ライフサイエンスコーパス: nitro group

1 e primary amine moiety is transformed into a nitro group).

2 amed dZ, the electron withdrawing unit was a nitro group.

3 ional interlobe interactions mediated by the nitro group.

4 he 4-nitro group of CB1954 rather than the 2-nitro group.

5 nd geometry to within 2.8 A of the inhibitor nitro group.

6 the hemin which stabilizes the highly polar nitro group.

7 ono-NP is dependent upon the position of the nitro group.

8 l group with evidence for ion pairing at the nitro group.

9 enium ion that is strongly stabilized by the nitro group.

10 phile structure and the approach mode of the nitro group.

11 he strong electron-withdrawing nature of the nitro group.

12 beta- and delta-carbons with respect to the nitro group.

13 Previously reported representatives bear a 3-nitro group.

14 ization onto the secondary aromatic ring and nitro group.

15 the product resulting from reduction of the nitro group.

16 ammonium cation and the oxygen atoms of the nitro group.

17 ities, including ketone, alkene, alkyne, and nitro groups.

18 nyl, cyclopropyl, pyridyl, aryl, benzyl, and nitro groups.

19 tivating groups including acetyl, cyano, and nitro groups.

20 ups, including methoxy, alcohol, ketone, and nitro groups.

21 s, including methoxy, alcohol, aldehyde, and nitro groups.

22 tert-butyldiphenylsilyl ether, and aliphatic nitro groups.

23 oms and the oxidation of nitrogen atoms into nitro groups.

24 the complexity of the process involving two nitro groups.

25 and this is particularly true for aliphatic nitro groups.

26 s, amides, aldehydes, nitriles, halides, and nitro groups.

27 which favour the preferential adsorption of nitro groups.

28 hance selectivity toward analytes containing nitro groups.

29 ino groups present will have originally been nitro groups.

30 s at least some of the oxygen comes from the nitro-groups.

31 lopenta[b]indolines with versatile vinyl and nitro-groups.

32 ence involving (1) reduction of the aromatic nitro group, (2) condensation of the aniline or hydroxyl

33 of the first azole molecule bonded to seven nitro groups, 4-nitro-3,5-bis(trinitromethyl)-1H-pyrazol

34 to bind at both active sites with only the 2-nitro group able to participate in hydride transfer from

35 ce of other reactive functionality including nitro groups, alkenes, and halogens.

36 leavages on the fatty acid backbone near the nitro group, allowing its localization within the FA aky

37 bercular and antiparasitic agents containing nitro groups, along with a patent survey on hypoxia-acti

38 Previously, it was discovered that a 3-nitro group and a 9-methoxy group afforded enhanced biol

39 exploration of the chemical potential of the nitro group and a putative reaction mechanism are discus

40 ed dipole stacking interaction between the 5-nitro group and base 3' to the templating lesion explain

41 ituted OPE by electrochemically reducing the nitro group and by varying the pH of the electrolyte.

42 ydrate is used for both the reduction of the nitro group and the hydrolysis of nitrile, and atmospher

43 ignificant directing interaction between the nitro group and the incoming nucleophilic palladium cata

44 source of hydrogen for the reduction of the nitro group and the reaction rate was accelerated by an

45 adiazole lead, carrying reduced forms of the nitro group and/or oxidized forms of a sulfur atom, disp

46 tter are more acceptable pharmacophores than nitro groups and also tend to increase the water solubil

47 des were treated with Pd/C, H2 to reduce the nitro groups and cyclized with nitrous acid, and the cor

48 ch polymorphs are the interactions among the nitro groups and phenyl rings of those crystals.

49 separately reduced both the para- and ortho-nitro groups and produced glycosylated products that acc

50 the XPS peak of the N 1s electrons of the NT nitro groups and the DPV peak of electroreduction of the

51 ructure contains a tertiary amino group, two nitro-groups and a trifluoromethyl- group.

52 ry nitrogen-15 isotope effect ((15)k) in the nitro group, and (for the monoester and diester) the sec

53 e spectra indicated irreversible loss of the nitro group, and a dramatic but reversible decrease in R

54 reducible functional groups such as alkenyl, nitro group, and even internal alkyne intact.

55 phenyl-alpha-d-mannopyranoside, reducing its nitro group, and reacting it with thiophosgene to produc

56 mples such as an olefin, a ketone, nitriles, nitro groups, and an aryl iodo substituent or a benzyl e

57 hows functional group tolerance for alkenes, nitro groups, and aryl halides, including aryl iodides.

58 rray of functional groups, including esters, nitro groups, and enolizable ketones.

59 The process tolerates nitro groups, and it efficiently generates sterically hi

60 particular, the reaction between Ti and the nitro group appears to prevent short circuits resulting

61 All nitro groups are electronically isolated and thus are re

62 The nitro groups are involved in cation-cation and cation-io

63 vey on hypoxia-activated prodrugs containing nitro groups, are also covered.

64 By implementation of both the azido and nitro group as sulfide-reactive functionalities on the s

65 ction of multiple bonds, azides, imines, and nitro groups, as well as benzyl group and allyl group de

66 d symmetric etioheme I modified with a bulky nitro group at a single meso position.

67 minor isomers are shown to place their bulky nitro group at the canonical delta-meso (8%) and alpha-m

68 etermine that the hemin is oriented with the nitro group at the canonical gamma-meso position of nati

69 he comparable population of the isomers with nitro groups at the hydrophobic alpha- and delta-meso po

70 stacked head-to-tail, with the plane of the nitro group being tilted above the plane of the benzene

71 Analogues substituted with a nitro group bind to mature amyloid fibrils, and the acti

72 gest that 1,3-disiloxanediols bind weakly to nitro groups but are strongly activating for catalysis.

73 e replacement of the potentially genotoxic 3-nitro group by 3-chloro and 3-fluoro substituents, resul

74 The direct substitution of a nitro group by a hydroxide represents the most favorable

75 followed by nucleophilic attack on the TBNS nitro group by Cys-215 of PTP1B to form a reversible, co

76 The displacement of the aromatic nitro group by dioxygenases has only recently been descr

77 Photoexcitation of nitro groups by a high-energy laser is not required; the

78 Selective reduction of the nitro group can be accomplished.

79 sibly because their less sterically hindered nitro groups can be released more easily as nitrite and

80 reactive and the least selective: all three nitro groups can be substituted using an excess of thiol

81 tivity to afford products with the vinyl and nitro groups cis to each other is observed with a 4-subs

82 ing of NS1 and in local solvation around NS1 nitro group, consistent with changes of NS1 fluorescence

83 is carried out in an (16)O2 atmosphere, CAM nitro groups contain both (18)O and (16)O, suggesting th

84 For the first time both nitro group containing aryl/heteroaryl iodides and bromi

85 rogen from alpha-C(sp3) -H in ethanol to the nitro group coupling it to the redox reactions between C

86 intensities of NAB modes associated with the nitro group decreased significantly, and the XPS indicat

87 es incorporating three adjacent non-coplanar nitro groups demonstrated higher sensitivity to impact,

88 avior between pyrrolidines with or without a nitro group, demonstrating the strong nitro-group-depend

89 amine group to one of the two O atoms in the nitro group denotes the most accessible route in the uni

90 hout a nitro group, demonstrating the strong nitro-group-dependent periselectivity.

91 ks above the FMN, and in active site B the 4-nitro group does, explaining why reduction of either nit

92 emically modify proteins and reduce aromatic nitro groups due to their intrinsic chemical reactivity

93 The elimination of the nitro group during lactone formation is a previously unr

94 by rate- and enantioselectivity-determining nitro group elimination.

95 s afforded products of substitution of the p-nitro group exclusively.

96 n with 2,3-dimethoxy-8,9-methylenedioxy or 3-nitro groups exerted strong effects on antiproliferative

97 an indole-boron-difluoride complex bearing a nitro group exhibited significant solvatochromic behavio

98 (2)-locked anilido-pyridine furnished with a nitro group exhibits redox-ambipolarity, i.e., reversibl

99 Indium-mediated reduction of the nitro group followed by acylation of the resulting amine

100 Mild reduction of the nitro group followed by an acid-mediated cyclodehydratio

101 The method involves in situ reduction of the nitro group followed by condensation with aldehydes to f

102 Reduction of the nitro group followed by derivatization of the so formed

103 Subsequent reduction of the nitro group followed by hydrolysis of the oxazoline ring

104 ams can be obtained via hydrogenation of the nitro group followed by in situ cyclization.

105 Catalytic reduction of the nitro group followed by reaction with NBS resulted in th

106 ds 6 and 7 respectively, by reduction of the nitro groups followed by diazotization of the amines.

107 nt nitroreduction pathway and thus require a nitro group for their activity.

108 Second, we confirmed the necessity of both nitro groups for antimycobacterial activity through exte

109 tance of certain molecular fragments, such a nitro groups, for the outcome of a mutagenicity study.

110 y, triarylamines bearing formyl, acetyl, and nitro groups formed CTCs behaving as good fluorescence c

111 acids as inexpensive, readily available, and nitro group-free aminating reagents.

112 onsistent with a random removal of the first nitro group from either the terminal (C-1 and C-3) posit

113 C monooxygenase catalyzes the removal of the nitro group from MNC to form 2-hydroxy-5-methylquinone.

114 regioselectivity for removal of the central nitro group from NG and that transforms TNT but did not

115 e, a 2.4-fold selectivity for removal of the nitro group from the C-2 position of 1,2-DNG was also de

116 that removes either the terminal or central nitro groups from NG and that reduces 2-cyclohexen-1-one

117 and selective PDE4D inhibitors, absent of a nitro group, from our prior structure-activity relations

118 0.9), compounds containing halogen atoms or nitro groups gave a lower predicted ESI response.

119 roducing a methyl group at the a-position of nitro group generated two diastereomers, the greater pot

120 e 4-nitro group of CB1954, rather than the 2-nitro group, giving the more cytotoxic reduction product

121 in place of an aromatic C-H bond (that is, a nitro group, halogen or boronic acid) and a subsequent f

122 In this reaction, the nitro group has a chameleonic role, first as an electron

123 The experiments indicated that the nitro group has influence on regioselectivity of the rea

124 e a long history of use in therapeutics, the nitro group has toxicity issues and is often categorized

125 In general, drugs containing nitro groups have been extensively associated with mutag

126 Nitro groups have played a central and decisive role in

127 e predicted to catalyze the formation of the nitro group, have also been identified.

128 now show the typical activity of Au(0)NPs in nitro group hydrogenation.

129 Reduction of the nitro group in 13 to an amine, followed by reductive ami

130 hesized incorporating a strategically placed nitro group in a position para to the benzylic carbon fo

131 In this protocol, the nitro group in nitromethanes functions as recursive carb

132 g macrocycle ring-opening and insertion of a nitro group in one of the four aromatic rings.

133 (15(V/K) refers to the nitro group in p-nitrophenyl sulfate).

134 migration and that the presence of an ortho nitro group in the aminating agent plays a critical role

135 Compound 4 is the isomer that has the nitro group in the best orientation at the es transporte

136 ample with the strongly electron-withdrawing nitro group in the gamma position.

137 gen in the quinoline ring and a halogen or a nitro group in the indole ring have enhanced antiplasmod

138 from energetically favorable stacking of the nitro group in with pi-electrons of the adjacent base.

139 MIP-PS spectroscopic detection of nitrile or nitro group in ~130 molecules was demonstrated.

140 Thus, both nitro groups in 3,5-dinitrobenzylsulfanyl-containing ant

141 te of DprE1 may trigger the reduction of the nitro groups in a manner similar to the von Richter reac

142 Selective installation of halo and nitro groups in heterocyclic backbone through a transiti

143 additional interactions of the hydroxyl and nitro groups in pNCS with Asp-356, Gln-357, Arg-404, and

144 om the separate reduction of the quinone and nitro groups in the molecules.

145 Chemoselective reduction of nitro groups in the presence of activated heteroaryl hal

146 (cyano-dZ) having a cyano group instead of a nitro group, including its synthesis, pK(a), rates of ac

147 ecreasing as the number of bonds between the nitro groups increases, except for the 1,5-dinitronaphth

148 The oxygens of the substrate nitro group interact both with amino acid residues and w

149 g expansion centred on the conversion of the nitro group into a singlet nitrene.

150 Introduction of a para-nitro group into the benzene ring of the diene enabled s

151 reaction with nitric acid to insert aromatic nitro-groups into the benzene rings, followed by treatme

152 This AAD process only occurred when a nitro group is bonded to the 4-position of the initial e

153 The nitro group is considered to be a versatile and unique f

154 The nitro group is easily reduced with hydrogen over a Raney

155 of the biological results suggests that the nitro group is important for Top1 inhibition and the met

156 esized in this study are examples, where the nitro group is introduced into the fjord region, for whi

157 ced potency compared to NH-3, indicating the nitro group is not required for antagonism.

158 oup does, explaining why reduction of either nitro group is observed.

159 with protoheme or mesoheme, we show that the nitro group is on the 4-vinyl.

160 the derivatives 12-14 in which the aromatic nitro group is replaced by amine, guanidine, or sulfonam

161 The nitro group is required for both activities in all compo

162 The nitro group is spontaneously eliminated as nitrite conco

163 ty of azole compounds with a large number of nitro groups is likely due to their inherent thermal ins

164 re, and evidence related to drugs containing nitro groups is rather contradictory.

165 Although a small number of drugs include the nitro group, it is generally not regarded as being "drug

166 (15)N nitro group labeled RDX ((15)N-[RDX], 50 atom %) was spi

167 lective Boc-deprotection or reduction of the nitro group, leading to further functionalized 3-substit

168 Polynitrocalix[4]arenes with reducible nitro groups located at the upper rim represent molecule

169 ystematically prepared using combinations of nitro groups, methoxy groups, and hydrogen atoms in an e

170 l transformations between aromatic amine and nitro groups modified on the CuNE surface.

171 ible binding orientations, and the reducible nitro group must be located para to the mustard.

172 Only the analogues with shifted nitro groups, namely, 2,5-dinitrobenzylsulfanyl oxadiazo

173 osine (3-NT) from Tyrosine (Tyr) by adding a nitro group (-NO2) with nitrating agents.

174 iene-dienophile and endo/exo approach of the nitro group) not only aligns with experimental observati

175 s no hydrogen-bonding partners for the polar nitro group of 4-NBP within the hydrophobic active site.

176 n aryl-amine precursor (NH2-CAM) to the aryl-nitro group of CAM catalyzed by the non-heme diiron clus

177 n increase in selectivity for reducing the 4-nitro group of CB1954 rather than the 2-nitro group.

178 st active mutant is also selective for the 4-nitro group of CB1954, rather than the 2-nitro group, gi

179 imer complex via interactions with the ortho nitro group of CDNB or FDNB and provide insight into the

180 measurements of the electro reduction of the nitro group of flunitrazepam at ca. -0.71 to -0.78 V vs.

181 ic nucleophilic substitution reaction of the nitro group of meso-nitroporphyrins with azide and vario

182 ew TS devoid of hydrogen bonding between the nitro group of nitrostyrene and carboxylic acid of proli

183 acking interactions with C13 and C15 and the nitro group of X14 is pointing out of the major groove.

184 In solution, the electron-withdrawing nitro groups of both compounds establish a resonance equ

185 The nitro groups of energetic compounds are readily reduced

186 It also reduced the nitro groups of Nit(V), forming p-aminophenyl arsenate (

187 ineNO- group was added para and ortho to the nitro groups of the dinitrophenyl ring.

188 In each site, the nitro groups of the prodrug make direct H-bond contacts

189 ration (i.e., the irreversible addition of a nitro group) of the Alzheimer-related peptide amyloid-be

190 Arylation occurs ortho to the nitro group offering a synthetic route to polyfluorinate

191 In order to assess the role of the nitro group on base stacking interaction, sequences were

192 moiety on one end of the car coupled with a nitro group on the other end.

193 f 3, which contained an electron-withdrawing nitro group on the phenyl ring, produced a single diaste

194 se labile stereogenic center adjacent to the nitro group on the piperidinone ring, while the undesire

195 Modeling studies showed that the nitro group on the pyrene ring at the 8-position can pro

196 1,6-ANP and Gua-C8-1,8-ANP), which contain a nitro group on the pyrene ring covalently linked to the

197 Unique features include stacking of the nitro group on Z with the adjacent nucleobase ring in th

198 G:C pairs, perhaps to accommodate the large nitro group on Z.

199 Electron-withdrawing substituents such as nitro groups on the phenyl ring cause higher quantum yie

200 successfully incorporated oxime, ketone, and nitro groups on the polymer backbone, without radical cl

201 The hydroxy functionality between nitro groups on the pyrazole ring promotes physical stab

202 onating (hydroxyl) and electron-withdrawing (nitro) groups on the phenyl ring of Phe to affect the in

203 henols showed an exponential decay, with the nitro-group on the aromatic ring found to control the fo

204 o the electrochemical reduction of the three nitro-groups on the TNT molecule.

205 9 was synthesized by (18)F displacement of a nitro group or an iodonium ylide.

206 e single phenyl ring were either an ester, a nitro group, or a sulfonamide group.

207 ributions of the pi-electrons present in the nitro group, other physical parameters such as solvation

208 ronaphthalene, steric interactions force the nitro groups out of the plane of the naphthalene ring, d

209 uperior selectivity for hydrogenation of the nitro group, outperforming both conventional Pd nanopart

210 yst is highly selective for reduction of the nitro group over other unsaturated bonds, tolerant to a

211 hydride induce nonenzymatic reduction of the nitro groups present in these compounds to the correspon

212 yl and ethyl esters, enolizable ketones, and nitro groups provided that cesium carbonate is employed

213 The synthesis took advantage of efficient nitro-group reactions with the A/B/C ring skeleton const

214 e adduct was then followed by chemoselective nitro group reduction and cyclization using nickel borat

215 imination occurred, leading to the selective nitro group reduction reaction on the syn-alpha-amino es

216 with 2 equiv of the acrylamides, followed by nitro group reduction, afforded the desired amino-polyes

217 elopment for H2S detection include azide and nitro group reduction, nucleophilic attack, and CuS prec

218 ading the molecule either by dealkylation or nitro-group reduction have been identified.

219 he competitive hydrogenation, achieving 100% nitro-group reduction selectivity in the hydrogenation o

220 to a carbon black support which facilitates nitro-group reduction.

221 e bond formation and aromatic/heteroaromatic nitro-group reductions represent two of the most commonl

222 sive and efficient procedure is outlined for nitro-group reductions, using industrial iron in the for

223 zoate followed by catalytic reduction of the nitro group, reductive coupling with 2-acetamido-6-formy

224 by a [3 + 2] cycloaddition/extrusion of the nitro group/regioselective 6-endo cyclization domino seq

225 10(-8) M 4-NBA as its ligand, implying that nitro group removal of nitroaromatic compounds may be es

226 Nitro group removal via ammonia release is an important

227 The olefinic nitro group renders these derivatives electrophilic at t

228 rally identical to CT325 except for an inert nitro group replacing the reactive nitroso group.

229 Chemical reduction of the nitro group resulted in rapid expulsion of the cytotoxic

230 This reaction proceeds via reduction of the nitro group, resulting in in situ imine formation follow

231 4 and 6 with a benzylic nitrogen para to the nitro group showed little selective cytotoxicity despite

232 s 3 and 5 with a benzylic oxygen para to the nitro group showed potent selective cytotoxicity in nitr

233 Here we demonstrate that incorporation of a nitro group significantly stabilizes the LUMO, and hence

234 cal formation, and direct observation of the nitro group-stabilized semiquinone radical.

235 In active site A the 2-nitro group stacks above the FMN, and in active site B t

236 Vinyl nitro groups substantially decrease the reactivity, whil

237 oup substitution with N-nucleophiles and the nitro-group substitution with thiophenols and rationaliz

238 where an appropriate bioisostere replaced a nitro group that had a direct role in binding.

239 8), starting with the replacement of an aryl nitro group that posed a potential liability.

240 ester], a derivative of aspirin containing a nitro group that releases nitric oxide in a sustained fa

241 s the main chain nitrogen of Thr41 and the 4-nitro group the Lys14 side chain.

242 lass of nucleophiles is substituted with a y-nitro group, the Mannich-initiated cascade is now divert

243 overs various aspects of agents that contain nitro groups, their bioreductive activation mechanisms,

244 ives electrophilic at the carbon beta to the nitro group, thus competent for Michael addition reactio

245 sistent with the 4e-, 4H+ reduction of the 7-nitro group to a hydroxylamine species; the second more

246 aromatic ring using an electron-withdrawing nitro group to activate that fluorine.

247 Reduction of the nitro group to an amino group yields 12, which is treate

248 iring bioreductive activation of an aromatic nitro group to exert an antitubercular effect.

249 roindole, followed by the elimination of the nitro group to furnish pyrazole-fused indoles.

250 on and a subsequent ipso-substitution of the nitro group to produce 1-tetralones with two contiguous

251 ociated ion channel that is used to target a nitro group to redox-mediated regulatory sites on the re

252 by electrochemical reduction of the terminal nitro groups to amines.

253 thionite is added subsequently to reduce the nitro groups to amines; in theory, the only amino groups

254 orating the pores vary from polar cyano- and nitro- groups to nonpolar alkyl groups.

255 atment with sodium borohydride to reduce the nitro-groups to primary amines.

256 ubstrates (e.g., those containing esters and nitro groups) to be utilized in our amination protocols.

257 g electron withdrawing substituents, such as nitro groups, to superoxide-driven nucleophilic attack.

258 A denitration step renders the nitro group "traceless" and delivers secondary, tertiary

259 titution of activated nitroarenes to realize nitro group transformations.

260 yield of O(6)-BG following reduction of the nitro group trigger.

261 d oxindoles with the formal reduction of the nitro group under redox-neutral conditions.

262 on of a nitronate or by equilibration of the nitro group under thermodynamic control.

263 ional groups, such as halogen, carbonyl, and nitro groups, underwent reaction with TMDS to give the c

264 at have a 4-formyl-benzamido group where the nitro group used to be.

265 achieved via reductive deoxygenation of the nitro groups using a slight excess of triphenylphosphine

266 for the chemoselective reduction of aromatic nitro groups using samarium(0) metal in the presence of

267 esigned in such a way that it interacts with nitro group via strong hydrogen bonding interaction, whi

268 Its nitro group was considered to be a source of the brain r

269 1,2-DNG, a 1.3-fold selectivity for the C-1 nitro group was determined.

270 dazole derivatives directed by a manipulable nitro group was developed.

271 The mechanism of release of the nitro group was unknown.

272 g a bioisosteric carboxylate in place of the nitro group, was examined.

273 Analogues lacking the nitro group were not cytotoxic.

274 Two independent pairs of equivalent nitro groups were identified whose reduction potential d

275 nating diphenylamino or electron-withdrawing nitro groups were synthesized as well as their linear an

276 h as a triazine, a ketone, an aldehyde, or a nitro group, were tolerated in these exchange reactions,

277 as esters, enolizable ketones, nitriles, and nitro groups, were tolerated by the combination of hydro

278 ed H-cell for selective hydrogenation of the nitro group when multiple reducible groups are present.

279 missive pai-conjugated enamines containing a nitro group, which generally behaves as strong quenchers

280 ibited by the large electron affinity of the nitro group, while CID efficiency remains unaffected by

281 on of an alkyl radical by abstraction of the nitro group with a stannyl radical.

282 troarenes at a position ortho or para to the nitro group with formation of anionic sigma(H) adducts.

283 uorine and chlorine may substitute for the 3-nitro group with minimal loss of Top1 poisoning activity

284 intermediates, followed by reduction of the nitro group with Raney Ni.

285 id derivatives, followed by reduction of the nitro group with tin chloride, generated a resin-bound o

286 ion of linker amine moieties oxidize to form nitro groups within NH(2)-MIL-101, Fe leaching, identifi