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1 m-containing penicillins, cephalosporins and nocardicins.
2 lactam structures related to monobactams and nocardicins.
3                         S-Adenosylmethionine:nocardicin 3-amino-3-carboxypropyltransferase catalyzes
4         While the nocK mutant still produced nocardicin A at levels near that seen for wild-type N. u
5 ielded mutants that maintained production of nocardicin A at levels similar to the wild-type strain.
6 c pathway, coordinating the initial steps of nocardicin A biosynthesis to the production of its pHPG
7 ules pointing to a pentapeptide precursor in nocardicin A biosynthesis, unless module skipping or oth
8 was the only N-oxidizing enzyme required for nocardicin A biosynthesis.
9                                          The nocardicin A biosynthetic gene cluster was recently iden
10 ence of mRNA transcripts for the early-stage nocardicin A biosynthetic genes.
11  a positive transcriptional regulator of the nocardicin A biosynthetic pathway, coordinating the init
12 escribed and its role in the biosynthesis of nocardicin A discussed.
13                           Paradoxically, the nocardicin A gene cluster encodes two non-ribosomal pept
14                        Like isopenicillin N, nocardicin A has a tripeptide core of non-ribosomal orig
15 rans was sufficient to restore production of nocardicin A in the disruption mutant.
16                                              Nocardicin A is a monocyclic beta-lactam isolated from t
17                                              Nocardicin A is a monocyclic beta-lactam isolated from t
18                                              Nocardicin A is the most potent of a series of monocycli
19 ne that did not produce detectable levels of nocardicin A or the early precursor p-hydroxybenzoyl for
20        The biosynthetic gene cluster for the nocardicin A producer Nocardia uniformis subsp. tsuyaman
21                                              Nocardicin A production was restored in the nocL mutant
22 and found to encode proteins in keeping with nocardicin A production, including the nocardicin N-oxyg
23    Insertional mutagenesis of nocJ abolished nocardicin A production, while the l-homoseryl isomer, i
24  the nocardicin homoseryl side chain in both nocardicin A with isonocardicin A, and nocardicin C with
25 ep is likely involved in the biosynthesis of nocardicin A, a rare but precedented editing event in th
26            The most potent of this series is nocardicin A, containing a syn-configured oxime moiety,
27 n of the 2'-amine of nocardicin C to provide nocardicin A, it was uncertain whether NocL was the only
28      Within the biosynthetic gene cluster of nocardicin A, nocR encodes a 583-amino-acid protein with
29 e S-adenosylmethionine, and a second column, nocardicin A-agarose, specifically bound the desired tra
30 me-forming enzyme required for production of nocardicin A.
31 sis of the monocyclic beta-lactam antibiotic nocardicin A.
32                   In the biosynthesis of the nocardicins, a specialized C domain prepares the embedde
33                                          The nocardicins are a family of monocyclic beta-lactam antib
34 sporins, the monobactams, and the monocyclic nocardicins, as well as the vancomycin family of glycope
35 ingular contrast, the thioesterase domain of nocardicin biosynthesis mediates both the effectively co
36 tases NocA and NocB that lie at the heart of nocardicin biosynthesis, a family of monocyclic beta-lac
37 formis, and therefore has no obvious role in nocardicin biosynthesis, the nocL disruptant failed to g
38                       Notably present in the nocardicin biosynthetic gene cluster is nocJ, encoding a
39 shown to effect oxidation of the 2'-amine of nocardicin C to provide nocardicin A, it was uncertain w
40  both nocardicin A with isonocardicin A, and nocardicin C with isonocardicin C.
41 nt accumulated the biosynthetic intermediate nocardicin C, confirming its role as the sole oxime-form
42 onfirmation of its role as the PLP-dependent nocardicin C-9' epimerase responsible for interconversio
43  phenolic site in the beta-lactam substrates nocardicin E, F, and G, a late step of the biosynthesis
44 tion to the critical beta-lactam ring of the nocardicin family of antibiotics.
45 through an unusual ether linkage to the core nocardicin framework.
46 erase responsible for interconversion of the nocardicin homoseryl side chain in both nocardicin A wit
47  with nocardicin A production, including the nocardicin N-oxygenase, NocL, in addition to genes of un
48        To further detail the role of NocL in nocardicin production in N. uniformis, and to examine th
49 in high-resolution crystal structures of the nocardicin thioesterase domain in ligand-free form and r