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1 ediction of STAR3D is more accurate for both non-homologous and homologous RNAs than other state-of-t
2 ulatory GTPases, but is atypical in having a non-homologous, C-terminal domain of approximately 20 kD
3 to those observed in Cdk2 KO mice including non-homologous chromosome pairing, unrepaired double-str
5 d chromatin bridges between the telomeres of non-homologous chromosomes in Atrecq4A at metaphase I, i
7 e, no mechanism able to specifically inhibit non-homologous crossovers has been described in allopoly
8 ene for the main crossover pathway, prevents non-homologous crossovers in allotetraploid Brassica nap
10 romosome segregation requires suppression of non-homologous crossovers while levels of homologous cro
12 deletion of genomic sequence or insertion of non-homologous DNA at the edited locus in a cell line sp
15 coni protein D2, ATM protein expression, and non-homologous DNA end joining protein expression and fu
18 ing site-specific nuclease digestion through non-homologous DNA end-joining, as opposed to single str
19 ndant proteins and test it on a large set of non-homologous domains, as well as on the set of protein
20 ing partners promotes the rapid unbinding of non-homologous dsDNA and drives strand exchange forward
22 ce that selection for RPS5 involves multiple non-homologous effectors and multiple pathogen species.
27 iple cell lines, we found that the canonical non-homologous end joining (C-NHEJ) factor XLF promotes
28 mpared to HR, whereas Ku-dependent classical non-homologous end joining (C-NHEJ) has a minimal role t
30 ngly none of the components of the canonical non-homologous end joining (C-NHEJ) pathway were identif
32 pair is usually facilitated by the classical non-homologous end joining (C-NHEJ), or homologous recom
34 a mutated (ATM); and inhibitors of classical non-homologous end joining (cNHEJ) and alternative end j
36 ndependent function for LRF in the classical non-homologous end joining (cNHEJ) pathway of double-str
39 ain repair pathways used to resolve DSBs are Non-Homologous End Joining (NHEJ) and Homologous Recombi
40 promotes the two major DSB repair pathways, non-homologous end joining (NHEJ) and homologous recombi
41 ebrafish (Danio rerio) and livestock through non-homologous end joining (NHEJ) and homology-directed
42 trand break repair that buttresses canonical non-homologous end joining (NHEJ) and is manifest in NHE
44 HD1 is required for DNA damage signaling and non-homologous end joining (NHEJ) at unprotected telomer
60 m the RAG post-cleavage complex (PCC) to the non-homologous end joining (NHEJ) machinery to promote a
61 capabilities; however, the preponderance of non-homologous end joining (NHEJ) mediated repair events
63 and breaks (DSBs) are repaired by either the non-homologous end joining (NHEJ) or homologous recombin
64 regulated process performed predominantly by non-homologous end joining (NHEJ) or homologous recombin
65 implicates breaks followed by repair through non-homologous end joining (NHEJ) or stalled fork repair
66 reaks that can undergo DNA repair either via non-homologous end joining (NHEJ) or, in the presence of
67 se IIIalpha is a component of an alternative non-homologous end joining (NHEJ) pathway for DNA double
73 kinase (DNA-PK) plays a critical role in the non-homologous end joining (NHEJ) repair pathway and the
75 B-mediated homologous recombination (HR) and non-homologous end joining (NHEJ) repair systems, leadin
76 ught to arise from a moderate attenuation of non-homologous end joining (NHEJ) repair, the role of DE
79 knockout MEFs exhibited distinct defects in non-homologous end joining (NHEJ) when compared to their
81 nit (DNA-PKcs) plays a key role in mediating non-homologous end joining (NHEJ), a major repair pathwa
82 Non-allelic homologous recombination (NAHR), non-homologous end joining (NHEJ), and microhomology-med
83 for sequence-specific gene knockout through non-homologous end joining (NHEJ), but it remains ineffi
84 ir factors, in particular those required for non-homologous end joining (NHEJ), do not form discrete
85 non-allelic homologous recombination (NAHR), non-homologous end joining (NHEJ), fork stalling and tem
86 hen can become the substrate for error-prone non-homologous end joining (NHEJ), generating mutations
87 xcision repair (NER), mismatch repair (MMR), non-homologous end joining (NHEJ), homologous recombinat
89 common DSB repair mechanism in human cells, non-homologous end joining (NHEJ), rejoins broken DNA en
92 air by homologous recombination (HR) but not non-homologous end joining (NHEJ), using HeLa cell lines
93 s of either homologous recombination (HR) or non-homologous end joining (NHEJ), whereas SUMO2/3 was r
94 -strand breaks are repaired predominantly by non-homologous end joining (NHEJ), which directly ligate
95 tly reported the involvement of WT TDP-43 in non-homologous end joining (NHEJ)-mediated DSB repair, w
96 e Alb locus in mouse liver is mainly through non-homologous end joining (NHEJ)-mediated knock-in.
113 insights into LINP1's ability to facilitate non-homologous end joining (NHEJ). We characterized LINP
114 t provides DNA ligase activity for classical non-homologous end joining (the predominant DNA double-s
115 that errors in DNA repair pathways, such as non-homologous end joining and homologous recombination,
117 e other five types of solid tumors, in which non-homologous end joining and microhomology end joining
118 ted stochastic model of DNA damage repair by non-homologous end joining and of gamma irradiation-indu
119 otein and combined deficiencies in classical non-homologous end joining and p53 predispose to RAG-ini
120 the choice of homologous recombination over non-homologous end joining and potentially other mutagen
121 e found that MMSET is required for efficient non-homologous end joining as well as homologous recombi
123 RNF168 rescues 53BP1 recruitment involved in non-homologous end joining but not BRCA1 recruitment for
124 the interference of high LET radiation with non-homologous end joining but not homologous recombinat
125 roach to reduce the toxicity associated with non-homologous end joining by promoting the use of homol
126 tivation of the p97-ATX3 complex affects the non-homologous end joining DNA repair pathway and hypers
127 de DNA end binding proteins required for the non-homologous end joining DNA repair pathway, increases
130 We found Cas9-gRNA achieved 7-8x higher non-homologous end joining efficiencies (3%) than reTALE
132 t acetylation of H4 regulates binding of the non-homologous end joining factor 53BP1, which engages c
133 G2 shepherd the broken DNA ends to classical non-homologous end joining for proper repair, roles for
134 ting functional redundancy between Rad18 and non-homologous end joining for tolerance of oxidative DN
136 Repair of DNA double-strand breaks (DSBs) by non-homologous end joining is critical for neural develo
139 repair (HR), while counteracting error-prone non-homologous end joining of DNA double-strand breaks.
141 ther demonstrate that the excursions promote non-homologous end joining of dysfunctional telomeres an
142 derived hiPSCs where successful deletion and non-homologous end joining of up to 725 kb reframed the
143 A double-strand breaks can be eliminated via non-homologous end joining or homologous recombination.
144 wed by repair through either the error-prone non-homologous end joining or the homology directed repa
145 s in a G1-like DNA repair mode which favours non-homologous end joining over interchromosomal recombi
146 double-strand DNA break (DSB) repair via the non-homologous end joining pathway, as unrepaired DSBs a
152 led to enhanced phosphorylation of DNA-PK, a non-homologous end joining repair protein, in Hec-108 ce
154 removal of histone H3 from the genome during non-homologous end joining was promoted by both ATM and
155 EGFR mutation is associated with a defect in non-homologous end joining, a major pathway for DNA doub
156 ecombination, an error-free mechanism, or by non-homologous end joining, a process susceptible to int
157 ctionally contribute to efficient resection, non-homologous end joining, and tolerance to DNA-damagin
158 lta defects in Tel1/ATM kinase signaling and non-homologous end joining, consistent with the role of
159 in vivo genome editing method, combined with non-homologous end joining, enabling permanent chromosom
160 at take part in homologous recombination and non-homologous end joining, respectively, were transcrip
163 damage-tolerance in G(1) (because of back-up non-homologous end joining-mediated DSB repair), yet Rad
176 dent on Ku70/80 and LIG4, or the alternative non-homologous end-joining (A-NHEJ), which relies on PAR
178 elomere fusions require either the classical non-homologous end-joining (C-NHEJ) pathway dependent on
180 ng mechanisms, the main process is classical non-homologous end-joining (C-NHEJ) which relies on Ku b
181 or critical role in ICL repair was seen for non-homologous end-joining (cku-80) or base excision rep
182 CC4-like factor (XLF) functions in classical non-homologous end-joining (cNHEJ) but is dispensable fo
184 e repair of DNA double-strand breaks (DSBs): non-homologous end-joining (NHEJ) and homologous recombi
186 ase II (TOP2) are rejoined by TDP2-dependent non-homologous end-joining (NHEJ) but whether this promo
188 to be associated with the components of the non-homologous end-joining (NHEJ) complex and participat
189 rate that combined inactivation of the XRCC4 non-homologous end-joining (NHEJ) DNA repair gene and p5
190 Allele-specific gene disruption induced by non-homologous end-joining (NHEJ) DNA repair offers a po
191 HDR) is limited by the competing error-prone non-homologous end-joining (NHEJ) DNA repair pathway.
192 GE syndrome, as an integral component of the non-homologous end-joining (NHEJ) DSB repair pathway.
196 that inactivating terminal components of the non-homologous end-joining (NHEJ) machinery or of the BR
197 the X family that has been implicated in the non-homologous end-joining (NHEJ) pathway during repair
199 roduction of insertion-deletions (INDELs) by non-homologous end-joining (NHEJ) pathway underlies the
201 depleting HP1 from cells did not affect the non-homologous end-joining (NHEJ) pathway: instead it el
202 ed via the single-strand annealing (SSA) and non-homologous end-joining (NHEJ) pathways in a manner d
204 osomes and generate genome rearrangements by non-homologous end-joining (NHEJ) processes in specializ
205 dation of a novel assay to measure mutagenic non-homologous end-joining (NHEJ) repair in living cells
207 homology directed repair (HDR) and decreased non-homologous end-joining (NHEJ) repair, suggesting tha
208 efficiency, which are typically repaired by non-homologous end-joining (NHEJ) resulting in nonspecif
210 n (HR) repair with a concomitant decrease in non-homologous end-joining (NHEJ), accounting for the im
211 e between high-fidelity (HF) and error-prone non-homologous end-joining (NHEJ), as well as between pr
212 syl-DNA phosphodiesterase 2 (TDP2)-dependent non-homologous end-joining (NHEJ), but whether this proc
213 DNA-PKcs; encoded by PRKDC) functions in DNA non-homologous end-joining (NHEJ), the major DNA double
214 ever, mutagenic events caused by error-prone non-homologous end-joining (NHEJ)-mediated repair are in
220 )p53(-/-) MEFs, homologous recombination and non-homologous end-joining activities were significantly
221 on are predominantly mediated by alternative non-homologous end-joining activity that may employ eith
223 timated frequencies of accurate or mutagenic non-homologous end-joining and gene correction by homolo
224 ks between the target sequences, stimulating non-homologous end-joining and homologous recombination.
225 repair occurs in cells fully proficient for non-homologous end-joining and is not compensated by DNA
226 short palindromic repeats (CRISPR)/Cas9 and non-homologous end-joining by deleting the repeat region
227 protein NONO was found to be involved in the non-homologous end-joining DNA repair process and in pol
228 sh that REV7 blocks DSB resection to promote non-homologous end-joining during immunoglobulin class s
234 demonstrate the importance of TDP2-dependent non-homologous end-joining in protecting both gene trans
235 bioluminescence imaging, that the assay for non-homologous end-joining is sensitive, quantitative, r
236 SWI/SNF and RSC enzymes is inhibited by the non-homologous end-joining machinery, and that their rec
238 s expressing BCR-ABL1 utilize an alternative non-homologous end-joining pathway (ALT NHEJ) to repair
239 amage response (DDR) and instrumental in the non-homologous end-joining pathway (NHEJ) used to detect
240 rrow failure syndrome) codes for a canonical non-homologous end-joining pathway factor, that the RNA
241 leotides during gap-filling synthesis in the non-homologous end-joining pathway of double-strand brea
243 in the proximity of the break were due to a non-homologous end-joining pathway, while larger deletio
244 in E. dermatitidis through disruption of the non-homologous end-joining pathway, with three individua
246 This overexpression triggers SSB repair and non-homologous end-joining pathways to increase DNA repa
250 a novel component regulating the switch from non-homologous end-joining to homologous recombination.
251 double-strand break repair switches from DNA non-homologous end-joining to homologous recombination.
252 ribution of DNA ligase 4-dependent classical non-homologous end-joining to long-range inter-chromosom
253 functions of DNA ligase 1 in replication and non-homologous end-joining uniquely position and capacit
256 DNA repair towards faster and more accurate non-homologous end-joining, including in post-mitotic pr
257 breakpoint junctions revealed signatures of non-homologous end-joining, non-allelic homologous recom
258 involved defective base excision repair and non-homologous end-joining, pathways required for repair
262 nferred when structurally distinct and hence non-homologous enzymes show the ability to catalyze the
263 from head-to-head and head-to-tail oriented "non-homologous" FRT partners are a 4-noded knot and a 5-
264 the other hand, N-glycan structures found on non-homologous glycoproteins do not show significant glo
266 ) N-linked glycan library and PDB homologous/non-homologous N-glycoprotein sets indicate that GS-alig
267 In contrast, breakpoints associated with non-homologous (NH) mechanisms often have sequence micro
268 n different organs, formed from sequentially non-homologous polypeptide chains and affecting human or
269 large scale, DSB formation is suppressed on non-homologous portions of the sex chromosomes via the D
270 to double-stranded DNA, and a suppression of non-homologous primer annealing and nonspecific amplific
271 chmark sets consisting collectively of 1,153 non-homologous protein targets, where CEthreader detecte
272 he protocol was tested on a large set of 285 non-homologous proteins and generated structural models
273 reconstructions of TCPM mutants in which the non-homologous proteins are individually deleted, we pro
274 The approach was tested on a set of 158 non-homologous proteins collected from the CASP experime
276 ket database to predict binding ligand of 75 non-homologous proteins that bind one of seven different
277 othelial cell loss of KRIT1, CCM2 or PDCD10, non-homologous proteins that form an adaptor complex.
279 separating training and test mutations from non-homologous proteins, which reflects inherent correla
281 sis and robustness tests, we create a set of non-homologous, purely synthetic, minimal promoters for
282 ydrolase family GH30) and then applied it to non-homologous (putative) retaining beta-glucosidases ca
283 dsDNA molecule allows dsDNA to extend along non-homologous Rad51-ssDNA filaments and remain stably b
284 by driving the swift unbinding of dsDNA from non-homologous Rad51-ssDNA filaments, while at the same
285 e normally unstable binding of that dsDNA to non-homologous RecA-ssDNA filaments, whereas pulling on
286 efficiency of both homologous and the other non-homologous recombination, as well as increases sensi
287 d that the relative levels of homologous and non-homologous repair in a given fungal species may play
288 d mechanism involving template switching and non-homologous repair mediates the formation of balanced
289 ts a shift in emphasis for new entries, from non-homologous representatives covering EC reaction spac
291 e same drug (methotrexate) binds to multiple non-homologous RLM drug targets with different topologie
297 the second end must be processed to remove a non-homologous tail before completing repair by gene con
299 oupling a microhomology search to removal of non-homologous tails and microhomology-primed synthesis
300 cular dynamics simulations performed on nine non-homologous viral protein structures and from variati