ライフサイエンスコーパス: non-coding region

1 several of the introns and in the downstream non-coding region.

2 with all except one having mutations in the non-coding region.

3 ral gene, but by alterations in the upstream non-coding region.

4 a sox10:Gal4VP16 transgenic construct into a non-coding region.

5 ften unclear, especially when they appear in non-coding regions.

6 vel variants and/or may be uninformative for non-coding regions.

7 of other SNPs, most of which are located in non-coding regions.

8 fic statistical models of protein-coding and non-coding regions.

9 rs they may be used to chart and explore the non-coding regions.

10 on compared to both non-synonymous sites and non-coding regions.

11 139 microsatellites, of which 71 were in the non-coding regions.

12 removing 26% of predicted genes that are in non-coding regions.

13 o the group of coding exons and the group of non-coding regions.

14 y low specificity due to the large amount of non-coding regions.

15 h the coding regions being "whiter" than the non-coding regions.

16 sts a tight control over length expansion of non-coding regions.

17 d genetic markers including those located in non-coding regions.

18 nd non-specific genes are long in coding and non-coding regions.

19 as 14,919 bp in its entirety with few, short non-coding regions.

20 or synergistic epistasis in the evolution of non-coding regions.

21 istent with very weak selection in conserved non-coding regions.

22 Parallel evolution was also identified in non-coding regions.

23 usly unnoticed, subtle functional signals in non-coding regions.

24 mic locations and between protein-coding and non-coding regions.

25 ' regions, with partial sharing of 5' and 3' non-coding regions.

26 n the gene number and the characteristics of non-coding regions.

27 PIT elements appear to occur exclusively in non-coding regions.

28 bserved at all codon positions as well as in non-coding regions.

29 n-coding sequences is stronger than that for non-coding regions.

30 e they often have small effects and occur in non-coding regions.

31 is limited by the fact that most loci are in non-coding regions.

32 tory structure including coding and adjacent non-coding regions.

33 of differential DNA methylation occurring in non-coding regions.

34 at 13 non-canonical loci, with two involving non-coding regions.

35 ter data to identify deleterious variants in non-coding regions.

36 (ASHCEs) that predominantly (>99%) reside in non-coding regions.

37 80% in coding regions and approaching 90% in non-coding regions.

38 ncing indicating disease-causing variants in non-coding regions.

39 s is known about cancer-causing mutations in non-coding regions.

40 icated because most GWAS SNPs are located in non-coding regions.

41 dispersed throughout approximately 40 kb of non-coding regions.

42 ritization of genomic variants in coding and non-coding regions.

43 challenging due to a lack of annotations in non-coding regions.

44 al protein coding regions in these putative 'non-coding' regions.

45 The A+U-rich element (ARE) in the 3' non-coding region (3' NCR) of short-lived cytokine mRNAs

46 The 220 nucleotide 5'non-coding region (5'NCR) of the human immunoglobulin he

47 5%, better overall accuracy (particularly in non-coding regions), a consistent threshold that can be

48 r point mutations and structural variants in non-coding regions across 2,658 genomes from the Pan-Can

49 of sequence conservation revealed over 5,000 non-coding regions actively conserved across all three s

50 gene expression analysis revealed that this non-coding region alteration is associated with the sign

51 Non-coding regions amplified beyond oncogene borders hav

52 A majority of these variants reside in non-coding regions and are co-inherited with hundreds of

53 in humans, which fall almost exclusively in non-coding regions and are enriched near genes involved

54 isorders (AUD), usually identify variants in non-coding regions and cannot by themselves distinguish

55 he human genome is significantly higher than non-coding regions and chromosomes.

56 lop an srRNA vaccine platform with optimized non-coding regions and demonstrate immunogenicity and sa

57 gle nucleotide variants (SNVs) that occur in non-coding regions and determined the regulatory functio

58 non-modified nucleosides but with optimized non-coding regions and enhanced antigen expression.

59 Sequence analysis of the non-coding regions and enzymatic characterization of the

60 es and traits, yet many of these SNPs are in non-coding regions and hard to interpret.

61 spective nucleotide triplet substitutions in non-coding regions and in 4-fold degenerate sites.

62 between the bending potential of coding and non-coding regions and its impact on the translational p

63 ed by combining models of protein-coding and non-coding regions and models of regulatory sites near g

64 wide association study (GWAS) signals map to non-coding regions and potentially point to non-coding v

65 e proportion of risk variants are located in non-coding regions and remain unexplained by current exp

66 sociations between mutations in MTB genes or non-coding regions and resistance, followed by validatio

67 o A:T, their distribution between coding and non-coding regions and synonymous-to-non-synonymous muta

68 Thus, the non-coding regions and the gene sets in prokaryotes seem

69 k.hmm, heuristic Markov models of coding and non-coding regions and the Gibbs sampling multiple align

70 The majority of these are in non-coding regions, and are commonly assigned to the nea

71 minantly inherited ataxias with mutations in non-coding regions, and dominantly inherited ataxias wit

72 of the identified associated variants are in non-coding regions, and presumably influence gene expres

73 regions, such as coding exons and conserved non-coding regions, and use it to guide cross-species co

74 rotein-coding regions, which is not found in non-coding regions, and used them to distinguish protein

75 The evolution of non-coding regions appears to be determined primarily by

76 The variants are located in a non-coding region approximately 300 kb upstream from the

77 at a large proportion of sites in conserved non-coding regions are associated with very small fitnes

78 and more evidence to suggest that conserved non-coding regions are biologically significant since th

79 ated lineage-specific substitution rates for non-coding regions are considered classic signatures of

80 of genomic sequence labeling into coding and non-coding regions are followed by the rounds of model p

81 ocated on separate linkage groups, but their non-coding regions are highly similar, consistent with a

82 gene sequences show that both the coding and non-coding regions are non-random.

83 that most individual mutations in conserved non-coding regions are only slightly deleterious but are

84 Similar to coding region transcription, non-coding regions are split at transcriptional sites.

85 Although non-coding regions are sprinkled with short (<200 bp) is

86 well established for coding genes; however, non-coding regions are thought less likely to be determi

87 ing because indels caused by a single cut in non-coding regions are unlikely to produce a functional

88 ng the regulatory sindels, especially in the non-coding regions, are underdeveloped.

89 The model prioritizes non-coding regions associated with regulation of importa

90 ied our MGW-prioritization approach to three non-coding regions associated with systemic lupus erythe

91 the use of these tools to identify conserved non-coding regions between the human and mouse genomes,

92 modifiers and transcription factors to bind non-coding regions can lead to changes in gene regulatio

93 specific HLA peptides derived from annotated non-coding regions could elicit anti-tumor immune respon

94 quences require models of protein coding and non-coding regions derived either from experimentally va

95 In addition to modifications in non-coding regions, editing contributes to diversificati

96 tively uniform and intra- and inter-operonic non-coding regions evolve congruently.

97 Some non-coding regions exhibited high mutation frequencies,

98 ntation conditions confirmed that coding and non-coding regions explained aspartic and glutamic acid

99 Although >90% of somatic mutations reside in non-coding regions, few have been reported as cancer dri

100 ease-associated genetic variants that lie in non-coding regions found by genome-wide association stud

101 n-coding RNAs with reported drivers in their non-coding regions from 32 cancer types by computational

102 sequence, the remaining rare variants in the non-coding region have no apparent impact on risk.

103 hat accompany the calculated curves indicate non-coding regions have a significantly lower (G+C) comp

104 man and mouse genomes has revealed that many non-coding regions have levels of sequence conservation

105 bout the effect mutations in these conserved non-coding regions have on fitness and how many of them

106 ential relevance of recurrent alterations in non-coding regions identified with WGS and highlight the

107 Conserved non-coding regions identify potentially functional DNA t

108 esults suggest that genome-wide variation in non-coding regions impacts on RAD21 transcript levels in

109 entified structural variants (SVs) affecting non-coding regions, implicating recurrent deletions in t

110 by two different methods, (i) comparison of non-coding regions in conserved operons, and (ii) neural

111 ecent years have revealed essential roles of non-coding regions in gene regulation.

112 ered, such example adds to the importance of non-coding regions in human pathology.

113 f cell type-specific epigenetic variation of non-coding regions in neuropsychiatric disorders is incr

114 edict functional variants in both coding and non-coding regions in order to understand phenotype and

115 guide sequences that target both coding and non-coding regions in spCas9 CRISPR system across human,

116 we show that a class of conserved, primarily non-coding regions in tetrapods originated from a previo

117 ation can shed light on how polymorphisms in non-coding regions in the human genome might underlie ph

118 new insights into the system-level roles of non-coding regions in the human genome.

119 The sizes of non-coding regions in the Longidoridae nematodes were ve

120 perties and differentiate between coding and non-coding regions in the nucleotide chain.

121 ces not only from coding exons but also from non-coding region including core promoters generated by

122 sequences can identify coding and conserved non-coding regions, including regulatory elements, and p

123 e also identify novel recurrent mutations in non-coding regions, including the 3' region of NOTCH1, w

124 eletion of any intergenic or deeply intronic non-coding region, indicating that proximal regulatory s

125 eared anomalous, occurring within coding and non-coding regions, indicating pervasive transcription i

126 genes showed signs of purifying selection in non-coding regions, indicating that adolescence-active g

127 te that sequences corresponding to the mtDNA non-coding region interact with the inner membrane in a

128 We found that rs11187065, located in the non-coding region (intron 1) of insulin-degrading enzyme

129 of a gene caused by a small deletion in the non-coding region is a novel mechanism, which to the bes

130 Elucidating functionality in non-coding regions is a key challenge in human genomics.

131 As such, examining non-coding regions is important for understanding tyrosi

132 icant fraction of Pol III transcription from non-coding regions is not subjected to Xist-mediated tra

133 entifying these transcriptional regions from non-coding regions is the first step towards lincRNA rec

134 s, the strongest effect variants mapped to a non-coding region known to regulate SIM1, previously ass

135 or complex dermatologic diseases fall within non-coding regions, making assignment of function diffic

136 ms (SNPs) (including imputed ones) fall into non-coding regions, making it difficult to associate sta

137 iabetes (T2D), yet most of these loci lie in non-coding regions, masking the underlying molecular mec

138 These results suggest that SVs within non-coding regions may play an important role in ADHD de

139 point mutations within stem-loop V of the 5'-non-coding region (NCR) reduce neurovirulence and cell-s

140 s-acting sequences within the genomic RNA 3' non-coding region (NCR).

141 mately 700 additional termination signals in non-coding regions (NCR) far away from the nearest annot

142 We investigated the role of the 3' non-coding region of a mouse voltage-gated potassium cha

143 exanucleotide repeat expansion GGGGCC in the non-coding region of C9orf72 is the most common cause of

144 alligator cathelicidin gene into a targeted non-coding region of channel catfish (Ictalurus punctatu

145 n of the GGGGCC hexanucleotide repeat in the non-coding region of chromosome 9 open reading frame 72

146 caused by a triplet repeat expansion in the non-coding region of either the DMPK (DM1) or CNBP (DM2)

147 ribed and amplified with primers from the 5' non-coding region of HCV and HGV by a nested polymerase

148 toxin-encoding dsRNA segments in that the 3' non-coding region of its plus strand has no sequence hom

149 ts that polymorphic genetic variation in the non-coding region of mitochondrial DNA (the 16184-16193

150 Because so much of the non-coding region of pag-3 was conserved, the control of

151 GGGGCC repeats in a non-coding region of the C9orf72 gene have been identifi

152 exanucleotide GGGGCC repeat expansion in the non-coding region of the C9orf72 gene is the most common

153 expanded GGGGCC hexanucleotide repeat in the non-coding region of the C9orf72 gene on chromosome 9p21

154 ession of expanded CCUG repeat RNAs from the non-coding region of the CCHC-type zinc finger nucleic a

155 Phylogenetic inference using the non-coding region of the chloroplast psbA gene resolves

156 n of the GGGGCC hexanucleotide repeat in the non-coding region of the Chromosome 9 open-reading frame

157 S (cold sensitive), has a mutation in the 5' non-coding region of the fur gene while the two other mu

158 sites in a relatively small region of the 5' non-coding region of the gene.

159 ease-associated risk loci are located in the non-coding region of the genome and therefore, their tar

160 Sequences of the non-coding region of the plastid psbA minicircle (psbA(n

161 12) is caused by CAG repeat expansion in the non-coding region of the PPP2R2B gene.

162 nslocations and/or point mutations in the 5' non-coding region of the putative oncogene BCL-6, that a

163 ms were due to alternative splicing but in a non-coding region of the transcript such that only one t

164 We report that the non-coding region of this virus, HPV type 77, contains a

165 on of RITOLS replication occurs in the major non-coding region of vertebrate mtDNA and is effectively

166 GSE9 evolves from a previous non-coding region of wild rice Oryza rufipogon through t

167 Many of the eQTLs in the non-coding regions of a gene, or linked to nearby genes,

168 Mutations at specific hotspots in non-coding regions of ADGRG6, PLEKHS1, WDR74, TBC1D12 an

169 ns contain varying lengths of the coding and non-coding regions of beta - HYDROXYISOBUTYRYL-CoA HYDRO

170 the function of polymorphisms in coding and non-coding regions of class IB alcohol dehydrogenase (AD

171 ucleotide sequence repeats within coding and non-coding regions of different genes.

172 entification of gene-specific probes from 3' non-coding regions of different members can assist in th

173 hnique for selective amplification of the 3' non-coding regions of different wheat HSP16.9 genes by r

174 ur model specifically studies the effects of non-coding regions of DNA (in this case, CpG sites) on m

175 dentification of regulatory sequences within non-coding regions of DNA is an essential step towards e

176 tivity of DNMT3A colocalize with H3K36me2 at non-coding regions of euchromatin.

177 Mutations in coding and non-coding regions of FUS cause amyotrophic lateral scle

178 dentify potential regulatory elements in the non-coding regions of genes.

179 Ligand binding to structural elements in the non-coding regions of messenger RNA modulates gene expre

180 ent (IRE) is a 30nt RNA motif located in the non-coding regions of mRNAs of proteins involved in iron

181 ingle nucleotide polymorphisms (SNPs) in the non-coding regions of PEA15, including three frequent va

182 ctural partitions and between the coding and non-coding regions of plastid genomes, a significant cor

183 additional single-nucleotide variants in the non-coding regions of PRNP, but no novel structural vari

184 The significance of editing within non-coding regions of RNA is poorly understood.

185 results uncover a function for ribosomes on non-coding regions of RNAs and reveal the mechanisms und

186 Sequence homologies to the non-coding regions of several cereal genes were also exp

187 The 5'-non-coding regions of six mRNAs were shown to contain in

188 Hexanucleotide expansions, GGGGCC, in the non-coding regions of the C9orf72 gene were found in maj

189 a statistical approach to isolate coding and non-coding regions of the cancer genome that appear enri

190 ied by stage of disease and driver counts in non-coding regions of the cancer genome, in addition to

191 ore meaningful prediction in both coding and non-coding regions of the cancer genome.

192 inserting PCR-generated donor amplicons into non-coding regions of the corresponding genes.

193 ate eye enhancers in intron eight and the 3' non-coding regions of the dac locus defined by clusters

194 aused by expansions of C(C)TG repeats in the non-coding regions of the DMPK and CNBP genes, and DM pa

195 The leader and trailer non-coding regions of the EBOV genome likely regulate it

196 Mutations in PIGY can occur in coding and non-coding regions of the gene and cause variable phenot

197 tric illness and the frequent implication of non-coding regions of the gene by association analysis f

198 ion frequency repeats have been found in the non-coding regions of the gene.

199 ch 68.4% involved associations with flanking non-coding regions of the gene.

200 osable element (TE) that are abundant in the non-coding regions of the genes of many plant and animal

201 majority of GWAS-implicated variants are in non-coding regions of the genome and require in depth fo

202 deletions and duplications in the coding and non-coding regions of the genome and therefore require s

203 e association studies (GWASs) are located in non-coding regions of the genome and thought to act thro

204 Recent work annotating the non-coding regions of the genome has contributed to post

205 ics and genotype imputation, we annotate the non-coding regions of the genome in breast cancer cells

206 genes, aberrant enhancer element activity at non-coding regions of the genome is a key driver of tumo

207 r understanding of the rules that govern the non-coding regions of the genome is less complete than o

208 Enhancers are non-coding regions of the genome that control the activi

209 ion factors, other protein coding genes, and non-coding regions of the genome with regulatory potenti

210 However, most of these loci are in non-coding regions of the genome, and the causal mechani

211 available functional information relevant to non-coding regions of the genome, and, importantly, led

212 De novo genes emerge from previously non-coding regions of the genome, challenging the tradit

213 rtion of tagSNPs have been identified within non-coding regions of the genome, distinguishing functio

214 d in genome-wide association studies fall in non-coding regions of the genome, indicating their mecha

215 e vast majority of these SNPs are located in non-coding regions of the genome, the mechanisms by whic

216 For somatic point mutations in coding and non-coding regions of the genome, we propose CScape, an

217 For somatic point mutations in coding and non-coding regions of the genome, we propose CScape-soma

218 en identified, the vast majority residing in non-coding regions of the genome.

219 sed by unstable microsatellite expansions in non-coding regions of the genome.

220 associated with human disease are located in non-coding regions of the genome.

221 nown aetiological variants in the coding and non-coding regions of the genome.

222 enome-wide association studies (GWAS) lie in non-coding regions of the genome.

223 hich reside within large haplotype blocks in non-coding regions of the genome.

224 variants are often not causal and reside in non-coding regions of the genome.

225 llenge is magnified for variants residing in non-coding regions of the genome.

226 variants that are likely to be causal are in non-coding regions of the genome.

227 e association study (GWAS) risk loci fall in non-coding regions of the genome.

228 Coding and 5' and 3' non-coding regions of the GP VI gene were analyzed by po

229 Non-coding regions of the human genome are important for

230 NVs) and copy number variants (CNVs), in the non-coding regions of the human genome can play an impor

231 ce, especially chromosomal rearrangements in non-coding regions of the human genome, remains one of t

232 f human structural variants, particularly in non-coding regions of the human genome.

233 r a closer look at variations present in the non-coding regions of the human genome.

234 de association studies (GWAS) are located in non-coding regions of the human genome.

235 effect, pathogenic or neutral, of indels in non-coding regions of the human genome.

236 the potential pathogenic impact of indels in non-coding regions of the human genome.

237 is a silent substitution, and four occur in non-coding regions of the leptin receptor.

238 promoters and exon 7s primarily affects the non-coding regions of the message.

239 of 709 examples each, taken from coding and non-coding regions of the same genome.

240 clinically relevant sites in both coding and non-coding regions of the transcriptome.

241 Most splicing variants lie in non-coding regions of the transcripts.

242 eases are caused by repeat expansions in the non-coding regions of their resident genes.

243 The non-coding regions of tumour cell genomes harbour a cons

244 of gene containing transcripts, possess long non-coding regions (often >45 kb) and remain chromatin b

245 a genome-wide significant 62 kilo base (kb) non-coding region on chromosome 7p14.1 where de novo del

246 mutations affecting RNA-binding proteins and non-coding regions on RNAs, highlighting the importance

247 crucial role in the study of the effects of non-coding regions on the molecular classification of ca

248 Two non-coding regions, one in each paralog, appear to be un

249 is limited because many associations are in non-coding regions or difficult to target genes.

250 prehensive deep learning model to prioritize non-coding regions, outperforming other human lineage-sp

251 ritize functional DNA elements in coding and non-coding regions, particularly through use of in silic

252 By treating phylogenetically footprinted non-coding regions (PFRs) as proxies for CRMs, we endeav

253 In addition to wide-spread editing in non-coding regions protein recoding by RNA editing allow

254 ne or two protein-coding genes and conserved non-coding regions putatively involved in replication an

255 human CBFA1 gene, therefore, contains the 5' non-coding region rather than a human OSF2 homolog.

256 variants, with the vast majority falling in non-coding regions resulting in no eventual protein prod

257 ied out in Xenopus oocytes, we found that 3' non-coding region sequences of mKv1.4 mRNAs did not sign

258 p, which consists of both human and mouse 5' non-coding regions, served as a case study.

259 Their impact on retrotransposons in non-coding regions shed light on important aspects of ma

260 Two other non-coding regions showed nine changes, all associated w

261 Highly conserved non-coding regions showing rapid sequence changes along

262 loid wheat highlights the regulatory role of non-coding region structures in mRNA stability, and how

263 more sequence is under natural selection in non-coding regions [such as transcription-factor binding

264 genomic regions and also showed that defined non-coding regions, such as first introns of genes and r

265 de association studies (GWAS), >90% occur in non-coding regions, suggesting a strong regulatory compo

266 mall-effect variants(1) located primarily in non-coding regions, suggesting that the underlying causa

267 elaxation is much more profound in conserved non-coding regions than in protein-coding regions, and t

268 repeats (Di-SSRs) in the genomes, coding and non-coding regions than non Vampire Pathogens (N_VP).

269 r the presence of cis mutations in the major non-coding region that might influence their origins or

270 graphical reports are offered for coding and non-coding regions that annotate the potential impact of

271 y and clinical covariates and detect loci in non-coding regions that are difficult to interpret.

272 Our success can be attributed to shorter 3' non-coding regions that are typical of higher-plant gene

273 dozens of allele-specific binding events in non-coding regions that could distinguish between diseas

274 ding those targeting intergenic and intronic non-coding regions that eluded previous exome focused st

275 Many disease-associated loci are found in non-coding regions that house regulatory elements.

276 downstream gene interactions and integrating non-coding regions that may be regulating gene expressio

277 tifies 37 candidate sequences (in coding and non-coding regions) that fold to the target aptamer stru

278 54 and, except for two differences in the 3'-non-coding region, the remainder of the sequence is iden

279 thin MCSs (approximately 70%) resides within non-coding regions; thus, the majority of sequences cons

280 al impact of sequence variation in conserved non-coding regions to impact complex cis-element structu

281 eview a GRB-based approach to assign loci in non-coding regions to potential target genes, and apply

282 s the contribution of genetic alterations in non-coding regions to tumorigenesis and tumor progressio

283 Non-coding regions, typically covered by sparse off-targ

284 Moreover, two independent insertions in a non-coding region upstream of the pilE gene suggest that

285 nsive sequence conservation was found in the non-coding regions upstream of the pag-3 exons, in sever

286 The improved accuracy in non-coding regions was mainly achieved using novel repet

287 pathogenic variant, targeted re-analysis of non-coding regions was performed on GS data.

288 from the polyprotein coding region to the 3' non-coding region we have further developed a cell-based

289 To further characterize the burdening of non-coding regions, we used NIMBus to screen transcripti

290 variants in morphology-associated coding and non-coding regions, weighted by their effect sizes.

291 with high CpG/UpA sequences inserted into a non-coding region were similarly replication defective.

292 While most indels at non-coding regions were a single base pair, 3 base pair

293 ut those somatic mutations that occur at the non-coding regions where AR binds DNA.

294 lanced accuracy in coding regions and 69% in non-coding regions, whereas even higher accuracy may be

295 tified were used to map potential regulatory non-coding regions, which in turn were employed to predi

296 lanced accuracy in coding regions and 70% in non-coding regions, while even higher accuracy may be ac

297 of these members appeared distinct in the 3' non-coding region with only 48% identity.

298 gh degree of identity in both the coding and non-coding regions with both the murine G-CSF (85%) and

299 majority of GWAS variants are located within non-coding regions with no functional role.

300 ost mutations in cancer genomes occur in the non-coding regions with unknown impact on tumor developm