ライフサイエンスコーパス: new

1 We use hydrological modeling and new 1200-year tree-ring reconstructions of summer soil m

2 operties, which may pave a new way to design new 3D graphene devices with preserved 2D electronic pro

3 e presence of a helper adenovirus to yield a new AAV variant that then serves as a template for evolv

4 A new Abeta-independent hypothesis emerges where the amylo

5 The origin of land plants was accompanied by new adaptations to life on land, including the evolution

6 We further validated the functions of 3 new adipose IR genes by overexpression-based phenotypic

7 These new agents can be classified into different groups, main

8 r, but in addition may help provide a useful new alternative strategy to control ovarian tumor progre

9 Approximately 3.4% of new and 18% of recurrent cases of TB are multidrug-resis

10 These observations open new and interesting questions on the function and regula

11 emote sensing datasets promise qualitatively new and more abundant data on the underlying processes a

12 ssion of gender norms, with the emergence of new and more horizontal forms of social differentiation

13 all families of porous ions and represents a new and powerful method for the synthesis of porous soli

14 We present 2 new animal models that will serve to elucidate the under

15 play library based on the variable domain of new antigen receptor (VNAR) was used for in vitro select

16 rocumulenes and sets the scene for a host of new applications for CO(2)-derived polymers.

17 We then introduce a new approach designed specifically to find radically dis

18 In this study, we describe a new approach for preparing islets that enhances islet fu

19 We believe this new approach holds tremendous promise in reproducibly re

20 erload or inhibition of Na/Ca(mito) may be a new approach to ameliorate metabolic dysregulation in he

21 s the versatility of the enzyme, providing a new approach to facilitate novel applications.

22 entify people at risk for AKI and to develop new approaches to improve AKI outcomes.

23 urveys the current progress of this exciting new area.

24 Finally, we highlight new areas of research and novel strategies that may shed

25 monoicy likely favoured the colonisations of new areas, especially in the Miocene that was a key epoc

26 confirming known interactions and predicting new associations.

27 We present a new, automated method for arriving at a classification o

28 g those used by insect navigators, opening a new avenue for the investigation of the neural basis of

29 antagonist, such as ICT12035, can provide a new avenue for the treatment of cancers.

30 episignatures and, most significantly, opens new avenues for accurate diagnosis and clinical assessme

31 ing into frameworks of memory function opens new avenues of study and even therapies for hippocampal

32 the ISR can be modulated promises to uncover new avenues to diminish pathologies resulting from it fo

33 elity of translation initiation by OCM opens new avenues to understand alternative translation mechan

34 kably plastic, and that dynamic GNs generate new biosynthetic pathways in different Brassicaceae line

35 Recent advances in new cancer treatment modalities (e.g., gene and immune t

36 and the search to identify and characterize new cancer-related organisms is ongoing.

37 an approach (BeviMed(4)) identified multiple new candidate PID-associated genes, including IVNS1ABP.

38 tructure in miRNA cleavage by developing the new CAP-STRUCTURE-seq method to capture the intact mRNA

39 y-6 (P6), representing a barrier to building new cardiac muscle in adults.

40 rden of premenopausal breast cancer for both new cases and deaths compared with higher income countri

41 We forecast rates of new cases for COVID-19 under different social distancing

42 There were 121 (12%) HHCs that had new cases of TB identified: 17 (2%) were confirmed, 33 (

43 s their affinity to PIPs we have developed a new cell free assay based on the ability of the receptor

44 opens many exciting avenues but also create new challenges.

45 In this work, we designed a new chemotherapeutic drug candidate against cancer, name

46 rtebrates through genomic comparisons with a new chromosome-scale sequence of the invertebrate chorda

47 rapid trait refinement and adaptation to the new citrate niche, while also suggesting a recalcitrant

48 ute a new class of polyurethanes (PUs) and a new class of materials featuring an unprecedented backbo

49 esulting materials respectively constitute a new class of polyurethanes (PUs) and a new class of mate

50 Furans merit consideration as a new class of therapeutic agents for controlling cancer m

51 Trifluoromethyl sulfoxides are a new class of trifluoromethylthiolating reagent.

52 veloped to inhibit enzyme activity; however, new classes of small molecules that endow new functions

53 The new classification includes 2 classes, 6 types and 33 su

54 We identify five new colonies, and 21 additional colonies previously unre

55 indings establish that evolution can produce new complex molecular structures and functions via simpl

56 gans and other animals may reveal additional new compound families and signaling paradigms.

57 cone, 2'-hydroxy-3-phenylpropionate, and two new compounds, namely (Z)-1,6-bis(2-hydroxyphenyl)-3,4-d

58 Here, we described a new, comprehensive system of in silico methods that take

59 reservoirs is introduced to demonstrate the new concept of "structronics" (a neologism derived from

60 ted scaffolds is of interest when developing new conducting or electrochromic materials as well as in

61 p of multidisciplinary experts in the field, new core criteria based on contemporary cardiovascular i

62 ture during the sport practice by means of a new "correction approach".

63 The development of new CRISPR-Cas genome editing tools continues to drive m

64 kinetic registration can be used to develop new criteria for comprehensive diagnostics of autoimmune

65 In this work, two new curvature-based angularity indices are introduced an

66 partments in patients with MS, which include new data and practical comments for electroradiology tec

67 sly published blood transcriptomic data with new data from a prospective human immunodeficiency virus

68 the well-established mouse model of TB, our new data provide evidence that the alarmin S100A8/A9 med

69 te of incidence does, presenting a promising new data type for the application of statistical indicat

70 Until its new definition in the fourth edition of the WHO classifi

71 As a result, nanoscale curvature provides a new degree of freedom to manipulate 3D graphene electric

72 ngs, providing a framework for the design of new DEL synthesis technologies to enable next-generation

73 Ac D1-MSNs and may prove a useful target for new depression therapeutics.

74 of histology and mutation information, with new developments in DNA methylation classification.

75 trans-acting lncRNAs in vivo, and generating new developments in high-throughput screening used to id

76 With new developments in the area of advanced biobased fibers

77 We apply the AWA methodology to evaluate a new diagnostic test developed in the Rapid Diagnostics i

78 More generally, these data bring a new dimension to the nuclear theranostic model by showin

79 scribe the partial cranium and skeleton of a new diprotodontian marsupial from the late Oligocene (~2

80 These results provide a new direction for future investigation of the diverse bi

81 tanding of non-volatile switching and open a new direction in precision defect engineering, down to a

82 ther, these emerging methods offer promising new directions in the study of natural selection.

83 can help to identify and characterize these new disease-causing genes.

84 The most common therapeutic needs involved new drugs (n = 149, 51.0%), cell regeneration (n = 115,

85 New drugs or combinations are needed to improve patient

86 This RGC network forms a new electrical channel combining the ON and OFF feedforw

87 e made from standard output with no need for new engineering.

88 This involved a new ephaptic coupling, in which an excitatory synapse ge

89 rt disease guidelines have been updated with new evidence and provides newer options for diagnosis an

90 ressed with evidence updates to identify any new evidence and to help determine which topics should b

91 ata was originally described as a cycad, but new evidence from cuticle structure suggests that it is

92 In this review, I will highlight new evidence indicating that neonatal T cells are not in

93 New evidence reported by Solomon et al. that hippocampal

94 This is a qualitative synthesis of new evidence with existing meta-analyses, and studies ha

95 iolate)](-) structure, which is supported by new EXAFS data.

96 With these new examples, we perform the first cross-kingdom structu

97 rophage immunometabolism in atherosclerosis, new exciting concepts and potential targets for interven

98 Notably, most of these mutations create new exons.

99 A new family of robust, non-toxic, water-compatible ruthen

100 New, fast-acting T2-targeting biologics (already used fo

101 Here, we review these new findings, focusing on studies performed on human bet

102 progress will impact the academic sector as new forms of research based on large amounts of data wil

103 Here, we describe a new fossil specimen from Drimolen Main Quarry, dated fro

104 Here, we advance existing hypotheses with a new framework that accounts for quantitative FLS variati

105 on of TET1-targeted neuronal genes, offering new functional and mechanistic understanding of NONO in

106 liable because of its potential of unveiling new functionalities of the genomic expressions, which mi

107 Recent studies have demonstrated new functions of individual members of the FABP family.

108 r, new classes of small molecules that endow new functions to enzymes via proximity-mediated effect a

109 the COVID-19 pandemic have exposed humans to new fungi and viruses, with unknown consequences.

110 To enable a new generation of anti-viral vaccines, we designed self-

111 gencies and training programs must support a new generation of scientists and clinicians who work in

112 The anniversary provides a chance for a new generation to take a look back, to see how science h

113 After a new genome is sequenced and assembled, structural gene a

114 In total, 22 new geriatric variables were imported from the ACS NSQIP

115 NIH RePORTER was queried for new grants (R01, -03, -21) awarded to Departments of Sur

116 administrative organization to conform to a new healthcare environment while still providing high-qu

117 logy is entering an exciting time where many new high-resolution structures of large complexes and me

118 , D-serine, an endogenous amino acid, offers new hope as a therapeutic agent for refractory TLE.

119 uld push the output performance of TENG to a new horizon.

120 2018, Philadelphia identified an outbreak of new human immunodeficiency virus (HIV) infections among

121 entific process of cyclically preregistering new hypotheses in between waves of data collection, we i

122 orphans from a structural point of view, and new I(2)-IR ligands are urgently required for improving

123 i image-quality phantoms designed to fit the new imaging system.

124 s increasingly important with the arrival of new immunotherapy modalities.

125 ll model of KSHV infection and established a new infection model of primary lymphatic endothelial cel

126 cell culture and in vivo This work provides new insight into how flaviviruses control pathogenesis a

127 This study provides a new insight into the metabolism of IVD cells under nutri

128 These studies provide new insight into the sequence requirements for developin

129 Our goals are to provide a means of deriving new insights and infection control strategies based on t

130 These results bring new insights for studies with venom compounds, PIs, and

131 This model provides new insights into charge-ordering phenomena in transitio

132 nd biochemical data, we attempt to summarize new insights into hERG-specific function and articulate

133 rative disease-modelling strategy may reveal new insights into mechanisms of cardiac disease and serv

134 The methodology promises new insights into phosphorus as well as other structural

135 This work affords new insights into realizing a stable Li metal anode for

136 Molecular modeling studies provided new insights into the chemical features required for opt

137 Taken together, our data provide new insights into the differentiation of transposons and

138 of conjugated polymers, thus also providing new insights into the molecular design guidelines for th

139 contact dynamics as guidance cues may yield new insights into the regulation of innate immunity.

140 mental properties of lncRNA genes, revealing new insights into the RNA structure-function relationshi

141 t forward an alternate mechanism, drawing on new insights into the role of the medial temporal lobe i

142 eetahs (Acinonyx jubatus) to demonstrate how new insights into the socio-spatial organization of this

143 We provide new insights into the tissue-specific functions of VDRs

144 This study provides new insights into YAP as a broad transcriptional repress

145 However, new insights suggest that non-haemodynamic tubulo-toxic

146 rom generally expanding to incorporate these new insights.

147 New key questions focused on the yield of alternative HB

148 FC plays a causal role in the acquisition of new learning and not just in the extinction or reversal

149 These findings shed new light on GM-CSF biology in sterile tissue inflammati

150 fer cellular functions are beginning to shed new light on the interplay of components involved in mul

151 Our findings reveal new links between avian physiology, ecology, behaviour a

152 face and many more plasmid vectors, but also new links of the plasmids to advanced bioinformatic tool

153 tions from which they have disappeared or to new locations where biologists hypothesize they have a g

154 This has implications for the design of new long-residence-time TSPO ligands.

155 the promise they hold for the development of new management strategies in agriculture and forestry.

156 Overall, we indicated this new material may be developed as an anti-bacterial agent

157 Taken together, these new materials and methods provide access to colloidal cr

158 New materials have been explored, including green materi

159 al factors and viral pathogens and provide a new means of targeted attenuation for next-generation ro

160 Our study revealed a new mechanism by which platelets promote the metastasis

161 Thus, our findings provide a new mechanism for social memory formation, through regul

162 ntify dependencies that point to potentially new mechanisms.

163 Taken together, these data not only provide new mechanistic insight into how a unique collagen fragm

164 AD3 promoter methylation in TAFs and provide new mechanistic insights on the selective poor response

165 This new method allowed calculation of kinetic features of th

166 For testing M3C, we developed clusterlab, a new method for simulating multivariate Gaussian clusters

167 a simulation experiment, and showed that the new method is more powerful with less Type I error than

168 termediates at low temperature and creates a new method to characterize elusive intermediates in mult

169 Overall, this study reports new methodologies to synthesize SH probes, while providi

170 can be made highly atom economic, makes this new methodology a very appealing option for this archety

171 New methods for investigating human astrocytes are urgen

172 netic basis of sex determination may lead to new methods of managing these troublesome weeds.

173 ostatic health, the responses to injury, and new methods to study lung repair and regeneration.

174 n in sequence and structure, we introduced a new metric designated 'contact proximity deviation' that

175 es an initial allylic substitution to form a new Michael acceptor, followed by the addition of a seco

176 the intrinsic kinetic mechanism to result in new molecular and cellular functionality.

177 Our results identify new molecular and morphological traits associated with p

178 The present study unravels a new molecular system for vesicle-based axonal transport

179 ism is being redefined by the development of new molecular tools, tumour modelling systems and precis

180 lateau and northern India, diversifying into new, more arid habitats after environmental conditions s

181 Thus, the new mouse line is an ideal tool to study cytotoxic T lym

182 The new multicore ring fibers provide a new platform for exp

183 es, and 62 mycorrhizal species, including 29 new mycorrhizal genomes.

184 inspired rational design and engineering of new nanomaterials to incorporate desired enzymes into th

185 Synaptogenesis is essential in forming new neurocircuits during development, and this is mediat

186 evolution could drive a pathogen to colonize new niches, interrogation of sequenced E. coli O157:H7 g

187 The detected new nonsense mutation in the TYMP gene would be very imp

188 We proposed a new normalization method, labeled MIXnorm, for FFPE RNA-

189 e assessed the feasibility of eradicating 60 new (not yet established) and 35 emerging (established w

190 us replacement of senescent taste cells with new ones generated by adult taste stem cells.

191 ntrast enhanced subtraction imaging provides new opportunities for molecular diagnostics and image-gu

192 ility to tune the anomalous phase, and opens new opportunities for superconducting spintronics, and n

193 al catalysis and physical hydrogels opens up new opportunities to administer and modulate the mobilit

194 vel interaction between endocan and EGFR and new opportunities to effectively target endocan-EGFR reg

195 inary therapeutic results that could provide new options for cell-based therapeutics with curative in

196 ich accelerates the discovery of a series of new oxide perovskite catalysts with improved OER activit

197 the designable structure space and offers a new paradigm for designing proteins with tunable geometr

198 Our findings also uncover a new pathogenic mechanism by which beta-catenin promotes

199 Data from the clinical booking system (new patient and follow-up visits) for all clinical provi

200 New permanent pacemaker was placed in 46 (18.3%).

201 atients who underwent outpatient procedures, new persistent opioid use was similarly correlated with

202 ) compared with patients who did not develop new persistent use.

203 ions of tracers and tracer ratios to provide new perspectives on sulfate, NO(x,) and particle acidity

204 ctly on living mammalian cells, which offers new perspectives to better understand virus-glycan inter

205 iron biology but also for the development of new pharmacologic agents that exploit or target TMPRSS6

206 It provides new pharmacological content, including molecular targets

207 The new phased array selectively alters the directional and

208 Thus, the new pipeline may significantly boost the performance of

209 The new multicore ring fibers provide a new platform for experiments of quantum effects in low-l

210 A series consisting of new polyaminoisoprenyl derivatives were prepared in mode

211 unities for superconducting spintronics, and new possibilities for realizing and characterizing topol

212 he knowledge gained in this study would open new possibilities for the design and synthesis of molecu

213 ubiquitination of ribosomes has emerged as a new posttranslational modification that regulates protei

214 lity and reversibility will be discussed and new potential applications will be introduced.

215 of these diseases, which can help accelerate new prevention strategies.

216 We propose some new prospective hallmarks that might apply to both cance

217 ed by global or HDAC3/6-selective HDACi, and new protein synthesis was not required for gene suppress

218 New pS22-Lamin A/C binding was accompanied by increased

219 ies to synthesize SH probes, while providing new reagents to study protein depalmitoylation.

220 he meningococcal group B vaccine 4CMenB is a new, recombinant protein-based vaccine that is licensed

221 ity does not correlate with the evolution of new regions but appears late in synapsid evolution.

222 cleus that was repeatedly duplicated to form new regions.

223 g the oncology landscape, bringing with them new requirements and challenges for next-generation canc

224 New research frameworks that simultaneously address prod

225 large amounts of data will be possible, and new research needs will be requested by the technology i

226 New research on full-fat dairy products high in saturate

227 ndrocyte development and repair and reveal a new role for Nedd4 in glial biology.

228 These studies define a new role for Notch3 in manipulating the tumor microenvir

229 ies and how studies of CHC22 have identified new routes for GLUT4 trafficking.

230 ion of synthesized compounds has highlighted new SAR, and low toxicity profiles of pyroglutamides her

231 Further, the new SCNP resists uptake by cells allowing extracellular

232 d activity that allows participants to learn new sensorimotor schemes.

233 In this paper, we present ADEPT, a new sequence alignment strategy for GPU architectures th

234 However, new sequencing approaches, particularly whole-genome seq

235 copes for high-throughput efficiency and the new sequencing chemistry removes limitations bound by se

236 oint-of-care tests and discuss the basis for new serologic tests.

237 merging with nearest neighbours or spawning new skyrmions is favoured to attain a lower energy state

238 m Denmark, Scotland, England, and Australia (New South Wales and Western Australia).

239 on of G. vaginalis and descriptions of three new species - Gardnerella leopoldii, Gardnerella piotii,

240 We present Spectrum, a new spectral clustering method for complex omic data.

241 This system should be regarded as a new standard for both small-bowel diagnosis and monitori

242 In 2008, The Joint Commission implemented a new standard mandating a detailed evaluation of a provid

243 adykinesia pathophysiology will serve as the new starting point for clinical and experimental purpose

244 ars and older and free of ASCVD at baseline, new statin use was significantly associated with a lower

245 We developed LeafCutterMD, a new statistical framework that significantly improves th

246 the formation of pyrrolidine rings bearing a new stereogenic center on the C2 of the five-membered ri

247 ng cancer cell metabolism and development of new strategies for the treatment of lethal PC.

248 ted understanding of early embryogenesis and new strategies for therapeutic intervention in early pre

249 Herein, we have developed a new strategy using proteins as structure-directed agents

250 New structural classes of antibiotics are rare, structur

251 he database is regularly self-updating, once new structures are deposited in the PDB.

252 e in conjunction with cytoplasmic extract, a new study finds that microtubule end density negatively

253 A new study reveals how differences in tubulin populations

254 A new study shows that one of them does while using unexpe

255 A new study shows that they are also involved in taste per

256 uncertainty in the allocation of proteins to new sub-cellular niches, as well as in the number of new

257 ex vivo These findings might pave a way for new synthetic lethal combination therapies.Significance:

258 This understanding may lead to new targets or approaches for drug development or treatm

259 hear wave elastography (SWE) is a relatively new technique for measuring tissue elasticity.

260 esistant cells, suggesting the potential for new therapeutic interventions, directed against evolving

261 ormalities observed in patients and suggests new therapeutic modalities.

262 ome of which are parasite-specific, opens up new therapeutic possibilities.

263 vated striatum may prompt the development of new therapeutic principles for Parkinson's disease.

264 ent infection may lead to the development of new therapeutic strategies against chronic CHIKV disease

265 of neuron-cancer interactions will elucidate new therapeutic strategies for these presently lethal br

266 s provide preclinical proof of concept for a new therapeutic strategy and address an unmet need for t

267 Hence, we identify new therapeutic targets and putative therapeutic approac

268 lication of signaling kinetics to developing new therapeutics requires reliable kinetic assays and an

269 nd their understanding could offer potential new therapies for CRSwNP (incurable disease).

270 ing of arrhythmia mechanisms, diagnosis, and new therapies.

271 ar events, which may guide the evaluation of new therapies.

272 as well as the discovery and development of new therapies.

273 anistic insights assisted the discovery of a new Ti(salen) catalyst, which substantially expanded the

274 A new tissue sample embedding and processing method is pre

275 to provide social scientists with a powerful new toolbox they can use to better understand environmen

276 Here, we present new tools to overcome these limitations.

277 argeted suppression of IL17RA is a promising new topical treatment strategy for psoriasis.

278 hway driving melanogenesis will help develop new treatment approaches targeting this oncogenic cascad

279 ms underlying UC has led to the emergence of new treatments.

280 itch holds enormous potential for developing new treatments.

281 As a new type of imaging spectroscopy, SMOLM exposes the orga

282 -IgG) have been increasingly recognised as a new type of neuroinflammatory disorder.

283 th a number of algorithmic improvements in a new version of the duplex analysis software, Du Novo 2.0

284 To validate the efficiency of this new version, analyses for GM12878 individual autosomes w

285 decrease in microvessel density, and reduced new vessel formation.

286 lication, underwent cell lysis, and released new virus.

287 hene electrical properties, which may pave a new way to design new 3D graphene devices with preserved

288 This approach provides a new way to evaluate and constrain computational models w

289 Proponents have pointed to the existence of New World crops, such as the sweet potato and bottle gou

290 of 5 Mount Sinai Health System hospitals in New York City between February 27 and June 26, 2020.

291 ught to study the relationship between LVEF, New York Heart Association class on presentation, and th

292 eloped refractory heart failure to disabling New York Heart Association functional classes III/IV (5.

293 program at New York-Presbyterian Hospital in New York, NY rapidly and comprehensively transitioned it

294 In New York, SIR for Broome and Tioga counties were 0.93 an

295 g the pandemic, the heart failure program at New York-Presbyterian Hospital in New York, NY rapidly a

296 nder women, in Bangkok, Thailand and Harlem, New York.

297 along a 1200 km latitudinal transect across New Zealand (NZ).

298 Groups of juvenile New Zealand White rabbits were administered 3 sequential

299 , the effective reproductive number, R(e) of New Zealand's largest cluster decreased from 7 to 0.2 wi

300 vaccine involving 46 individuals in Dunedin, New Zealand, during 2012-2014.

301 e-directed agents to direct the formation of new ZMOFs that can act as versatile platforms for the in