ライフサイエンスコーパス: neuronal activity

1 signals, phototoxicity, and unphysiological neuronal activity).

2 variable and was positively correlated with neuronal activity.

3 pha-synuclein depend on specific patterns of neuronal activity.

4 gonists, aiming to perturb, but not abolish, neuronal activity.

5 have ultraweak photon emission (UPE) during neuronal activity.

6 ion, and therefore possibly able to modulate neuronal activity.

7 cial step in electrophysiological studies of neuronal activity.

8 , whereas later in development it suppresses neuronal activity.

9 xpression in a distinct manner compared with neuronal activity.

10 dicating that increasing BIN1 drives greater neuronal activity.

11 nal enhancers that appear to be modulated by neuronal activity.

12 pal size, phenocopying the inhibition of Crz neuronal activity.

13 ost widely employed techniques to manipulate neuronal activity.

14 invisible to standard methods of monitoring neuronal activity.

15 ise from nonsinusoidal signals ubiquitous in neuronal activity.

16 tatic responses are tightly coordinated with neuronal activity.

17 ulates the balance of lick- and taste-driven neuronal activity.

18 input elicit homeostatic plastic changes in neuronal activity.

19 ular H(+) loads associated with increases in neuronal activity.

20 kinetics of the ionic channels that underlie neuronal activity.

21 e wavelength GECIs, when used for imaging of neuronal activity.

22 he membrane potential of neurons, and, thus, neuronal activity.

23 s whose progression is robustly regulated by neuronal activity.

24 a neural stem cell grafts, and modulation of neuronal activity.

25 quately to the increase in energy demands of neuronal activity.

26 ty, exhibiting changes indicative of altered neuronal activity.

27 axis is involved in HCAR1 downmodulation of neuronal activity.

28 role in controlling normal and pathological neuronal activity.

29 erates natural oscillations from coordinated neuronal activity.

30 elial genes whose expression is regulated by neuronal activity.

31 ng-term plasticity in response to changes in neuronal activity.

32 re modified in strength during physiological neuronal activity.

33 e context of behaviorally driven patterns of neuronal activity.

34 F4G1 function and chemogenetic inhibition of neuronal activity.

35 io and more precise evaluation of correlated neuronal activity.

36 ges in alpha evoked by osmotic challenge and neuronal activity.

37 synaptic plasticity are tightly regulated by neuronal activity.

38 ns gene expression, cardiac contraction, and neuronal activity.

39 tatic maintenance of physiological levels of neuronal activity.

40 by recurrent seizures driven by synchronous neuronal activity.

41 s an fMRI-based surrogate of "resting-state" neuronal activity.

42 o ion channels, enabling rapid modulation of neuronal activity.

43 coincided with enhanced cFos expression for neuronal activity.

44 ns in slc12a2b/NKCC1b mutants is affected by neuronal activity.

45 in which blood flow was not correlated with neuronal activity.

46 r autocrine factor in regulating hippocampal neuronal activities.

47 or choosing regions of interest in recording neuronal activities.

48 calcium signaling responds to alterations in neuronal activity across a wide range.

49 de arrays, in vivo, to simultaneously record neuronal activity across all laminae of the spinal dorsa

50 There were four major findings: First, neuronal activity adjusted the balance between SUMO conj

51 a direct causal relationship between newborn neuronal activity and affective behavior.

52 nd suggest a key role for Kir as a sensor of neuronal activity and an amplifier of retrograde electri

53 or A(1)R are essential for the regulation of neuronal activity and animal behaviour.

54 at microglia are also critical modulators of neuronal activity and associated behavioural responses i

55 imits increases in cerebral perfusion during neuronal activity and augments decreases in cerebral per

56 ms involving Epha/Efna signaling, correlated neuronal activity and axon competition.

57 ly reversible control of cellular signaling, neuronal activity and behavior.

58 mHtt aggregates is inversely correlated with neuronal activity and blocked by inhibiting caspases in

59 maging, we identified defects in spontaneous neuronal activity and calcium signaling in both organoid

60 ssociated neurons, iGECI detects spontaneous neuronal activity and electrically and optogenetically i

61 d ablation or genetic manipulations to alter neuronal activity and examined the effects on synaptic i

62 er rates in cultured brain cells under basal neuronal activity and found that protein turnover is inf

63 BLA neuronal activity and function, such as fear conditionin

64 normally positive effects of estrogen on SF1 neuronal activity and glucose balance control to paradox

65 le astrocyte acts as a delay factor for fast neuronal activity and integrates fast neuronal sensory p

66 ay provide a powerful tool to reveal dynamic neuronal activity and intra-axonal transport function as

67 However, the relationship between neuronal activity and intracellular calcium in these neu

68 be essential for large-scale coordination of neuronal activity and investigate here whether genuine C

69 cies below ~100 Hz is a pervasive feature of neuronal activity and is thought to regulate communicati

70 ownstream of BDNF to critically regulate VMH neuronal activity and metabolic function.

71 id production corresponding to the levels of neuronal activity and metabolism.

72 cate that neuropeptides can effectively tune neuronal activity and modulate locomotor output patterns

73 cers influence neuronal function, increasing neuronal activity and modulating the function of the cir

74 inued expansion of fluorescent reporters for neuronal activity and novel strategies for indicator exp

75 Neuronal activity and orientation/direction selectivity

76 are initiated improves our ability to model neuronal activity and our interpretation of electrophysi

77 iPSC-derived neurons with rapamycin reduced neuronal activity and partially reversed gene expression

78 eural processing, including those induced by neuronal activity and proposed as a substrate for a pote

79 distinct from synaptic plasticity driven by neuronal activity and requires increased postsynaptic di

80 t of dopamine release and cell-type-specific neuronal activity and simultaneous subsecond monitoring

81 The iMSN-D2Rs modulate neuronal activity and synaptic transmission, exerting co

82 GCs contribute to chronic pain by augmenting neuronal activity and that these changes are consistent

83 lyses is that the relationship between local neuronal activity and the blood oxygenation level depend

84 lelic mutations in TSC2 resulted in elevated neuronal activity and upregulation of cell adhesion gene

85 tical microscopy of rapid, cellular-resolved neuronal activity and whole-brain macroscopy of slow hae

86 espond to neuronal activation by suppressing neuronal activity, and ablation of microglia amplifies a

87 siological and optical methods for measuring neuronal activity, and requires no training.

88 Interestingly, astrocyte-induced DMS neuronal activities are regulated by adenosine metabolis

89 Stimuli that modulate neuronal activity are not always detectable, indicating

90 that govern whether and how attention alters neuronal activity are not known.

91 In the brain, attention-related changes in neuronal activity are observed in widespread structures.

92 By contrast, in response to heightened neuronal activity, ARNT2 recruits the neuronal-specific

93 is hypothesized to bidirectionally regulate neuronal activity around a stable set point to compensat

94 Thus, our results identify neuronal activity as a critical target of early-life str

95 d mice exhibited normal synaptic density and neuronal activity as measured by density of VGLUT2(+) pu

96 ation, a widespread operation that describes neuronal activity as the ratio of a numerator (represent

97 that the vasculature responds to changes in neuronal activity associated with experience by regulati

98 g tracking microscopy to monitor whole-brain neuronal activity at cellular resolution in freely movin

99 tage indicators (GEVIs) enable monitoring of neuronal activity at high spatial and temporal resolutio

100 Optical technologies allowing modulation of neuronal activity at high spatio-temporal resolution are

101 processing in the brain requires monitoring neuronal activity at high spatiotemporal resolution.

102 Toll-2 gain of function and neuronal activity at the critical period increased cell

103 The absence of PlexA1, neuronal activity, Bax and Bak, or caspase-9 leads to th

104 c, and behavioral approaches, we reveal that neuronal activity bidirectionally balances microglial as

105 Traveling patterns of neuronal activity-brain waves-have been observed across

106 (WM) may not always be stored in persistent neuronal activity but can be maintained in 'activity-sil

107 vels, it modulates synaptic transmission and neuronal activity, but at much higher levels mediates ne

108 to be sensitive to the level of spontaneous neuronal activity, but the specifics of how neurotransmi

109 Here, we show that increasing neuronal activity by chronic treatment with the FDA-appr

110 Using varied animal models that stimulate neuronal activity by peripheral inflammation, optogeneti

111 n as satellite glial cells (SGCs) potentiate neuronal activity by releasing pro-inflammatory cytokine

112 We show here that long-term increase of neuronal activity by the FDA-approved drug 4-aminopyridi

113 We have developed a technique to record neuronal activity by using a coaxial guide tube and shar

114 Neuronal activity can be modulated by mechanical stimuli

115 ystem, where behavior, circuit function, and neuronal activity can be precisely quantified.

116 Neuronal activity can modify Alzheimer's disease patholo

117 , including Abeta, and for understanding how neuronal activity can modulate diurnal processes.

118 ng rate homeostasis in response to increased neuronal activity can occur in the absence of neuronal-a

119 defined as abnormal transient discharges of neuronal activity, can affect the entire brain circuitry

120 e intrinsic calcium transient as a marker of neuronal activity changes in the narcoleptic VGAT-Cre mi

121 Strikingly, we found that blocking neuronal activity completely prevented and could even re

122 more, previous studies of the BLA have found neuronal activity consistent with a value representation

123 retardation protein (FMRP) target mRNAs and neuronal activity contributing to elevated basal neurona

124 novel mechanism by which autophagy regulates neuronal activity: control of intrinsic excitability via

125 We sought to understand whether neuronal activity could regulate BBB properties.

126 es brain hyperemia provides insight into how neuronal activity couples with endothelial cells.

127 s the NCoR2 co-repressor complex to suppress neuronal activity-dependent regulatory elements and main

128 cal brain extracellular pH homeostasis via a neuronal activity-dependent release of bicarbonate.

129 s of the mutant mice exhibit impaired global neuronal activity-dependent transcription in response to

130 or normal brain function, and that defective neuronal activity-dependent transcription may be a mecha

131 Here, we show that neuronal activity-driven Bax/Bak-caspase signaling induc

132 Neuronal activity drives growth of glial malignancies th

133 ings showed elevated infralimbic cortex (IL) neuronal activity during CS onset and freezing cessation

134 Analyzing neuronal activity during human seizures is pivotal to un

135 llum must regulate the dimensionality of its neuronal activity during motor learning and control to c

136 ing learning revealed changes in phasic mPFC neuronal activity during risky-seek actions but not duri

137 me cells. Therefore, we recorded hippocampal neuronal activity during spatial working memory and aske

138 vision (VMHvl) revealed distinct patterns of neuronal activity during USV(+) and USV(-) mounting, and

139 Characterizing acute ischemic neuronal activity dynamics is important for understandin

140 We evaluated and compared neuronal activity (e.g., network formation and maturatio

141 Persistent alterations in neuronal activity elicit homeostatic plastic changes in

142 -to-threshold mechanism, in which increasing neuronal activity elicits each action independently at s

143 calcium imaging as a quantitative readout of neuronal activity for ultrasound neuromodulation.

144 een local and global processing, we recorded neuronal activity from the primary visual cortex (V1) of

145 We recorded AIP neuronal activity from two macaques while they observed

146 Population-level recording of neuronal activity further revealed potential subcircuit-

147 Taken together, our findings show that neuronal activity has the potential to modify TSPO level

148 Recent studies have shown that increases in neuronal activity have an important role in the prolifer

149 Axon guidance molecules and neuronal activity have been implicated in the establishm

150 he NMDA activated NO pathway on sound-driven neuronal activity imply a key role for NO signaling in a

151 wn about its expression or direct effects on neuronal activities in the hippocampus.

152 ms are a fundamental and defining feature of neuronal activity in animals including humans.

153 ggesting that the astrocyte would respond to neuronal activity in any of the sensory modalities, perh

154 hypersynchrony after physiologically evoked neuronal activity in awake adult mice.

155 pressing (GFAP(+)) glia modulate nociceptive neuronal activity in both the peripheral nervous system

156 d ratio by 27-fold, and enabled recording of neuronal activity in culture with 60-s temporal resoluti

157 GCaMP6, has been used to successfully record neuronal activity in deeper neocortical layers and parts

158 llows tracking of dopaminergic signaling and neuronal activity in distinct circuits in vivo.

159 kefulness and sleep in auditory cortex (AC), neuronal activity in downstream regions remains unknown.

160 hanism: seeing lip movements first modulates neuronal activity in early visual cortices at frequencie

161 We tested the role of neuronal activity in oligodendrogenesis, using designed

162 Here, we explored whether increasing neuronal activity in one of these projection areas could

163 Reduced neuronal activity in patient-derived NRXN1(+/-) hiPSC-ne

164 ic tools that allow high-fidelity control of neuronal activity in preclinical models have begun to el

165 so prevented MD- and FC-induced reduction of neuronal activity in response to visual or conditioned a

166 s a minimally invasive tool for manipulating neuronal activity in rodent and primate models with fewe

167 Whether or how such movements affect neuronal activity in sensory cortical areas remains larg

168 such as balancing excitation and structuring neuronal activity in space and time.

169 naptic loss, motor neuron death, and reduced neuronal activity in spinal sensory-motor circuits.

170 studies were designed to examine the role of neuronal activity in stress-induced CSF1 signaling and m

171 Neuronal activity in the brain is variable, yet both per

172 ic acid type A (GABA(A)) receptors to dampen neuronal activity in the brain(1-5).

173 ial behaviour deficits by directly affecting neuronal activity in the central nervous system.

174 Interestingly, either inhibition of neuronal activity in the cortex or deletion of Bax/Bak i

175 tations, such as synaptic scaling, stabilize neuronal activity in the face of perturbations.

176 em: acting as a sensory network, they detect neuronal activity in the form of elevated extracellular

177 , indicating that its reversal is not due to neuronal activity in the graft.

178 on within APP suppressed in vivo spontaneous neuronal activity in the hippocampus of anesthetized Thy

179 main about whether and how tES can influence neuronal activity in the human brain.

180 Neuronal activity in the lateral habenula (LHb), a brain

181 k shows that chronic stress induces aberrant neuronal activity in the medial PFC, and that neuronal h

182 nnovative optogenetic approach, we increased neuronal activity in the mouse superior colliculus, a ma

183 imaging, we detected evoked and spontaneous neuronal activity in the mouse visual cortex, with fluor

184 rience shapes the interplay between CREB and neuronal activity in the neocortex of awake mice.

185 Here we show that neuronal activity in the OFC is causal to economic choic

186 To test these hypotheses, we recorded neuronal activity in the orbitofrontal and anterior cing

187 , we conclude that regulated interactions of neuronal activity in the prefrontal-amygdala pathways cr

188 ral rescue was accompanied by a reduction in neuronal activity in the primary somatosensory cortex dy

189 Here we show that neuronal activity in the primary somatosensory cortex ti

190 hallmarks result in an overall reduction of neuronal activity in the spinal sensory-motor circuit.

191 Behavior can be guided by neuronal activity in visual, auditory, or somatosensory

192 red by all-optical laser scanning, we imaged neuronal activity in vivo at up to 3,000 frames per seco

193 ches have been used to manipulate and record neuronal activity in vivo, with a recent focus on techno

194 e transfer of EVs from blood is triggered by neuronal activity in vivo.

195 1 PHOTOACTIVATED QUASAR3 (PAQUASAR3) REPORTS NEURONAL ACTIVITY IN VIVO.: a, Schematic of the paQuasAr

196 cells that express cFos protein, an index of neuronal activity, in brain tissue and benchmarked it ag

197 periods-reflecting transient suppressions of neuronal activity-in the area surrounding focal cortical

198 d movements result in overall suppression of neuronal activity; in ambient light, the same head movem

199 Inhibition of Crz neuronal activity increased pupal size, whereas it hardl

200 iately after plantar formalin injection, DRG neuronal activity increases substantially and this activ

201 To characterize network-level changes in neuronal activity induced by chronic opiate exposure, we

202 glia-neuron interactions and demonstrate how neuronal activity influences microglial process dynamics

203 Yet how neuronal activity influences these processes remains lar

204 clude that local Process S dynamics reflects neuronal activity integrated over time, and global Proce

205 Neuronal activity is associated with transmembrane ionic

206 Spatiotemporally synchronised neuronal activity is central to sensation, motion and co

207 Perturbation of neuronal activity is key to understanding the brain's fu

208 sible mechanism by which attention modulates neuronal activity is to control the efficacy of communic

209 rocytes, while its role in the regulation of neuronal activity is unknown.

210 fluctuations in blood oxygenation (indexing neuronal activity) is relevant for neuronal specializati

211 Additionally, hypoactive shifts in neuronal activity (isoflurane anesthesia and CaMKIIa Gi

212 control seems to depend most prominently on neuronal activity itself.

213 However, hyperactive shifts in neuronal activity (kainate status epilepticus and CaMKII

214 Neuronal activity leads to an increase in local cerebral

215 We investigated whether alterations in RFRP neuronal activity led to changes in puberty onset, ferti

216 whereas individual mutant isoforms decrease neuronal activity levels in control hiPSC-neurons.

217 te that modulation of chronic stress-induced neuronal activity limits microglia-mediated neuronal rem

218 Neuronal activity mapping revealed bilateral motor corte

219 n three-dimensional snapshots of whole-brain neuronal activity maps using single OA excitations, and

220 ridization to quantify the colabeling of the neuronal activity marker Fos, and dopamine Drd1- and Drd

221 s reveal how the Sema6D-PlexA1 signaling and neuronal activity may play a cooperative role in refinin

222 d outline future directions to elucidate how neuronal activity might influence these processes.

223 n the present study, we investigated whether neuronal activity modifies TSPO levels in the adult cent

224 wn to play a role in generating the aberrant neuronal activity observed in TLE.

225 Here we show that neuronal activity of hippocampal mossy cells is enhanced

226 hese subcortical structures, we recorded CDh neuronal activity of macaque monkeys before and during u

227 tric systems for simultaneous measurement of neuronal activity of male zebra finches and vocalization

228 Further, neuronal activity often relies critically on these chemi

229 However, monitoring neuronal activity over long periods of time is technical

230 es to collagenase was accompanied by altered neuronal activity (p = 0.002) and elevated neuronal MMP-

231 precisely determine the interaction between neuronal activity patterns and transcription factor acti

232 n from primary visual cortex (V1) population neuronal activity patterns in 24 human adults (17 female

233 Perceptual experiences may arise from neuronal activity patterns in mammalian neocortex.

234 r protecting memories is the reactivation of neuronal activity patterns representing those memories.

235 ed synaptic vesicle dynamics and changed the neuronal activity patterns.

236 In oscillatory systems, neuronal activity phase is often independent of network

237 Previous research showed that spontaneous neuronal activity presents sloppiness: the collective be

238 pends on finely tuned interactions to afford neuronal activity propagation over long distances while

239 he role of glia in supporting and modulating neuronal activity, providing compelling evidence of glia

240 likely because of interrupting the timing of neuronal activity rather than excitability, as stimulati

241 experience-dependent synapse elimination and neuronal activity reduction.

242 E STATEMENT Both axon guidance molecules and neuronal activity regulate axon elimination to refine ne

243 Our work reveals a neuronal activity-regulated role for microglia in modify

244 euronal activity can occur in the absence of neuronal-activity-regulated transcription.SIGNIFICANCE S

245 In particular, neuronal activity regulates BBB efflux transporter expre

246 edominant source of central serotonin, where neuronal activity regulates complex emotional behaviors.

247 However, how neuronal activity regulates synaptic vesicle recycling i

248 Furthermore, we found that neuronal activity regulates the expression of circadian

249 indicate that NKCC1b is required to maintain neuronal activity-related solute homeostasis at the axon

250 ef goal in neuroscience is to understand how neuronal activity relates to behavior, perception, and c

251 the generation and maintenance of sequential neuronal activity remain unclear.

252 al-time and direct monitoring of large-scale neuronal activity remains difficult, owing to the perfor

253 Thus, OFC neuronal activity represents a long-term cue-reward asso

254 Thus, neuronal activity restores synaptic connections and impr

255 study reveals that 4-AP-induced increase of neuronal activity restores synaptic connectivity and fun

256 ly used in optogenetics to optically control neuronal activity, rhodopsins that function with longer-

257 ally organized correlate of locally recorded neuronal activity (Schwalm et al., 2017).

258 of ischemic pathophysiology and determining neuronal activity signatures of ischemia.

259 (i)-coupled receptors for the fine tuning of neuronal activity.SIGNIFICANCE STATEMENT Expression of t

260 First, we measured neuronal activity simultaneously in early [primary visua

261 To gain a more objective measure of the neuronal activity that contributes to patient symptoms a

262 Our study demonstrates that neuronal activity that is induced by acute stress can dr

263 eceptors (GPCRs) is critical for controlling neuronal activity that shapes neuromodulatory outcomes.

264 pse can be modulated in vivo by the state of neuronal activity, that autophagosomes undergo UNC-16/JI

265 Stimulating neuronal activity through chemogenetic (DREADDs), physio

266 GABBR2 inhibits neuronal activity through G protein-coupled second-messe

267 ifically respond to bi-directional shifts in neuronal activity through increased calcium signaling.

268 sible synaptic plasticity rules can organize neuronal activity to form sequences whose statistics mat

269 Our model uses neuronal activity to predict expected time of future mot

270 needs and must coordinate relevant brainwide neuronal activity to produce the appropriate behavior.

271 the repellent signaling of Sema6D-PlexA1 and neuronal activity to regulate axon elimination.SIGNIFICA

272 feedforward signaling mechanism that couples neuronal activity to the homeostatic maintenance of axon

273 9), an endopeptidase secreted in response to neuronal activity, to contribute to the antidepressant e

274 The basic structure of the neuronal activity underlying hand control is thus fundam

275 cal utility of HFOs, the spatial context and neuronal activity underlying these local field potential

276 To explore how cortical neuronal activity underpins sequence discrimination, we

277 events abstinence-induced increases in dBNST neuronal activity, underscoring the therapeutic potentia

278 tracking, which both demonstrated consistent neuronal activity upon repeated stimulation.

279 nal properties, including neurite length and neuronal activity, using multielectrode arrays and patch

280 ransistor-based construct to monitor in vivo neuronal activity via a longitudinal study in mice and u

281 ow doses of DCZ (1 or 3 mug per kg) enhanced neuronal activity via hM3Dq within minutes in mice and m

282 Intrinsic neuronal activity was assessed using resting-state blood

283 A dramatic pause of neuronal activity was recorded immediately prior to the

284 As hypercapnia is known to suppress neuronal activity, we studied whether naked mole-rats mi

285 Behavior and neuronal activity were significantly influenced by the o

286 n the task similarly relied on increments in neuronal activity when activity has costs.

287 isplay fast kinetics, similar to spontaneous neuronal activity, whereas sustained responses last seve

288 al bioenergetics is dynamically coupled with neuronal activities, which are altered by hypoxia-induce

289 r, and elevated Drd1-signaling decreases SCN neuronal activity, which we posit disinhibits downstream

290 Recording cell-specific neuronal activity while monitoring behaviors of freely m

291 PO mRNA and protein levels after stimulating neuronal activity with distinct stimuli, including desig

292 itical for coupling the metabolic demands of neuronal activity with excitatory neurotransmission.SIGN

293 Imaging neuronal activity with high and homogeneous spatial reso

294 lity to remotely and non-invasively modulate neuronal activity with millimeter precision.

295 lanted in the rat cerebral cortex can detect neuronal activity with remarkably high signal-to-noise r

296 d WM requires either persistent or transient neuronal activity, with stable or dynamic representation

297 intracellular calcium serves as a readout of neuronal activity within lamina I neurons, providing a u

298 Visual stimulation and locomotion increased neuronal activity without affecting somato-dendritic cou

299 proposed modulatory effect of irradiation on neuronal activity without causing cellular death require

300 anching rates are commonly used as models of neuronal activity, yet they lack any such time-dependenc