ライフサイエンスコーパス: nitric oxide production

1 h permeability edema), and nitrite/ nitrate (nitric oxide production).

2 nitrite/nitrate concentrations (a marker of nitric oxide production).

3 receptors and increase cytosolic Ca(2+) and nitric oxide production.

4 by limiting LDL oxidation via stimulation of nitric oxide production.

5 ide, but rather to suppression of macrophage nitric oxide production.

6 e effector response by increasing macrophage nitric oxide production.

7 ial nitric oxide synthase protein levels and nitric oxide production.

8 ilization of dysfunctional EPCs with blocked nitric oxide production.

9 ascular endothelial growth factor-stimulated nitric oxide production.

10 the increases were blocked by inhibitors of nitric oxide production.

11 be involved in the regulation of endothelial nitric oxide production.

12 se regulator function and is associated with nitric oxide production.

13 icant negative correlation between TCF11 and nitric oxide production.

14 al cofactor for catecholamine, serotonin and nitric oxide production.

15 fects are prevented by restoring endothelial nitric oxide production.

16 s, in a dose-dependent manner, and triggered nitric oxide production.

17 nducing arginase I expression and inhibiting nitric oxide production.

18 igation by stimulating pulmonary endothelial nitric oxide production.

19 nvolved in acid resistance and inhibits host nitric oxide production.

20 tion of nuclear factor-kappaB activation and nitric oxide production.

21 COX-2 increases 4-HPR-induced apoptosis and nitric oxide production.

22 roxyphenyl)retinamide (4-HPR) by suppressing nitric oxide production.

23 -activated pathways, endotoxin tolerance, or nitric oxide production.

24 te interleukin-6 secretion but did not alter nitric oxide production.

25 nitric oxide synthase, leading to decreased nitric oxide production.

26 res, but to have no effect on LPS-stimulated nitric oxide production.

27 euronal nitric oxide synthase activation and nitric oxide production.

28 ects of LPS by inhibiting the stimulation of nitric oxide production.

29 h as proliferation, particle engulfment, and nitric oxide production.

30 sduction of ICSBP with IRF-1 clearly induces nitric oxide production.

31 ter Eph B4 stimulation, indicating increased nitric oxide production.

32 ed bone resorption in the presence of normal nitric oxide production.

33 ation, reduced HO-1 expression and increased nitric oxide production.

34 oxide synthase from caveolae, and preventing nitric oxide production.

35 cytokine-stimulated granuloma formation and nitric oxide production.

36 nd IFN-gamma resulted in iNOS expression and nitric oxide production.

37 mal coupling of extracellular stimulation to nitric oxide production.

38 l recovery, which manifest as an increase in nitric oxide production.

39 iotensin system and inhibition of intrarenal nitric oxide production.

40 y IC + IFN-gamma-induced iNOS expression and nitric oxide production.

41 e, despite displaying a marked deficiency in nitric oxide production.

42 pha-melanocyte-stimulating hormone decreased nitric oxide production.

43 ducible nitric-oxide synthase expression and nitric oxide production.

44 er trauma-hemorrhage via endothelial derived nitric oxide production.

45 l immunity, gamma interferon production, and nitric oxide production.

46 compromised in their ability to downregulate nitric oxide production.

47 ascular resistance and disturbed endothelial nitric oxide production.

48 re abolished by inhibition of either AMPK or nitric oxide production.

49 e from THP-1 cells as well as superoxide and nitric oxide production.

50 laxation of human and animal airways through nitric oxide production.

51 airway nerves as the source of TLR7-induced nitric oxide production.

52 on through nitric oxide synthase 2-dependent nitric oxide production.

53 re associated with HIF isoform regulation of nitric oxide production.

54 +/- 120.1 micromol/l, p = 0.003), decreased nitric oxide production (25.2 +/- 10.8 micromol/l to 22.

55 a stronger bactericidal activity with higher nitric oxide production, a more proinflammatory polarize

56 zed E(h) of Cys/CySS stimulated H2O2 but not nitric oxide production, activated nuclear factor-kappaB

57 play an essential role in the regulation of nitric oxide production after a septic challenge.

58 low-density lipoprotein reduces endothelial nitric oxide production (an important mediator of vasore

59 Previous studies documented impaired nitric oxide production and altered caveolin expression

60 TMEV infection through preemptive antiviral nitric oxide production and antiviral STAT1 activation.

61 rom the internal store in endothelial cells, nitric oxide production and artery relaxation.

62 hosphorylation of eNOS, whereas it decreased nitric oxide production and bioactivity.

63 effect of soy isoflavone supplementation on nitric oxide production and blood pressure in menopausal

64 drial Ang system is coupled to mitochondrial nitric oxide production and can modulate respiration.

65 Tumor necrosis factor-alpha increased nitric oxide production and caused similar increase in S

66 MDSCs with ibrutinib significantly impaired nitric oxide production and cell migration.

67 The nitric oxide production and cytokine secretion in rat pe

68 ion of renal kallikrein expression increased nitric oxide production and dampened renal superoxide pr

69 Moreover, DATS restored nitric oxide production and decreased endothelial nitric

70 synthesis, restored cellular BH4 levels and nitric oxide production and decreased radiation-induced

71 activated the JAK/STAT1/IRF1 axis, inducing nitric oxide production and driving caspase-8/FADD-media

72 Finally, HHcy potentiated HG-suppressed nitric oxide production and eNOS activity in HAECs, whic

73 suring mechanosensing, which is essential to nitric oxide production and flow-induced vasodilation.

74 important role in the regulation of iNOS and nitric oxide production and hence could account for some

75 ortance of the simultaneous consideration of nitric oxide production and inactivation when investigat

76 ally ill patients with sepsis have increased nitric oxide production and increased bone resorption, w

77 Milder suppression of nitric oxide production and inducible nitric oxide synth

78 ed in a significant decrease in MCAO-induced nitric oxide production and inducible nitric-oxide synth

79 Th1 cells, but not Th2 cells, induced nitric oxide production and inhibited intracellular para

80 nt macrophages, stimulating iNOS expression, nitric oxide production and interleukin-1 (IL-1) release

81 This cascade requires prostanoid/nitric oxide production and is independent of Wnt/LRP5.

82 ability to activate macrophages in vitro for nitric oxide production and killing of Leishmania major

83 soy isoflavone supplementation to stimulate nitric oxide production and lower blood pressure in meno

84 ormal vascular function via endothelial cell nitric oxide production and modulation of Ca(2+) handlin

85 Limb nitric oxide production and muscle phospho-endothelial n

86 Inhibitors of nitric oxide production and of SNO blocked PAF-induced S

87 features of microglial activation including nitric oxide production and phagocytosis.

88 ssociated with increased iNOS expression and nitric oxide production and prevented by L-NIO, an enzym

89 ave found reductions of basal and stimulated nitric oxide production and responses to exogenous nitri

90 Insights into mechanisms regulating nitric oxide production and signaling and their integrat

91 response requires protein kinase A-dependent nitric oxide production and subsequent PAK2 phosphorylat

92 nostic tests, including measurement of nasal nitric oxide production and systematic analysis for muta

93 eprived motor neuron survival by suppressing nitric oxide production and the consequent peroxynitrite

94 ilar to estrogens, are believed to stimulate nitric oxide production and thus lower blood pressure.

95 nitric oxide synthase (iNOS) expression and nitric oxide production and to inhibit beta cell functio

96 antagonist, anakinra, efficiently decreased nitric oxide production and vascular proliferation and r

97 ly in neurons, is critical for CO(2)-induced nitric oxide production and vasodilation.

98 s hypertension and atherosclerosis, in which nitric oxide production and/or biological activity is im

99 Tyr-99 revealed that this nitration reduces nitric-oxide production and increases eNOS decoupling co

100 duced increase in urinary nitrates/nitrites (nitric oxide production) and 8-isoprostane (oxidative st

101 (CPSI, related to urea cycle and endogenous nitric oxide production) and complement factor H-related

102 ated protein product has defects in folding, nitric oxide production, and binding of cofactors.

103 nteractions in vivo by endothelial-dependent nitric oxide production, and by direct modulation of leu

104 , regulates permeability, leukocyte traffic, nitric oxide production, and coagulation, and harbors di

105 ibit increased gamma interferon (IFN-gamma), nitric oxide production, and delayed-type hypersensitivi

106 factor-kappaB (NF-kappaB) subunit p65, lower nitric oxide production, and diminished CHOP expression

107 resulted in impaired fungicidal ability, low nitric oxide production, and elevated synthesis of inter

108 etermining organism survival, superoxide and nitric oxide production, and expression of the cytokines

109 ndothelial nitric oxide synthase expression, nitric oxide production, and heme oxygenase-1 (HO-1) exp

110 nitric oxide synthase uncoupling, decreased nitric oxide production, and increased superoxide genera

111 essed by proliferation rate, apoptosis rate, nitric oxide production, and inflammatory markers TNF-al

112 II (inducible) nitric oxide synthase (iNOS), nitric oxide production, and inhibition of DNA synthesis

113 rditis virus (EMCV)-induced iNOS expression, nitric oxide production, and iPLA2 enzymatic activity in

114 's anti-Plasmodium defense as a substrate of nitric oxide production, and its availability therefore

115 ssel permeability, leukocyte/EC interaction, nitric oxide production, and mechanotransduction.

116 ltures, and gene expression, collagenase and nitric oxide production, and NF-kappaB activation were d

117 otein kinase C translocation and activation, nitric oxide production, and nitric oxide-activated poly

118 Total leukocyte counts, myeloperoxidase, nitric oxide production, and proteins were all significa

119 loperoxidase activity and total cell counts, nitric oxide production, and proteins.

120 otaxis, endothelial inflammation, oxidation, nitric oxide production, and thrombosis reveal other dim

121 that high doses of nonspecific inhibitors of nitric oxide production are contraindicated in septic sh

122 uced energy deficiency, and (ii) the role of nitric oxide production as a potential mechanism for ene

123 s, and considerable evidence points to local nitric oxide production as an important but complex regu

124 activate macrophage NF-kappa B signaling and nitric oxide production, as well as the MAP kinase p38,

125 ctivator of transcription (STAT) pathway and nitric oxide production, as well as the promotion of ade

126 cid citrulline, which may reflect changes in nitric oxide production, as well as various phospho- and

127 rn, Northern, and Western blot analysis, and nitric oxide production assays.

128 ile there can be detrimental consequences of nitric oxide production at pathological concentrations,

129 osure to high glucose, with the reduction in nitric oxide production being the most notable.

130 the TLR7 antagonist IRS661 and by inhibiting nitric oxide production but not by inhibiting prostaglan

131 ucible nitric oxide synthase, also increased nitric oxide production but this response was reduced by

132 ent of zinc deficiency-induced intracellular nitric oxide production but was attenuated by the additi

133 is dependent on NMDA receptor activation and nitric oxide production, but little else is known about

134 ing pathway is not involved in TNF-alpha and nitric oxide production, but, interestingly, negatively

135 Inhibition of nitric oxide production by activated macrophages by usin

136 using the Limulus amebocyte lysate assay and nitric oxide production by alveolar macrophage.

137 sors have been used to measure extracellular nitric oxide production by BALB/c mouse macrophages.

138 Nitric oxide production by cells subjected to pulsatile

139 Nitric oxide production by cultured cells was measured e

140 AM stimulates nitric oxide production by endothelial cells, whereas PA

141 Deficits in nitric oxide production by endothelial nitric oxide synt

142 te-macrophage colony-stimulating factor] and nitric oxide production by human and murine monocyte/mac

143 I-C) + IFN-gamma-induced iNOS expression and nitric oxide production by human islets are prevented by

144 Gram-negative bacteria induces cytokine and nitric oxide production by inflammatory cell types.

145 that lipopolysaccharide increases medullary nitric oxide production by iNOS induction, resulting in

146 in complement-mediated phagocytosis, inhibit nitric oxide production by macrophage-like cells, protec

147 IFN-gamma fails to induce iNOS expression or nitric oxide production by macrophages isolated from IRF

148 I isozymes, participate in the regulation of nitric oxide production by modulating the availability o

149 A + IFN-gamma-stimulated iNOS expression and nitric oxide production by mouse islets.

150 sRNA + IFN-gamma-induced iNOS expression and nitric oxide production by mouse peritoneal macrophages

151 Nitric oxide production by pex cells was dependent upon

152 nitric oxide synthase (iNOS) expression and nitric oxide production by rat, mouse, and human islets.

153 NOS-dependent nitric oxide production by S. scabies was also reduced i

154 arinic and nicotinic receptor activation and nitric oxide production by using immunocytochemistry for

155 Nitric oxide production by various routes was sufficient

156 Estrogen receptor regulation of nitric oxide production by vascular endothelium may invo

157 ietary supplementation aimed to increase the nitric oxide production can also be beneficial.

158 Thus, differences in nitric oxide production cannot account for the different

159 guanosine 3', 5'-monophosphate, an index of nitric oxide production, compared with WT mice.

160 Previous studies have suggested that loss of nitric oxide production contributes to these changes.

161 onstitutive iNOS expression and, implicitly, nitric oxide production, contributing to the poor surviv

162 trogen receptor (ER)-mediated stimulation of nitric oxide production, demonstrated by preinjecting th

163 Elevated nitric oxide production did not occur after FAK depletio

164 Inhibition of nitric oxide production did not significantly affect the

165 Nitric oxide production doubles within 10 min exposure t

166 is important for developing ways to control nitric oxide production during angiogenesis and in many

167 NNFC caused a progressive drop in nitric oxide production during flow cessation followed b

168 Blocking CX3CR1 or nitric oxide production during G-CSF treatment reduces e

169 Phagocytic cell reduction in nitric oxide production during interactions with cryptoc

170 nal hyperemia by suppressing NMDAR-dependent nitric oxide production during neural activity.

171 chemokine expression, cell recruitment, and nitric oxide production during primary LVS infection and

172 factor alpha (TNF-alpha) mRNA and increased nitric oxide production during T. parva lethal infection

173 g either CD23 upregulation or CD23-dependent nitric oxide production eliminated the enhanced antifung

174 had no effect, and inhibition of endogenous nitric oxide production failed to increase TF expression

175 s fast responses and an initial overshoot of nitric oxide production for given doses of TNF and IFN-g

176 72 h was shown to dose-dependently increase nitric oxide production from 6-day-old retinal cultures.

177 , which were consistently unable to suppress nitric oxide production from activated macrophages.

178 Nitric oxide production from AMs of HHCs increased on Da

179 have indicated the importance of sufficient nitric oxide production from arginine during normal frac

180 In rat cerebellar slices, we activated nitric oxide production from each isoform of nitric oxid

181 Under proatherogenic conditions, nitric oxide production from endothelial cells is reduce

182 ectoenzyme on T cells, controls the rate of nitric oxide production from GSNO and thus markedly affe

183 However, to our knowledge, evidence of nitric oxide production from HU metabolism in humans has

184 se-mediated pathway as a potential source of nitric oxide production from hydroxyurea.

185 These results demonstrate nitric oxide production from the ferric catalase oxidati

186 ium influx, tumor necrosis factor-alpha, and nitric oxide production in a concentration-dependent man

187 rasite Toxoplasma gondii is able to suppress nitric oxide production in activated macrophages.

188 herapy also significantly increased vascular nitric oxide production in apoE(-/-) mice.

189 -SP1 induced the ability of MSP-1 to inhibit nitric oxide production in bone marrow macrophages.

190 Cytokines stimulate nitric oxide production in bone, and high concentrations

191 ble nitric oxide synthase and stimulation of nitric oxide production in chondrocytes by octacalcium p

192 mor growth assays reveal that Notch-mediated nitric oxide production in endothelial cell requires VEG

193 This study uncovers a novel mechanism of nitric oxide production in endothelial cells in tumors,

194 importance, shear stress does not stimulate nitric oxide production in endothelial cells on fibronec

195 RBC-derived ATP, which is known to stimulate nitric oxide production in endothelial cells, resulting

196 In addition, it stimulates nitric oxide production in endothelial cells, which may

197 ylcooxygenases (COX-1 and COX-2), aromatase, nitric oxide production in endotoxin-stimulated macropha

198 ases in interleukin-8, GRO-alpha, MCP-1, and nitric oxide production in HeLa and AGS cells, despite s

199 ctive effect of copper depends on endogenous nitric oxide production in hippocampal neurons, demonstr

200 educed by 30% cytokine-induced apoptosis and nitric oxide production in INS-1E cells.

201 rk form the basis for real-time detection of nitric oxide production in living cells.

202 proinflammatory cytokines and suppression of nitric oxide production in macrophages.

203 pha-melanocyte-stimulating hormone regulates nitric oxide production in melanocytic cells by modulati

204 Nitric oxide production in murine J774A.1 cells, as well

205 hVEGF-B induced nitric oxide production in NP macrophages (P < 0.05).

206 nefitted from (1) documentation of low nasal nitric oxide production in PCD and (2) discovery of bial

207 s work is to demonstrate that RBCs stimulate nitric oxide production in platelets by employing a cont

208 response against lipopolysaccharide-induced nitric oxide production in rat PBMCs were positively cor

209 tion of inducible nitric-oxide synthase, and nitric oxide production in RAW 264.7 cells.

210 anticoronavirus activity, and suppression of nitric oxide production in RAW264.7 cells (a measure of

211 hanisms that induce TIMSC and the effects on nitric oxide production in response to endotoxin.

212 ed by arterial endothelial cells, especially nitric oxide production in response to physiologic stimu

213 Enhanced nitric oxide production in sepsis is related to suggeste

214 nitric oxide synthase inhibitor to decrease nitric oxide production in septic shock.

215 MnSOD siRNA also reduced nitric oxide production in supernatants of IPAH-ECs.

216 ain and prevented nerve injury-evoked excess nitric oxide production in the DRG, whereas administerin

217 Nitric oxide production in the grafts was increased by C

218 anisms of altered myocyte function caused by nitric oxide production in this setting are not establis

219 dothelial cell proliferation, migration, and nitric oxide production in vitro and increased expressio

220 creased inflammatory responses and increased nitric oxide production in vitro in response to Salmonel

221 dothelial nitric oxide synthase activity and nitric oxide production, increased aortic cyclooxygenase

222 oglia exposed to 15-30 microm zinc increased nitric oxide production, increased F4/80 expression, alt

223 and Ca(2+) influx, which activates low-level nitric oxide production, increases apical membrane Cl(-)

224 n; the finding that inhibiting superoxide or nitric oxide production inhibits both peroxynitrite prod

225 Inhibition of strain-related prostanoid and nitric oxide production inhibits strain-related (and bas

226 unctional analysis revealed that endothelial nitric oxide production is decreased by Notch inhibition

227 that MyD88- and Card9-mediated IFN-gamma and nitric oxide production is essential for protection agai

228 ible nitric oxide synthase, in which ROS and nitric oxide production is greatly decreased; (iii) a kn

229 ed association with actin filaments but peak nitric oxide production is transient due to actin S-nitr

230 lial dysfunction, characterized by decreased nitric oxide production, is one of the early features in

231 that arginase activity, which inhibits host nitric oxide production, is post-translationally stimula

232 ent increases in reactive oxygen species and nitric oxide production leading to increased caspase 3 a

233 pression profiles, oxygen consumption rates, nitric oxide production levels, shear stress responses,

234 s are associated with improper regulation of nitric oxide production, making NOS a therapeutic target

235 vessel wall shear stress and, consequently, nitric oxide production may contribute to heightened sys

236 ric oxide synthase--the gene responsible for nitric oxide production--may be affected by air pollutan

237 The resulting increase in nitric-oxide production might be critical to the atherop

238 elerated calcium influx (n = 9) and enhanced nitric oxide production (n = 12) (vs four and eight cont

239 ue to defective oxidative phosphorylation or nitric oxide production), Na+ influx through voltage-gat

240 systemic hypertension or changes in cerebral nitric oxide production needs to be evaluated.

241 -X(L) in the regulation of cytosolic Ca(2+), nitric oxide production (NO), c-Jun NH(2)-terminal kinas

242 transport and ii) fluid shear stress induced nitric oxide production (NO).

243 Inhibiting nitric oxide production (Nomega-nitro-L-arginine, 50 mic

244 thelial nitric oxide synthase contributed to nitric oxide production, only inducible nitric oxide syn

245 he differences appear to be due to defective nitric oxide production or bioavailability and might exp

246 ot activate macrophage NF-kappa B signaling, nitric oxide production or inducible nitric-oxide syntha

247 tivation of NF-kappaB, but it did not affect nitric oxide production or iNOS gene expression.

248 Mitochondrial inhibition did not affect nitric oxide production or MAP kinase phosphorylation, w

249 M N(omega)-nitro-L-arginine (LNNA) to block nitric oxide production, or 10(-5) M glibenclamide to bl

250 t dsRNA + IFN-gamma-induced iNOS expression, nitric oxide production, or the inhibitory actions of th

251 dothelial sodium channel activation, reduced nitric oxide production, oxidative stress, and inflammat

252 ealthy children, HDL(CKD) strongly inhibited nitric oxide production, promoted superoxide production,

253 Inhibition of local Nitric Oxide production reduced firing rates but did not

254 a demonstrate that differential flow-induced nitric oxide production regulates matrix-specific PAK si

255 ry network to modulate adaptive immunity via nitric oxide production, reminiscent of the monocytic su

256 deprivation can be attributed to diminished nitric oxide production resulting from the activity of t

257 e MEK/ERK pathway potentiates LPS-stimulated nitric oxide production, suggesting that LPS-stimulated

258 carrying mutant p53 and that a high level of nitric oxide production suppresses tumor growth and meta

259 ne stimulation in these cells also activated nitric oxide production that was blocked by sigma1-recep

260 ities (tubule formation, cell migration, and nitric oxide production) that were mediated by rcav-1 st

261 ency prevents NMDA receptors from triggering nitric oxide production, thereby attenuating the flow in

262 ages may determine the rate and magnitude of nitric oxide production, thereby regulating the cytotoxi

263 ut (KO) mice, indicating that the absence of nitric oxide production through iNOS is not compensated

264 ndothelial cells, PTX3 significantly blunted nitric oxide production through the matrix metalloprotei

265 lcium signals in primary cells that activate nitric oxide production to increase ciliary beating and

266 sRNA + IFN-gamma induces iNOS expression and nitric oxide production to similar levels by macrophages

267 ssembly of supramolecular complexes coupling nitric oxide production to upstream and downstream compo

268 hrough its regulation of eNOS expression and nitric oxide production to vascular hyperpermeability an

269 ant induction of reactive oxygen species and nitric oxide production trigger marrow vessel leakiness,

270 endently confirmed by an increase in myocyte nitric oxide production upon extracellular application o

271 ell-induced immunosuppression is mediated by nitric oxide production via inducible nitric oxide synth

272 Nitric oxide production was assessed by measuring the ra

273 ur previous studies showed that T/HS-induced nitric oxide production was associated with lung injury,

274 Furthermore, renal nitric oxide production was decreased, and homogenates f

275 s cultured on more compliant substrates, and nitric oxide production was enhanced.

276 Splenic nitric oxide production was impaired in infected memTNF

277 Basal nitric oxide production was increased and endothelial ni

278 Finally, inhibition of nitric oxide production was lethal, indicating that high

279 Nitric oxide production was measured by Griess reaction,

280 Nitric oxide production was measured by the Griess react

281 TLR7-mediated nitric oxide production was measured using a fluorescent

282 Furthermore, nitric oxide production was prevented and, more importan

283 To determine whether altered nitric oxide production was responsible, plasma nitrite

284 ducible nitric oxide synthase expression and nitric oxide production was severely impaired in the INS

285 Nasal nitric oxide production was very low in PCD (nl/minute;

286 ell lysis would be detrimental to epithelial nitric oxide production we hypothesized that perforin wa

287 els, cytokine levels, eicanosoid levels, and nitric oxide production were compared between strains.

288 Cell proliferation rate and nitric oxide production were increased and apoptosis rat

289 Both Limulus amebocyte lysate activity and nitric oxide production were related to the degree of op

290 We further revealed that IL-6 and nitric oxide production were significantly higher by wil

291 nction and endothelial dependent relaxation (nitric oxide production) were determined using an organ

292 ate dehydrogenase membrane leakage assay and nitric oxide production, were used to determine if these

293 -induced activity of the HRE is dependent on nitric oxide production, which acts as a diffusible para

294 tis virus (EMCV) induces iNOS expression and nitric oxide production, which are unaffected by a domin

295 Moreover, endothelial stiffening reduces nitric oxide production, which promotes smooth muscle ce

296 and 23 mo) to characterize changes in renal nitric oxide production with age.

297 nti-TGF-beta treatment resulted in increased nitric oxide production within parasitized lesions.

298 function by increasing arginase activity and nitric oxide production, without affecting reactive oxyg

299 Reduction of HAP through inhibition of nitric oxide production worsened the recovery from FHVOO

300 eatment showed no effects on tube formation, nitric oxide production, wound healing or cell prolifera