ライフサイエンスコーパス: neuropilin-2

1 ing the expression of the guidance receptor, Neuropilin-2.

2 aterals depends on plexin-A3, plexin-A4, and neuropilin-2.

3 omomultimerize and form heteromultimers with neuropilin-2.

4 Here, we show that neuropilin-2, a coreceptor for some of the class 3 semap

5 n part by directly stimulating expression of neuropilin-2, a coreceptor for VEGF-C.

6 Neuropilin-2, a receptor for secreted semaphorins, is ex

7 We also describe the identification of neuropilin-2, a related neuropilin family member, and sh

8 uidance defects are observed in mice lacking neuropilin-2, a Semaphorin receptor.

9 Moreover, we show that neuropilin-2 also binds tLyP-1 and that this binding equ

10 The axon-guidance-associated proteins neuropilin-2 and dehydropyriminidase-related protein-2 w

11 neuropilin-2 and semaIV are expressed in strikingly comp

12 the ability of ST8SiaIV/PST to polysialylate neuropilin-2 and SynCAM 1, suggesting that Arg(82) plays

13 owed that SEMA3F formed a complex with NRP2 (neuropilin-2) and plexin A1.

14 cule, synaptic cell adhesion molecule 1, and neuropilin 2 are discussed.

15 family member, and show that neuropilin and neuropilin-2 are expressed in overlapping, yet distinct,

16 and the O-glycan-containing linker region of neuropilin-2 are necessary and sufficient for its polysi

17 Neuropilin-1 and neuropilin-2 bind differentially to different class 3 se

18 lylated at approximately 50% of the level of neuropilin-2 but not polysialylated when it lacks its cy

19 VEGFR-3(+) DC in normal corneas are VEGF-C(-)neuropilin-2(-), but express VEGF-C in inflammation.

20 ding (CUB) and coagulation factor domains of neuropilin-2 confer specificity to the Sema IV repulsive

21 how that dual expression of ACE2 with either neuropilin-2, ephrin receptor A7, solute carrier family

22 hippocampus in establishing specific Npn-2 (neuropilin-2)-expressing limbic tracts.

23 We generated a knock-out mutation in the neuropilin-2 gene by gene targeting in embryonic stem ce

24 e Sema3F receptor and identify key roles for neuropilin-2 in axon guidance in the PNS and CNS.

25 GFR-3, its ligand VEGF-C and the co-receptor neuropilin-2, in normal and inflamed corneas and charact

26 of its receptors, VEGFR-2, neuropilin-1, and neuropilin-2, in paraffin-embedded samples from 21 vesti

27 Here, we show that neuropilin-2 is a receptor for the secreted semaphorin S

28 Our results show that neuropilin-2 is an essential component of the Sema3F rec

29 Our results show that floor plate-derived neuropilin-2 is developmentally regulated, functioning a

30 ncipally by Plexin-A4, whereas signaling via Neuropilin-2 is mediated principally by Plexin-A3.

31 f floor plate-derived, but not axon-derived, neuropilin-2 is required for precrossing axon pathfindin

32 One of these substrates, neuropilin-2, is a VEGF and semaphorin co-receptor that

33 We show that deficiency of one of the neuropilin 2 ligands of the class III semaphorin family,

34 gnizes and docks on an acidic surface of the neuropilin-2 MAM domain to polysialylate O-glycans on th

35 overshooting after crossing, reminiscent of Neuropilin-2 mutant embryos.

36 Neuropilin-2 mutant mice exhibit profound and distinct e

37 nction of neuropilin-2 through analysis of a neuropilin-2 mutant mouse, which is viable and fertile.

38 d in neural and vascular patterning, such as neuropilin-2 (NETO2), a plexin domain containing recepto

39 mplex in brain with Sema3F receptor subunits Neuropilin-2 (Npn-2) and PlexinA3 (PlexA3) through an Np

40 Here we show that NrCAM interaction with neuropilin-2 (Npn-2) is critical for semaphorin 3F (Sema

41 nerated mice with a targeted deletion in the neuropilin-2 (Npn-2) locus.

42 Analysis of the vomeronasal nerve in neuropilin-2 (npn-2) mutant mice reveals pathfinding def

43 guidance cue semaphorin 3F (Sema3F) and its neuropilin-2 (Npn-2)/plexinA3 (PlexA3) holoreceptor medi

44 ding Sema3F, and its holoreceptor components neuropilin-2 (Npn-2, also known as Nrp2) and plexin A3 (

45 that neural crest cells express the receptor neuropilin 2 (Npn2), while its repulsive ligand semaphor

46 Here, we show that neuropilin-2 (NRP-2), a multifunctional nonkinase recept

47 We show here that neuropilin-2 (NRP-2), a receptor for the semaphorin and

48 ared the PBR sequence requirements for NCAM, neuropilin-2 (NRP-2), and synaptic cell adhesion molecul

49 etermine the structures of Pentamer bound to neuropilin 2 (NRP2) and a set of potent neutralizing ant

50 The semaphorin 3F coreceptors neuropilin 2 (Nrp2) and plexin-A3 (PlxnA3) may play an i

51 s for the family of semaphorin guidance cues neuropilin 2 (Nrp2) and plexin-A3 (PlxnA3) play an impor

52 screen identified the transmembrane protein neuropilin 2 (NRP2) and tetraspanin CD63 as factors for

53 a3f, but not Sema3b, phenocopies the loss of neuropilin 2 (Nrp2) for axonal wiring of GC-D+ neurons.

54 ooth muscle as a major site of expression of neuropilin 2 (Nrp2) in mice and humans.

55 Here, we report that neuropilin 2 (NRP2) is upregulated in both de novo and t

56 and protein expression analysis showed that neuropilin 2 (NRP2), a key factor for vascular developme

57 Here we demonstrate that Neuropilin 2 (Nrp2), a receptor for the axon guidance cu

58 guidance cue, Semaphorin 3F and its receptor Neuropilin 2 (Nrp2), influence dendritic spine maintenan

59 An axon guidance molecule, Neuropilin 2 (Nrp2), is known to mediate targeting of ol

60 islet cells produced the semaphorin receptor neuropilin 2 (Nrp2).

61 y interacting with the cell surface receptor neuropilin 2 (NRP2).

62 We previously showed that neuropilin 2 (Nrp2)/semaphorin 3F (Sema3F) signaling is

63 surface receptors transduce VEGF-C signals: neuropilin-2 (Nrp2) and VEGF-receptor (VEGFR)-2/3.

64 Neuropilin-1 (NRP1) and neuropilin-2 (NRP2) are both receptors for semaphorins,

65 Here, we show that the expression of Neuropilin-2 (NRP2) controls EGFR protein levels, thereb

66 Neuropilin-2 (NRP2) is a non-tyrosine kinase receptor fr

67 Neuropilin-2 (NRP2) is a widely expressed membrane-bound

68 eptors, plexins and neuropilins, among which neuropilin-2 (NRP2) is highly expressed in lymphatic end

69 Neuropilin-2 (NRP2) is well known as a co-receptor for c

70 vascular endothelial growth factor (VEGF) to neuropilin-2 (NRP2) on tumor cells is a potential strate

71 observed that a transmembrane protein called neuropilin-2 (NRP2) plays a contributory role in forming

72 Neuropilin-2 (Nrp2), a candidate ASD gene, is a critical

73 r and lymphatic endothelial cells expressing neuropilin-2 (NRP2), a novel mechanism for a tumor angio

74 motif bound specifically and selectively to neuropilin-2 (NRP2), a receptor expressed by myeloid cel

75 Here, we report that neuropilin-2 (NRP2), a receptor for vascular endothelial

76 Here, we report that neuropilin-2 (NRP2), which functions as a vascular endot

77 ell surface and secreted proteins, including Neuropilin-2 (NRP2).

78 through distinct holoreceptors that include neuropilin-2 (Nrp2)/plexinA3 (PlexA3) and neuropilin-1 (

79 europilin-1 oligomers, the Sema IV signal by neuropilin-2 oligomers, and the Sema E signal by neuropi

80 inating oligodendrocytes (OLs) and increased neuropilin-2(+) OLs with a stress-response and anti-apop

81 Cytokeratin 20, neuropilin-2, p21, and p33ING1 were selected among the t

82 on of lymphatic endothelial cells (LEC) in a neuropilin-2-, plexin-D1-, and plexin-A1-dependent manne

83 Here, we show that neuropilin-2/plexin-A1 are also coexpressed on commissur

84 Secreted semaphorins signal through neuropilin-2/plexin-A1 receptor complexes on post-crossi

85 a3G increased excitatory synapse density via neuropilin-2/PlexinA4 signaling and through activation o

86 VEGF receptors, semaphorin 3F, neuropilin 1, neuropilin 2, podoplanin, and LYVE-1 by quantitative (re

87 To understand the biochemical basis of neuropilin-2 polysialylation, we created a series of dom

88 e surface of the MAM domain are critical for neuropilin-2 polysialylation.

89 In mice, deletion of the Neuropilin-2 receptor in Pro-opiomelanocortin neurons di

90 reted semaphorins, whereas 82% expressed the neuropilin-2 receptor.

91 s type I SGN process extension by activating Neuropilin-2 receptors expressed on SGNs.

92 cause repulsion by binding Neuropilin-1 and Neuropilin-2, respectively.

93 The Sema3F receptor neuropilin-2 selectively binds beta2Chn, and ligand enga

94 Neuropilin-1 and neuropilin-2 show specificity in binding to different cl

95 d semaphorins Sema III, Sema E, and Sema IV, neuropilin-2 shows high affinity binding only to Sema E

96 Floor plate-specific deletion of neuropilin-2 significantly reduces the presence of precr

97 A10 elevated genes, including neuropilin 1, neuropilin 2, slit2 and adenylyl cyclase-activating pept

98 Sema K1 does not bind to neuropilin-1 or neuropilin-2, the two receptors implicated in mediating

99 four genes, Ctla4, Icos, Als2cr19, and Nrp2 (neuropilin-2), thereby excluding a major candidate gene,

100 Here, we have studied the function of neuropilin-2 through analysis of a neuropilin-2 mutant m

101 semaphorin 3F (Sema3F) bind to the receptor neuropilin-2 to confer chemorepulsive responses in vitro

102 he transmembrane nontyrosine kinase receptor neuropilin-2 was found to be essential for the VEGF-C-me

103 This was not the case for neuropilin-2, which is polysialylated when either membra

104 ort the identification of a related protein, neuropilin-2, whose mRNA is expressed by developing neur