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1 f an epithelium that may apply to vertebrate neurulation.
2 ion in the mammalian PCP gene Vangl2, during neurulation.
3 gation is essential for proper completion of neurulation.
4 contribute to the final events of vertebrate neurulation.
5 extension movements during gastrulation and neurulation.
6 extension movements during gastrulation and neurulation.
7 MEKK4-regulated p38 activity is critical for neurulation.
8 the role of blf in convergent extension and neurulation.
9 ion, whereas hypochordal cells ingress after neurulation.
10 ial region of the presumptive somites during neurulation.
11 phogenetic movements during gastrulation and neurulation.
12 spatially restricted during gastrulation and neurulation.
13 n of FLASH in the notochord of embryos after neurulation.
14 the mouse Zic2 is required for the timing of neurulation.
15 tial regulator of apical constriction during neurulation.
16 estis and in a highly dynamic pattern during neurulation.
17 g roles for both cobl and Vangl2 in midbrain neurulation.
18 opore closure and a stimulation of secondary neurulation.
19 ry role for heparan sulphate in mouse spinal neurulation.
20 convergent extension from other processes of neurulation.
21 n movements are crucial to proper vertebrate neurulation.
22 ing of the neural plate during initiation of neurulation.
23 ls (NPCs) undergo rapid proliferation during neurulation.
24 s have focused primarily on gastrulation and neurulation.
25 h as those occurring during gastrulation and neurulation.
26 In Xenopus, the first of these is neurulation.
27 ecificity of this genetic effect for cranial neurulation.
28 ted and the expression domain altered during neurulation.
29 s capacity was restricted to early stages of neurulation.
30 ism controlling tail outgrowth and secondary neurulation.
31 egulation of electrical development prior to neurulation.
32 rface ectoderm that are essential for spinal neurulation.
33 teratogens acting at the earliest stages of neurulation.
34 he cellular architecture required for proper neurulation.
35 t this proteolytic cleavage is essential for neurulation.
36 oning cells along the caudal neuraxis during neurulation.
37 nteracting their tendency to disperse during neurulation.
38 changes in tissue morphology associated with neurulation.
39 produce the morphogenetic forces that drive neurulation.
40 eath (apoptosis) in the tissues required for neurulation.
41 epithelium and epidermal ectoderm throughout neurulation.
42 ed closure of the cranial neural tube during neurulation.
43 rmation of the hindbrain is disrupted during neurulation.
44 overgrowth of the neural plate during early neurulation.
45 on of the neural plate or neural tube during neurulation.
46 orphogenetic processes, including vertebrate neurulation.
47 H3K4me3 distribution during gastrulation and neurulation.
48 ation and anterior expansion at the onset of neurulation.
49 ction for GAS1 in SHH signaling during early neurulation.
50 m the Brillouin signal of embryos undergoing neurulation.
51 l plate tissue as the embryo is experiencing neurulation.
52 ling and defective ectodermal patterning and neurulation.
53 i-germ layer developmental potential through neurulation.
54 he control of morphogenetic movements during neurulation.
55 'transition zone' from primary to secondary neurulation.
56 and molecular mechanism of mammalian spinal neurulation.
57 diminished MI status and failure of cranial neurulation.
58 d for the predominance of filopodia in early neurulation.
59 roduction during late gastrulation and early neurulation.
60 n events, we term this phenomenon junctional neurulation.
61 6) are not dependent on rax activity through neurulation.
62 ocesses referred to as primary and secondary neurulation.
63 dysraphism results from defective secondary neurulation.
64 ns in embryonic neuroepithelial cells during neurulation.
65 ed fluid flow during late gastrulation/early neurulation.
66 hat promotes apical cell constriction during neurulation.
67 oth pathways maintains the population during neurulation.
68 e-field and telencephalic cells during early neurulation.
69 such as gastrulation, mesoderm formation and neurulation.
70 y ability, and gene expression profile after neurulation.
71 correct de novo asymmetry orientation during neurulation.
72 uces multiaxial mirror symmetry in zebrafish neurulation.
73 al tube, the CNS precursor, is shaped during neurulation.
74 larity plays an essential role in vertebrate neurulation.
75 the establishment of the neural tube during neurulation.
76 he extensive morphogenetic cell movements in neurulation.
77 issue plasticity and tissue integrity during neurulation.
78 he potentially disruptive process of teleost neurulation.
79 es such as gastrulation, tube formation, and neurulation.
80 phalic pallial (dorsal) specification during neurulation.
81 efects in mitotic spindle orientation during neurulation.
82 erm and neuroepithelium, before the onset of neurulation.
83 o the junction between primary and secondary neurulations.
86 evelled homologs, Dvl1 and Dvl2, that during neurulation a homologous mammalian PCP pathway regulates
87 d undergo convergence-extension movements of neurulation, although their principal contribution was t
89 n continues in the same cell lineages during neurulation and axis formation, however, during the tail
90 Thus, Abl and Arg play essential roles in neurulation and can regulate the structure of the actin
93 t in both Abl and Arg suffer from defects in neurulation and die before 11 days postcoitum (dpc).
97 and extension movements during gastrulation, neurulation and epidermis defects and enhanced phenotypi
99 f frog (Xenopus laevis) from gastrulation to neurulation and find dorsal tissues stiffen from less th
100 coupling cell division and morphogenesis at neurulation and indicate a previously unrecognized mecha
101 is recruited specifically during junctional neurulation and its misexpression within a limited time
102 events within the nervous system, including neurulation and neural tube closure, cellular migration,
104 thelial to mesenchyme cell transition during neurulation and plays a role in limb bud development.
105 hypophyseal canal is present from the end of neurulation and represents the anteriormost neural tube,
106 ng to focus cellular events occurring during neurulation and reveal novel molecular mechanisms implic
107 The MAPK kinase kinase MEKK4 is required for neurulation and skeletal patterning during mouse develop
108 e time of gastrulation and neurulation, both neurulation and somitogenesis initiate apparently normal
109 with the role of PCD in events ranging from neurulation and synaptogenesis to the elimination of adu
110 from a radial to linear organization during neurulation and that microtubules function in conjunctio
111 ogenous PtdCho synthesis is important during neurulation and that perturbed choline metabolism contri
112 ve junctions of neuroepithelial cells during neurulation and that Xena knockdown disrupts cell behavi
114 ns is potentially homologous with vertebrate neurulation and thus may help elucidate the evolutionary
115 sary for induction of Pax3 expression during neurulation and thus providing a molecular mechanism for
116 tion of several genes that are important for neurulation and vascular development in the Ikbkap(-)(/)
117 hway plays a conserved role in NT formation (neurulation) and is reported to regulate both NEC elonga
122 tion of dorsal cell fates of ectoderm during neurulation, and regional differentiation of the neural
123 edict that the critical time is early during neurulation, and the critical cells are the ectodermal c
124 ly colonization of the hindgut shortly after neurulation, and the other states that sacral crest cell
125 undergo progressive epithelialization during neurulation, and thus provide a convenient in vivo cellu
128 late border remain heterogeneous until early neurulation, at which time progenitors become progressiv
131 is expressed at the time of gastrulation and neurulation, both neurulation and somitogenesis initiate
132 in; Ncdh) is known for its important role in neurulation, brain development and regulation of synapti
133 related gene), play essential roles in mouse neurulation, but their functions in the subsequent devel
134 ational alterations occurring at the time of neurulation by assessing differential roles of Htt and m
135 These data support a direct normalization of neurulation by folic acid in humans and suggest a metabo
137 cell polarity (PCP) signalling might control neurulation by promoting the convergence of neural proge
139 y days), which results in aberrant secondary neurulation, can explain the observed pattern of anomali
140 and 11.5 of gestation, exhibiting defects in neurulation, cell proliferation, and heart development.
143 tants die perinatally and display defects in neurulation, craniofacial structures, and the formation
145 istinct from the known genes associated with neurulation defects, and isolation of this gene will ass
146 perturbed gastrulation not only explains the neurulation defects, but also provides a unifying etiolo
147 yos are developmentally retarded and exhibit neurulation defects, suggesting that YY1 may have additi
148 deletion die in utero and display defects in neurulation, demonstrating an important functional role
150 We demonstrate that although the mode of neurulation differs at the morphological level between a
151 cdh 19 or ncad impairs cell movements during neurulation, disrupting both the directedness of cell mo
153 ants, the remaining morphogenic processes of neurulation do not appear to occur in absence of vertica
154 distinct ectodermal domains in the course of neurulation, during the establishment of cell lineages.
155 stigators are now attempting to recapitulate neurulation events in stem cell-derived organoids, and o
159 c asymmetry pathway, but are required during neurulation for the maintenance of adequate levels of th
160 ed universal perinatal death with defects in neurulation, fusion of the cerebral hemispheres, formati
161 inally, we show that cobl interacts with the neurulation gene Vangl2 to facilitate midbrain neural tu
163 o, an understanding of the dynamic nature of neurulation has been hampered due to its in utero develo
164 e of the cellular mechanisms responsible for neurulation have been described in a number of vertebrat
165 development, whereas CREBBP is essential for neurulation, hematopoietic differentiation, angiogenesis
169 ttern technology to recapitulate early human neurulation in large numbers of nearly identical structu
172 at measures changes in cell movements during neurulation in response to differential cell adhesion.
175 upling of the entire region of active spinal neurulation in the mouse embryo as a prerequisite for su
176 e prosencephalic neural folds during primary neurulation in the mouse, consistent with forebrain morp
177 n of the zebrafish neural keel and secondary neurulation in the posterior axis of chicken and mouse.
178 which developmental processes operate during neurulation in this region is therefore pivotal to unrav
181 zation of the central nervous system, termed neurulation in vertebrates, is a critical step in embryo
183 C5 to be expressed throughout the period of neurulation in wild-type mice and localized the expressi
184 Much like DAPLE, MPDZ is induced during neurulation in Xenopus and is required for apical constr
189 Bmp2 expression correlates with upper spinal neurulation (in which DLHPs are absent); that Bmp2-null
190 tion of folate action by methotrexate during neurulation induces NTDs by inhibiting folate interactio
191 Additionally, disrupting endocytosis during neurulation inhibits AC in hingepoint cells, resulting i
197 tage-gated K+ current (IKv) near the time of neurulation is followed about 6 h later by a rapidly act
199 The potential for SNX3 to function in human neurulation is revealed by a point mutation identified i
201 at neural fold elevation during mouse spinal neurulation is vulnerable to deletion of the VANGL plana
202 revin), which is normally detectable late in neurulation, is abolished in these alpha6 integrin-pertu
204 rs in the mouse neuroepithelium and disrupts neurulation, leading to NTDs in diabetic pregnancy.
205 xample, failure of neural fold fusion during neurulation leads to open neural tube defects including
206 w that removal of the notochord during early neurulation leads to the complete failure of hypochord d
208 l margin of the neural plate at the start of neurulation move to the dorsal midline using distinctive
209 pite recent advances in our understanding of neurulation, neural tube defects continue to be a major
213 hylation of a Pax3 CpG island decreased upon neurulation of embryos and formation of neuronal precurs
214 cal development could be analyzed only after neurulation, once myocytes could be morphologically iden
215 neural plate border during gastrulation and neurulation, overlapping the domain of neural crest indu
216 NC-1 expression is highly dynamic and, after neurulation, preferentially defines prospective cortical
217 complete gastrulation normally but arrest at neurulation prior to the formation of the neural plate.
223 y the proteins that became methylated during neurulation, rat embryos were first cultured on methioni
224 late border lineages only commences at early neurulation, rather than at gastrulation as previously p
226 ress two issues: (1) which aspects of normal neurulation require Xdsh function; and (2) what role con
228 e exencephaly is due to a primary failure of neurulation, resulting from a lack of mid/hindbrain dors
229 CM) is a developmental defect arising during neurulation, resulting in abnormal neural tube developme
230 g of chick ectoderm from primitive streak to neurulation stage, to explore cell state diversity and h
232 nt the nature of the metabolic defect in the neurulation-stage embryo that is corrected by folic acid
233 s, largely due to the challenge of accessing neurulation-stage embryos (3-7 weeks post-conception).
234 C) is known to be essential, and we examined neurulation-stage embryos for PKC expression and applied
236 piblast from late gastrulation through early neurulation stages to define transcriptional changes in
237 a typical duration of 2 h (gastrulation and neurulation stages), intricacies of image pre-processing
240 ural plate begin expressing AmphiDll and, as neurulation terminates, these cells are incorporated int
242 cts on morphogenesis during gastrulation and neurulation that result in dramatic shortening of the an
247 idisation, we show that, at the beginning of neurulation, the ventral-to-dorsal gradient of BMP activ
248 d interactions with laminin are required for neurulation, they are not required for the initial proce
249 forced to occur in ectopic locations during neurulation, they orchestrate the development of mirror-
250 n and cytoskeletal dynamics is essential for neurulation, though it remains unclear how these two pro
251 road embryonic midline prevents the onset of neurulation through wide spacing of the neural folds.
252 amma, RARgamma2, RXRalpha, and RARgamma from neurulation to HH10 in the normal and vitamin A-deficien
255 cetylation and phosphorylation that disrupts neurulation under diabetic conditions by diminishing the
256 morphoregulatory molecules expressed during neurulation underlie induction and patterning of the for
257 transcriptional changes from gastrulation to neurulation using single-cell-Multiplex-Spatial-Transcri
259 nsient ectopic Wnt-8 expression during early neurulation was sufficient to repress anterior head deve
260 paran sulphate proteoglycans in mouse spinal neurulation, we administered chlorate, a competitive inh
264 their delamination and differentiation after neurulation when NPCs normally acquire organized apical
265 rmal patterning completed only at the end of neurulation when the pluripotency-like signature becomes
266 e gastrocoel and into the deep region during neurulation, whereas hypochordal cells ingress after neu
267 orachischisis result from failure of primary neurulation, whereas skin-covered spinal dysraphism resu
269 xt of the complex morphogenesis required for neurulation, which in zebrafish involves a characteristi
270 isation of the forebrain neural plate during neurulation, which must fold a sheet into a tube while e
271 phogenetic movements during gastrulation and neurulation while its role in hematopoiesis may be redun
272 tube closure and arrests development during neurulation with concomitant reduction in tubulin polyme
273 lls spanning the entire ectoderm late during neurulation with ectodermal patterning completed only at
274 after laying (stage XI) to stages 6-7 (early neurulation), with precise spatial and temporal control.
275 found that although zebrafish embryos begin neurulation without a conventional epithelium, medially