ライフサイエンスコーパス: neuronal differentiation

1 d interventions can guide them through their neuronal differentiation.

2 em to study changes driving and accompanying neuronal differentiation.

3 hange to a glial morphology and reduction in neuronal differentiation.

4 disrupted wild type NSCs demonstrate delayed neuronal differentiation.

5 ies of Zeb2 are required for EDN3 to prevent neuronal differentiation.

6 the microtubule-actomyosin interfaces during neuronal differentiation.

7 up-regulation of specific genes critical for neuronal differentiation.

8 e insulin-like peptides, which induce lamina neuronal differentiation.

9 duces Pax6 expression, whereas Ebf1 promotes neuronal differentiation.

10 ulates synaptic gene expression and inhibits neuronal differentiation.

11 spensable for their maintenance and controls neuronal differentiation.

12 or, Ptch1, in control of cell signalling and neuronal differentiation.

13 horizontal basal cells (HBCs) and subsequent neuronal differentiation.

14 isions while in markedly disparate stages of neuronal differentiation.

15 hand, resulted in only partial inhibition of neuronal differentiation.

16 pression of glycolytic enzymes and decreased neuronal differentiation.

17 and ameliorated the observed alterations in neuronal differentiation.

18 d expression of ZEB2 but did not undergo any neuronal differentiation.

19 stem cells (aNSCs) affects proliferation and neuronal differentiation.

20 x2 and Nestin, and lacks markers of glial or neuronal differentiation.

21 ng to neuronal migration delays, and altered neuronal differentiation.

22 t can trigger signaling pathways involved in neuronal differentiation.

23 tional requirement of Cdk5 activation during neuronal differentiation.

24 nal regulator of FKBP5 and can contribute to neuronal differentiation.

25 to Eurl impair progenitor proliferation and neuronal differentiation.

26 progenitor pool, and subsequently increased neuronal differentiation.

27 group binding at the MNX1 locus during early neuronal differentiation.

28 xidation state of cytosolic glutathione upon neuronal differentiation.

29 l neurogenesis, neural plate patterning, and neuronal differentiation.

30 own-regulating mTOR expression and promoting neuronal differentiation.

31 crease of Cdk5 activity during rat and mouse neuronal differentiation.

32 l as cellular structure changes accompanying neuronal differentiation.

33 ne expression which is essential for correct neuronal differentiation.

34 the UPS and the chaperones tightly controls neuronal differentiation.

35 ion of genes pertaining to proliferation and neuronal differentiation.

36 ing exclusively and redundantly in promoting neuronal differentiation.

37 nelle fusion and promoted the early phase of neuronal differentiation.

38 der endogenous conditions in a cell model of neuronal differentiation.

39 itive and negative role on proliferation and neuronal differentiation.

40 ed EZCs without altering oligodendroglial or neuronal differentiation.

41 we find that NPCs place an early priority on neuronal differentiation.

42 tion in this context is essential for proper neuronal differentiation.

43 on of hiPSCs via cellular reprogramming, and neuronal differentiation.

44 vels at its target promoters and compromises neuronal differentiation.

45 uction is only responsible for astrocyte and neuronal differentiation.

46 e networks of HVC of singing males concerned neuronal differentiation.

47 pe of poised genes activated at the onset of neuronal differentiation.

48 al glia proliferation and prevents premature neuronal differentiation.

49 s regulate the initiation and progression of neuronal differentiation.

50 ntral to neural progenitor proliferation and neuronal differentiation.

51 cells (NPCs), Ybx1 controls self-renewal and neuronal differentiation.

52 hanism underlies the Hox control of terminal neuronal differentiation.

53 behind the morphogenetic furrow to allow for neuronal differentiation.

54 gets by controlling target proliferation and neuronal differentiation.

55 central nervous system and thereby supports neuronal differentiation.

56 ebrain specification, cell proliferation, or neuronal differentiation.

57 xis, and of the transition of progenitors to neuronal differentiation.

58 and to mediate signaling by RTKs that induce neuronal differentiation.

59 purinoceptors induced a two-step process of neuronal differentiation.

60 ing c-Fos expression or its activity impairs neuronal differentiation.

61 nscriptional regulatory networks controlling neuronal differentiation.

62 n progenitors, where G34R/V mutations impair neuronal differentiation.

63 ting that this molecule negatively regulates neuronal differentiation.

64 tation specifically affects NPC survival and neuronal differentiation.

65 genesis and the transition of progenitors to neuronal differentiation.

66 lipid synthesis-activating activity impaired neuronal differentiation.

67 tion, recover H3K4me3 signalling and improve neuronal differentiation.

68 These proteins are related to neuronal differentiation.

69 g of downstream transcription factors during neuronal differentiation.

70 borders that act as a source or regulator of neuronal differentiation.

71 lls and its levels increase in parallel with neuronal differentiation.

72 gulatory and morphologic changes during iPSC-neuronal differentiation.

73 te properly, with a pronounced deficiency in neuronal differentiation.

74 l in vitro gene expression profiles of human neuronal differentiation.

75 n of gain-of-function mutant channels during neuronal differentiation.

76 lear movement and spatially varying rates of neuronal differentiation.

77 l progenitors and, subsequently, postmitotic neuronal differentiation, a relatively poorly understood

78 on the stability of Ngn2 protein and on its neuronal differentiation activity in vivo in the develop

79 ine-Proline (SP) sites for regulation of its neuronal differentiation activity, although the potentia

80 on of the progenitor population, and delayed neuronal differentiation, all key features of the develo

81 Genes up-regulated during in vitro neuronal differentiation also displayed a tendency for u

82 cells reduced cell proliferation and induced neuronal differentiation, an effect phenocopied by miR-1

83 can be established during earlier stages of neuronal differentiation and (ii) neurogenic niches in t

84 ETH on rat multipotent NSC proliferation and neuronal differentiation and adult hippocampal neurogene

85 lter the expression of genes associated with neuronal differentiation and apoptosis, as well as synap

86 NCCs is sufficient to recapitulate premature neuronal differentiation and apoptotic death of neural p

87 ls steadily increase at the AIS during early neuronal differentiation and at the same time closely sp

88 d with a transcriptional program that favors neuronal differentiation and decreases recurrence-free s

89 3 accumulation mainly near genes involved in neuronal differentiation and dendrite formation.

90 rs regulates physiological processes such as neuronal differentiation and dendritic and axonal growth

91 nd morphine treatment in vitro increases NSC neuronal differentiation and dendritogenesis, suggesting

92 yonic mouse cortex, Pnky knockdown increases neuronal differentiation and depletes the NSC population

93 mmalian brain and upregulated in response to neuronal differentiation and depolarization.

94 confirm that EMSCs can promote intrinsic NSC neuronal differentiation and domesticating astrocyte beh

95 progenitor development, neuronal migration, neuronal differentiation and early neuronal connectivity

96 Localized isoforms were induced during neuronal differentiation and enriched for motifs associa

97 y, we demonstrate that ATXN3 is required for neuronal differentiation and for normal cell morphology,

98 DIPG proliferative potential, by repressing neuronal differentiation and function.

99 e the gene expression patterns necessary for neuronal differentiation and function.

100 yses we found that (1) MYT1L is required for neuronal differentiation and identified ID1, a HLH inhib

101 pigenetic changes, consistent with increased neuronal differentiation and in correlation with changes

102 l transcription factor ASCL1 leads to robust neuronal differentiation and inhibits clonogenic potenti

103 the multifunctional co-receptor Cdo promotes neuronal differentiation and is important for the functi

104 g early zygote formation, embryogenesis, and neuronal differentiation and is intolerant to haploinsuf

105 sitive non-invasive, real-time monitoring of neuronal differentiation and maturation are highly deman

106 E) and is a transcription factor involved in neuronal differentiation and maturation.

107 canonical roles of developmental cues during neuronal differentiation and maturation.

108 t MOR mediates the effect of morphine on NSC neuronal differentiation and maturation.

109 icated in many important functions including neuronal differentiation and memory formation.

110 results reveal unexpected parallels between neuronal differentiation and mesenchymal-to-epithelial t

111 ssion of genes that regulate the cell cycle, neuronal differentiation and migration in NfiB(-/-) brai

112 monstrated that sumoylation of Foxp1 affects neuronal differentiation and migration in the developing

113 loss leads to aberrations in proliferation, neuronal differentiation and migration in the embryonic

114 be a very useful tool for quality control of neuronal differentiation and moreover, for neurogenic co

115 idating the influences of mechanical cues on neuronal differentiation and neuritogenesis.

116 and signaling pathways play crucial roles in neuronal differentiation and plasticity.

117 in like growth factor-1 receptor (IGF-1R) on neuronal differentiation and polarization in vivo in mam

118 ~1100 transcripts and ~2200 proteins during neuronal differentiation and polarization.

119 mimics human opiate addiction, increases NSC neuronal differentiation and promotes neuronal dendrite

120 sults demonstrate a novel role for ARID1B in neuronal differentiation and provide new insights into t

121 ETH enhanced NSC proliferation and neuronal differentiation and reduced Abeta toxin-mediate

122 8 and miR-137, which are co-expressed during neuronal differentiation and simultaneously lost in glio

123 g the untimely activation of genes promoting neuronal differentiation and stem cell quiescence.

124 implicated in opiate dependence, whether NSC neuronal differentiation and subsequent dendritogenesis

125 APC expression, thereby driving neocortical neuronal differentiation and suppressing oligodendrocyte

126 neurotrophic factor (BDNF) is essential for neuronal differentiation and survival.

127 f microglia, and cell autonomously regulates neuronal differentiation and survival.

128 Rho family GTPases play integral roles in neuronal differentiation and survival.

129 rs can alter the expression of regulators of neuronal differentiation and synapse formation and funct

130 K1A is a serine/threonine kinase involved in neuronal differentiation and synaptic plasticity and a m

131 Zinc and copper are involved in neuronal differentiation and synaptic plasticity but the

132 eam of precocious cell cycle exit, premature neuronal differentiation, and abnormal mitosis patterns.

133 deficient IGF-1-dependent Akt signaling and neuronal differentiation, and accordingly, Sox2-dependen

134 ation of genes associated with neurogenesis, neuronal differentiation, and function.

135 d the proliferation of NPCs, inhibited their neuronal differentiation, and impaired the excitatory sy

136 r cell proliferation, induction of premature neuronal differentiation, and interruption of neural tis

137 n factors, neurogenesis, the cell cycle, and neuronal differentiation, and m(6)A tagging promotes the

138 -derived cell (ENCC) proliferation, promoted neuronal differentiation, and reduced expression of Gdnf

139 he brain play a role in learning and memory, neuronal differentiation, and regulation of the stress r

140 ding proliferation of neural progenitors and neuronal differentiation, and stimulated neurite outgrow

141 ion of genes involved in cell proliferation, neuronal differentiation, and synaptic assembly.

142 ox protein, MEC-15, have opposing effects on neuronal differentiation, and that the chaperones negati

143 that the majority of genes activated during neuronal differentiation are silent in neural stem cells

144 Focusing on neuronal differentiation as a model, we observed that sl

145 Depletion of Phf21b in vivo inhibited neuronal differentiation as cortical progenitors lacking

146 lation of layer formation and layer-specific neuronal differentiation at prenatal developmental stage

147 Neural connectivity requires neuronal differentiation, axon growth, and precise targe

148 urogenic program, including Notch signaling, neuronal differentiation, axon guidance and synapse form

149 receptor TrkC play crucial trophic roles in neuronal differentiation, axon outgrowth, and synapse de

150 rbofuran-altered TGF-beta signaling impaired neuronal differentiation (BrdU/DCX(+) and BrdU/NeuN(+) c

151 es in conjunction with retinoic acid-induced neuronal differentiation brings about progeny virus prop

152 erized the effects on human neurogenesis and neuronal differentiation brought about by MeCP2 deficien

153 developmental process, with a requirement in neuronal differentiation but not cell survival.

154 Nup210 as a critical regulator of muscle and neuronal differentiation, but how this nucleoporin exert

155 TRKA and RET signaling, two RTKs that induce neuronal differentiation, but retained responses to EGFR

156 at carbofuran inhibits NSC proliferation and neuronal differentiation by altering TGF-beta signaling.

157 bution of FlnA/AR complex and PI3-K delta to neuronal differentiation by androgens and NGF is also no

158 NGF induces neuronal differentiation by modulating [Ca(2+)]i.

159 The transcription factor ztf-11 promotes neuronal differentiation by repressing other cell fates

160 exon of Flna in NPCs, Rbfox proteins promote neuronal differentiation by switching Ninein from a cent

161 vidual BMPs promote progenitor patterning or neuronal differentiation by their activation of differen

162 r regulator of epithelial polarity, controls neuronal differentiation by transcriptionally repressing

163 These findings reveal that in vitro human neuronal differentiation can be used to translate the po

164 Early replacement of PTBP1 by PTBP2 during neuronal differentiation causes a concerted set of splic

165 We demonstrate that upon neuronal differentiation, cellular demand for copper inc

166 -) induced stem cells exhibit an inefficient neuronal differentiation combined with an increased cell

167 more severe enteric anomalies and increased neuronal differentiation compared to mice with mutations

168 Zeb2(Delta/+) EPCs had increased neuronal differentiation compared to Zeb2(+/+) cells.

169 expression exhibited higher NPC numbers and neuronal differentiation compared with aged WT animals.

170 actor (REST), a master negative regulator of neuronal differentiation, controls neurogenesis by preve

171 -124 in embryonic carcinoma cells undergoing neuronal differentiation correlated with down-regulation

172 r, rescues the cell growth, translation, and neuronal differentiation defects associated with the EIF

173 Loss of Cln5 results in neuronal differentiation deficits and delays in interneu

174 iptional regulator is known to contribute to neuronal differentiation during development and to progr

175 dditionally enriched for modules involved in neuronal differentiation during fetal development.

176 h are generally quiescent and do not undergo neuronal differentiation during homeostasis, we show tha

177 s-mediated control of NPCs' self-renewal and neuronal differentiation during mammalian corticogenesis

178 t activate the G protein Galphas and promote neuronal differentiation evoke Galphas internalization i

179 at enhancement of miR-34a expression impairs neuronal differentiation, expression of synaptic protein

180 .6 x 10(-2) to 3.4 x 10(-5)) and accelerated neuronal differentiation following treatment with all-tr

181 y validated, including identifying a role in neuronal differentiation for phosphosites in SMARCC2, a

182 rturbations revealed a functional overlap in neuronal differentiation for the cotargeting pair miR-13

183 ls of FTLD-Tau by Neurogenin2-induced direct neuronal differentiation from FTLD-Tau patient iPSCs.

184 at the neural-specific lncRNA Pnky regulates neuronal differentiation from neural stem cells and medi

185 , significantly correlate with expression of neuronal differentiation genes and better prognosis but

186 represses the expression of region-specific neuronal differentiation genes, thereby controlling the

187 arget whose activation promotes silencing of neuronal differentiation genes.

188 The presence and role of UNC-45A in neuronal differentiation have been largely unknown.

189 (aNSCs) and MBD1 deficiency leads to reduced neuronal differentiation, impaired neurogenesis, learnin

190 Accordingly, miR-511 increased neuronal differentiation in cells and enhanced neuronal

191 elated to synapse formation, maintenance and neuronal differentiation in CSB neurons using unbiased R

192 This suggested that delays in neuronal differentiation in epb41l5-deficient embryos ar

193 ZEB2 and EWS, which regulates metastasis and neuronal differentiation in ES, respectively.

194 il to exit the cell cycle underlies aberrant neuronal differentiation in low choline embryos.

195 ently enhanced NSC proliferation and reduced neuronal differentiation in mice, increasing the numbers

196 s between multiple regulatory factors during neuronal differentiation in mice, we characterised genom

197 ction of a small subset of cPCDH genes after neuronal differentiation in monolayers, 10-month-old cor

198 ue experiments, revealed that EZH2 represses neuronal differentiation in neuroblastoma in a PRC2-depe

199 Fibrinogen inhibited neuronal differentiation in SVZ and hippocampal NSPCs wh

200 er of proliferating NSCs and neuroblasts and neuronal differentiation in the dentate gyrus (DG) of th

201 , we demonstrate that ARID1B is required for neuronal differentiation in the developing brain, such a

202 l cytoskeletal dynamics and is essential for neuronal differentiation in the developing brain.

203 ETH potently induced NSC proliferation and neuronal differentiation in the hippocampus-derived NSC

204 iatal development, also supported by reduced neuronal differentiation in the LGE of Meis1(-/-) embryo

205 nscript abundance across postnatal stages of neuronal differentiation in vivo and in culture.

206 RhoGEFs are implicated in various aspects of neuronal differentiation, including dendritogenesis and

207 Therefore, neuronal differentiation is associated with upregulation

208 progenitors are not maintained normally and neuronal differentiation is compromised: rx3-derived ff1

209 Neuronal differentiation is inhibited in the hippocampus

210 Thus, TrkB-dependent neuronal differentiation is involved in the sustained an

211 sults suggest that the apparent hierarchy of neuronal differentiation is not irreversible and that li

212 t whether and how they relate to TF-directed neuronal differentiation is poorly investigated.

213 nly observed in individuals with CHARGE, and neuronal differentiation is reduced in CHARGE patient-de

214 ously proposed that the timing of vertebrate neuronal differentiation is regulated by molecular oscil

215 How metabolism is reprogrammed during neuronal differentiation is unknown.

216 op SNPs were mapped to genes associated with neuronal differentiation, locomotor behaviour, schizophr

217 igodendrocyte marker gene PPP1R14a and other neuronal differentiation marker genes.

218 Expression of neuronal differentiation markers is ablated in both KIF1

219 companied by premature ectopic expression of neuronal differentiation markers.

220 r that regulates chromatin and expression of neuronal differentiation markers.

221 sed in the nervous system where it regulates neuronal differentiation, migration and axonal outgrowth

222 ent, but mechanistic studies have focused on neuronal differentiation, migration, and synaptogenesis,

223 over 5 broad conditions: self-renewal, early neuronal differentiation, neural precursor cells (NPCs),

224 During neuronal differentiation, nonfunctional ORs are expresse

225 42 peptides and impairs the self-renewal and neuronal differentiation of adult hippocampal neural pro

226 eficiency could reduce the proliferation and neuronal differentiation of adult neural stem cells in v

227 Focusing on the first hours of neuronal differentiation of adult subventricular zone-de

228 , but to impairments in the self-renewal and neuronal differentiation of AHNPCs that modulate affecti

229 brain neural stem cells, the activation and neuronal differentiation of enteric glia are regulated b

230 Pretreatment with METH also decreased neuronal differentiation of HIV-infected NPCs in both in

231 the first time, that SGSMs do not affect the neuronal differentiation of hNPCs while selectively decr

232 several genes simultaneously and stimulating neuronal differentiation of human induced pluripotent st

233 we report that NONO plays a key role during neuronal differentiation of mESCs.

234 strongly suppressed Rap2a, thereby promoting neuronal differentiation of neural stem cells (NSCs) and

235 For example, soft substrates promote the neuronal differentiation of neural stem cells (NSCs) by

236 in some neuroblastoma cell lines and induced neuronal differentiation of NGP cells.

237 gulated genes but also rescues the defective neuronal differentiation of Nono-deficient mESCs.

238 cts of calcium channels and purinoceptors on neuronal differentiation of normal mouse embryonic stem

239 Nonetheless, the neuronal differentiation of NPCs that proliferated durin

240 overexpression of Mbd3 significantly blocked neuronal differentiation of NPCs, and Mbd3 depletion res

241 ex plays a critical role in self-renewal and neuronal differentiation of NPCs.

242 ing molecules into lipid rafts for promoting neuronal differentiation of NSCs, and meanwhile, inhibit

243 esion site incurs massive astroglial but not neuronal differentiation of NSCs.

244 somal methylation activity and MLL4-mediated neuronal differentiation of NT2/D1 cells.

245 eased to regulate MOR gene expression during neuronal differentiation of P19 cells, suggesting a cons

246 tional as it displayed the ability to induce neuronal differentiation of PC12 cells.

247 differentially promote the proliferation and neuronal differentiation of qNSCs, aNSCs, and TACs.

248 Thus, we studied the impact of SGSMs on the neuronal differentiation of ReNcell VM (ReN) human neura

249 vitro multi-electrode arrays (MEAs) and the neuronal differentiation of stem cells offers the capabi

250 Also, the treatment with AgNPs increased 44% neuronal differentiation of the harvested NSCs.

251 rs involved in the induction, patterning and neuronal differentiation of the hypothalamus, highlighti

252 the precocious and transient acceleration of neuronal differentiation of these cells.

253 ects of each single therapy, and facilitated neuronal differentiation of transplanted cells and matur

254 abnormal blood vessel networks and advanced neuronal differentiation of tumor cells.

255 2 is essential for controlling apoptosis and neuronal differentiation of V-SVZ progenitors before and

256 d find the seasonal gene networks related to neuronal differentiation only in the HVC.

257 PSCs) that were subjected to either directed neuronal differentiation or differentiation into cerebra

258 er release in human neurons without changing neuronal differentiation or synapse formation.

259 lar model sensitive to small perturbation of neuronal differentiation pathways.

260 theoretical model support the proposal that neuronal differentiation pattern is regulated by transie

261 In the zebrafish retina, neuronal differentiation proceeds in two stages with emb

262 for sensitive and quantitative monitoring of neuronal differentiation processes.

263 e transdifferentiation is closely related to neuronal differentiation processes.

264 NPCs, thus enabling proper activation of the neuronal differentiation program under neurogenic cue.

265 ate neural progenitor cell proliferation and neuronal differentiation programs observed in vivo remai

266 ional cascades otherwise required to execute neuronal differentiation programs.

267 to overcome these inefficiencies and improve neuronal differentiation protocols, we need to take into

268 cific proteins, their mRNA expression during neuronal differentiation recapitulated embryonic neuroge

269 n CRISPR/Cas9-edited organoids produce early neuronal differentiation, reduced progenitor self-renewa

270 that function in cellular morphogenesis and neuronal differentiation, reflecting cardinal features o

271 The role of NCAM2 in neuronal differentiation remains, however, poorly unders

272 in Zeb2(Delta/+) EPCs restored inhibition of neuronal differentiation, similar to incubation of Zeb2(

273 hannel anchoring mechanisms depending on the neuronal differentiation state.

274 applying compounds that are known to promote neuronal differentiation such as the gamma-secretase inh

275 terferes with neurodegeneration but promotes neuronal differentiation, suggesting that stabilization

276 ST is a master regulator of neurogenesis and neuronal differentiation that has not been previously im

277 ired for nerve growth factor (NGF)-dependent neuronal differentiation through anterograde transport o

278 Our data indicate a role of AR in neuronal differentiation through regulation of APC/C(Cdh

279 NCX3 isoforms could play a relevant role in neuronal differentiation through the modulation of [Ca(2

280 y, these data show that NCX1 participates in neuronal differentiation through the modulation of ER Ca

281 vate identity-specific effector genes during neuronal differentiation to define the structural and fu

282 e findings suggest the environment modulates neuronal differentiation to optimize the behavior of the

283 pha and ERRgamma increase significantly upon neuronal differentiation to sustain the transcription of

284 Coupling retinoic acid (R), an inducer of neuronal differentiation, to VP pulse stimulation attenu

285 vailing model suggests that N1-Src regulates neuronal differentiation via cytoskeletal dynamics in th

286 Using this method, neuronal differentiation was comparable between the thre

287 To identify chromatin mechanisms of neuronal differentiation, we characterized chromatin acc

288 To elucidate the role of DNA methylation in neuronal differentiation, we developed a new protocol fo

289 to single pluripotent stem cells undergoing neuronal differentiation, we discover that up to 20% of

290 ndidate circRNAs for a potential function in neuronal differentiation, we find that circZNF827 repres

291 These proteins, which play ancient roles in neuronal differentiation were first recruited to the dor

292 associated with the progress and quality of neuronal differentiation were identified.

293 that neurogenesis, neuronal development, and neuronal differentiation were likely controlled by these

294 inhibitory effects on NSC proliferation and neuronal differentiations were also mitigated by Drp-1 i

295 ranscription factor) and NeuN (biomarker for neuronal differentiation) were investigated together wit

296 APP expression remained stable during neuronal differentiation, whereas APP processing changed

297 the robustly increased Cdk5 activity during neuronal differentiation, which activator is responsible

298 mbryonic RGCs by stimulating their premature neuronal differentiation while preventing quiescence in

299 are involved in progenitor proliferation and neuronal differentiation whilst miR-934 inhibition resul

300 activity acts as a sensor to directly couple neuronal differentiation with redox environments in the