ライフサイエンスコーパス: neutral evolution

1 genetic analyses showed purifying selection (neutral evolution).

2 y less infectious than their parents (nearly neutral evolution).

3 is consistent with a strong role for nearly neutral evolution.

4 a multienzyme complex shaped by constructive neutral evolution.

5 s-consistent with the theory of constructive neutral evolution.

6 limit of recurrences (i(*)) driven solely by neutral evolution.

7 e changes to variant fitness, recapitulating neutral evolution.

8 ransitions to be permanent in the absence of neutral evolution.

9 , branching evolution and effectively almost neutral evolution.

10 erved at higher rates than expected based on neutral evolution.

11 and their growth through both Darwinian and neutral evolution.

12 thought that K = u holds very generally for neutral evolution.

13 lection pinpointed several regions under non-neutral evolution.

14 on-adaptive mechanisms, such as constructive neutral evolution.

15 that Pyl appeared in MaThg1 as the result of neutral evolution.

16 91 ( approximately 94%) sites have undergone neutral evolution.

17 sitions are less biased by the hypothesis on neutral evolution.

18 to localised mutational biases coupled with neutral evolution.

19 e human gene pool faster than expected under neutral evolution.

20 (SH) and those introduced meiotically during neutral evolution.

21 ved in S. franciscanus bindin is a result of neutral evolution.

22 ion of S. franciscanus bindin is a result of neutral evolution.

23 ility type, provided an internal standard of neutral evolution.

24 Fst among loci is greater than expected from neutral evolution.

25 edits were frequently lost, consistent with neutral evolution.

26 e can be introduced and maintained solely by neutral evolution.

27 cancer associations are largely governed by neutral evolution.

28 rum that follows the 1/f law consistent with neutral evolution.

29 of gene expression levels and patterns and 2-neutral evolution accompanied by selective constraint.

30 h rapid and slow evolution, than those under neutral evolution across pig, mouse, and human.

31 ormance to the McDonald and Kreitman test of neutral evolution all indicate that random mutation foll

32 This observation has led to a belief that neutral evolution along these paths can drive transition

33 compared to the statistical expectations of neutral evolution and "Out of Africa" dispersal modeling

34 Both showed that under a model of neutral evolution and exponential growth, the mean Hammi

35 idence to distinguish natural selection from neutral evolution and has been associated with different

36 ological malignancies, the interplay between neutral evolution and natural selection is also disputed

37 We show that neutral evolution and nucleotide substitution rates up t

38 oss environments, which has implications for neutral evolution and the molecular clock.

39 also pseudogenes in M. leprae showed nearly neutral evolution, and their relative ages were similar

40 First, many important genes show evidence of neutral evolution as a consequence of relaxed selection

41 amics compared with the expected change from neutral evolution at the branches of potential functiona

42 nterference-free null model assuming initial neutral evolution before immune response elicitation.

43 ion is not caused by differences in rates of neutral evolution but instead appears to be related to d

44 s modes, including branching, punctuated and neutral evolution, but it is unclear why a particular pa

45 larity is usually viewed as the signature of neutral evolution, but several lines of evidence indicat

46 cancerous stage may be modulated en route to neutral evolution by the combination of two factors: spa

47 tworks has reached the target state, further neutral evolution can lead to an increase in both the mu

48 rajectories, long considered the hallmark of neutral evolution, can arise even when mutations are str

49 Several tests of neutral evolution employ the observed number of segregat

50 Neutral evolution enables tolerance of hypermutation, wh

51 This shows that neutral evolution explores phenotype space and can play

52 There was insufficient evidence to reject neutral evolution for 6 genes encoding signaling compone

53 f cancer and aging is crucial to parsing out neutral evolution from natural selection, 2 processes th

54 seed plants and we propose the constructive neutral evolution hypothesis as a plausible explanation

55 A test of the neutral evolution hypothesis, through use of the Hudson/

56 xpression evolution are considered: 1-purely neutral evolution (i.e., no selective constraint) of gen

57 In contrast with neutral evolution in a homogenous environment, as demons

58 ectrum follows a 1/f power law expected from neutral evolution in a particular intermediate frequency

59 yang phenomenon can be explained by strictly neutral evolution in a well-mixed population.

60 ion within the glb1 locus is consistent with neutral evolution in all four taxa.

61 w that, in contrast to published criticisms, neutral evolution in an exponentially growing tumor can

62 important consequences for the occurrence of neutral evolution in clonal populations.

63 among genes that are active in the GRN, and neutral evolution in genes that are not included in the

64 s the relative role of natural selection and neutral evolution in producing biogeographic patterns.

65 ndent datasets for evaluating the pattern of neutral evolution in the human genome, for example, they

66 l where age at first reproduction influences neutral evolution in the nuclear genome.

67 we discuss the role of natural selection and neutral evolution in the production of linear clonal arc

68 we identify a nearly universal shift toward neutral evolution in tumors that resist treatment and de

69 Our data show hallmarks of neutral evolution, including similar rates of synonymous

70 We find that periods of neutral evolution increase rates of adaptation to the ne

71 We present a theoretical approach to model neutral evolution independent of the infinite-sites assu

72 Neutral evolution is a frequently used model to analyse

73 This process of neutral evolution is an important mode of genetic change

74 ased on the framework developed we show that neutral evolution is not an adequate description of the

75 the population during the whole period under neutral evolution) is a powerful indicator of departures

76 olved under natural selection, as opposed to neutral evolution, is a major goal of evolutionary biolo

77 Our theory quantitatively describes how neutral evolution leads to marginally stable proteins an

78 With respect to purely neutral evolution, levels of change in gene expression b

79 mmetry pattern that is inconsistent with the neutral evolution model, and reflects their functional r

80 Under a neutral evolution model, each mononucleotide or oligonuc

81 cute viral decline stage than predicted by a neutral evolution model.

82 Proteins with such partly neutral evolution nonetheless have no fewer protein inte

83 y matched cohort we found evidence for rapid neutral evolution of HCV in persons with rapid progressi

84 pecies, with mean patterns suggesting nearly neutral evolution of life-course variability.

85 To provide a baseline for neutral evolution of the trait, we estimate the distribu

86 he) (GAA) therefore attributes the seemingly neutral evolution of the two spacers to their escape fro

87 We tested for departures from neutral evolution on the basis of partial sequences of E

88 These include nonlinear and neutral evolution; polyclonality of driver mutations and

89 ing from genetic drift in which constructive neutral evolution progressively incorporates weakly stab

90 ein, with omega = 1, < 1, and > 1 indicating neutral evolution, purifying selection, and positive sel

91 round this locus were also suggestive of non-neutral evolution, raising the possibility that the evol

92 ous evolution rate in those regions than the neutral evolution rate.

93 vers by neighbors (coalescence), after which neutral evolution reestablishes the province and the pat

94 Bole1b sequence increased, resulting in net neutral evolution relative to Bole1b across the entire 5

95 ral selection, recent studies uncovered that neutral evolution shapes clonal evolution in a significa

96 Statistical tests of neutral evolution showed that a few haplotypes predomina

97 Using neutral evolution simulations, we identified 4,098 subst

98 Second, proteins undergo neutral evolution so that the fitness landscape has a fl

99 mmelinids, variation in copy number, and non-neutral evolution suggests overlapping or fluid function

100 sistent with the predictions of constructive neutral evolution than an adaptive process: quaternary s

101 es of this model while being consistent with neutral evolution theory, thereby unifying observations

102 have patterns of variation incongruent with neutral evolution: They have too much or too little vari

103 in repeat regions can be explained by adding neutral evolution to what is already known about the mut

104 s with a strong signal of secondary contact; neutral evolution under this history produces clines as

105 -ta region, while significant deviation from neutral evolution was not found in all O. sativa groups.

106 Here, in the context of neutral evolution, we examine the interplay between a po

107 Also for neutral evolution, where species with exactly the same p

108 ns to what would be expected by chance under neutral evolution, which can be estimated from the pheno

109 The model of neutral evolution with selective constraint predicts a r

110 or mariner transposon evolution that expects neutral evolution within particular hosts, with selectio

111 tterns of sequence diversity consistent with neutral evolution, yet loci near the proximal breakpoint