ライフサイエンスコーパス: neuronal migration

1 dyslexia (DD) owing to its important role in neuronal migration.

2 ndent of normal neocortical neurogenesis and neuronal migration.

3 c of the model cargo Cadherin-2 also reduces neuronal migration.

4 /3 complex is a cell-autonomous regulator of neuronal migration.

5 RNAi have comparable effects on postmitotic neuronal migration.

6 they displayed significant defects in GnRH-1 neuronal migration.

7 leading process during the terminal phase of neuronal migration.

8 nic brain, including progenitor division and neuronal migration.

9 demonstrate that cytoplasmic FBXO41 promotes neuronal migration.

10 ted proteins that regulate axon guidance and neuronal migration.

11 nctions, such as hypoxic preconditioning and neuronal migration.

12 cerebral cortex, a consequence of defective neuronal migration.

13 ar brush cells (UBCs), indirectly disrupting neuronal migration.

14 the centrosome and the nucleus, and disrupts neuronal migration.

15 evelopment, particularly in neurogenesis and neuronal migration.

16 embryos, cilia appear to be dispensable for neuronal migration.

17 downstream target of PHF6 in the control of neuronal migration.

18 onarily conserved role for this cell type in neuronal migration.

19 nt in the nasal mucosa and subsequent GnRH-1 neuronal migration.

20 gely in floor plate cells to regulate caudal neuronal migration.

21 thin the bounds of the nuclear lamina during neuronal migration.

22 ecreted and short-range guidance cues direct neuronal migration.

23 ers focal adhesion size and number to effect neuronal migration.

24 of human PROKR2) during early stages of GnRH neuronal migration.

25 and GRD domains of Dab2ip are important for neuronal migration.

26 ssion of phosphomimetic Ser2512 FLNA impairs neuronal migration.

27 ed calcium permeability, thereby fine-tuning neuronal migration.

28 ding domain of Nesprin-2 was dispensable for neuronal migration.

29 adhesions, thereby disrupting cell intrinsic neuronal migration.

30 nesin, is sufficient, remarkably, to support neuronal migration.

31 ctor known to guide axon/dendrite growth and neuronal migration.

32 tubule organization during cell division and neuronal migration.

33 reased BDNF may mediate cocaine's effects on neuronal migration.

34 e migratory and stationary phases to sustain neuronal migration.

35 sion is critical for proper neurogenesis and neuronal migration.

36 chanism that maintains actin dynamics during neuronal migration.

37 This illustrates the role of rotatin in neuronal migration.

38 polar to bipolar transition and glial-guided neuronal migration.

39 erotopia, presumably caused by disruption of neuronal migration.

40 loping brain, uPA induces neuritogenesis and neuronal migration.

41 ed effects in the auditory system but not in neuronal migration.

42 progenitor proliferation, morphogenesis, and neuronal migration.

43 and severely and dominantly disrupt cortical neuronal migration.

44 in Reelin signaling, a critical regulator of neuronal migration.

45 cells (OEC) is imperative for normal GnRH-1 neuronal migration.

46 a nuclear translocation process required for neuronal migration.

47 lan involving angiogenesis, neurogenesis and neuronal migration.

48 ing and neuronal-branching regulation during neuronal migration.

49 nstream targets involved in neurogenesis and neuronal migration.

50 neural progenitors in vivo is detrimental to neuronal migration.

51 merase 2, and Integrator similarly regulates neuronal migration.

52 e cerebral cortex and allow for the study of neuronal migration.

53 ired for normal progenitor proliferation and neuronal migration.

54 mplex that controls CDK5 activity to promote neuronal migration.

55 tein Reelin is an important factor directing neuronal migration.

56 mpairs critical developmental events such as neuronal migration.

57 ed for their effect on CAMK2 function and on neuronal migration.

58 how Reelin controls the cytoskeleton during neuronal migration.

59 s to brain malformation and abnormalities of neuronal migration.

60 d no evidence for overt radial or tangential neuronal migrations.

61 neuronal abnormalities indicative of altered neuronal migration [4].

62 Neuronal migration, a key event during brain development

63 ases stable microtubules and leads to slower neuronal migration, abnormal centrosome position and abe

64 nd its dysfunction in PDE is associated with neuronal migration abnormalities and other structural br

65 ese mice before the onset of seizures reveal neuronal migration abnormalities, reduced number of inte

66 The neuronal migration abnormality is explained by a weakene

67 ore complex environment for neurogenesis and neuronal migration, adding new arenas in which neurodeve

68 Dab2ip down-regulation severely disrupts neuronal migration, affecting preferentially late-born p

69 otubule-associated protein, is essential for neuronal migration, although a clear mechanistic underst

70 These include cargoes involved in neuronal migration and a Drosophila snx6 mutant displays

71 Mutations in human LIS1 cause abnormal neuronal migration and a smooth brain phenotype known as

72 rsectin 1 (ITSN1) in mice leads to defective neuronal migration and ablates Reelin stimulation of hip

73 In the developing CNS, TSP-1 is involved in neuronal migration and adhesion, neurite outgrowth, and

74 e cerebral cortex that results from impaired neuronal migration and although several genes have been

75 eoglycans (HSPGs), are essential to regulate neuronal migration and axon development.

76 s essential roles in neuronal proliferation, neuronal migration and axon guidance and has been implic

77 neurodevelopmental disorder with defects in neuronal migration and axon outgrowth.

78 ssential roles in neural development include neuronal migration and axon pathfinding.

79 CDC2 in ciliary function, which affects both neuronal migration and axonal outgrowth.

80 proteins with overlapping functions in both neuronal migration and axonal outgrowth.

81 e a variety of cellular functions, including neuronal migration and axonal pathfinding in the brain.

82 e have reported that Big2 inhibition impairs neuronal migration and binds to FlnA, and its loss promo

83 Loss of Arf1 activity disrupts neuronal migration and cell adhesion.

84 lin dependent kinase 5 (Cdk5) contributes to neuronal migration and cell cycle control during embryog

85 l insights and fresh perspectives concerning neuronal migration and connectivity in the mesencephalon

86 individuals revealed that genes critical for neuronal migration and cortex organization (TUBG1, FLNA,

87 omologous to mechanisms that regulate radial neuronal migration and cortical lamination in the develo

88 ) axons, whereas EphA7 affects both cortical neuronal migration and CT axon guidance.

89 we identify a novel cytoplasmic regulator of neuronal migration and demonstrate that its inactivation

90 eelin signaling pathway, and is critical for neuronal migration and dendrite outgrowth during develop

91 e dominant-negative form of ARF6 rescues the neuronal migration and dendritic outgrowth defects induc

92 ral development, such as cell proliferation, neuronal migration and differentiation, providing a reli

93 on of new neurons, neuronal development, and neuronal migration and differentiation.

94 BicD2 cargo and help explain BicD2's role in neuronal migration and human disease.

95 rs for upper layer neurons leads to impaired neuronal migration and inappropriate branching, sponge-m

96 ngation of cilia is not essential for proper neuronal migration and laminar organization or establish

97 osome 7q11.23, including genes important for neuronal migration and maturation (LIMK1 and CLIP2), is

98 rotein-2 (MeCP2) dysfunction on iPSC-derived neuronal migration and maturation (reduced neurite outgr

99 demonstrate an essential role of TBC1D24 in neuronal migration and maturation and highlight the phys

100 in is an extracellular protein essential for neuronal migration and maturation during development, an

101 The DYX1C1 has also been shown to affect neuronal migration and modulate estrogen receptor signal

102 Similar, albeit less striking, neuronal migration and morphological defects were observ

103 Defects in early neuronal migration and morphology, electrophysiological

104 s morphological abnormalities and defects in neuronal migration and morphology.

105 onment plays a critical role in coordinating neuronal migration and neurite outgrowth during neural c

106 and CSPG-coated substrate on cell adhesion, neuronal migration and neurite outgrowth.

107 y of membrane protein complexes required for neuronal migration and neuroependymal integrity.

108 protein, and demonstrate a role for VRK1 in neuronal migration and neuronal stem cell proliferation.

109 associated with neurogenesis, axonogenesis, neuronal migration and neurotransmission.

110 its orthologs regulate conserved aspects of neuronal migration and outgrowth in the nervous system b

111 ggest that Rnasel-1 plays important roles in neuronal migration and pathfinding as well as in angioge

112 n-5 regulates the rate and directionality of neuronal migration and possibly the cessation of migrati

113 (MT)-associated proteins (MAPs) involved in neuronal migration and process outgrowth.

114 lin receptors, as evidenced by the prominent neuronal migration and radial glial defects in hippocamp

115 Here, we document severe defects in neuronal migration and reduced numbers of neurons in lam

116 ent is associated with extensive deficits in neuronal migration and substantial hypertrophy of neuron

117 cently emerged as a molecular determinant of neuronal migration and synapse formation during cortical

118 pression of MIG-10 isoforms rescued both the neuronal migration and the canal outgrowth defects, show

119 nnectivity in the cerebral cortex; defective neuronal migration and the resultant connectivity change

120 neurons is already established during their neuronal migration and well before significant synapse f

121 at is disrupted in MKS and causes defects in neuronal migration and Wnt signalling.

122 egulates the expression of genes involved in neuronal migration, and a functional assay showed that C

123 4 haploinsufficiency mice exhibit a delay in neuronal migration, and a significant increase in the nu

124 rk1 knockdown significantly impairs cortical neuronal migration, and affects the cell cycle of neuron

125 developmental events such as cell division, neuronal migration, and axon guidance are still prominen

126 ve been previously associated with dyslexia, neuronal migration, and ciliary function.

127 vestigated defects in cortical neurogenesis, neuronal migration, and differentiation in NfiB(-/-) bra

128 anscripts involved in cell cycle regulation, neuronal migration, and differentiation in qNSCs.

129 ain subunits, motors of nucleokinesis during neuronal migration, and in human induced pluripotent ste

130 the KIF20B minimal binding domain inhibited neuronal migration, and in vivo migration assays suggest

131 ant increase in cell and head size, aberrant neuronal migration, and induction of seizures, concordan

132 ges of cell proliferation and specification, neuronal migration, and late cortical organisation.

133 precursor proliferation and differentiation, neuronal migration, and neurite outgrowth.

134 me activity is important for neuritogenesis, neuronal migration, and neurodevelopment.

135 w role for NEUROD2 during the late stages of neuronal migration, and our analysis of its genomic targ

136 neuronal function during cell proliferation, neuronal migration, and postmigrational development: the

137 of RG cells to provide a stable scaffold for neuronal migration, and suggest that the transition in m

138 transients that determine neuronal polarity, neuronal migration, and synapse assembly in the developi

139 animals that have defects in axon guidance, neuronal migration, and the outgrowth of the processes o

140 rted genetic perturbations to disrupt normal neuronal migration-and thus positioning-in a population

141 The molecular etiologies of neuronal migration anomalies are highly enriched for gen

142 Contemporary models for neuronal migration are grounded in the view that virtual

143 We find that adult neurogenesis and neuronal migration are not unusual in naked mole rat bra

144 h serve as both stem cells and scaffolds for neuronal migration, are crucial for cortical development

145 primates, with implications for patterns of neuronal migration, area patterning, and cortical foldin

146 that cocaine can alter tangential and radial neuronal migration as well as BDNF expression in the emb

147 , displacement of mitotic NPCs, and impaired neuronal migration, as assessed both ex vivo and in vivo

148 e stress (MSR3B), ubiquitination (FBXW8) and neuronal migration (ASTN2), as well as enzymes targeted

149 that radial glia function as a scaffold for neuronal migration at early stages of tectal development

150 ding neural progenitor cell differentiation, neuronal migration, axon extension and the folding of th

151 tors and neurotrophic factors that influence neuronal migration, axon guidance pathways, and neurite

152 formation requires the precise regulation of neuronal migration, axon guidance, and dendritic arboriz

153 re recently, including in the later steps of neuronal migration, axon navigation, and synaptogenesis.

154 t the NOVA family of RBPs play a key role in neuronal migration, axon outgrowth, and axon guidance.

155 tor (RhoGEF) TRIO acts as a key regulator of neuronal migration, axonal outgrowth, axon guidance, and

156 hypothyroxinemia in rodents induces cortical neuronal migration brain lesions resembling those of aut

157 tablish that IP6K1 physiologically regulates neuronal migration by binding to alpha-actinin and influ

158 n to activate signalling cascades regulating neuronal migration by binding to lipoprotein receptors.

159 Both Rnd2 and Rnd3 promote neuronal migration by inhibiting RhoA signaling, but the

160 Finally, Zac1 controlled neuronal migration by regulating Pac1 transcription, a r

161 lamina in neurons, perhaps through abnormal neuronal migration, causes the epilepsy and early ataxia

162 utcome compared to those related to abnormal neuronal migration (class II) or abnormal cortical organ

163 pendymal disruption, but the extent to which neuronal migration contributes to this phenotype is unkn

164 gulates several biological processes such as neuronal migration, cytoskeletal dynamics, axonal guidan

165 This syndrome may arise from a neuronal migration defect during development caused by d

166 r material, and knockdown of Cep85l causes a neuronal migration defect in mice.

167 craniofacial features, ocular colobomata and neuronal migration defect.

168 ental phenotypes, including brain growth and neuronal migration defects, astrogliosis and oxidative s

169 of SDCCAG8 carrying a human mutation causes neuronal migration defects.

170 genital muscular dystrophies associated with neuronal migration defects.

171 ions of brain cortical development caused by neuronal migration defects.

172 s, we demonstrated that MTOR p.S2215F caused neuronal migration delay and cytomegaly, while RPS6 p.R2

173 asymmetric centrosome inheritance leading to neuronal migration delays, and altered neuronal differen

174 Type I lissencephaly is a neuronal migration disorder caused by haploinsuffiency o

175 Type I lissencephaly, a neuronal migration disorder characterized by cognitive d

176 Cobblestone brain malformation (COB) is a neuronal migration disorder characterized by protrusions

177 ht into how cortactin and DCX, a known human neuronal migration disorder gene, participate in this pr

178 ive neurodevelopmental trait consisting of a neuronal migration disorder, and our data implicate GCP2

179 Genes mutated in human neuronal migration disorders encode tubulin proteins and

180 r using nonrodent model systems for studying neuronal migration disorders.

181 y linking DYX1C1 with many genes involved in neuronal migration disorders.

182 ging from mild cognitive impairment (MCI) to neuronal migration disorders.

183 logue Lis1, which is crucial for nuclear and neuronal migration during brain development.

184 insic polarity and extracellular cues guides neuronal migration during cerebellar development.

185 are usually single-gene disorders affecting neuronal migration during cerebral cortical development.

186 , a MT-associated protein (MAP) required for neuronal migration during cortical development [4, 5], b

187 The best studied defects are in neuronal migration during corticogenesis and in the hipp

188 , Lpd contributes to neuronal morphogenesis, neuronal migration during development and its C. elegans

189 Neuronal migration during development is necessary to fo

190 n-binding protein filamin A (FLNa) regulates neuronal migration during development, yet its roles in

191 compartments that play an important role in neuronal migration during development.

192 reveal that Nckap1 loss of function promotes neuronal migration during early cortical development.

193 of adhesion proteins plays a crucial role in neuronal migration during neocortical development.

194 w here that NudC, like Lis1, is required for neuronal migration during neocorticogenesis and we ident

195 Cone packing and neuronal migration during pit formation combined to form

196 overed crucial roles for lamins B1 and B2 in neuronal migration during the development of the brain.

197 Elucidating neuronal migration dynamics in the gyrencephalic, or fol

198 y associated with dyslexia and implicated in neuronal migration (DYX1C1, DCDC2, KIAA0319) and white m

199 THBS2), tissue differentiation (e.g., CHN2), neuronal migration (e.g., NDE1), myelination (e.g., UGT8

200 l delay/autism, possibly by interfering with neuronal migration early in cortical development.

201 ts suggest that RGP-guided inside-out radial neuronal migration facilitates the initial assembly of l

202 Neuronal migration from a germinal zone to a final lamin

203 ate from rhombic lips, the first analysis of neuronal migrations from these lips was performed with m

204 These results identify a novel neuronal migration gene with a specific role in interkin

205 myloid-beta precursor protein (APP), a known neuronal migration gene.

206 expression of nervous system development and neuronal migration genes such as RELN and associate with

207 l aspects of neuronal development, including neuronal migration, growth cone collapse, dendrite branc

208 opmental processes, such as neurogenesis and neuronal migration, guide precise circuit assembly.

209 affecting auto-phosphorylation also affected neuronal migration, highlighting the importance of tight

210 s was sufficient to disturb neurogenesis and neuronal migration in a similar manner to Mecp2 knockdow

211 hydrolase 1B1 (LIS1), a critical mediator of neuronal migration in developing brain, is expressed thr

212 rthermore, knockdown of vasohibins disrupted neuronal migration in developing mouse neocortex.

213 interneuron leading process dynamics during neuronal migration in mice and provides insight into how

214 FBM neurons in zebrafish, but their roles in neuronal migration in mouse have not been investigated i

215 Moreover, we observed aberrant Tuj1(+) neuronal migration in RB-KO organoids and upregulation o

216 Although much less is known about neuronal migration in species with a gyrencephalic corte

217 Together, these results provide insight into neuronal migration in the adult mammalian nervous system

218 ic transcriptional pathway that orchestrates neuronal migration in the brain, with important implicat

219 at FBXO41 is a critical factor, not only for neuronal migration in the cerebellum, but also for its l

220 nal proliferation in the embryonic brain and neuronal migration in the cerebellum.

221 y facilitating the VLDLR-Dab1 axis to direct neuronal migration in the cortex and hippocampus and to

222 at another proneural factor, Ascl1, promotes neuronal migration in the cortex through direct regulati

223 role for B-type lamins (lamins B1 and B2) in neuronal migration in the developing brain.

224 nd its transmembrane receptor, Robo-1, repel neuronal migration in the developing central nervous sys

225 Post-mitotic neuronal migration in the developing cerebral cortex inv

226 ctrum of brain malformations due to impaired neuronal migration in the developing cerebral cortex.

227 is sufficient to dominantly disrupt cortical neuronal migration in the developing mouse brain, strong

228 DYX1C1 has been associated with dyslexia and neuronal migration in the developing neocortex.

229 e initial discovery that loss of p35 impairs neuronal migration in the embryonic brain prompted inten

230 ty supported callosal projections and radial neuronal migration in the embryonic neocortex.

231 d a viral labeling technique for visualizing neuronal migration in the ferret, a gyrencephalic carniv

232 e also adapted a well characterized assay of neuronal migration in the hawkmoth Manduca to show that

233 e also adapted a well characterized assay of neuronal migration in the hawkmoth, Manduca sexta, to sh

234 rt that knockdown of PHF6 profoundly impairs neuronal migration in the mouse cerebral cortex in vivo,

235 a developmental role for CCM3 in regulating neuronal migration in the neocortex.

236 e with remarkably region-specific effects on neuronal migration in the posterior cortex, reflecting d

237 ays that microtubules can support successful neuronal migration in vivo.

238 Our findings underscore that aberrant neuronal migration, inhibitory/excitatory imbalance, and

239 n, and this is required for proper GABAergic neuronal migration into the substantia nigra pars reticu

240 that Netrin-1 from distinct sources controls neuronal migrations into the substantia nigra.

241 ct, in vivo evidence for a wandering form of neuronal migration involved in the addition of new neuro

242 rotrusions and synapses of young brain after neuronal migration is complete.

243 Neuronal migration is critical for establishing neocorti

244 at the formation of parallel axon fibers and neuronal migration is disrupted in Nav2 mutants.

245 Neuronal migration is essential for the development of t

246 n impairment, suggesting the role of VRK1 in neuronal migration is partly noncatalytic.

247 DNF positively influences various aspects of neuronal migration, maturation, and survival in the deve

248 During neuronal migration, MgcRacGap also concentrates in the p

249 ucturing of MTs facilitate distinct modes of neuronal migration necessary for laminar organization of

250 them to function in cell-cell communication, neuronal migration, neurite outgrowth, neuronal pathfind

251 etailed insight into the cell proliferation, neuronal migration, neuronal axon guidance during the in

252 in particular neural progenitor development, neuronal migration, neuronal differentiation and early n

253 n vitro and in vivo, including neurogenesis, neuronal migration, neuronal survival and axon guidance.

254 rely ataxic gait in mice, which show delayed neuronal migration of granule neurons in the developing

255 Developmental defects such as impaired neuronal migration or neurodegeneration are thus detrime

256 teracts the deleterious effect of miR-128 on neuronal migration, outgrowth and intrinsic physiologica

257 D-1, which compromises the inside-out radial neuronal migration pattern in the developing neocortex.

258 xpression of Pac1 rescued the Zac1 knockdown neuronal migration phenotype.

259 ockdown but not knockout shows a neocortical neuronal migration phenotype.

260 embryos did not exacerbate the Vangl2(Lp/+) neuronal migration phenotype.

261 y is not required for cortical neurogenesis, neuronal migration, polarization, or survival.

262 ignificance of this well-established orderly neuronal migration remains largely unclear.

263 te proliferation, programmed cell death, and neuronal migration, respectively.

264 at the forces imparted on the nucleus during neuronal migration result in nuclear membrane (NM) ruptu

265 al development typically caused by deficient neuronal migration resulting in cortical thickening and

266 NOS1AP overexpression disrupts neuronal migration, resulting in increased cells in inte

267 evere brain malformation in which failure of neuronal migration results in agyria or pachygyria and i

268 Neuronal migration segregates motor neurons into distinc

269 n with this disorder suffer from deficits in neuronal migration, severe intellectual disability, intr

270 rmation thought to be mainly due to abnormal neuronal migration, shows that the evolved folding is pe

271 f RhoA signaling and differential control of neuronal migration stages.

272 e find that kinesin-1 inhibition accelerates neuronal migration, suggesting a novel role for the oppo

273 The 50 genes in the network function in neuronal migration, synaptic transmission, signaling, tr

274 s system development and function, including neuronal migration, synaptogenesis, synaptic plasticity,

275 dk5) and its activator p35 are important for neuronal migration that is regulated by basic helix-loop

276 ment is crucial for further neurogenesis and neuronal migration, the underlying mechanisms are still

277 GTPases, have been implicated in regulating neuronal migration, their respective roles in the tangen

278 Vrk1 knockdown, suggesting that VRK1 affects neuronal migration through an APP-dependent mechanism.

279 tablish that missense KIF21B variants impede neuronal migration through attenuation of kinesin autoin

280 We report that Hem regulates neuronal migration through stabilizing WAVE.

281 Basal structures influence neuronal migration, tissue integrity, and proliferation

282 Neurogenesis is integrated with neuronal migration to ensure proper development of the c

283 Reelin choreographs neuronal migration to establish laminar structures durin

284 nding the genetic regulation of cell number, neuronal migration to proper layers, columns, and region

285 ells in the nasal mucosa, and impairs GnRH-1 neuronal migration to the brain.

286 s neural stem cell maintenance in the VZ and neuronal migration to the CP.

287 t that pre-existing DA neurons modulate GABA neuronal migration to their final destination, providing

288 of neuronal precursor cells, facilitates the neuronal migration toward injured areas, and shows survi

289 te the role and mechanisms of Fat-PCP during neuronal migration using the murine facial branchiomotor

290 We conclude that neuronal migration utilizes a cytoskeletal pathway analo

291 esults in the disruption of neurogenesis and neuronal migration via dysregulation of microtubule (MT)

292 Postmitotic neuronal migration was independently disrupted at the mu

293 Similar to the rodent, we found that neuronal migration was predominantly radial at early pos

294 Since BDNF can influence tangential neuronal migration, we added BDNF to the culture medium

295 ogenitor cells and impairment of postmitotic neuronal migration, were also observed.

296 rference studies in rats suggested a role in neuronal migration whereas subsequent work with double k

297 e is known about the mechanisms of axophilic neuronal migration, whereby neurons travel along axon pa

298 on of Rnd proteins, integrate the process of neuronal migration with other events in the neurogenic p

299 thalamic nuclei; EphA4 affects only cortical neuronal migration, with no visible effects on the guida

300 Zac1 misexpression also blocked neuronal migration, with Zac1-overexpressing neurons pau