ライフサイエンスコーパス: non-specific

1 of docking approaches (i.e. docking software-non-specific).

2 9, and show that the lower band is likely non-specific.

3 Clinical characteristics were non-specific.

4 aptive response is, in fact, stereotyped and non-specific.

5 at anti-SUMO1 immunolabelling at synapses is non-specific.

6 ensation, and pharmacological inhibitors are non-specific.

7 ive Vif 107-115, although recapitulated, are non-specific.

8 iogenesis by CpG-ODN is pervasive and tissue non-specific.

9 as admitted to the emergency department with non-specific abdominal symptoms.

10 However, owing to non-specific accumulation of the contrast agent and its

11 Parkinson's disease is often associated with non-specific action tremor, which is usually treated wit

12 Local anaesthetics block pain through non-specific actions at all Nav channels, but the discov

13 variants that display significantly reduced non-specific activities compared with its wild-type coun

14 e and tropicamide also produced increases in non-specific activity levels, whereas biperiden did not.

15 d vaccines on the treatment of patients with non-specific acute febrile illnesses is not considered.

16 efer to such nanoformulations with decreased non-specific adhesivity and receptor targeting as 'DART'

17 en 20 coating method is developed to inhibit non-specific adsorption between alpha-Syn and nanopore s

18 blocked sensor surface that exhibits minimal non-specific adsorption for singleplex measurements of e

19 ified devices exhibited considerably reduced non-specific adsorption of albumin, lysozyme, and immuno

20 included a PEG-based dithiol, minimised the non-specific adsorption of other proteins and was sensit

21 However, the hydrophobicity of PDMS leads to non-specific adsorption of proteins and other molecules

22 The results highlighted the reduced non-specific adsorption of proteins onto PNE with respec

23 uling layer not only effectively reduces the non-specific adsorption on the biosensor but also decrea

24 e method is able to circumvent the effect of non-specific adsorption, a major issue in the field of b

25 n on the electrodes' surface and to decrease non-specific adsorption, a Self-Assembled Monolayer (SAM

26 n result in undesirable side effects such as non-specific adsorption, protein denaturation, and steri

27 hich served as the blocking agent to prevent non-specific adsorption.

28 create the nanolenses, can mitigate against non-specific, adventitious nanoparticle binding, without

29 nt following protease digestion to eliminate non-specific aggregates and monomers.

30 Ps and ampetoids trigger extensive and rapid non-specific aggregation of intracellular biomacromolecu

31 ocortin receptors in the VMH of rats using a non-specific agonist melanotan II (MTII), compared to ve

32 tosterone and DHT treatment increased tissue non-specific alkaline phosphatase (Alpl) mRNA expression

33 icrofluidic chamber, our platform suppresses non-specific amplification caused by non-optimal PCR des

34 ecule HRM provides insight into specific and non-specific amplification in LAMP that are difficult to

35 However, elimination of non-specific amplification remains a key challenge for t

36 ool, we investigate a potential mechanism of non-specific amplification.

37 were 21 amnestic, 12 non-amnestic, and seven non-specific amyloid-negative Alzheimer's disease cases.

38 A list of non-specific and false positive interactors is presented

39 e, and because presenting symptoms are often non-specific and fluctuating.

40 ion of leading causes of death, but both are non-specific and focus on a single underlying cause.

41 h as the use of topical corticosteroids, are non-specific and have serious side effects which limits

42 determining where enrichment analyses report non-specific and non-robust findings, we are able to ass

43 All adverse events were non-specific and of mild or moderate intensity apart fro

44 Both non-specific and parasite-specific IgMs were generated i

45 the evidence for and potential mechanisms of non-specific and sex-differential effects of vaccines, a

46 In the presence of exosomes, the non-specific and weaker binding between aptamers and the

47 Recent insights suggest that non-specific and/or promiscuous enzymes are common and a

48 suggestive of bacterial infection are often non-specific, and there is no definitive test for the ac

49 shing between specifically bound lipids, and non-specific, annular interactions is a challenging prob

50 remain poorly defined and treatment involves non-specific antibiotics.

51 lar training adaptations, but the effects of non-specific antioxidants on exercise training-induced v

52 Two non-specific drugs and one non-specific aptamer, tested as stringent control candid

53 ally mimic rheumatologic conditions owing to non-specific arthralgia and back pain.

54 Three OptAux predicted non-specific auxotrophic strains-with diverse metabolic

55 ed knockouts included a diverse set of novel non-specific auxotrophs that result from inhibition of m

56 ds to renal-exclusive clearance and ultralow non-specific background binding.

57 uction in binder diversity and enrichment of non-specific binders to ensure the best possible selecti

58 NA interactions, which are often obscured by non-specific binding at concentrations approaching in vi

59 for all protein biomarkers, while minimizing non-specific binding compared to more commonly used stra

60 onditions, shows optimum specific and little non-specific binding in phosphate buffered saline.

61 This increase is achieved while keeping non-specific binding low as established in control tests

62 ion procedure was optimized to eliminate the non-specific binding of antigen on the membrane surface.

63 tasensor does not have significant levels of non-specific binding of bovine serum albumin and human s

64 Non-specific binding of NPs to tumor ECM components was

65 m albumin (BSA) was used for blocking of the non-specific binding sites.

66 To prevent non-specific binding the gold surface was treated with 3

67 AgA, and Smu_63c amyloid from monomers, but non-specific binding to bacterial cells in the absence o

68 After adjusting for non-specific binding to PEG-coated beads, the mean perce

69 avidity for importin alpha7 while preventing non-specific binding to viral RNA.

70 Non-specific binding was prevented by blocking free spac

71 This revealed the importance of minimizing non-specific binding within the relatively adhesive, 'st

72 ectropolymerized benzoic acid (BA), to avoid non-specific binding.

73 y and mismatch DNA sequences, overcoming the non-specific binding.

74 optimal blocking buffer for restraining the non-specific binding.

75 ext, the sensor surface was blocked to avoid non-specific binding.

76 also bestow an advantage for weak, sequence non-specific binding.

77 ells differentiated in situ, whereas antigen-non-specific BRM cells were maintained as memory cells.

78 nhibitors of MMP-14 by modifying the natural non-specific broad MMP inhibitor protein N-TIMP2 to inte

79 activity emerge [7], whereas prior to this, non-specific bursts of activity occur in response to nox

80 y to mediate protective immunity via antigen non-specific bystander killing, a function we show is de

81 chromatin capture (PAtCh-Cap), relies on the non-specific capture of chromatin-bound proteins via the

82 % of amnestic versus 94% of non-amnestic and non-specific cases.

83 g and voltage-dependent excitation involving non-specific cation channels.

84 g and voltage-dependent excitation involving non-specific cation channels.

85 rt from ligand-specific receptor-mediated to non-specific caveolar transcytosis.

86 promote bacteria attachment while preventing non-specific cell and protein fouling.

87 oped devices are prone to partially focus on non-specific cells or cells associated with the specific

88 ict at the heart of aggregative development: non-specific cellular binding provides a strong ecologic

89 biopsies were within normal limits or showed non-specific changes.

90 anner and others that could be considered as non-specific changes.

91 existing hematopoietic system with toxic and non-specific chemotherapy, radiation, or both.

92 677 deaths), symptomatic diagnoses including non-specific chest pain, dyspnoea and syncope (1368 [6%]

93 lenging as most of the patients present with non-specific chronic leg pain.

94 re with a separable DNA-binding domain and a non-specific cleavage domain).

95 as possible, however a greater proportion of non-specific cleavage variants were observed relative to

96 A quantitative estimation of these non-specific cleavages may enable simulating realistic H

97 based on laboratory examinations because of non-specific clinical features, which usually entails th

98 evalence was 13.5% (95%CI: 10.9-16.4%) among non-specific clinical populations, 31.6% (95%CI: 25.8-37

99 Each of these cases had a non-specific clinical presentation.

100 novel co-factors Csx27 and Csx28, as well as non-specific collateral RNA damage.

101 wers transcription factor residence time and non-specific collisions during sampling for DNA targets.

102 most cases high-resolution structures of the non-specific complexes are unavailable.

103 case definitions must be used to distinguish non-specific complications of severe disease (eg, hypoxi

104 ovement that would allow for a directionally non-specific component of preparatory visual-motor gain

105 y neurons are broadly tuned in vivo and show non-specific connectivity in slice.

106 ificity was assessed through comparison with non-specific control lesions (n = 135) and with control

107 s proved by recovery of antigen-specific and non-specific cytokine production via metformin-mediated

108 e blood after intravenous administration and non-specific damages to highly proliferating cells, incl

109 enotypes are compensated and that secondary, non-specific defects accumulate over time.

110 nisopliae (Ma549), indicative of generalist (non-specific) defenses.

111 cognized as difficult to transfect cells and non-specific delivery would inevitably cause unwanted sy

112 Specific and non-specific desensitization and changes in surface IgE

113 There was little or no non-specific desensitization when lung mast cells were e

114 Rather than being a non-specific diagnosis, disseminated TB is a distinct, l

115 We speculate that the association with non-specific DNA afforded by polymerization may enable r

116 values of the free energies of specific and non-specific DNA binding and protein-protein cooperativi

117 DNA binding predictions and the addition of non-specific DNA binding domains.

118 lis ParB forms multimeric networks involving non-specific DNA binding leading to DNA condensation.

119 ve abundance of specific, near-specific, and non-specific DNA binding modes of LacI in vivo, showing

120 ce recognition; and the third contributes to non-specific DNA binding.

121 -specific RNA cleavage, RNA target-dependent non-specific DNA cleavage, and cOA generation.

122 ctrochemical measurements accomplished using non-specific DNA fragments mixed with samples, revealed

123 centromere DNA sequence parS and to adjacent non-specific DNA over multiple kilobases in a phenomenon

124 -atom modification can significantly inhibit non-specific DNA polymerization caused by mis-priming.

125 MatP links matS sites with ZapB and/or with non-specific DNA to promote optimal pairing of sister te

126 itions (K+, Na+), TALEs bind to specific and non-specific DNA with nearly equal affinity.

127 ossessing three histone-binding domains, one non-specific DNA-binding module, and several motifs for

128 nfolds when ETV6 binds to either specific or non-specific DNA.

129 assembly of a NucC homohexamer competent for non-specific double-strand DNA cleavage.

130 Finally, potential ancestry-specific and non-specific drug candidates were identified.

131 Two non-specific drugs and one non-specific aptamer, tested

132 structural simulation, a fused pol Sdbh with non-specific dsDNA binding protein Sso7d in the N-termin

133 ness research with inclusion of controls for non-specific effects is needed to define a range of addi

134 Given that the non-specific effects of some vaccines are now being test

135 asingly suggests that vaccines can also have non-specific effects on unrelated infections and disease

136 n of UBSM contractility is likely to be from non-specific effects on VDCCs and K(V) 2 channels.

137 We disentangle specific and non-specific effects that control Hsp90's ATPase functio

138 Furthermore, many of these non-specific effects, as well as the pathogen-specific e

139 esemble true null mutants without detectable non-specific effects.

140 nition motif, apparently as a consequence of non-specific electrostatic interactions, supporting the

141 es suggest that active cargo loading reduces non-specific encapsulation of cellular proteins, particu

142 lts and drive the generation of biologically non-specific enrichment results as well as highly fragil

143 te vasodilatory effects of 17beta-estradiol (non-specific estrogen receptor (ER) agonist), PPT (ERalp

144 ks in chronic low back pain (cLBP) given its non-specific etiology and complexity.

145 nostaining was not affected by the number of non-specific events captured on the membrane.

146 Minor non-specific facial dysmorphism was also noted in some i

147 th variable neurodevelopmental anomalies and non-specific facial features.

148 in displacement experiments might influence non-specific factors not directly related to navigation

149 Other symptoms were non-specific fever (in 1607 [23%] patients), respiratory

150 ge tumor diagnosis is likely attributable to non-specific findings.

151 cell types recapitulated water-specific and non-specific fluid appetite caused by the two distinct d

152 s to the DNA backbone, as well as minimizing non-specific fluorescent dye adsorption.

153 fuse Cascade to the dimerization-dependent, non-specific FokI nuclease domain(8-11) and achieve RNA-

154 FA reduction, however, is non-specific for microscopic underpinnings such as aberr

155 sensing-based framework in combination with non-specific genetic tools to infer candidate neurons co

156 states influence stimulus processing through non-specific, global mechanisms, such as spontaneous flu

157 and high selectivity when compared to other non-specific glycolytic proteins such as d-glucose-6-pho

158 Harnessing such non-specific hydrophobic interactions could have wide ap

159 ated mammalian peroxidases in the context of non-specific immune defense.

160 n understanding if oral vaccination provides non-specific immunity to other infections so that the co

161 ine adjuvant and is under investigation as a non-specific immunomodulator.

162 while those of resveratrol and curcumin are non-specific in that they stem from strong interference

163 s and platelets during steady state limiting non-specific inflammation, but bacterial infection trigg

164 nC-SAC first distinguishes specific from non-specific interaction frequencies, then generates 3D

165 icted mobility (that is, limited diffusion), non-specific interactions between probes are prevented,

166 We show that HelD prevents non-specific interactions between RNAP and DNA and disso

167 NA over monovalent cations, which attenuates non-specific interactions between TALEs and DNA and furt

168 e for optimal binding efficiency and reduced non-specific interactions for label-free detection of MP

169 ltration spin cups and centrifugation remove non-specific interactions in a gentle, uniform manner an

170 s to successfully eliminate the specific and non-specific interactions of protected asparaginase with

171 These nanocomposites prevent non-specific interactions while enhancing electron trans

172 d stabilizes the structure through transient non-specific interactions with importins.

173 evidence that it additionally displays soft, non-specific interactions with the ribozyme.

174 However, charged mutations can mediate non-specific interactions, and it is unclear to what ext

175 basic histone proteins, shielding them from non-specific interactions, facilitating their deposition

176 ture of a target molecule and the removal of non-specific interactions.

177 nce the target scFv binding and minimize the non-specific interactions.

178 l amine polyethylene glycol chain to prevent non-specific interactions.

179 tion for distinguishing between specific and non-specific interactions.

180 with a different species of Bacillus to test non-specific interference using a portable surface plasm

181 ably leading to supramolecular structures or non-specific intermolecular interactions like van der Wa

182 ease (kappaw=0.73 [0.68-0.78]); moderate for non-specific interstitial pneumonia (NSIP; kappaw=0.42 [

183 Lithium changed expression of RNAs in both non-specific (inverse to sequence length) and specific (

184 nstrate that AA-TT condensation is driven by non-specific ion-DNA interactions.

185 The MOF acetyltransferase-containing Non-Specific Lethal (NSL) complex is a broad transcripti

186 ng assays in the separation of specific from non-specific ligand binding and, provides a suitable com

187 -free and selective detection of Sola l 7, a non-specific lipid transfer protein (nsLTP) found in tom

188 he complete primary structure of a monomeric non-specific lipid transfer protein 1 (nsLTP1), with mol

189 mustard seeds, we identified 2S albumin and non-specific lipid transfer proteins (nsLTP) as the prot

190 Non-specific lipid transfer proteins (nsLTPs) are cation

191 Non-specific lipid transfer proteins (nsLTPs) reported f

192 Patients with LD are more likely to report non-specific long-term sequelae, especially those experi

193 Thus, non-specific loss of proteins from companion cells to si

194 Non-specific low back pain affects people of all ages an

195 Because non-specific low back pain does not have a known pathoan

196 The prevalence of non-specific main chain-mediated interactions demonstrat

197 ds to DNA in a length-dependent but sequence non-specific manner and compacts DNA by forming DNA loop

198 AZD6765 impaired performance in a non-specific manner.

199 ging and magnetization transfer imaging in a non-specific manner.

200 muscle metabolite that is an insensitive and non-specific marker of kidney function, but is now used

201 More focus at the moment has been on non-specific markers of neurodegeneration, and in partic

202 Actinonin, a non-specific matrix metalloprotease inhibitor, improved

203 replication origin specificity by preventing non-specific MCM helicase loading.

204 d headgroup recognition or flat surfaces for non-specific membrane binding and both types of interact

205 w can also contribute to trained immunity, a non-specific memory of earlier encounters that in turn f

206 ility of LCM formation was investigated as a non-specific method for removal of a water-soluble dye f

207 NS, Lsr2 binds DNA in sequence-dependent and non-specific modes.

208 Cross-reactivity studies with non-specific molecules proved high specificity of the ar

209 variants which alter the odds of developing non-specific mouth ulcers and replicate these in an inde

210 However, non-specific multi-site fluorescent labeling often resul

211 Furthermore, a succinct discussion on non-specific mycobactin biosynthesis inhibitors and the

212 P = 0.003) as a monogenic cause of mild and non-specific neurodevelopmental delay.

213 studies is low when assessing patients with non-specific, neurological phenotypes.

214 ighly accurate manner while minimizing their non-specific off-target effects on normal tissues.

215 d eye disease (TED) (41 scans, 31 patients), non-specific orbital inflammation (NSOI) (22 scans, 14 p

216 n 384-well format and is sensitive to known, non-specific palmitoylation inhibitors.

217 baseline, the most frequent cluster was the Non-Specific Pattern (42%), and the least frequent the M

218 rmation, except in the hydrolysate using the non-specific peptidase because of its high free amino ac

219 The hydrolysate obtained from the non-specific peptidase contained a larger variety of pyr

220 dases (pepsine, chymosine, thermolysin and a non-specific peptidase from Aspergillus melleus), contai

221 r with the protein drug, which can result in non-specific permeation of the intestine as well as enha

222 e thus suppressing true MO phenotypes whilst non-specific phenotypes would remain.

223 ificance in candidate genes in patients with non-specific phenotypes.

224 Here we show that manipulation of the non-specific phospholipase C1, NPC1, alters silicon cont

225 nitial PROPPIN-membrane binding is driven by non-specific PIP interactions.

226 to environmental stress based on general and non-specific plant species mechanisms.

227 Hence non-specific plasticity may offer a benefit in noisy env

228 that memory retrieval may benefit from this non-specific plasticity when the applied sparse binary i

229 itory neurons is inconsistent with the local non-specific pooling of excitatory inputs and that inhib

230 ese findings challenge the generality of the non-specific pooling principle for inhibitory neurons, s

231 proaches in the mouse have led to the "local non-specific pooling principle" of inhibitory connectivi

232 r signals a) emerge on average shortly after non-specific prediction error signals, b) arise earliest

233 evidently obscured in physiological salt by non-specific, predominantly electrostatic interactions.

234 First, a non-specific "preparatory" system learns aversive facial

235 The effectiveness of some non-specific proteases in reducing raw peanut allergenic

236 rials to improve hydrophilicity and decrease non-specific protein adsorption while retaining cellular

237 s bio-recognition elements and preventers of non-specific protein binding, respectively.

238 ilica@Au particles was implemented to resist non-specific protein binding; 4) application of anti-PSA

239 Finally, Dpp1p, Dpp2p and Dpp3p are non-specific pyrophosphatases responsible for farnesol s

240 Conversely, non-specific recognition of gTSSA-I by non-endemic malar

241 the exclusion of bvFTD when normal, whereas non-specific regional metabolism abnormalities should no

242 hree different plants, our results support a non-specific relationship between Micromonospora and leg

243 Chronic non-specific respiratory symptoms are difficult to manag

244 to use in clinical practice in patients with non-specific respiratory symptoms to predict response to

245 to inhaled corticosteroids in patients with non-specific respiratory symptoms.

246 ypes of apoptosis induction than are lineage-non-specific, retinoic-acid-differentiated hPSCs.

247 , we argue that regarding proteins as merely non-specific rigid inclusions is flawed, and each protei

248 NA the ability to withstand competition from non-specific RNA and at least in part may explain the fa

249 The CTD tip competes against non-specific RNA binding, facilitates dsRNA release, and

250 o the presence of moderate concentrations of non-specific RNA competitors, which considerably delay t

251 n phase separation is induced by addition of non-specific RNA.

252 Non-specific RNAs exerted particularly large inhibitory

253 This event activates its non-specific RNase activity, which enables cleavage of a

254 In addition, these systems possess the non-specific RNase Csm6, which provides further protecti

255 However, Experiment 3 showed that when using non-specific saliency emphasis of the outcome, the salie

256 goal was to characterize the details of the non-specific search mode to complement the crystal struc

257 ithin groups and including participants with non-specific self-identification.

258 ensitivity, prolonged stability, and lack of non-specific sensor fouling may enable long-term in situ

259 selectivity towards the target DNA over the non-specific sequences and also it was cost and time-eff

260 Substitution of deleted nucleotides with non-specific sequences restores spliceosome assembly and

261 ly not disease-specific but rather part of a non-specific, shared response to health and disease.

262 s, even cells whose responses are considered non-specific show tailoring of their transcriptional rep

263 dsRNA-based tension sensor exhibited strong non-specific signal unrelated to cellular forces.

264 ions of diffusion-limited mass transport and non-specific signals.

265 -computed-tomography (CT), for which various non-specific signs for IPA have been described.

266 rmediate; inhibition of fatty acid synthase; non-specific SIRT inhibition; and activation of protein

267 Mismatches also converted non-specific sites into high-affinity sites, and high-af

268 aximizes discrimination between specific and non-specific sites.

269 Thus, non-specific sodium influx via bonafide calcium channels

270 the signaling and phenotypic consequences of non-specific sodium permeation via calcium channels rema

271 simple mechanism for the binding of ssDNA to non-specific SSBs may be at play, which explains the dis

272 itation of low spatial resolution due to the non-specific stimulation characteristics of electrical s

273 ilizing the native fold, they are relatively non-specific, suggesting additional mechanisms contribut

274 ion cycle including a sylvatic reservoir and non-specific symptom set.

275 Many people are asymptomatic or have non-specific symptoms such as lethargy, itch, or loss of

276 sease is not always suspected because of its non-specific symptoms, and the diagnostic tests routinel

277 Non-specific symptoms, as well as the lack of a cost-eff

278 TB), which can easily be overlooked owing to non-specific symptoms, chronic and cryptic protean clini

279 Top infectious categories included non-specific symptoms, skin, and respiratory for ESRD; a

280 ly it presents after 30 weeks gestation with non-specific symptoms.

281 CRP is a non-specific systemic marker of chronic inflammation and

282 dominantly repress the development of other, non-specific T cell lineages has not been fully elucidat

283 gests that this is achieved via reduction of non-specific tissue binding.

284 onsider the reduction in response time to be non-specific to the Simon task, and cast our interpretat

285 the protein-associated interactions from the non-specific topological domains.

286 peptides (AMPs) is largely hindered by their non-specific toxicity against mammalian cells, which is

287 find CRISPRi does not exhibit any detectable non-specific toxicity recently observed with CRISPR nucl

288 d challenges in terms of treatment including non-specific toxicity, chemoresistance and relapse.

289 manual stimulation of triceps surae muscles (non-specific training) and without any intervention.

290 and catalyse both sequence-specific cis- and non-specific trans-RNA cleavage(8).

291 tu, and show that PfCRT does not mediate the non-specific transport of other metabolites and/or ions.

292 ing potential overall immunosuppression from non-specific Tregs.

293 Macropinocytosis coordinates non-specific uptake of macromolecules and fluid.

294 In contrast, less, more diffuse, and non-specific uptake without localization to these key re

295 ish specific binding to tumour collagen from non-specific uptake.

296 hich unfolding grip is primarily mediated by non-specific van der Waal's interactions between core si

297 ion strategy is warranted to control for the non-specific variations among samples across different e

298 ted in these lineages and might provide both non-specific viral defence and access to nucleotides.

299 Clinical and laboratory findings were non-specific, while imaging features with computed tomog

300 TN1A neurons can drive the activity of a sex-non-specific wing motoneuron, hg1, which is also require