ライフサイエンスコーパス: nonactivated

1 hereas apical canaliculi appeared relatively nonactivated.

2 A convenient approach toward nonactivated 1-alkyl-2-(trifluoromethyl)azetidines as a

3 rmed a prospective clinical trial to compare nonactivated 4-factor prothrombin complex concentrate (4

4 f LN DCs prior to their activation generates nonactivated Ag-pulsed DCs that recruit Ag-specific T ce

5 the first time, aromatic as well as various nonactivated aliphatic alkenes could be oxidized to affo

6 and stereochemical techniques applicable to nonactivated aliphatic systems remain largely elusive du

7 isible-light-mediated difunctionalization of nonactivated alkenes offers a sustainable and efficient

8 The hydroalkylation of nonactivated alkenes with methyl bromoacetate was perfor

9 ls for light-mediated difunctionalization of nonactivated alkenes, eliminating the requirement of aux

10 kene classes that can be employed, including nonactivated alkenes, which have so far been elusive for

11 h very few known to catalyze the cleavage of nonactivated alkenes.

12 howed that solvent effects were weak for the nonactivated alkoxyamine 1 (diethyl (1-(tert-butyl(1-(py

13 sfer (ART) to achieve C(sp(3))-N coupling of nonactivated alkyl Bpins under mild, redox-neutral condi

14 fast, efficient, and selective oxidation of nonactivated alkyl C-H groups employing H(2)O(2) as term

15 dialkylation of complex 2 with activated and nonactivated alkyl halides, including propargyl derivati

16 een reported for cross-coupling reactions of nonactivated alkyl halides.

17 An efficient cyclocarboamination reaction of nonactivated alkynes with aziridines, catalyzed by Lewis

18 The reactivity of these newly synthesized nonactivated alpha-CF3-aziridines was evaluated by apply

19 Furthermore, nonactivated alpha-CF3-aziridines were easily transforme

20 gamma subunit at the catalytic site of both nonactivated and activated forms of PDE6.

21 To probe the quaternary structure of nonactivated and activated forms of the kinase, we used

22 aled differences in the labeling patterns of nonactivated and activated FXIII.

23 Based on the ratios of nonactivated and activated segments within cTFs, we prop

24 pha(M)beta(2) and alpha(X)beta(2), including nonactivated and activated U937 and THP-1 monocytoid cel

25 Nonactivated and deactivated aryl halides were successfu

26 he effect of supernatants isolated from both nonactivated and IFN-gamma-activated HFRPE cells were co

27 The supernatants of both nonactivated and IFN-gamma-activated HFRPE cells were is

28 Nonactivated and in vitro-activated human platelets were

29 ts also demonstrate that: 1) splenic and PLN nonactivated and naive T cells use different molecular m

30 both splenic and peripheral lymph node (PLN) nonactivated and naive T cells, and used both S1P and th

31 uce naive MBP-specific T cells responding to nonactivated APCs to differentiate into a unique, toleri

32 TGF-beta1 in response to activated, but not nonactivated, APCs presenting MBP.

33 ve syn-1,4-diamination protocol using simple nonactivated arenes and amines.

34 ective for a wide range of arenes, including nonactivated arenes bearing simple functionalities such

35 nded to the deprotonation of several further nonactivated arenes to yield the corresponding beta-dike

36 electrophiles capable of reacting even with nonactivated arenes under ambient conditions.

37 to catalytically promote the HIE of a series nonactivated arenes under mild reaction conditions using

38 zed dearomative functionalization of simple, nonactivated arenes with Grignard reagents has been esta

39 u-catalysis to perform 1,2-hydroamination on nonactivated arenes.

40 st two decades, the formal hydroamination of nonactivated aromatic compounds remains an unsolved chal

41 eveloped transformations were realized using nonactivated aromatic ketones and amino acids as C-N sou

42 ranslation of new methodologies for labeling nonactivated aromatic molecules with (18)F remains a cha

43 re report synthetic catalysts that hydrolyze nonactivated aryl esters at pH 7, via cooperative action

44 In contrast, nonactivated ATG5-knockout BMMs actually restricted C. n

45 bolites were investigated in supernatants of nonactivated (baseline) and lipopolysaccharide-activated

46 )/K(m), and by catalyzing the elimination of nonactivated benzisoxazoles), its impaired stability pre

47 volve the relocation of existing spines from nonactivated boutons or the outgrowth of newly formed sp

48 to result from the insertion of the terminal nonactivated C horizontal lineC double bond into the Au-

49 new strategy for the catalytic iodination of nonactivated C(sp(3))-H bonds.

50 1r2s2 tetramer both when alone or within the nonactivated C1 complex.

51 rted over 30 years ago revealed that latent, nonactivated C5 binds specifically and reversibly to C6

52 orm oxidative halogenations of activated and nonactivated carbon centers.

53 se recent approaches to amide synthesis from nonactivated carboxylic acids and derivatives as well as

54 We found that median levels of nonactivated caspase 2 and 3 were higher in AML than in

55 CD4(+) T cells are refractory to infection, nonactivated CD4 T cells present in lymphoid and mucosal

56 Nonactivated CD4+CD25+ regulatory T cells constitutively

57 Small numbers of nonactivated CD4+CD45RO+CXCR5+ T cells are also found in

58 IEC-activated CD8+ T cells, but not nonactivated CD8+ T cells, were suppressive in function.

59 dependent areas of human lymphoid organs are nonactivated cells and belong to a separate lineage that

60 In nonactivated cells these preclustered structures and the

61 vity greater than that of Raf-1 derived from nonactivated cells, and aggregation of the FcepsilonRI d

62 of the LYN and FYN kinases were increased in nonactivated cells, suggesting the involvement of a LYN-

63 found to be three times higher than that of nonactivated cells.

64 No DNA fragmentation was induced in nonactivated cells.

65 a similar conformational change in Syk from nonactivated cells.

66 g the platelet thrombus, reducing effects on nonactivated circulating platelets.

67 onally, TNF-alpha expression is increased in nonactivated, circulating C/EBPepsilon-deficient neutrop

68 ation that requires the cleavage of multiple nonactivated CO bonds.

69 s in suppressing HOXC6 gene expression under nonactivated conditions.

70 owever, we have previously reported that the nonactivated conformation of alpha2beta1 integrin can al

71 Likewise, EMT could be distinguished from nonactivated control fibroblasts, suggesting that EMT do

72 ivated wild-type p21ras, compared with their nonactivated counterparts.

73 fic thermal [2 + 2]-cycloaddition across the nonactivated cumulene double bond, forming distal cycloa

74 xamples where C-C bond oxidative addition of nonactivated cyclopropanes is exploited in reaction desi

75 litate regioselective C-C bond activation of nonactivated cyclopropanes.

76 M. tuberculosis grew equally well within nonactivated DCs and M phi.

77 DEC205 into mice, Ag presentation occurs by nonactivated DCs, which leads to induction of regulatory

78 was detected in both resting T cells and the nonactivated EL4 T cell line, and was up-regulated in bo

79 T lymphocytes react minimally with nonactivated endothelial cells (ECs).

80 LPG treatment of nonactivated endothelial cells also suppressed by 55 to

81 drogen atom at the terminal olefin moiety of nonactivated enynes, which was found previously in the b

82 60 nM) is reduced 3-4-fold compared with the nonactivated enzyme; the kinetics of cGMP exchange to ac

83 By analyzing the activated and nonactivated enzymes on SDS-polyacrylamide gel electroph

84 ic activity of approximately 57% that of the nonactivated ferrous form of the enzyme.

85 acrophages fostered Shigella replication and nonactivated fibroblast cells fostered both Shigella rep

86 anisotropic ECM architecture, compared with nonactivated fibroblasts.

87 Nonactivated films display a similar oxidic nature but e

88 In contrast, nickel centers in nonactivated films exist predominantly as Ni(III).

89 strate-directable Heck-Matsuda reaction with nonactivated five-membered olefins.

90 2 with its activator UAF1 deubiquitinate the nonactivated form of Notch in cell culture and in vitro.

91 es (Kd = 1-100 nM) composed of activated and nonactivated forms of p38alpha and a splice variant of M

92 eking tests after prolonged withdrawal, with nonactivated Fos-negative neurons.

93 Whereas nonactivated gammadelta T cells had little effect on the

94 ive (GFP+) neurons compared with surrounding nonactivated GFP-negative (GFP-) neurons 90 min after th

95 lterations within activated GFP-positive and nonactivated GFP-negative mPFC neurons following yohimbi

96 n about conformational changes proceeding in nonactivated HCN2 channels when cAMP binds.

97 Expression of the agonist antigen by nonactivated hematopoietic cells produced mostly CD4(+)C

98 Cross-linking of the nonactivated holoenzyme with N-(gamma-maleimidobutyroxy)

99 l lymphocytes or ZAP-70- CLL cells expressed nonactivated Hsp90.

100 cellularly but only rarely on the surface of nonactivated human eosinophils.

101 of the strength of adhesion of activated and nonactivated human neutrophils to a substratum, which is

102 The interaction of purified nonactivated human NK cells with target cells overnight

103 l amounts of CD62L from detergent lysates of nonactivated human PBL.

104 m of cell-mediated cytotoxicity, utilized by nonactivated human peripheral blood NK cells against a v

105 y minutes after injection in recipient mice, nonactivated human platelets become significantly activa

106 moniae organisms inhibited activated but not nonactivated human T cell proliferation.

107 In the present study, freshly isolated, nonactivated, human NK cells were shown to express TNF,

108 eement with selective expression of CD62L on nonactivated ILCP.

109 ng c-type heme-containing peptides that uses nonactivated IMAC resin.

110 Nonactivated IMCs and IDCs function as APCs, but activat

111 cells (IDCs) are potent T cell suppressors, nonactivated IMCs and IDCs promote T cell activation and

112 g optogenetics to stimulate activated versus nonactivated inputs revealed stronger synapses between c

113 dy, we show that the interaction between the nonactivated integrin and a ligand resulted in the activ

114 tion of breast cancer cells that express the nonactivated integrin.

115 t has a high affinity for both activated and nonactivated integrin.

116 Altogether these results indicate that the nonactivated integrins can induce cellular signaling, bu

117 ulin in the adhesion complexes formed by the nonactivated integrins.

118 NO binds to sGC to form a six-coordinate, nonactivated, intermediate (k(on) > 1.4 x 10(8) M(-1).s(

119 JNK3 alpha 1 had Vmax 715-fold greater than nonactivated JNK3 alpha 1 and MKK7-activated JNK3 alpha

120 JNK3 alpha 1 had Vmax 250-fold greater than nonactivated JNK3 alpha 1.

121 In nonactivated keratocytes, the expression of alpha3(IV) c

122 lular communication with themselves and with nonactivated keratocytes.

123 alpha 1 had no increase in Vmax compared to nonactivated levels and had no phosphorylation on the ba

124 type HSPB5 can transition reversibly between nonactivated (low activity) and activated (high activity

125 ut were undetectable in the supernatant from nonactivated lymphocytes.

126 Nonactivated lymphoid cells attach preferentially to pol

127 Adhesion of nonactivated lymphoid cells to polymeric ECM components

128 expression of the SPI2 spiC gene recorded in nonactivated macrophages depends on PhoQ.

129 In this study, we show that nonactivated macrophages express basal levels of mTNF-al

130 ype eradicated intracellular Shigella, while nonactivated macrophages fostered Shigella replication a

131 Lm escaped from vacuoles of nonactivated macrophages within 30 min of infection.

132 ast, the virulent strain caused an influx of nonactivated macrophages, neutrophils, and significant e

133 inked drugs without promoting drug uptake by nonactivated macrophages.

134 tivated neurons that was not observed in the nonactivated majority of neurons.

135 ither PoA or IoC is compared with binding to nonactivated MEK.

136 involves interfering with phosphorylation of nonactivated MEK1 by the upstream kinase, B-RAF.

137 Conversely, the K d from nonactivated MEK1 for four of the compounds varies betwe

138 Nonactivated, membrane-associated PDE (PDE-M, alpha beta

139 to suppress 80% of the basal activity of the nonactivated, membrane-bound PDE6 holoenzyme at concentr

140 ted to the site of inflammation maintained a nonactivated memory phenotype and did not express ex viv

141 meworks and enables the functionalization of nonactivated methylene B-C(sp(3))-H bonds for the first

142 iseased brains, as well as isolation of pure nonactivated microglia by FACS.

143 rly stages of tumor brain invasion more than nonactivated microglia.

144 n/Fe- and Fe/Fe-bound states, as well as the nonactivated Mn/Mn-bound state.

145 levels of transferrin receptor expression in nonactivated monocytes and with an inability to up-regul

146 looxygenase PG synthase 2 (PGS(2)/ COX-2) in nonactivated monocytes of humans with insulin-dependent

147 onocytes after 10 min activation compared to nonactivated monocytes.

148 increases cell surface hyaluronan (HA), and nonactivated mononuclear leukocytes bind to virus-induce

149 In infections of nonactivated mouse macrophages, HN878 grew more quickly.

150 press angiogenic activity, whereas normoxic, nonactivated MPMs do not.

151 In contrast to normoxic, nonactivated MPMs, inducible nitric oxide synthase-inhib

152 -1 RNA was detected in both "activated" and "nonactivated" mucosal CD4+ T cells.

153 and glycolytic metabolism were evaluated in nonactivated murine peritoneal macrophages (MPhi0) and m

154 d aziridination of olefins using anilines as nonactivated N atom precursors and an iodine(III) reagen

155 Because the chemistry of nonactivated N-aryl aziridines is underexplored, the rea

156 despite clear evidence for TCR signaling in nonactivated naive T cells, these data argue against the

157 umor-infiltrating lymphocytes in humans; (c) nonactivated natural killer (NK) cells in rats; and (d)

158 identifies direct inputs to activated versus nonactivated neuronal populations.

159 lpha6, and beta3 subunit genes compared with nonactivated neurons.

160 Activated and control nonactivated NGFXAT mice were subjected to different exp

161 r and the total cytotoxic activity of mature nonactivated NK cells within various tissues.

162 of the mechanisms that enable EBV to infect nonactivated, noncycling B cells provide compelling evid

163 After intravenous injection of nonactivated or activated platelets, human xenografts sh

164 distinguishing mitogen-activated (P(+)) from nonactivated (P(-)) AP-1 complexes.

165 eight tumors examined with wild-type ras and nonactivated p21ras demonstrated these alterations.

166 ctures and a novel assay to measure K(d) for nonactivated p38alpha.

167 ults indicate that in the female Wistar rat, nonactivated PAH showed a stereospecific preference for

168 Addition of MIP-3 beta to nonactivated PBMCs had no effect on cytokine production.

169 The properties of nonactivated PDE can be restored upon addition of gamma

170 t inhibitory gamma subunits bind to form the nonactivated PDE holoenzyme (alphabetagamma(2)).

171 concentrations and high cGMP concentrations, nonactivated PDE undergoes activation of cGMP hydrolysis

172 Furthermore, data suggest that nonactivated PDE5 with "super-high" affinities for silde

173 The effectiveness of E4021 to inhibit nonactivated PDE6 (with bound inhibitory gamma subunits)

174 ages to levels sustained by a phoQ mutant in nonactivated phagocytes, suggesting that most NO-depende

175 markers of activated neutrophils revert to a nonactivated phenotype as activated cells make contact w

176 bovine WC1(+) gammadelta T cells expressed a nonactivated phenotype relative to CD62L, CD45RO, and CD

177 early Ag(+)/adjuvant(-) DC population with a nonactivated phenotype, resulting from the earlier targe

178 immunodeficiency viruses (SHIVs) exhibited a nonactivated phenotype.

179 position of naphthalene and to activated and nonactivated phenyl substrates was compared for the firs

180 Here we report on the role of nonactivated phenylalanine 4-monooxygenase activity in r

181 taining TFPI, prothrombin, calcium ions, and nonactivated platelets or factor V and phospholipids, TF

182 ergoing apoptosis may become proadhesive for nonactivated platelets.

183 xynucleotide to both TNF-alpha-activated and nonactivated PMNs.

184 rs in both activated (CD25+ and HLA-DR+) and nonactivated populations, although it is restricted to C

185 nes via enantioselective oxidation of strong nonactivated primary and secondary C(sp(3))-H bonds in r

186 The protocol is also applicable to nonactivated primary as well as pai-activated benzylic a

187 Although nonactivated primary T cells cultured with 10 to 1000 nM

188 cytotoxicity by up to 2,600-fold that of the nonactivated prodrug.

189 ICOShigh Treg induced Tr1 cells in nonactivated RC and Th2 cells in preactivated RC.

190 ands can down-regulate signaling by moving a nonactivated receptor into the endocytic pathway.

191 most dramatic effect on the affinity of the nonactivated recombinant PDE5 for sildenafil, revealing

192 detailed structural analysis of R2lox in the nonactivated, reduced, and oxidized resting Mn/Fe- and F

193 receptor, continues to phosphorylate nearby nonactivated rhodopsin.

194 Further, 7 matched activated/nonactivated samples were sequenced using the Trugene HI

195 surface, platelets retained their spherical nonactivated shape.

196 Specific covalent cross-linking of nonactivated signal transducer and activator of transcri

197 Here we show that nonactivated Smad3, but not Smad2, undergoes proteasome-

198 The treatment involved delivery of 10% w/w nonactivated sodium persulfate (Na2S2O8) solution to the

199 n T cell activation, we used a population of nonactivated spleen cells from mice that expressed a tra

200 Mn(2+)-activated alpha(4)beta(1) and to the nonactivated state of the integrin that exists in 1 mm M

201 h cGMP-independent modulation of PDE5 in the nonactivated state, possibly through protein-protein int

202 y low number of transferrin receptors in the nonactivated state, similar to the typically low level e

203 y and catalytic domains of Palphabeta in its nonactivated state.

204 ifically to keep expression levels below the nonactivated state.

205 PDE5 could be converted from a low-activity (nonactivated) state to a high-activity state upon cGMP b

206 The activated, but not the nonactivated, state supported tumor cell arrest during b

207 and distinctive features of activated versus nonactivated states, the water distribution along the ch

208 ligomers and are sequestered from solvent in nonactivated states.

209 nometallic species involved are derived from nonactivated substrates (pyridine and terminal alkynes),

210 tron from numerous donors such as ethers, or nonactivated substrates like toluene or acetonitrile, an

211 Nonactivated substrates such as benzene, toluene, and de

212 e deuteration of aromatic molecules, several nonactivated substrates such as naphthalene, diphenylace

213 Notably, the reaction successfully couples nonactivated substrates, which expands the scope of acce

214 ons as high as 10(5), for both activated and nonactivated substrates.

215 pyrimidine nucleoside from a free base and a nonactivated sugar in a plausible prebiotic reaction.

216 f alloantigen, iNOS induction is confined to nonactivated T cells and does not depend on MHC molecule

217 constitutive expression of CCR5 and CXCR4 by nonactivated T cells and macrophages, but significantly

218 Analysis of why nonactivated T cells are more resistant, whereas activat

219 Fifty percent of nonactivated T cells in MCC-expressed PD-1, a marker of

220 led that TCDD treatment of activated but not nonactivated T cells led to down-regulation of cellular

221 ion of c-FLIP using small interfering RNA in nonactivated T cells made them sensitive to TCDD-induced

222 nse of Hsp70 treatment when activated versus nonactivated T cells were used.

223 (IELs) bear properties of both activated and nonactivated T cells, although the significance of that

224 In nonactivated T cells, CD4 molecules are clustered in sma

225 in vitro antileukemic effects in contrast to nonactivated T cells.

226 + and CD8+ T cells and in both activated and nonactivated T cells.

227 very by rescuing mutant virus replication in nonactivated T cells.

228 er levels of apoptosis compared with similar nonactivated T cells.

229 late the following biodistribution data: (a) nonactivated T lymphocytes in rats; (b) interleukin 2-ac

230 hesis, the number of reactions that apply to nonactivated terminal alkenes in a catalytic enantiosele

231 matrelvir and other M(pro) inhibitors with a nonactivated terminal alkyne group positioned similarly

232 Limiting quantities of nonactivated terminal olefins (1 equiv) and slight exces

233 A catalytic intermolecular amination of nonactivated tertiary C(sp(3))-H bonds (BDE of 96 kcal.m

234 tern blot analysis, we studied the levels of nonactivated (uncleaved) caspase 2 and 3 in peripheral b

235 aved probe in the presence of high levels of nonactivated, uncleaved probe, a difficult task to attai

236 yl small molecule antagonist, compound A, to nonactivated very late antigen-4 (VLA4) was examined in

237 vide evidence that a substantial fraction of nonactivated visual pigments becomes phosphorylated thro

238 atelets with different receptor antagonists, nonactivated, washed human platelets were allowed to adh

239 Under normal cell cycle conditions, nonactivated XCds1 constitutively associates with a Xeno