensory neuron-specific ablation of the mechanically activated i

7 Here we present data suggesting that neuron-specific actin-binding drebrin A may be a part of

8 d putrescine increase expression of p35, the neuron-specific activator of Cdk5, and rat DRG neurons t

9 inct set of transcription factors, including neuron-specific activity-dependent factors.

10 The discovery of a neuron-specific adhesion molecule as an EV-D68 receptor

11 Glial cell- or neuron-specific Aldh2 deficiency did not affect voluntar

12 agy marker LC3-II were reduced, suggesting a neuron-specific alteration in autophagosome turnover.

13 (NOVA2) protein is a major factor regulating neuron-specific alternative splicing (AS), previously as

14 ered an association between axonogenesis and neuron-specific alternative splicing.

15 described a unique neuroprotective role for neuron-specific alternatively spliced isoforms of endoph

16 They are typically neuron-specific, although recent evidence pointed to the

17 Together, neuron-specific and canonical IIS/FOXO-regulated targets

18 While the constitutive/neuron-specific and conditional/ubiquitous overexpressio

19 Both neuron-specific and GABA-specific recombination of the P

20 expression, yielded large sets of predicted neuron-specific and non-neuron-specific genes.

21 type-specific expression of circular RNAs-a neuron-specific and nuclear-enriched RNA arising from th

22 uirement for HSF-1 in this phenotype was IL2 neuron-specific and required the downstream expression o

23 icating that neuronal aging is an intrinsic, neuron-specific, and genetically regulated process.

24 s to glial-specific (antikeratin) as well as neuron-specific (anti-Hu) antigens, indicating that both

25 ether, these data identify OXR1 as the first neuron-specific antioxidant modulator of pathogenesis an

26 s PPIL1 patient mutation knockin mice showed neuron-specific apoptosis.

27 Using neuron-specific approaches to measure and manipulate kin

28 Neuron-specific AR signaling was required for the develo

29 Here, we used a forebrain neuron-specific aromatase KO (FBN-ARO-KO) mouse model to

30 These effects are neuron specific, as PS1 affects the EGFR of neither glia

31 Neuron-specific associations of the ArPIKfyve-Sac3 heter

32 ATP1A3 encodes the alpha-subunit of a neuron-specific ATP-dependent transmembrane sodium-potas

33 We generated ubiquitous and neuron-specific Bcl7a and Bcl7b single and double knocko

34 Using neuron-specific betaarr2-KO mice, we show that the antip

35 swimming and foraging, while systemic or V2a neuron-specific blockage of Mc4r promotes locomotion.

36 s, confirming Arc-dVenus to be an excitatory neuron-specific but non-layer-specific activity reporter

37 promoter, and two versions of the excitatory neuron-specific Ca(2+) /calmodulin-dependent kinase subu

38 t dynamin-1 (Dyn1), previously assumed to be neuron-specific, can be selectively activated in cancer

39 a neuron-derived exosomes (NDEs), containing neuron-specific cargo, has permitted characterization of

40 The neuron-specific cation chloride cotransporter KCC2 plays

41 Neuron-specific caveolin-1 overexpression improves motor

42 nd others showed that mutations in the major neuron-specific CerS1, which synthesizes 18-carbon fatty

43 regulate cell survival, differentiation, and neuron-specific characteristics.

44 We also generated CRISPR-mediated neuron-specific circadian clock knockouts.

45 In contrast to Drp1, the neuron-specific classical dynamin dynamin-1 (Dyn1) has b

46 apses of a nervous system are defined by the neuron-specific complement of electrical synapse constit

47 n a previous study, we showed that pyramidal-neuron specific conditional knockout (cKO) of syntaxin-4

48 brogating OGT, using a temporally controlled neuron-specific conditional knockout mouse model, recapi

49 enerated a pan-retinal and rod photoreceptor neuron-specific conditional KO mouse lacking MSI1 and MS

50 We identified a bipolar neuron-specific core regulatory circuit SE upstream of V

51 abnormal bioenergetic function, as well as a neuron-specific defect in glucose utilization, in the DL

52 Neuron-specific deletion of Ahr, or constitutive overexp

53 imals with GABA-neuron-specific or glutamate-neuron-specific deletion of Esr1.

54 Using genetic strategies enabling neuron-specific deletion of estrogen receptor alpha (Esr

55 but molecular and cellular phenotypes after neuron-specific deletion of H3K4 methyl-regulators remai

56 l deletion of Kiss1r (Kiss1r(-/-)) or a GnRH neuron-specific deletion of Kiss1r (Kiss1r(d/d)) display

57 Neuron-specific deletion of Notch genes decreased these

58 Arcuate proopiomelanocortin (POMC) neuron-specific deletion of Ptpn1 causes a similar, but

59 ith a neurogenic origin of these phenotypes, neuron-specific deletion of Scyl2 also caused perinatal

60 LepR neuron-specific deletion of Sh2b1 abrogates leptin-stimu

61 However, loss of AIS proteins by the neuron-specific deletion of the master AIS scaffold Anky

62 th global or corticotropin-releasing hormone neuron-specific deletion, had impaired systemic glucose

63 e enhanced following global, but not sensory neuron-specific, deletion of maternal Ube3a in mice.

64 in the ubiquitously expressed DYNC1H1 cause neuron-specific disease.

65 Here, we show that neuron-specific disruption of UPF2, an NMD component, in

66 osphatase 2A (PP2A) regulatory subunit, as a neuron-specific Drp1 activator in vivo Bbeta2 KO mice of

67 inal environment and to induce expression of neuron-specific effector mechanisms.

68 d US9 binding to these tegument proteins has neuron-specific effects on virus HSV assembly, a process

69 and another membrane protein, US9, which has neuron-specific effects, promote the anterograde transpo

70 er's disease and observed that expression of neuron-specific endophilin-B1 isoforms declined with dis

71 cortical neuron cultures, overexpression of neuron-specific endophilin-B1 isoforms protected against

72 Additionally, protein and mRNA levels of neuron-specific endophilin-B1 isoforms were also selecti

73 ease pathogenesis where amyloid-beta reduces neuron-specific endophilin-B1, which in turn enhances am

74 We found that rs31746 mapped to a long-range neuron-specific enhancer element shown previously to reg

75 ption factors (TFs), Isl1 and Lhx3, to motor-neuron-specific enhancers.

76 c receptors for the molecular recognition of neuron specific enolase (NSE) biomarker.

77 rs progastrin releasing peptide (ProGRP) and neuron specific enolase (NSE) is presented, which involv

78 cularly imprinted electrochemical sensor for neuron specific enolase (NSE) was developed by electroch

79 y selected and cysteine modified epitopes of neuron specific enolase (NSE), as-synthesized gold nanop

80 lpropyl)imidazolium bromine ionic liquid and neuron specific enolase (NSE).

81 % vs 11%; 23 vs 4%, respectively), and serum neuron specific enolase greater than 33 ng/mL (23% vs 8%

82 .e., the epitope) or a target protein (i.e., neuron specific enolase) in buffer.

83 duced increases in serum S100beta, GFAP, and neuron specific enolase.

84 urden, plasma chromogranin A (>/=600 mug/L), neuron-specific enolase (>/=25 mug/L), and classic gradi

85 tio, 5.58; 95% CI, 2.56-12.16), and elevated neuron-specific enolase (false-positive rate, 0.12; 95%

86 sensor for ultrasensitive diagnosis of human neuron-specific enolase (NSE) cancer biomarkers.

87 ection of carcinoembryonic antigen (CEA) and neuron-specific enolase (NSE) in a clinical sample with

88 Neuron-specific enolase (NSE) is a widely-used biomarker

89 has been successfully used for detection of neuron-specific enolase (NSE), a traumatic brain injury

90 ks were analyzed for the neuromarkers S100B, neuron-specific enolase (NSE), and glial fibrillary acid

91 ical (PEC) immunosensor for the detection of neuron-specific enolase (NSE).

92 Tau had higher accuracy than serum neuron-specific enolase (NSE; the area under the receive

93 /chemokine (C-C motif) ligand 2 (p = 0.030), neuron-specific enolase (p = 0.006), and S100b (p = 0.01

94 tivariate analysis, markedly elevated plasma neuron-specific enolase (P = 0.016; hazard ratio, 2.9; 9

95 uantitative PLR correlated with higher serum neuron-specific enolase (Spearman r = -0.52, p < 0.0001)

96 llin 2 [ADM2], histamine receptor H1 [HRH1], neuron-specific enolase [NSE] [ENO2], neuronal protein g

97 cancer had a higher level of tumor markers (neuron-specific enolase and cytokeratin fragment 21-1).

98 concentrations peaked earliest, followed by neuron-specific enolase and finally myelin basic protein

99 Finally we identified two TMs (neuron-specific enolase and pro-gastrin-releasing peptid

100 Serum neuron-specific enolase and S100b concentrations were in

101 eviously characterized biomarkers, including neuron-specific enolase and S100B protein.

102 acy, defined as the geometric area under the neuron-specific enolase curve from 24 to 72 hours after

103 ignificant differences in the area under the neuron-specific enolase curve, or a composite end point

104 Confounders of neuron-specific enolase elevation should be actively con

105 Performance Category 1-2 had confounders for neuron-specific enolase elevation.

106 icant changes were detected in the levels of neuron-specific enolase from preseason values (median, 6

107 corneal reflexes, presence of myoclonus, and neuron-specific enolase greater than 75 microg/L; accura

108 All three patients with neuron-specific enolase greater than 90 mug/L and Cerebr

109 d case reviews of good outcome patients with neuron-specific enolase greater than 90 mug/L and poor o

110 Using best specificity, serum S100b and neuron-specific enolase had optimal positive and negativ

111 em reflexes in normothermia (p = 0.013), and neuron-specific enolase higher than 33 mug/L (p = 0.029)

112 Neuron-specific enolase is an easily available, observer

113 than 90 mug/L and poor outcome patients with neuron-specific enolase less than or equal to 17 mug/L (

114 The majority of 14 patients with neuron-specific enolase less than or equal to 17 mug/L w

115 e score), the tumor burden, and the baseline neuron-specific enolase level.

116 Exenatide did not reduce neuron-specific enolase levels and did not significantly

117 (a total of 137 lactate dehydrogenase and 77 neuron-specific enolase observations), the statistical f

118 electroencephalography reactivity, and serum neuron-specific enolase offers the best outcome predicti

119 A neuron-specific enolase serum concentration greater than

120 An neuron-specific enolase serum concentration less than or

121 We analyzed neuron-specific enolase serum concentrations 3 days afte

122 Neuron-specific enolase serum concentrations less than o

123 High neuron-specific enolase serum concentrations reliably pr

124 Receiver operator curves for serum S100b and neuron-specific enolase to classify favorable versus unf

125 osensory evoked potentials (SSEP), and serum neuron-specific enolase were performed in parallel, as p

126 tion, electroencephalography reactivity, and neuron-specific enolase yielded the best predictive perf

127 y can potentially measure injury to neurons (neuron-specific enolase), astrocytes (S100b), and axons

128 rker profiles (progastrin-releasing peptide, neuron-specific enolase, and chromogranin-A) were analyz

129 Enrollment leptin, neuron-specific enolase, and intracellular cell adhesion

130 The baseline levels of chromogranin A, neuron-specific enolase, and multiple soluble angiogenic

131 Preliminary data show that serum S100b, neuron-specific enolase, and myelin basic protein may ai

132 serum biomarkers (matrix metallopeptidase-9, neuron-specific enolase, and vascular cellular adhesion

133 Additionally, S100 protein, neuron-specific enolase, beta-amyloid protein, tau prote

134 also measured fasting serum chromogranin A, neuron-specific enolase, gastrin, glucagon, vasoactive i

135 , somatosensory-evoked potentials, and serum neuron-specific enolase, is recommended; however, no stu

136 illary acidic protein, CD11b), and neuronal (neuron-specific enolase, neuronal nitric oxide synthase)

137 Elevated baseline chromogranin A, neuron-specific enolase, placental growth factor, and so

138 ient, and these markers include 14-3-3, tau, neuron-specific enolase, S100B, and alpha-synuclein.

139 We measured serum neuron-specific enolase, S100b, and myelin basic protein

140 nt protein 1/chemokine (C-C motif) ligand 2, neuron-specific enolase, S100b, intercellular adhesion m

141 le outcome were 2.89 (95% CI, 1.09-7.73) for neuron-specific enolase, using a cutoff of 62.0 ng/mL, a

142 ase elevation should be actively considered: neuron-specific enolase-producing tumors, acute brain di

143 , somatosensory-evoked potentials, and serum neuron-specific enolase.

144 previously reported biomarkers of acute IS (neuron-specific enolase: area under the curve=0.69; inte

145 stic link between pathology and differential neuron-specific epigenetic regulation in distinct brain

146 First, a survival-based screen revealed neuron-specific essential genes and genes that improved

147 ent that associate with DNA methylation of a neuron-specific exon 17 promoter of the glucocorticoid r

148 e alternative splicing of activity-dependent neuron-specific exons, and attenuation of normal differe

149 n the NPC-to-neuron transition by regulating neuron-specific exons.

150 sis (ALS), we generated transgenic mice with neuron-specific expression of a super-repressor form of

151 fully restored to that of CST (-/-) mice by neuron-specific expression of complex gangliosides, but

152 GNIFICANCE STATEMENT This study reports that neuron-specific expression of IkappaB super-repressor mi

153 diversity is specified during development by neuron-specific expression of key transcription factors,

154 ne a bipartite boundary element critical for neuron-specific expression of UBE3A-ATS in humans.

155 expressed in induced human neurons and that neuron-specific expression of USP6 enhances learning and

156 requires UBE3A-ATS expression, and no other neuron-specific factors.

157 s were diminished in both global and sensory neuron-specific Fcgr1 knockout mice.

158 on and gentle touch, less is known about the neurons specific for mechanical pain.

159 er RNA (mRNA) and ribosomes are in a masked, neuron-specific form.

160 In situ RNA hybridization supported neuron-specific formation of NEAT1-based paraspeckles at

161 Unlike other neuron-specific Foxo1 knockout mice, Foxo1KO(Nkx2.1) mic

162 ites, providing fundamental insight into the neuron-specific function of NMD within the brain.

163 Combining primary sensory neuron-specific GCaMP3 imaging with a trigeminal neuropa

164 We used constitutive and neuron-specific gene ablation models targeting an integr

165 -compacted promoter/proximal enhancer of the neuron-specific gene doublecortin (Dcx) Once differentia

166 We found GPe PV(+) neuron-specific gene expression changes that suggested i

167 for their normal epigenetic development and neuron-specific gene expression profiles, and regulates

168 se neuronal regulators include the family of Neuron-Specific Gene family members (Nsg), NEEP21 (Nsg1)

169 t food abundance is encoded by combinatorial neuron-specific gene-expression of conserved TGFbeta and

170 l recognized in ctenophores, many bilaterian neuron-specific genes and genes of 'classical' neurotran

171 Clusters of Hcrt-neuron-specific genes are predicted to be regulated by s

172 ic disorders associate with distinct sets of neuron-specific genes but converge onto shared loci with

173 1 binding to known regulatory regions of the neuron-specific genes Dcx and Th days or even weeks befo

174 resses a large array of coding and noncoding neuron-specific genes important to synaptic plasticity i

175 s revealed lower expression of multiple 5-HT neuron-specific genes in BN compared to control Dahl sal

176 Oligodendrocyte- and neuron-specific genes were strongly overrepresented amon

177 s are enriched for regulatory information of neuron-specific genes, that ASEs provide cell-specific r

178 H3K27 acetylation and a robust activation of neuron-specific genes.

179 ge sets of predicted neuron-specific and non-neuron-specific genes.

180 Sensory-neuron-specific genetic deletion/silencing or local or s

181 of tau pathology and neuron death in part by neuron-specific, glia-independent mechanisms.

182 These studies reveal a neuron-specific glutathione defense mechanism that is es

183 s study, we generated and characterized AgRP neuron-specific Gpr17 knockout mice (Agrp-Gpr17(-/-)) to

184 In summary, AgRP neuron-specific Gpr17 knockouts phenocopy FOXO1 knockout

185 A recently developed mouse line expressing a neuron-specific hemagglutinin (HA)-tagged H3.3 protein w

186 patients, is substituted by AP3beta3B in the neuron-specific heterotetramer.

187 We expressed neuron-specific (hSyn promoter) DREADDs that were either

188 ilt a novel mouse model, combining inducible neuron-specific IGF-1R knock-out with AD transgenics.

189 age, in both mammals and C. elegans, but the neuron-specific IIS/FOXO targets that regulate these fun

190 ic, in keeping with observations that US9 is neuron specific.IMPORTANCE Herpes simplex virus (HSV) an

191 Due to neuron-specific imprinting, the paternal UBE3A copy is s

192 virus particles were novel because they were neuron specific, in keeping with observations that US9 i

193 vulnerable regions of the human brain that a neuron-specific inflammatory response may precede insolu

194 To enable neuron-specific information processing these projections

195 Furthermore, using neuron-specific infusion of pharmacological agents and m

196 cific effects on anterograde run parameters, neuron-specific inhibition of mitochondrial transport by

197 We describe a new neuron-specific inhibitor of viral infections in the cen

198 alitis, yet little is known about the innate neuron-specific inhibitors of viral infections in the CN

199 Here we identify neuron-specific intercellular adhesion molecule 5 (ICAM-

200 Dynamin-1, which was thought to be neuron specific, is activated by the Akt/GSK3beta signal

201 The neuron-specific isoform JNK3 is required for neuron dege

202 However, the role of the neuron-specific isoform JNK3 is unclear.

203 We found that a neuron-specific isoform of LSD1, LSD1n, which results fr

204 t studies suggest that dynamin-1, a presumed neuron-specific isoform of the large, membrane fission G

205 egulatory pathway allows the production of a neuron-specific isoform of unc-44 and an inhibitory isof

206 KCC2 is a neuron specific K(+)-Cl(-) co-transporter that controls

207 ne gradient of chloride, which is set by the neuron-specific K(+)-Cl(-) co-transporter KCC2.

208 KCC2 is a neuron-specific K(+)-Cl(-) cotransporter essential for e

209 Here we demonstrate that neuron-specific K(+)-Cl(-) cotransporter2 (KCC2) is a cr

210 ro functional assays, we establish that the "neuron-specific" K(+)Cl(-) co-transporter 2 (KCC2, Slc12

211 We propose that the long-time considered "neuron-specific" KCC2 co-transporter is expressed in pan

212 KIF3AC is a mammalian neuron-specific kinesin-2 implicated in intracellular ca

213 Sensory neuron-specific knock-out of OGT results in behavioral h

214 Using CIM6P/IGF2R inhibition in rats and neuron-specific knockdown in mice, here we show that hip

215 -of-function studies of Chrono including Avp neuron-specific knockout (KO) mice display a longer circ

216 ressed conditions in mice, while systemic or neuron-specific knockout of Pdcd4 reverses CRS-induced d

217 In behavior analyses, granule neuron-specific knockout of RNF8 or UBC13 impairs cerebe

218 Active transcription of the neuron-specific long non-coding RNA (lncRNA), UBE3A-ATS,

219 Here we examined the effect of the DA neuron-specific loss of GIRK channels on D2R-dependent r

220 Using neuron-specific manipulations combined with immunocytoch

221 o regulate distinct behavioral outcomes in a neuron-specific manner is poorly understood.

222 techniques influence synaptic responses in a neuron-specific manner.

223 Neuron-specific mapping of the genome-wide distribution

224 te of DCX-labeled cells by using mitotic and neuron-specific markers, retrograde tracings, and immedi

225 ion in infected neurons, thereby revealing a neuron-specific mechanism of metabolite-mediated ZIKV co

226 ssential homeostatic process in neurons, but neuron-specific mechanisms are poorly understood.

227 l-color live-cell imaging to investigate the neuron-specific mechanisms of constitutive autophagosome

228 (2020) report a neuron-specific microexon in eIF4G translation initiatio

229 miR-132 is a neuron-specific microRNA and plays a pivotal role in syn

230 We find that a neuron-specific microRNA, miR-138, represses expression

231 These miRs, especially the neuron-specific miR-124-3p, are potentially internalized

232 We hypothesized that motor neuron-specific miRNA expression changes are involved in

233 e investigated the role of a brain-enriched, neuron-specific miRNA, miR-124-3p, whose expression is h

234 We find that neuron-specific misexpression of TRP-4, the pore-forming

235 hiverer and then genetically deleted a major neuron-specific mitochondrial anchoring protein Syntaphi

236 In this study, we generated neuron-specific Mkk7 knockout mice (MKK7 cKO), which imp

237 rategy for neurodegenerative disease, but no neuron-specific modulators of caspase signaling have bee

238 Using viral-mediated, isoform and neuron-specific molecular tools, we find that the indivi

239 ptor DCC and DSCAM with polymerized TUBB3, a neuron-specific MT subunit in the brain, is required for

240 ework to further explore chip-scale axon and neuron specific neural stimulation, with future applicat

241 vation and neuronal demise is due to severe, neuron-specific, nicotinamide adenine dinucleotide (NAD(

242 pyramidal neurons using forebrain pyramidal neuron specific NMDA receptor 1 knockout mice.

243 mice with genetic manipulations targeting a neuron-specific nucleosome remodelling complex subunit,

244 Mice with either LepR neuron-specific or adult-onset, hypothalamus-specific ab

245 ects could be recapitulated in mice with pan-neuron-specific or cholinergic neuron-specific ablation

246 d by genetically manipulated mice with D2(+) neuron-specific or global deletion of p11.

247 (lox/lox) line to generate animals with GABA-neuron-specific or glutamate-neuron-specific deletion of

248 Using sensory neuron-specific overexpression of GRK2 or its kinase-dea

249 the constitutive/ubiquitous and conditional/neuron-specific overexpression of Hus1, mnk, mei-9, mus2

250 of neuronal structure and function, yet the neuron-specific pathways within which they act are poorl

251 ing protein, which makes the primarily motor neuron-specific phenotype rather unexpected.

252 -Enriched protein tyrosine Phosphatase) is a neuron-specific phosphatase that regulates N-methyl-D-as

253 Synapsin III (SynIII) is a neuron-specific phosphoprotein that plays a unique role

254 in mature neurons is largely mediated by the neuron-specific potassium-chloride cotransporter KCC2.

255 al in male Wistar rats and in male mice with neuron-specific PPARgamma deletion (PPARgamma((-/-))) an

256 that this protein may normally control some neuron-specific process.

257 are not required for gene expression and/or neuron-specific processing in the SNURF/SNRPN-UBE3A regi

258 that while RBFOX1 and RBFOX2 do not mediate neuron-specific processing of UBE3A-ATS, these proteins

259 P under the control of this putative sensory neuron specific promoter was generated and characterized

260 sociated viral vectors, driven by excitatory neuron-specific promoter elements, to manipulate circuit

261 rrying the human GBA gene under control of a neuron-specific promoter to an nGD mouse model.

262 t within cis-regulatory sequences, including neuron-specific promoters and superenhancers, affected b

263 The use of neuron-specific promoters can direct staining to mammali

264 ein-associated protein B (VAPB) protein with neuron-specific promoters have provided some insight int

265 This network enabled the discovery of the neuron-specific protein CRMP1 that targets aggregation-p

266 Here we examine the role of this neuron-specific protein in hippocampal plasticity and co

267 terminal hydrolase L1 (UCHL1), also known as neuron-specific protein PGP9.5 (PGP9.5) and Parkinson di

268 The induced neurons express neuron-specific proteins, generate action potentials and

269 The induced neuronal cells expressed various neuron-specific proteins, their mRNA expression during n

270 synGAP is a neuron-specific Ras and Rap GTPase-activating protein (G

271 Using 5-HT neuron-specific reduction of 5-HT1A autoreceptor gene ex

272 ith AgRP-Cre mice to generate mice with AgRP neuron-specific rescue of LepR.

273 The neuron specific RNA-binding proteins NOVA1 and NOVA2 are

274 trocytes and microglia, regulated in part by neuron-specific RNA-binding proteins NOVA2 and PTBP2.

275 lar heterogeneity, we also investigated a DA neuron-specific SGK1 knockout (KO).

276 Functional inhibition and neuron-specific silencing of PKCdelta attenuated spontan

277 Forebrain neuron-specific Sirt1 knock-out closely recapitulated th

278 Here we generated global and sensory neuron-specific Slack mutant mice and analyzed their beh

279 ge, LH surges could be induced in almost all neuron-specific SOCS3 knock-out mice on this diet.

280 We used neuron-specific SOCS3 knock-out mice to elucidate this a

281 As expected, male and female neuron-specific SOCS3 knock-out mice were protected from

282 adiol-induced GnRH/LH surge were overcome by neuron-specific SOCS3 knock-out.

283 ) was expressed under control of the sensory neuron-specific sodium channel (sns) gene to selectively

284 Vertebrates have evolved a neuron-specific splice variant of C-Src, N1-Src, which d

285 Perineuronal nets (PNNs) are conspicuous neuron-specific substructures within the extracellular m

286 AP3B2 encodes the neuron-specific subunit of the AP-3 complex.

287 Excitatory neuron-specific targeting was promoter-dependent, with a

288 To test if BoNT/C1 ad retains neuron-specific targeting without concomitant toxic host

289 ial to eliminate toxicity without disrupting neuron-specific targeting, thereby creating a molecular

290 IIS/FOXO neuron-specific targets are distinct from canonical IIS/

291 V)-GFP-Syntaxin1, all under the control of a neuron-specific Thy-1 promoter.

292 L) and PSEN1(L166P) under the control of the neuron-specific Thy-1 promoter; referred to here as 'APP

293 ellular accumulation, which was indicated by neuron-specific transcript analysis.

294 ibroblasts to neurons, we found that the pan neuron-specific transcription factor Myt1-like (Myt1l) e

295 We also studied the role of neuron-specific transcripts in the blood of healthy adul

296 Dozens of Hcrt-neuron-specific transcripts were identified and comprehe

297 d in Tsc2-deficient neurons, as well as in a neuron-specific Tsc1 conditional knock-out mouse model,

298 We find that neuron-specific Tsc1 deletion results in an increase in

299 rs is dependent on chloride extrusion by the neuron-specific type 2K(+)-Cl(-) cotransporter (KCC2).

300 nal is genetically controlled and determines neuron-specific variation in peptidergic function.