ライフサイエンスコーパス: non-neural

1 1) receptors of neural (cerebral cortex) and non-neural (adipocyte) origin in three different species

2 ing can be mimicked with antibody binding to non-neural agrin, supporting a mechanism of ligand aggre

3 se previous studies is the importance of the non-neural and preplacodal ectoderm, two critical precur

4 sociated with sexual arousal, and in diverse non-neural and reproductive tissues, suggesting a variet

5 tate fMRI (rsfMRI) scans, which will lead to non-neural artifacts in the rsfMRI signal.

6 to the mechanisms responsible for neural and non-neural aspects of the FXS phenotype.

7 is sufficient to confer this activity to the non-neural bHLH factor MyoD.

8 tissue architectures, showing that a minimal non-neural Bio-Electric Network (BEN) model that utilize

9 owever, it has not been shown whether or how non-neural bioelectric cell networks can support computa

10 standing the anatomical semantics encoded in non-neural bioelectrical networks, and of improved bioph

11 daptive, context-specific behavior occurs in non-neural biological systems.

12 tion the pineal progenitor domain within the non-neural border by repressing pineal fate and that the

13 Nuclear extracts from neural and non-neural cell lines contained a DNA-binding activity w

14 he association of FMRP with polyribosomes in non-neural cell lines has previously suggested that FMRP

15 KSRP is expressed in both neural and non-neural cell lines, although it is present at higher

16 mice causes abscission defects in neural and non-neural cell types, and postnatal lethality.

17 nce analysis and transcriptional activity in non-neural cell types.

18 dence of critical interactions with glia and non-neural cell types.

19 nct populations of progenitor, neuronal, and non-neural cells across our differentiation time course.

20 However, the p75NTR consistently appears in non-neural cells adjacent to those expressing Trk recept

21 a signal for programmed cell death, whereas non-neural cells do not.

22 expressed by specific subsets of neural and non-neural cells during embryogenesis and has been shown

23 pecies.Following spinal injury in zebrafish, non-neural cells establish an extracellular matrix to pr

24 ctions in the differentiation of neurons and non-neural cells have important implications not only fo

25 the primary cultures and contamination from non-neural cells have restricted the utility of these cu

26 By adapting optogenetics for use in non-neural cells in embryos, we show that developmentall

27 Reporter assays in central glial (CG-4) and non-neural cells indicated that a 1200-base pair (bp) 5'

28 in start site selection for both neural and non-neural cells indicates that the effect is general.

29 amine transporters (VMATs), one expressed in non-neural cells of the periphery (VMAT1) and the other

30 ever, how the growth cone differs from other non-neural cells remains unclear.

31 In non-neural cells REST is absent from the RE1 of the sile

32 Axonal growth through tubes of non-neural cells seemed to account for this specificity,

33 tion between neurons and between neurons and non-neural cells such as glia and muscle.

34 In this review, we focus on the impact of non-neural cells that participate in the neurogenic nich

35 h, and effects on the function of neural and non-neural cells within the nervous system have remained

36 e long been associated with proliferation in non-neural cells, although they are also expressed in po

37 orters and to trafficking in both neural and non-neural cells, and suggests a relationship between fa

38 ade involving neurons, glia, and potentially non-neural cells, and that interactions between these ce

39 ems within both neurons and glia, as well as non-neural cells, most notably in gonadal cells.

40 In non-neural cells, Rap signaling can antagonize Ras signa

41 In neural progenitor and non-neural cells, REST acts by repression of a subset of

42 results demonstrate that, in both neural and non-neural cells, transcription of the FMR1 gene is init

43 confers little if any transport activity in non-neural cells, we also determined its localization in

44 ich subserves regulatory volume increases in non-neural cells, whereas mature neurons express KCC2, w

45 osis in neurons but suppresses cell death in non-neural cells.

46 onal differences between Notch in neural and non-neural cells.

47 nd can then enter the nucleus in neurons and non-neural cells.

48 s without a marked effect on virus growth in non-neural cells.

49 ression occurred in astrocytes, neurons, and non-neural cells.

50 stasis, without affecting body patterning or non-neural cells.

51 old (+/- 3.7) more active in neurons than in non-neural cells.

52 itical effector of apoptosis in a variety of non-neural cells.

53 metalloprotease released by both neural and non-neural cells.

54 ensively after the expression of subunits in non-neural cells.

55 be expressed in a wide variety of neural and non-neural cells.

56 particular form of "forefront" signaling in non-neural cells.

57 h may benefit or harm surrounding neural and non-neural cells.

58 Cl(-) currents and taurine release in human non-neural cells.

59 neurons, glia, undifferentiated neurons and non-neural cells.

60 ptor insertion events observed previously in non-neural cells.

61 vercome many of the limitations of viral and non-neural cellular vectors, as well as pharmacologic an

62 of MWS and may underlie some sex-dependent, non-neural characteristics of this human inherited disor

63 les depending on the situations, while other non-neural chemotactic cells usually show uni-directiona

64 arkers in both ventral Xenopus epidermis and non-neural chick epiblast.

65 d smooth muscle contractility via neural and non-neural cholinergic pathways in the colon, the involv

66 were expressed in a previously unidentified non-neural CNS cell type.

67 gion-specific neurodegeneration, but also to non-neural co-morbidities.

68 all CNS neuroendocrine organs may require a non-neural contribution to form neurosecretory cells.

69 Both neural and non-neural control mechanisms may contribute to changes

70 ral crest neurons in the rostral portion and non-neural crest (nodose) neurons in the more central an

71 emonstrate Rdh10 is specifically required in non-neural crest cells prior to E10.5 for proper choanae

72 Our results elucidate a new function for the non-neural crest core mesoderm and specifically, mesoder

73 formations involved morphological changes to non-neural crest host beak tissues.

74 essed in melanoma cell lines compared with a non-neural crest kidney epithelial cell line (P < 1 x 10

75 The non-neural crest MdPA1 core mesoderm is needed to form m

76 y less than half in such embryos, implying a non-neural crest origin for a subset of them.

77 IBG uptake, of which only 2% (2/100) were of non-neural crest origin.

78 racterized for other neural crest tumors and non-neural crest tumors of childhood.

79 role in modulating growth and development of non-neural crest- derived tissues.

80 s but did so in mixed cultures of crest- and non-neural crest-derived cells; therefore, the endogenou

81 Our results reveal a variety of non-neural decision-making processes as manifestations o

82 the central nervous system can give rise to non-neural derivatives.

83 Wnt-13 remained expressed in non-neural differentiated NTERA-2 cells, even several we

84 induction, and are refractory to BMP-induced non-neural differentiation.

85 mbryonic stem cells undergoing predominantly non-neural differentiation.

86 mitive embryonic ectoderm into neural versus non-neural domains.

87 or grainyhead-like 2 (GRHL2) is expressed in non-neural ectoderm (NNE) and Grhl2 loss results in full

88 ctors position the border between neural and non-neural ectoderm and are required for the specificati

89 in the lateral neural plate is regulated by non-neural ectoderm and bone morphogenetic proteins.

90 pophyseal cells are exclusively derived from non-neural ectoderm and demonstrate that crosstalk betwe

91 domains; tfap2a is expressed in the ventral non-neural ectoderm and foxd3 in the dorsal mesendoderm

92 ntiating cells and allowed discrimination of non-neural ectoderm and otic lineage cells from off-targ

93 Wnt signals from the neural plate, non-neural ectoderm and paraxial mesoderm have all been

94 cesses, our results suggest ancient roles in non-neural ectoderm and regulating specific mesenchymal-

95 sensory neurons form at the boundary between non-neural ectoderm and the neural plate.

96 We find that neural and non-neural ectoderm are necessary and sufficient for fol

97 It has been suggested that both neural and non-neural ectoderm can contribute to the neural crest.

98 We report that in response to FGF the non-neural ectoderm can ectopically express several earl

99 These results suggest that the non-neural ectoderm can launch the neural crest program

100 Individual non-neural ectoderm cells on opposing sides of the neura

101 ryo, the organizer, can redirect the fate of non-neural ectoderm cells to form a complete, patterned

102 codes arise at the border of the neural- and non-neural ectoderm during anamniote vertebrate developm

103 nitiation signal acting from the extraocular non-neural ectoderm during optic vesicle evagination.

104 demonstrate that Dlx activity is required in non-neural ectoderm for the production of signals needed

105 Neural crest cells require BMP expressing non-neural ectoderm for their induction.

106 e border region between the neural plate and non-neural ectoderm from which multiple cell types, incl

107 we address the molecular mechanisms by which non-neural ectoderm generates neural crest.

108 leading to neural crest development via the non-neural ectoderm in amniotes and present a distinct r

109 neural crest (NC), cranial placode (CP), and non-neural ectoderm in multiple hPSC lines, on different

110 entiation were first recruited to the dorsal non-neural ectoderm in the tunicate-vertebrate ancestor

111 unction homologously to define neural versus non-neural ectoderm in Xenopus.

112 ncoding AP-2 gamma (Tfap2c), is expressed in non-neural ectoderm including transiently in neural cres

113 zed ectoderm, via meso-ectodermal, or neural-non-neural ectoderm interactions.

114 Expression in non-neural ectoderm is a conserved feature in amphioxus

115 We conclude that contact between neural and non-neural ectoderm is capable of inducing RBs, that BMP

116 tive BMP receptor, was transplanted into the non-neural ectoderm of un-manipulated hosts.

117 nteractions at the border between neural and non-neural ectoderm or mesoderm, and defined factors suc

118 Furthermore, the non-neural ectoderm responds to FGF by expressing the pr

119 differentiating cultures first expressed the non-neural ectoderm specific transcriptional factors TFA

120 ling across the interface between neural and non-neural ectoderm that is critical for inducing and pa

121 fusion protein expands the neural plate into non-neural ectoderm tissue whereas ectopic activation of

122 nd spatially restrict mesoderm, endoderm and non-neural ectoderm to their proper locations in the Xen

123 egulation of these neural crest markers, the non-neural ectoderm upregulates both BMP and Wnt molecul

124 ccurs in the inner or sensorial layer of the non-neural ectoderm where a subset of cells are chosen t

125 led an initially synchronous guidance toward non-neural ectoderm, followed by comparatively asynchron

126 epithelia that represent the mouse embryonic non-neural ectoderm, preplacodal ectoderm and otic vesic

127 chronological expression of marker genes of non-neural ectoderm, preplacodal ectoderm, and early oti

128 Signals from the non-neural ectoderm, the neural ectoderm, and the underl

129 influence the differentiation of neural and non-neural ectoderm, we show here that members of the Dl

130 ertebrate embryos is comprised of neural and non-neural ectoderm, with the border territory at their

131 nitors originate, at least in part, from the non-neural ectoderm.

132 eries of interactions between the neural and non-neural ectoderm.

133 eural folds at the border between neural and non-neural ectoderm.

134 the expanded neural plate abuts Dlx-positive non-neural ectoderm.

135 n extending throughout the entire neural and non-neural ectoderm.

136 rs is generated within the deep layer of the non-neural ectoderm.

137 al neural tube but are down-regulated in the non-neural ectoderm.

138 evidence, in vertebrates, of compartments in non-neural ectoderm.

139 ibited apical constriction in the neural and non-neural ectoderm.

140 o a millimetre-long neural tube covered with non-neural ectoderm.

141 diated via extracellular matrix synthesis by non-neural ectoderm.

142 tion that arises at the border of neural and non-neural ectoderm.

143 ted neurosecretory cells in the anteriormost non-neural ectoderm.

144 er between the neural plate and the adjacent non-neural ectoderm.

145 ectopic neurons that extend to the ventral, non-neural, ectoderm, but show no ectopic or enhanced no

146 onverting the lineage from neural/retinal to non-neural ectodermal and endo-mesodermal fates.

147 lx4b act to regulate bmp2b expression at the non-neural ectodermal border.

148 about functional roles for SoxB1 factors in non-neural ectodermal cell types, such as the neural pla

149 d2 and Smad1 signals to adopt mesodermal and non-neural ectodermal fates even at gastrula stages, aft

150 h as regionalized gene expression and neural/non-neural ectodermal patterning.

151 However, the mechanisms by which these non-neural elements contribute to CNS activity-dependent

152 ssel organoids leads to the incorporation of non-neural endothelial cells and microglia into the brai

153 in the neural ectoderm and E-cadherin in the non-neural (epidermal) ectoderm, and that each cadherin

154 Using the NM-ALM we discovered that non-neural extrinsic factors from differently sized host

155 autonomic neural activity rather than other, non-neural factors.

156 e of autonomic neural activity versus other 'non-neural' factors in the origin of BP and R-R variabil

157 on day 2, and the acquisition of neural and non-neural fates is now advanced by inhibition of Fgf si

158 Remarkably, MMP-9 deficiency also corrected non-neural features of Fmr1 deficiency-specifically macr

159 ng that TNBC is more complex than NTNBC; (2) non-neural functions related to cell-microenvironment in

160 rved core domain, all of which are absent in non-neural genes and, together, distinguish them from ra

161 neuronal progenitor fields by downregulating non-neural genes, notably the muscle specifier Macho-1 a

162 neuropeptides, metabolic enzymes, and other non-neural genes.

163 asal transcription both in neural (PC12) and non-neural (HeLa and glial) cell types.

164 Our data demonstrate that non-neural human somatic cells, as well as pluripotent s

165 ived from several types of neural as well as non-neural human tumors.

166 now demonstrate this effect in two separate non-neural, immortalized cell lines stably expressing a

167 ally in cells that normally express only the non-neural isoform of Neuroglian, we observed the genera

168 rent lesion-related tissue compartments: (a) non-neural lesion core, (b) astrocyte scar border, and (

169 entral role in creating a border against the non-neural lesion core.

170 necessary for axons to actively navigate the non-neural lesion site environment.

171 Generation of iN cells from non-neural lineages could have important implications fo

172 n cortical organoids, spinal motoneurons and non-neural lineages including melanocytes and pancreatic

173 nd premutation (54<n<200) cell lines of both non-neural (lymphoblastoid) and neural (primary astrocyt

174 The data add to the growing literature of non-neural manifestations of HD and implicate NO depleti

175 ochlear sensitivity, perhaps both neural and non-neural mechanisms.

176 of tumor cells throughout the brain, whereas non-neural metastases, as well as select lower grade gli

177 cs of learning and information processing in non-neural metazoan somatic cell networks.

178 Elav by Mei-P26, another RBP derepressed in non-neural miRNA pathway clones.

179 Even non-neural models can learn from a neural network teache

180 onomic arrangements of the Isoptera based on non-neural morphological and DNA sequence analyses.

181 major classes of retinal neurons, as well as non-neural Muller glial cells, are specified in young em

182 that the cell surface-binding LG domains of non-neural (muscle) agrin and perlecan promote AChR clus

183 itive immunohistochemical staining of all 13 non-neural normal human tissues, in contrast to none of

184 and thyroid glands, and no staining of other non-neural normal tissues.

185 ral ectoderm: chordotonal sensory organs and non-neural oenocytes.

186 mesoderm, in the specification of neural and non-neural organ-specific lineages, as well as cell surv

187 t decision-making and learning also occur in non-neural organisms [1], including singly nucleated cel

188 Gene expression in chick indicates that this non-neural origin of pineal progenitors is conserved in

189 The non-neural origin of the pineal organ reveals an underly

190 ntiation, and during differentiation along a non-neural pathway induced by hexamethylene bisacetamide

191 uding the anatomy and function of neural and non-neural pathways, diseases and disorders, manipulatio

192 , ESC aggregates transform sequentially into non-neural, preplacodal and otic-placode-like epithelia.

193 avior, local neural activity, and putatively non-neural processes.

194 ly divide embryonic ectoderm into neural and non-neural regions, followed by the emergence of neural

195 Ectopic ath5 expression in cultures of non-neural retinal pigment epithelial cells elicited tra

196 s are maintained by interactions between the non-neural roof plate and the neural rhombic lip.

197 ibed and post-transcriptionally repressed in non-neural settings.

198 uch as learning even in naturally occurring, non-neural, single-celled organisms.

199 cells, and Schwann cells and Trk-expressing non-neural smooth muscle and dendritic cells.

200 Apoptosis is also described in other non-neural structures such as the notochord, somites, mu

201 did not detect expression in the superficial non-neural structures that express the GABA synthase Gad

202 ences across homologous neuronal, glial, and non-neural subtypes.

203 s by comparing with three leading neural and non-neural techniques, concluding that CellVGAE outperfo

204 Repression of Elav in non-neural territories is crucial as misexpression here

205 d axonal processes as they migrate through a non-neural territory.

206 he first demonstration of PS1 abnormality in non-neural tissue and in diseases other than AD and sugg

207 We generalize connectionist methods to non-neural tissue architectures, showing that a minimal

208 CBP function in the Xenopus embryo abolishes non-neural tissue formation and, strikingly, initiates n

209 Alternatively spliced agrin isoforms in non-neural tissue including muscle lack the z8 insert an

210 PMP22 mRNAs can be detected in a variety of non-neural tissue, including epithelia.

211 in type I diabetes, has unclear function in non-neural tissue, it is important to understand its pat

212 locking the neuronal phenotype in vertebrate non-neural tissue, the invertebrate homolog is absent, r

213 ted neurons by silencing their expression in non-neural tissue.

214 d ASI to suppress innate immune responses in non-neural tissues against Pseudomonas aeruginosa in Cae

215 several other neuronal target genes, in both non-neural tissues and central nervous system neuronal p

216 on of neuron-specific tubulin in a subset of non-neural tissues and embryonic lethality.

217 efficient form of IDE expressed in brain and non-neural tissues and recommend novel regions of the ID

218 mates compared with lipids characteristic of non-neural tissues and show further acceleration of chan

219 e that humans produce a third form of GAD in non-neural tissues and that human islets, although they

220 ever, the identities of signals derived from non-neural tissues and the mechanisms by which these sig

221 ns: what are the requirements for Shroom3 in non-neural tissues and what factors control Shroom3 tran

222 SYN1 gene transcription is suppressed in non-neural tissues by the RE1-silencing transcription fa

223 ive medicine require an understanding of how non-neural tissues could process information.

224 f the nervous system and doublesex specified non-neural tissues culminated with claims that fruitless

225 Physiological stress in non-neural tissues drives aversive learning for sensory

226 e Trk receptors are expressed extensively in non-neural tissues during cell differentiation and tissu

227 severalfold higher than in other neural and non-neural tissues examined, consistent with the require

228 ion conducted in three brain regions and two non-neural tissues from humans, chimpanzees, macaque mon

229 PMP22 protein expression and localization in non-neural tissues have not been studied in detail.

230 for long-term repression of target genes in non-neural tissues in adult zebrafish.

231 r that directs expression to both neural and non-neural tissues in vivo.

232 and humans, but the role of PtdIns(3,5)P2 in non-neural tissues is poorly understood.

233 However, genes with essential roles in non-neural tissues may be missed in traditional loss-of-

234 arly developmental events in both neural and non-neural tissues may be modulated by opioid receptors.

235 Reports of Trk receptor transcripts in non-neural tissues raise the possibility that the sites

236 erentiates into neural tissues and also into non-neural tissues such as the choroid plexus in the bra

237 r (NGF) receptor TrkA is widely expressed in non-neural tissues suggesting pleiotropic functions outs

238 neurotrophin-3 (NT-3) is highly expressed in non-neural tissues that receive peripheral innervation,

239 size of neuronal populations that innervate non-neural tissues to the optimal requirements of these

240 of genes that encode heat shock proteins in non-neural tissues upon exposure to heat.

241 molecular mechanisms that pattern neural and non-neural tissues within the neuroectoderm remain unkno

242 p75NTR with the Trk receptors in developing non-neural tissues would support the hypothesis that the

243 n (PrP(C)) is widely expressed in neural and non-neural tissues, but its function is unknown.

244 Expression of GPIalpha btx in surrounding non-neural tissues, but not in neurons, does not prevent

245 bitors of oxidative death in both neural and non-neural tissues, but their precise mechanism of actio

246 or (p75NTR) has been detected in a number of non-neural tissues, especially during development.

247 wn to affect immune function in vitro and in non-neural tissues, little is known about how the local

248 eferentially grow as compared to neighboring non-neural tissues, resulting in dendrite overgrowth.

249 than the reported 2-3 kb mRNA predominant in non-neural tissues, we identified the major brain isofor

250 known to promote cell survival via Bcl-2 in non-neural tissues, we tested the hypothesis that estrad

251 REST/NRSF is expressed most highly in non-neural tissues, where it is thought to repress gene

252 eep serves metabolic functions in neural and non-neural tissues.

253 ervous tissue by silencing neuronal genes in non-neural tissues.

254 heir genes are expressed sex-specifically in non-neural tissues.

255 ishing connections with other neurons and/or non-neural tissues.

256 e transgene in brain, as compared with other non-neural tissues.

257 xpression of the neuronal ankyrin isoform in non-neural tissues.

258 e ovary, luciferase expression was absent in non-neural tissues.

259 o neurons by suppressing their expression in non-neural tissues.

260 the mammalian central nervous system and in non-neural tissues.

261 ntly of the Trk receptors in most developing non-neural tissues.

262 important for the innervation of developing non-neural tissues.

263 cord and electric lobe, and undetectable in non-neural tissues.

264 erg1, which is expressed in both neural and non-neural tissues.

265 the adult rat brain but are not detected in non-neural tissues.

266 o differentiate into a variety of neural and non-neural tissues.

267 anchor composition, exist between neural and non-neural tissues.

268 and also is present at much lower amounts in non-neural tissues.

269 emerging from cell-cell interactions within non-neural tissues.

270 ical region prevents UBE3A-ATS expression in non-neural tissues.

271 hat Su(Hw) is a repressor of neural genes in non-neural tissues.

272 to be broadly distributed in both neural and non-neural tissues.

273 inate the development of adjacent neural and non-neural tissues.

274 regulating the migration and organization of non-neural tissues.

275 pendent on transcellular signaling through a non-neural toll-like receptor, linking neural-specific g

276 exclusively cell associated and were mostly non-neural tropic.

277 These studies were followed by analysis of non-neural tumors such as colorectal carcinomas.

278 pus laevis embryos was transplanted into the non-neural ventral ectoderm of host embryos at the same