ライフサイエンスコーパス: neuropilin

1 e C-terminus of Sema3F with the b1 domain of neuropilin.

2 al domain of semaphorin and the b1 domain of neuropilin.

3 hat potently inhibits the binding of VEGF to neuropilin.

4 tC signal independently of the Robos and the Neuropilins.

5 e known primarily as ligands for plexins and neuropilins.

6 that acts through a mechanism distinct from neuropilins.

7 nteraction with their receptors, plexins and neuropilins.

8 s 1 (GIPC1, aka Synectin) interacts with the neuropilins.

9 We provide evidence that Neuropilin 1 (Nrp-1), highly expressed by Foxp3(+) T reg

10 ead, we found that ANGPTL4 binds directly to neuropilin 1 (NRP1) and NRP2 on endothelial cells (ECs),

11 Here we show that Neuropilin 1 (Nrp1) and Nrp2, transmembrane proteins wit

12 BMA nucleus, owing to reduced expression of neuropilin 1 (Nrp1) and Nrp2, two semaphorin receptors t

13 VEGF165 binds the transmembrane protein neuropilin 1 (NRP1) and promotes the migration, survival

14 mall molecule ligand for the VEGF-A receptor neuropilin 1 (NRP1) and the structural characterization

15 demonstrate that beta8 integrin (Itgb8) and neuropilin 1 (Nrp1) cooperatively promote CNS angiogenes

16 Moreover, high expression of PlGF receptor neuropilin 1 (Nrp1) correlates with poor overall surviva

17 Here we show that neuropilin 1 (NRP1) directly interacts with EBV gB(23-43

18 tion, bevacizumab decreased Ang1 and induced neuropilin 1 (NRP1) expression in tumor-associated macro

19 semaphorin SEMA3C, and their shared receptor neuropilin 1 (NRP1) in OFT development, the precise mech

20 Neuropilin 1 (NRP1) is a receptor for class 3 semaphorin

21 Neuropilin 1 (NRP1) is a transmembrane glycoprotein that

22 Neuropilin 1 (Nrp1) is a type I transmembrane protein th

23 We report here that Neuropilin 1 (Nrp1) is expressed at high levels by most

24 Neuropilin 1 (NRP1) plays an important but ill-defined r

25 analyses with in vitro assays, we show that neuropilin 1 (NRP1) promotes contralateral RGC projectio

26 of GlyRS, enabling GlyRS(CMT2D) to bind the neuropilin 1 (Nrp1) receptor.

27 by endothelial cells where it partners with neuropilin 1 (Nrp1) to form a functional receptor for th

28 The transmembrane receptor protein neuropilin 1 (Nrp1) was recently identified as an aberra

29 Neuropilin 1 (Nrp1), a coreceptor for class 3 semaphorin

30 Moreover, TAOK2 interacts with Neuropilin 1 (Nrp1), a receptor protein that binds the s

31 Emerging evidence suggests that neuropilin 1 (Nrp1), an originally defined coreceptor fo

32 ssel growth, endothelial cells (ECs) express neuropilin 1 (NRP1), and NRP1 associates with the recept

33 f these targets is the guidance cue receptor Neuropilin 1 (Nrp1), which is sensitive to the repellent

34 However, the addition of neuropilin 1 (Nrp1)-blocking antibody or siRNA knockdown

35 e identified the LD22-4 membrane receptor as neuropilin 1 (NRP1).

36 Syb2 associated with Neuropilin 1 and Plexin A1, two essential components of

37 izes the extrinsic pathway and requires both neuropilin 1 and plexin A3.

38 aging, as well as suggest miR-208a, AT2R and neuropilin 1 as potential therapeutic targets and mechan

39 Factor (VEGF)-dependent, proangiogenic GIPC1-Neuropilin 1 complex, recasting GIPCs as negative modula

40 study highlights the proangiogenic receptor neuropilin 1 in macrophages and microglial cells in glio

41 A novel role for myeloid cell-specific neuropilin 1 in mitigating sepsis.

42 Importantly, deletion of either neuropilin 1 or plexin A3 significantly reduces developm

43 betic female rats have reduced expression of neuropilin 1 that attenuates cardiomyopathy compared to

44 uterus-draining lymph nodes, comprising 70% neuropilin 1(+) tTregs and 30% neuropilin 1(-) pTregs.

45 omprising 70% neuropilin 1(+) tTregs and 30% neuropilin 1(-) pTregs.

46 iple combination of selection markers--CD34, neuropilin 1, and human kinase insert domain-containing

47 actor (VEGF), VEGF receptors, semaphorin 3F, neuropilin 1, neuropilin 2, podoplanin, and LYVE-1 by qu

48 evels of known A10 elevated genes, including neuropilin 1, neuropilin 2, slit2 and adenylyl cyclase-a

49 egulate axonal levels of the Sema3A receptor neuropilin 1.

50 moral M1, acting through the SEMA3A receptor neuropilin 1.

51 Further, we show that neuropilin-1 (NP-1) mediates both PS-dependent and PS-in

52 Interestingly, neuropilin-1 (Npn-1) is expressed by periocular neural c

53 ding of Sema3A to its high-affinity receptor Neuropilin-1 (Npn-1).

54 RPPR peptide, with affinity for the receptor neuropilin-1 (NRP), which is expressed on both endotheli

55 alpha(cont) and Gsalpha(KO) cells identified neuropilin-1 (Nrp-1) and granulin (Grn) as osteocytic-se

56 rived GBM cells expressing shRNAs of VEGF or neuropilin-1 (NRP-1) attenuate cancer stem cell markers,

57 that must be C-terminally exposed to trigger neuropilin-1 (NRP-1) binding, cellular internalization a

58 Instead, VEGF-A acts via the neuropilin-1 (NRP-1) co-receptor.

59 eport that expression of the VEGF coreceptor neuropilin-1 (NRP-1) coincides with expression of Brachy

60 actor (VEGF) and semaphorin-binding receptor Neuropilin-1 (Nrp-1) emerge as crucial determinants of M

61 tosis transport pathway that is regulated by neuropilin-1 (NRP-1) has recently been reported.

62 Heparin/heparan sulfate proteoglycans and neuropilin-1 (NRP-1) have been identified as co-receptor

63 gated the role of semaphorin 3A (Sema3A) and neuropilin-1 (Nrp-1) in lymphatic vessel maturation and

64 that trafficking of the angiogenic receptor neuropilin-1 (NRP-1) is abrogated by the liver kinase B1

65 raphy showed that the CendR peptides bind to neuropilin-1 (NRP-1) on the target cells.

66 Here, we report that neuropilin-1 (NRP-1) orchestrates communications between

67 One targets the neuropilin-1 (NRP-1) receptors of cancer cells through t

68 Recently, neuropilin-1 (NRP-1) was reported to bind and activate t

69 liver fibrosis, the axonal guidance molecule neuropilin-1 (NRP-1) was upregulated in activated HSCs,

70 , heparan sulfate proteoglycans (HSPGs), and neuropilin-1 (NRP-1) were demonstrated to facilitate HTL

71 and conditional knockout mice, we show that neuropilin-1 (NRP-1), a known receptor of VEGF, is neces

72 As a model, we have targeted neuropilin-1 (NRP-1), a membrane-bound receptor expresse

73 we demonstrate that a cell surface molecule, neuropilin-1 (Nrp-1), is expressed at high levels on nT

74 th heparan sulfate proteoglycans (HSPGs) and neuropilin-1 (NRP-1), two molecules important for HTLV-1

75 We identify Neuropilin-1 (NRP-1)-mediated activation of KDR signalin

76 progression by binding with its co-receptor, neuropilin-1 (NRP-1).

77 emma vesicle-associated protein-1 (PV-1) and neuropilin-1 (NRP-1).

78 h through interaction with the VEGF receptor neuropilin-1 (NRP-1).

79 g receptor as the transmembrane glycoprotein neuropilin-1 (NRP-1).

80 if with cell-and tissue penetration receptor neuropilin-1 (NRP-1).

81 actions with alphavbeta3/beta5 integrins and neuropilin-1 (NRP-1).

82 ule (CendR) motif that binds to cell surface neuropilin-1 (NRP1) and NRP2 receptors.

83 ein binds to lymphatic valves expressing the Neuropilin-1 (Nrp1) and PlexinA1 receptors.

84 VEGF receptors VEGFR1, VEGFR2 and Neuropilin-1 (NRP1) are mostly in 'Free State'.

85 ass spectrometry-based approach, we identify neuropilin-1 (NRP1) as a NE receptor that mediates uptak

86 n part, on signaling through the VEGF-VEGFR2-Neuropilin-1 (NRP1) axis.

87 In endothelial cells, neuropilin-1 (NRP1) binds vascular endothelial growth fa

88 rt that mice with a CD8(+) T cell-restricted neuropilin-1 (NRP1) deletion exhibited substantially enh

89 Neuropilin-1 (Nrp1) guides the development of the nervou

90 has implicated the transmembrane co-receptor neuropilin-1 (NRP1) in cancer progression.

91 efine the role of transmembrane glycoprotein neuropilin-1 (NRP1) in the expression of DDAHs and inves

92 Sema4a) and the Treg-cell-expressed receptor neuropilin-1 (Nrp1) interact both in vitro, to potentiat

93 Neuropilin-1 (Nrp1) is a cell surface molecule originall

94 Neuropilin-1 (NRP1) is a coreceptor for multiple extrace

95 Neuropilin-1 (Nrp1) is an essential receptor for angioge

96 Neuropilin-1 (NRP1) is an essential transmembrane recept

97 Neuropilin-1 (Nrp1) is required to maintain intratumoral

98 tion of circulating monocytes expressing the neuropilin-1 (Nrp1) receptor (Nrp1-expressing monocytes;

99 onset of Sema3A sensitivity and concomitant neuropilin-1 (NRP1) receptor expression and caused cell-

100 Neuropilin-1 (NRP1), a non-tyrosine kinase receptor, is

101 ligo G) reduce endothelial levels of surface neuropilin-1 (NRP1), a receptor shared by semaphorin 3A

102 Here, we demonstrate that neuropilin-1 (NRP1), a Semaphorin receptor expressed in

103 In this study, we found that neuropilin-1 (NRP1), known to bind furin-cleaved substra

104 disrupts the developmental downregulation of Neuropilin-1 (Nrp1), the receptor for Sema3A, in sensory

105 Neuropilin-1 (NRP1), which is a critical receptor implic

106 Mice that lack the transmembrane receptor neuropilin-1 (Nrp1), which modulates GAM immune polariza

107 e show this is a key endothelial function of neuropilin-1 (Nrp1), which suppresses the stalk-cell phe

108 The neuropilin-1 (NRP1)-MET signaling axis regulates the mot

109 Semaphorin3A (Sema3A) which both signal via neuropilin-1 (Nrp1).

110 dritic cell (pDC) marker, BDCA4, identifying neuropilin-1 (NRP1); and the helper T cell marker, CD4.

111 microenvironment by increasing the levels of neuropilin-1 (NRP1, a co-receptor of vascular endothelia

112 We also show that the semaphorin receptor neuropilin-1 acts cell-autonomously to control the devel

113 ration of siRNAs against the Sema3A receptor neuropilin-1 also resulted in polarization defects in vi

114 Patients with low baseline expression of neuropilin-1 also showed a trend toward improved overall

115 ded to associated cues of axon guidance like neuropilin-1 and F-actin.

116 First, aged Tregs had high expression of neuropilin-1 and Helios, and had a broad Vbeta repertoir

117 A and Slit2, and their respective receptors, Neuropilin-1 and Robo2.

118 ng of VEGF to low-affinity binding sites and neuropilin-1 and stimulates further growth factor recept

119 th factor A (VEGF-A) isoforms, expression of neuropilin-1 and VEGF receptor 1 in tumors or plasma, an

120 c vessel endothelial hyaluronan receptor 1), neuropilin-1 and VEGFR2 (vascular endothelial growth fac

121 force sensor and forms a mechanocomplex with neuropilin-1 and VEGFR2 that is necessary and sufficient

122 The arterial marker neuropilin-1 and venous marker EphB4 are ectopically exp

123 tivity of the CgA(1-373) was blocked by anti-neuropilin-1 antibodies as well as by nicotinic acetylch

124 Plasma VEGF-A and tumor neuropilin-1 are strong biomarker candidates for predict

125 We identified neuropilin-1 as a mediator of cancer cell invasion by a

126 Investigation of PlGF/Neuropilin-1 binding and function suggests a critical ro

127 matically removed in plasma, causing loss of neuropilin-1 binding and gain of antiangiogenic activity

128 The model predicts that Neuropilin-1 can induce differences in the surface-to-in

129 Mice with Treg cell-restricted Neuropilin-1 deficiency show tumor resistance while main

130 CI, 0.59 to 0.97) versus patients with high neuropilin-1 expression (HR, 1.07; 95% CI, 0.81 to 1.40;

131 Neuropilin-1 expression in anergic conventional CD4(+) T

132 Although neuropilin-1 expression in GBMs was previously shown, it

133 Baseline plasma VEGF-A levels and tumor neuropilin-1 expression were identified as potential pre

134 tract region that are attenuated by blocking neuropilin-1 function.

135 the translation of the guidance cue receptor Neuropilin-1 in RGCs, with Hermes knock-down resulting i

136 hosphorylation status and down-regulation of neuropilin-1 in the HemSCs demonstrate that VEGFR-2 and

137 e transfer experiments and the expression of neuropilin-1 indicate that these cells are predominantly

138 s a critical role for heparin-binding domain/Neuropilin-1 interaction and its regulation by plasmin p

139 Neuropilin-1 is a receptor for semaphorin3A (Sema3A), a

140 The cAMP-dependent guidance receptor neuropilin-1 is also lost from beta3GnT2(-/-) OSNs and a

141 surprise, we found that membrane-associated neuropilin-1 is polysialylated at approximately 50% of t

142 vation and RNA interference , we showed that neuropilin-1 is required for GBM cell migration.

143 action between fragmented chromogranin A and neuropilin-1 is required for tumor growth and represents

144 Neuropilin-1 maintains dimethylarginine dimethylaminohyd

145 MAOA-dependent activation of neuropilin-1 promoted AKT/FOXO1/TWIST1 signaling, allowi

146 e adhesion and suggest that targeting Sema3A-neuropilin-1 signaling may limit GBM infiltration.

147 ar tumor areas is regulated by Semaphorin 3A/Neuropilin-1 signaling; interference with this pathway e

148 Specific inhibition of neuropilin-1 significantly reduced CNS vascular permeabi

149 Specifically, pDCs upregulate neuropilin-1 to enable the long term interactions of pDC

150 implicate Sema3A as an autocrine signal for neuropilin-1 to promote GBM dispersal by modulating subs

151 stemmed from a failure to expand functional neuropilin-1(+) regulatory T (T reg) cells in the absenc

152 th, portal vessels undergo a transition from Neuropilin-1(+)Ephrin-B2(+) artery to EphB4(+) vein phen

153 crease in the pTreg to CD4(+)CD25(+)Foxp3(+) neuropilin-1(high) thymic Treg ratio by day 10.

154 ound was driven by the CD4(+)CD25(+)Foxp3(+) neuropilin-1(low) peripheral Treg (pTreg), resulting in

155 giogenic receptors (alphavbeta3 integrin and neuropilin-1) in vitro as well as in vivo.

156 of domain swap chimeras with sequences from neuropilin-1, a protein for which polysialylation had no

157 r to those of others following inhibition of neuropilin-1, a receptor previously implicated in TGFbet

158 finity for its primary receptor and binds to neuropilin-1, activating a tissue penetration pathway th

159 ication of sialoglycoproteins such as CD105, neuropilin-1, and CLEC14A, which have already been descr

160 (VEGF) and three of its receptors, VEGFR-2, neuropilin-1, and neuropilin-2, in paraffin-embedded sam

161 wth factor-A (VEGF-A), protein expression of neuropilin-1, and VEGF receptors-1 and -2 (VEGFR-1 and V

162 express similar levels of Sema3A receptors (neuropilin-1, cell adhesion molecule L1, and plexinA4),

163 rent iNKT subsets defined by CD4, NK1.1, and neuropilin-1, indicating that distinct functional subpop

164 that VEGF immobilization, interactions with Neuropilin-1, perturbations of VEGFR2 trafficking, and c

165 gesting that these receptors, in addition to neuropilin-1, play a role in the proangiogenic activity

166 dipocytes, probably through up-regulation of neuropilin-1, the OB-mediated enhanced hematopoiesis fun

167 tor complex comprising VEGFR2, PlexinD1, and neuropilin-1, thereby preventing degradation of internal

168 njugate (a peptide that binds to the protein neuropilin-1, which is highly expressed in tumours, and

169 rnalized into cultured tumor cells through a neuropilin-1-activated pathway and triggered cell death.

170 nd tLyP-1 internalize into cells through the neuropilin-1-dependent CendR internalization pathway.

171 tissue permeability in a tumor-specific and neuropilin-1-dependent manner, allowing coadministered d

172 ema3A decreases cell-substrate adhesion in a neuropilin-1-dependent manner.

173 istic insights into the regulation of PlGF-2/Neuropilin-1-mediated tissue vascularization and growth.

174 that SEMA3A acts as a potent attractant for neuropilin-1-positive (NRP-1-positive) MPs.

175 pment and is not required for maintenance of neuropilin-1-positive natural Tregs in the periphery, it

176 h 2 (ba2), is due to chemoattraction through neuropilin-1-vascular endothelial growth factor (VEGF) i

177 pendent on chemoattractive signaling through neuropilin-1-VEGF interactions.

178 its impaired binding to the VEGF co-receptor neuropilin-1.

179 nhanced Factor Xa inhibition, and binding of neuropilin-1.

180 hrough activation of VEGF and its coreceptor neuropilin-1.

181 increased binding of VEGF to its coreceptor neuropilin-1.

182 lar endothelial growth factor receptor-2 and neuropilin-1.

183 otif Arg-Pro-Leu targets VEGF receptor-1 and neuropilin-1.

184 pecific phosphorylation in vivo, mediated by Neuropilin-1.

185 olysialylation process than those regions of neuropilin-1.

186 n into cancer cells via the interaction with neuropilin-1.

187 esults support that Farp1 interacts with the Neuropilin-1/PlexinA1 complex and colocalizes with Plexi

188 he precursor, bound the VEGF-binding site of neuropilin-1; the C-terminal arginine (R(373)) of the se

189 Neuropilins-1/-2 (NRP1, NRP2) are receptors for semaphor

190 screen identified the transmembrane protein neuropilin 2 (NRP2) and tetraspanin CD63 as factors for

191 and protein expression analysis showed that neuropilin 2 (NRP2), a key factor for vascular developme

192 Here we demonstrate that Neuropilin 2 (Nrp2), a receptor for the axon guidance cu

193 guidance cue, Semaphorin 3F and its receptor Neuropilin 2 (Nrp2), influence dendritic spine maintenan

194 An axon guidance molecule, Neuropilin 2 (Nrp2), is known to mediate targeting of ol

195 islet cells produced the semaphorin receptor neuropilin 2 (Nrp2).

196 We previously showed that neuropilin 2 (Nrp2)/semaphorin 3F (Sema3F) signaling is

197 VEGF receptors, semaphorin 3F, neuropilin 1, neuropilin 2, podoplanin, and LYVE-1 by quantitative (re

198 A10 elevated genes, including neuropilin 1, neuropilin 2, slit2 and adenylyl cyclase-activating pept

199 d in neural and vascular patterning, such as neuropilin-2 (NETO2), a plexin domain containing recepto

200 mplex in brain with Sema3F receptor subunits Neuropilin-2 (Npn-2) and PlexinA3 (PlexA3) through an Np

201 Here we show that NrCAM interaction with neuropilin-2 (Npn-2) is critical for semaphorin 3F (Sema

202 guidance cue semaphorin 3F (Sema3F) and its neuropilin-2 (Npn-2)/plexinA3 (PlexA3) holoreceptor medi

203 ding Sema3F, and its holoreceptor components neuropilin-2 (Npn-2, also known as Nrp2) and plexin A3 (

204 Here, we show that neuropilin-2 (NRP-2), a multifunctional nonkinase recept

205 ared the PBR sequence requirements for NCAM, neuropilin-2 (NRP-2), and synaptic cell adhesion molecul

206 surface receptors transduce VEGF-C signals: neuropilin-2 (Nrp2) and VEGF-receptor (VEGFR)-2/3.

207 Here, we show that the expression of Neuropilin-2 (NRP2) controls EGFR protein levels, thereb

208 Neuropilin-2 (NRP2) is a non-tyrosine kinase receptor fr

209 eptors, plexins and neuropilins, among which neuropilin-2 (NRP2) is highly expressed in lymphatic end

210 Neuropilin-2 (NRP2) is well known as a co-receptor for c

211 ell surface and secreted proteins, including Neuropilin-2 (NRP2).

212 Moreover, we show that neuropilin-2 also binds tLyP-1 and that this binding equ

213 the ability of ST8SiaIV/PST to polysialylate neuropilin-2 and SynCAM 1, suggesting that Arg(82) plays

214 and the O-glycan-containing linker region of neuropilin-2 are necessary and sufficient for its polysi

215 lylated at approximately 50% of the level of neuropilin-2 but not polysialylated when it lacks its cy

216 Our results show that floor plate-derived neuropilin-2 is developmentally regulated, functioning a

217 f floor plate-derived, but not axon-derived, neuropilin-2 is required for precrossing axon pathfindin

218 gnizes and docks on an acidic surface of the neuropilin-2 MAM domain to polysialylate O-glycans on th

219 overshooting after crossing, reminiscent of Neuropilin-2 mutant embryos.

220 To understand the biochemical basis of neuropilin-2 polysialylation, we created a series of dom

221 e surface of the MAM domain are critical for neuropilin-2 polysialylation.

222 In mice, deletion of the Neuropilin-2 receptor in Pro-opiomelanocortin neurons di

223 s type I SGN process extension by activating Neuropilin-2 receptors expressed on SGNs.

224 The Sema3F receptor neuropilin-2 selectively binds beta2Chn, and ligand enga

225 Floor plate-specific deletion of neuropilin-2 significantly reduces the presence of precr

226 he transmembrane nontyrosine kinase receptor neuropilin-2 was found to be essential for the VEGF-C-me

227 n part by directly stimulating expression of neuropilin-2, a coreceptor for VEGF-C.

228 of its receptors, VEGFR-2, neuropilin-1, and neuropilin-2, in paraffin-embedded samples from 21 vesti

229 One of these substrates, neuropilin-2, is a VEGF and semaphorin co-receptor that

230 This was not the case for neuropilin-2, which is polysialylated when either membra

231 on of lymphatic endothelial cells (LEC) in a neuropilin-2-, plexin-D1-, and plexin-A1-dependent manne

232 Here, we show that neuropilin-2/plexin-A1 are also coexpressed on commissur

233 Secreted semaphorins signal through neuropilin-2/plexin-A1 receptor complexes on post-crossi

234 a3G increased excitatory synapse density via neuropilin-2/PlexinA4 signaling and through activation o

235 SEMA3F acts on its coreceptors, plexins and neuropilins, among which neuropilin-2 (NRP2) is highly e

236 has been confirmed through interactions with neuropilin and heparin.

237 in dimerization and binding to their cognate neuropilin and plexin receptors.

238 We recently identified Neuropilin and Tolloid like-2 (Neto2) as a novel accesso

239 ted by the single-pass transmembrane protein neuropilin and tolloid like-2 (Neto2).

240 The neuropilin and tolloid-like 1 and 2 proteins (Neto1 and

241 The neuropilin and tolloid-like proteins (NETO) 1 and NETO2,

242 y, we found that the intracellular region of neuropilin and tolloid-like proteins (Neto) 1 and Neto2,

243 ified and characterized the Drosophila neto (neuropilin and tolloid-like) as an essential gene requir

244 Thus, neuropilin and/or GIPC1 silencing may inhibit PDAC growt

245 receptor(s), we evaluated gene expression of neuropilins and plexins.

246 KARs associate with the auxiliary proteins neuropilin- and tolloid-like 1 and 2 (Neto1 and Neto2),

247 The putative KAR auxiliary subunit Neuropilin- and tolloid-like 2 (Neto2) is also expressed

248 s well as the putative KAR auxiliary subunit Neuropilin- and tolloid-like 2 (Neto2).

249 Neuropilins are a class of cell surface proteins implica

250 Neuropilins are co-receptors that mediate signaling of k

251 class 3 semaphorin family, but VEGF164, the neuropilin-binding isoform of the classical vascular gro

252 circulation-independent, and mediated by the neuropilin-binding RXXK tissue-penetration peptide motif

253 By reconstituting all possible plexin and neuropilin combinations, we found that SEMA3F acts throu

254 er semaphorin and VEGF competitively bind to neuropilin conflict.

255 of signaling via a plexin receptor without a neuropilin coreceptor.

256 nce molecules that signal through plexin and neuropilin coreceptors and since then have been establis

257 signaling without altering VEGF receptor or neuropilin expression.

258 tial co-receptors/attachment factors such as neuropilins, heparan sulfate and sialic acids and the pu

259 We investigated the role of neuropilins in response to cardiac injury and heart rege

260 We also analyzed the expression of neuropilins in synovial tissue and SF, as they may inter

261 ted that all known ligands and inhibitors of neuropilin interact with the b1 domain of neuropilin via

262 Neuropilin is an essential cell surface receptor that fu

263 All four neuropilin isoforms (nrp1a, nrp1b, nrp2a and nrp2b) were

264 The Neuropilin ligand Semaphorin3 enhances this interaction,

265 ro models, we show here that the alternative neuropilin ligand VEGF164 promotes the survival of migra

266 of retinal axons to Sema3D, Sema3E, or other neuropilin ligands at the midline, and consequently faci

267 Thus, the loss of both neuropilin ligands leads to an almost complete failure t

268 physical interaction and competition between neuropilin ligands.

269 Here, we determined that the discoidina neuropilin-like membrane protein DCBLD2 is upregulated i

270 Endothelial and smooth muscle cell-derived neuropilin-like protein (ESDN) is a neuropilin-related t

271 Endothelial and smooth muscle cell-derived neuropilin-like protein (ESDN) is up-regulated in the ne

272 ndantly through both its classical receptors neuropilin (NRP) 1 and, unconventionally, NRP2, while th

273 Neuropilin (NRP) 1 is a receptor for the vascular endoth

274 in the class 3 semaphorin (SEMA3) receptors neuropilin (NRP) 1 or 2 raised the possibility that each

275 eted glycoprotein SEMA3A binds its receptors neuropilin (NRP) 1 or NRP2 to position these axons for c

276 gands are known to repel neurites expressing Neuropilin (Nrp) and/or Plexin (Plxn) receptors.

277 The neuropilin (Nrp) family consists of essential multifunct

278 cular endothelial cadherin (VE-Cadherin) and neuropilin (NRP)-1 and 2, but not with junctional protei

279 transcription of VEGF receptor (VEGFR)-2 and neuropilin (NRP)-1, the primary receptors regulating end

280 ost & Microbe, Raaben et al. (2017) identify neuropilin (NRP)-2 as cell surface receptor and the tetr

281 Here, we report that neuropilin (NRP)-2, the high-affinity receptor for SEMA3

282 Neuropilins (Nrp) are type I transmembrane proteins that

283 The Neuropilins (Nrps) are a family of essential cell surfac

284 Neuropilins (NRPs) are trans-membrane receptors involved

285 Neuropilins (NRPs) are transmembrane receptors that bind

286 (VEGF) signaling in tumor cells mediated by neuropilins (NRPs) contributes to the aggressive nature

287 Neuropilins (NRPs), which have well-defined roles in Sem

288 al growth factor (VEGF) receptors, including neuropilins (NRPs), which regulate interstitial fluid fl

289 GFR1) and axonal guidance molecules known as neuropilins (NRPs).

290 Neuropilins (NRPs; NRP1 and NRP2) are the cell surface r

291 fically through binding of soluble Sema3A to Neuropilin/PlexinA coreceptors.

292 PDE4D interacts directly with Neuropilins, positive regulators of Hh pathway.

293 ibodies for VEGF receptor (VEGFR) 1 and 2 or neuropilin receptor 1 or by VEGFR2 inhibitors (SU 1498 a

294 lass 3 semaphorin SEMA3A signals through its neuropilin receptors, NRP1 and NRP2, to organise the axo

295 s, and tumor progression, through Plexin and neuropilin receptors.

296 he developing cerebellum, genetic removal of Neuropilins reduces Hh signaling activity and suppresses

297 -derived neuropilin-like protein (ESDN) is a neuropilin-related transmembrane protein expressed in EC

298 sphodiesterase 4D (PDE4D) acts downstream of Neuropilins to control Hh transduction and medulloblasto

299 of neuropilin interact with the b1 domain of neuropilin via a C-terminal arginine.

300 Although the neuropilins were characterized as semaphorin receptors t