ライフサイエンスコーパス: noncanonical

1 synthesis of sphingolipids but also produces noncanonical 1-deoxysphingolipids when using alanine as

2 s viral genome (canonical PRF), as well as a noncanonical -1 and -2 PRF that are stimulated by the in

3 Noncanonical 2,4,6-substituted pyrimidine analogues were

4 Here, we found that the noncanonical 5' cap-binding protein eIF3d was activated

5 tiated during viral entry stimulates a rapid noncanonical activation of Akt to drive the differentiat

6 y to understanding the mechanisms underlying noncanonical activation of G-protein signaling as well a

7 lasma membrane ERK activity involves Rap1, a noncanonical activator, and controls cell morphology and

8 canonical cis-inducible elements (SIEs) and noncanonical "AGG" elements at different loci.

9 ers enzymatic activity and reduces access to noncanonical, aggregation-prone states.

10 o the activation mechanism of TLR2/TLR1 by a noncanonical agonist.

11 ues, thereby distinguishing this subclass of noncanonical agonists from previously defined types of a

12 Here, we describe a diene-containing noncanonical amino acid (ncAA) capable of undergoing fas

13 incorporated the solvatochromic fluorescent noncanonical amino acid 3-((6-acetylnaphthalen-2-yl)amin

14 (Trp-RS):suppressor tRNA pair to insert the noncanonical amino acid 5-hydroxytryptophan (5-OHTrp) at

15 is confirmed by photocrosslinking using the noncanonical amino acid azidophenylalanine.

16 beling (STELLA) tags that introduce a single noncanonical amino acid either at the N- or C-terminus o

17 e report L-2-tellurienylalanine (TePhe) as a noncanonical amino acid for direct measurement of protei

18 Efficient terminal noncanonical amino acid mutagenesis is achieved using a

19 Here we use noncanonical amino acid mutagenesis to characterize the

20 lectrode voltage-clamp electrophysiology and noncanonical amino acid mutagenesis.

21 codons, and after the tRNA is charged with a noncanonical amino acid synthesizes proteins containing

22 acids in cell culture (pSILAC)/bioorthogonal noncanonical amino acid tagging (BONCAT) mass spectromet

23 p fluorometry, synthetic BigDyn analogs, and noncanonical amino acid-mediated photocrosslinking.

24 ino acid synthesizes proteins containing the noncanonical amino acid.

25 -specific incorporation of multiple distinct noncanonical amino acids (ncAAs) into a protein is an em

26 The genetic incorporation of noncanonical amino acids (ncAAs) into proteins has been

27 Although noncanonical amino acids (ncAAs) were first incorporated

28 ive platform for the construction of diverse noncanonical amino acids bearing all-carbon quaternary s

29 le to l-tryptophan, to synthesize a range of noncanonical amino acids from l-serine and indole deriva

30 boration of proteins and peptides containing noncanonical amino acids has occurred only recently.

31 ing the genetic code of cells to incorporate noncanonical amino acids into proteins is the scalable d

32 Genetic code expansion has enabled many noncanonical amino acids to be incorporated into protein

33 Noncanonical amino acids were used to show that a hydrog

34 nd in vivo production of proteins containing noncanonical amino acids.

35 basis of an SSO that produces proteins with noncanonical amino acids.

36 nhibitor, suggesting the involvement of both noncanonical and canonical autophagy in neutrophil engul

37 mparison with previous reports suggests that noncanonical and nontranscription-mediated receptor sign

38 physical interaction between CIPK23 and the noncanonical ankyrin domain in the cytosolic side of the

39 n samples into age groups, we found that the noncanonical antibody responses appeared to increase wit

40 KS4B is directed to the brush border using a noncanonical apical targeting sequence that maps to a pr

41 HAZV exploitation of COPI components in a noncanonical Arf1-independent process suggests that COPI

42 onserved structural features, but contains a noncanonical AT-hook-like motif through which it strongl

43 hat drives the atropospecific synthesis of a noncanonical atrop-defined small molecule.

44 Noncanonical atropisomers-shape-defined molecules that a

45 dic alkaloid tryptorubin A can be one of two noncanonical atropisomers.

46 esistance to both canonical (vismodegib) and noncanonical (atypical protein kinase C and MRTF inhibit

47 ed that LC3-associated phagocytosis (LAP), a noncanonical autophagic process dependent on Rubicon (ru

48 1 h postinfection affirmed the prevalence of noncanonical autophagy during early infection.

49 manipulate the autophagy pathway reveals new noncanonical autophagy routes, explains the exacerbation

50 These RNA molecules, formed by noncanonical back-splicing, have both regulatory and tra

51 subcomplex termed GLTSCR1/1L-BAF (GBAF; or "noncanonical BAF", ncBAF) uniquely contains bromodomain-

52 enic bypass of 8-oxodG, while 3'-preinserted noncanonical base pairs (3'-rA or 3'-rC) on NHEJ repair

53 romised by subtle changes in all 12 possible noncanonical base pairs at the 3'-end of the nicked repa

54 elucidate the biosynthetic pathway of these noncanonical bases.

55 tch in D2R coupling from canonical G(i/o) to noncanonical beta-arrestin signaling.

56 t involved in the interaction, documenting a noncanonical binding mode between MBL and beta2-GPI.

57 revealed that the DFG-1 valine controlled a noncanonical binding mode in CLK1, providing a rationale

58 everal diverse inhibitors exerted selective, noncanonical binding modes that exclusively target large

59 etermined that the ligands still bind at the noncanonical binding motif, but with fewer hydrogen-bond

60 In addition, we identified a secondary, noncanonical binding site (site 2), which enhances the b

61 ation for encoding the cellular synthesis of noncanonical biopolymers.

62 additional secondary metabolites produced by noncanonical biosynthetic pathways.

63 opantetheine thioester and thus represents a noncanonical C domain function.

64 These findings uncover a noncanonical cap-binding complex consisting of NCBP1/NCB

65 nents from core members of the canonical and noncanonical cascades to adaptor protein and ubiquitinat

66 This review focuses on noncanonical, CDK-independent functions of p27 in migrat

67 d screening strategy to identify hundreds of noncanonical CDSs that are essential for cellular growth

68 factor core-binding factor subunit beta as a noncanonical cofactor to stabilize the complex, the maed

69 or acylation and also traps ceftriaxone in a noncanonical configuration.

70 se regulators and a basis for distinguishing noncanonical configurations.

71 was sufficient for inhibition, suggesting a noncanonical, cytoplasmic mechanism.

72 tric pathogen Helicobacter pylori requires a noncanonical cytosolic chemoreceptor transducer-like pro

73 pheral components that modulate canonical or noncanonical desmosome functions still remain largely un

74 ld for this class of enzymes and possesses a noncanonical diiron active site architecture with a satu

75 lts reveal the presence of specific range of noncanonical DNA bases in conifer genomes implying poten

76 ich i-motifs are the most well-characterized noncanonical DNA motifs that have been detected in vivo

77 er, even if the studied G4 ligands increased noncanonical DNA structures at similar levels in nuclear

78 changes within the physiological range, such noncanonical DNA structures can be used as sensor core e

79 Quadruplex (G4) structures are four-stranded noncanonical DNA structures enriched at telomeres and on

80 G quadruplexes (G4s) and R loops are noncanonical DNA structures that can regulate basic nucl

81 Noncanonical DNA structures that retain programmability

82 ons for this functionally important class of noncanonical DNA structures.

83 Z1 that is essential for the formation of a noncanonical DNA superstructure.

84 tified the residues within the canonical and noncanonical EF-hand domains that can bind to multiple C

85 sic and translational studies have suggested noncanonical effects of coagulation factor inhibition th

86 ped stable cyclic thioether analogues of the noncanonical EGFD AspH substrates to avoid disulfide shu

87 revealed that AspH accepts substrates with a noncanonical EGFD disulfide connectivity (i.e. the Cys 1

88 Thus, our findings reveal a noncanonical eIF2 signaling pathway that controls select

89 ed BRAF inhibitor resistance is dependent on noncanonical EphA2 signaling, leading to increased melan

90 to demonstrate that the expression of active noncanonical EphA2-S897E in melanoma cells led to a mese

91 In this study, we identified noncanonical ephrin receptor (Eph) EphA2 signaling as a

92 esponses toward the classical as well as the noncanonical epitopes in mice, ferrets, and humans.

93 ses toward the major antigenic sites and the noncanonical epitopes of influenza B virus hemagglutinin

94 ion inhibition antibody responses toward the noncanonical epitopes.

95 finding that MEKK2 is a novel component of a noncanonical ERK pathway in osteoblasts that mediates ab

96 mpounds have a novel ATAD2 binding mode with noncanonical features including the displacement of all

97 are a class of noncoding RNAs produced by a noncanonical form of alternative splicing called back-sp

98 G-Quadruplexes are noncanonical four-stranded DNA secondary structures that

99 The U2AF heterodimer also has a noncanonical function as a translational regulator.

100 Y-RNAs in cellular processes has revealed a noncanonical function for many of these molecules.

101 anonical function in protein synthesis and a noncanonical function in antigen dependent-FcepsilonRI a

102 NA to the DNA damage response, centered on a noncanonical function of ATM, and demonstrates a role fo

103 These findings report a noncanonical function of caspase-3 by demonstrating its

104 Altogether, this study uncovers a noncanonical function of MPO enzyme in maintaining redox

105 Here, we uncovered a noncanonical function of U2AF1, showing that it directly

106 Each enzyme manifests a second, noncanonical function-transnitrosylation-that triggers a

107 in MPNST is due to a PRC2-independent (i.e., noncanonical) function of the enzyme or to redundancy wi

108 ural divergence of TadNaC6, coupled with its noncanonical functional features, provide unique opportu

109 Here, we identify a noncanonical, functional LsrB-type receptor in Clostridi

110 ysRS nuclear localization, thus facilitating noncanonical functions of hLysRS.

111 In this review, we discuss the noncanonical functions of tRNAs.

112 findings have revealed that many aaRSs have noncanonical functions, and several of the aaRSs have be

113 BR signaling-related roles of BRI1 from its noncanonical functions.

114 A genes are also discussed in light of their noncanonical functions.

115 ture-based efforts to selectively target the noncanonical G protein activation.

116 , ABC-transporter PEN3, calcium-ATPase ACA8, noncanonical Galpha protein XLG2 and H(+) -ATPases.

117 In addition, many noncanonical genes have intrinsic circadian rhythms, esp

118 or (nMRTF) resistance pathway that amplifies noncanonical Gli1 activity, but characteristics and driv

119 t Patched-dependent, Smoothened-independent, noncanonical Hedgehog signaling increases Wnt/Notch sign

120 Noncanonical Hedgehog signaling remains poorly character

121 PD-1H exhibits a noncanonical IgV-like topology including an extra "H" be

122 s have resulted in the identification of the noncanonical IkappaB kinase kinases IkappaB kinase e and

123 of noncoding transcription (Hox clusters and noncanonical imprinting).

124 rod proteins from Gram-negative bacteria or noncanonical inflammasome activation by lipopolysacchari

125 Mechanisms involved dysregulated noncanonical inflammasome activation caused by decreased

126 and caspase-11 in response to canonical and noncanonical inflammasome activation.

127 tracellular LPS detection and pyroptosis via noncanonical inflammasome and discuss the recently propo

128 acteria have been shown to activate a novel, noncanonical inflammasome by directly binding in the cyt

129 Activation of noncanonical inflammasome exerts two major effects: it a

130 e for pyroptosis downstream of canonical and noncanonical inflammasome signaling pathways.

131 bolished signaling by both the canonical and noncanonical inflammasomes.

132 ses the first human monogenic neomorphic and noncanonical inflammasomopathy/immunodeficiency.

133 tical regulators of such ATF4 induction, the noncanonical initiation factors eIF2D and DENR.

134 s initiated by both canonical cap-driven and noncanonical initiation strategies, most likely by targe

135 ritical, noncatalytic role for Exo1, through noncanonical interaction with polo kinase.

136 h a complex structure stabilized by multiple noncanonical interactions-revealed that a long-range ter

137 CA protomers from adjacent hexamers via two noncanonical interfaces, thus stabilizing the capsid.

138 At a global level, HX MS confirms the one noncanonical interprotomer interface in the Hsp104 hexam

139 mportance of organelle encounter dynamics in noncanonical intracellular transport.

140 athways, canonical (involving caspase-1) and noncanonical (involving caspase-4 and -5 in humans and c

141 SS4 and the other starch synthases, SS5 is a noncanonical isoform that lacks catalytic glycosyltransf

142 GFbeta)-induced canonical signaling with the noncanonical kinase cascades regulates glomerular hypert

143 We found that as the substrate of the noncanonical kinase NIK, the nfkb2 gene product p100, tr

144 an generate peptides of canonical as well as noncanonical lengths that still serve as stable MHC I li

145 e-1 domain [KASH]-like protein) form a novel noncanonical linker of nucleoskeleton and cytoskeleton (

146 icular hydantoin ring of Gh is stabilized by noncanonical lone pair-pai and CH-pai interactions, as w

147 lysis, we inferred that the newly identified noncanonical LsrB receptor shares a common ancestor with

148 ultivalent interactions can generate several noncanonical macroscopic binding dynamics, including a t

149 This noncanonical mechanism is distinct from the canonical mo

150 esis and to confer chemoresistance through a noncanonical mechanism.

151 the juxtamembrane domain, activates TrkB via noncanonical mechanisms that may involve altered interac

152 growth and invasiveness of breast cancer by noncanonical mechanisms unrelated to the previously cyto

153 id not have the same effect, suggesting that noncanonical MEK signaling regulates TREM2 trafficking.

154 A previously undescribed, noncanonical member of the NRPS condensation domain supe

155 g kinase 1) and its homologue IKKepsilon are noncanonical members of the inhibitor of the nuclear fac

156 ikely U/G mispairs) by MSH2 and MLH1 (likely noncanonical MMR).

157 ly function in the DNA damage response, many noncanonical mono(ADP-ribosylating) (MARylating) PARPs a

158 The site-specific incorporation of noncanonical monomers into polypeptides through genetic

159 Other "noncanonical" MPL exon 10 mutations have also been ident

160 These analyses reveal the noncanonical nature of the transformations at the core o

161 t axon degeneration in sensory neurons via a noncanonical necroptotic signaling mechanism.

162 ne and paracrine activation of canonical and noncanonical NF-kappaB in cHL cell lines.

163 have previously shown that activation of the noncanonical NF-kappaB pathway using an inhibitor of apo

164 HSPCs, which involves signaling through the noncanonical NF-kappaB pathway, protected these cells fr

165 ing in its degradation and activation of the noncanonical NF-kappaB pathway.

166 ored by deletion of A20 or inhibition of the noncanonical NF-kappaB pathway.

167 of apoptosis proteins (IAPs), which activate noncanonical NF-kappaB signaling and promote tumor cell

168 MDS HSPCs and indicate that interfering with noncanonical NF-kappaB signaling could prevent MDS progr

169 NIK-activated noncanonical NF-kappaB signaling induces pro-IL (interle

170 reveal that the epigenetic modulation of the noncanonical NF-kappaB signaling pathway by LSD1 is an e

171 mation, MDS HSPCs switched from canonical to noncanonical NF-kappaB signaling, a process that was dep

172 te that loss of Traf3 specifically activates noncanonical NF-kappaB signaling.

173 ivity, and the balance between canonical and noncanonical NF-kappaB signaling.

174 ) protein on Rab5+MAC+ endosomes, activating noncanonical NF-kappaB signaling.

175 SD1 regulated the downstream target genes of noncanonical NF-kappaB signaling.

176 tionally LSD1 was found to interact with the noncanonical NF-kappaB transcription factor p52.

177 TNFRSF14 are transcriptionally activated by noncanonical NF-kappaB, creating a continuous feedback l

178 This finding was associated with evidence of noncanonical NF-kappaB2 activation and a proinflammatory

179 Modulation of the noncanonical NF-kappaB2 pathway and its component TNF re

180 modulation and subsequent inhibition of the noncanonical NF-kappaB2 pathway, identifying a novel mec

181 We conclude that cyclin A2 functions in a noncanonical/non-cell cycle regulatory role to maintain

182 overview of these surprising, yet exciting, noncanonical, noncatalytic roles, and highlight how thes

183 The conserved actions of YME1L and noncanonical Notch signaling in animal models and patien

184 Moreover, the mitochondria-associated noncanonical Notch signaling pathway impinges on the RQC

185 ycemia and activate both canonical and rapid noncanonical NOTCH1 pathways that ultimately disrupt end

186 In this study, we demonstrate that SPD is a noncanonical NRF2 inducer, and that MAP1S is a component

187 says show that albopeptide originates from a noncanonical NRPS pathway featuring dehydration processe

188 We showed that only BBzeta CARs activated noncanonical nuclear factor kappaB (ncNF-kappaB) signali

189 in which the kinase domain is repurposed for noncanonical nucleotide binding or to stabilize unique,

190 Experimental investigations into abiotic noncanonical nucleotide synthesis reveal that many nonca

191 onical nucleotide synthesis reveal that many noncanonical nucleotides and related glycosides are form

192 heterocycles suggests that a wide variety of noncanonical nucleotides and related glycosides would ha

193 prebiotic syntheses of potentially ancestral noncanonical nucleotides may be of great importance for

194 th 2'-deoxy-7-amido-7-deazaguanosine (dADG), noncanonical nucleotides previously described, but a 100

195 ion is modifying the viral genome to contain noncanonical nucleotides.

196 ata suggest that the antiviral activities of noncanonical PARP isozyme activities are limited by the

197 Here, we characterize a noncanonical pathway implicating glycerophosphodiesteras

198 tes FIX in an FXI-dependent manner and (2) a noncanonical pathway in which plasma kallikrein directly

199 naling via STAT3, IL6 in OCCA signaled via a noncanonical pathway involving gp130, Src, and the Hippo

200 ducer, and that MAP1S is a component of this noncanonical pathway of NRF2 activation.

201 g is required for adequate expression of the noncanonical pathway precursors, the substrate complex c

202 ical pathway, signaled by caspase-1, and the noncanonical pathway, regulated by mouse caspase-11 and

203 on, as SHIP1 diverts PI3K signaling toward a noncanonical pathway.

204 e substrates of the developmental, so-called noncanonical, pathway are induced by inflammatory/canoni

205 te that autophagic components participate in noncanonical pathways distinct from classical autophagy.

206 ppears to have aspects of both canonical and noncanonical pathways in mammals.

207 Specifically, we describe noncanonical pathways of microRNA (miRNA) biogenesis and

208 ble of downstream signaling through distinct noncanonical pathways such as beta-arrestins in addition

209 tensive cross-talk between the canonical and noncanonical pathways, as well as among the NF-kappaB an

210 edominant central-memory stages and frequent noncanonical patterns.

211 he AF9 YEATS domain through incorporation of noncanonical Phe analogs with distinct electrostatics at

212 l PINK1/parkin-mediated mitophagy, alongside noncanonical PINK1/parkin mitophagy, in response to mito

213 Inhibition of the noncanonical poly(A) polymerase PAPD5, or the exosome RN

214 around poly(A) sites when compared to other noncanonical poly(A) signal-containing transcripts.

215 USE is preferentially localized upstream of noncanonical polyadenylation signals in Drosophila melan

216 t canonical dinucleotides (73%) and flanking noncanonical positions (27%), and calculate the positive

217 mutations in dominant DD-associated genes at noncanonical positions in splice sites.

218 H2 TAD mediates protein oligomerization in a noncanonical PRC2 context and is entirely sequestered.

219 L2 directly interacts with HSF1 protein at a noncanonical, proline-independent SH3 interaction motif.

220 facilitate the labeling of cellular RNA with noncanonical pyrimidine nucleosides.

221 ancestor with known LsrB receptors and that noncanonical receptors are present in bacteria from diff

222 rich stretch in this receptor domain forms a noncanonical recognition motif important for the interac

223 K., Novel noncanonical regulation of soluble VEGF/VEGFR2 signaling

224 In this work, we report new noncanonical regulatory properties of ultra-selective HD

225 We propose that noncanonical ribonucleotides, which would have been inev

226 reveal that the NS4A Y16 residue regulates a noncanonical Riplet-TBK1-IRF3-dependent, but RIG-I-MAVS-

227 ctly to actin in vitro and in vivo and has a noncanonical role directly regulating actin dynamics.

228 tion by TRIM5alpha, providing evidence for a noncanonical role for K63-linked ubiquitin in the proces

229 tes and 8-oxo-guanine (8-oxoG), suggesting a noncanonical role in base excision repair (BER).

230 altered tight junction integrity, but on its noncanonical role in regulating Notch/PI3K/Wnt/ beta-Cat

231 vel Raf1 isoform in humans that has a unique noncanonical role in regulating the double-stranded DNA

232 Here we report a noncanonical role of CBFB in translation regulation.

233 Together, our results suggest a noncanonical role of NEIL3 in genome integrity via its d

234 models, for example, by suggesting a novel, noncanonical role of the histone modification H3K9me3 in

235 RNA polymerase (Pol) III has a noncanonical role of viral DNA sensing in the innate imm

236 tional relevance and molecular basis of this noncanonical role remain unclear.

237 aspases have been identified, however, these noncanonical roles are not well documented and the mecha

238 , have also been reported, but many of these noncanonical roles remain enigmatic.

239 These data identify 'noncanonical' roles for ELMO1 as an important cytoplasmi

240 These results show that viruses use noncanonical routes for membrane sculpting and LC3 recru

241 hese data suggest that TGF-beta stimulates a noncanonical scaffolding action of PI3Kgamma, which recr

242 G-quadruplex (G4) is a noncanonical secondary structure of DNA or RNA which can

243 G-quadruplexes (G4) are noncanonical secondary structures formed in guanine-rich

244 hat reveals how the canonical (Ser(511)) and noncanonical (Ser(100)) 14-3-3 consensus sites on CaMKK2

245 nd disaggregation assays, we report that the noncanonical sHsp HSP-17 of Caenorhabditis elegans facil

246 fines the requirements for and mechanisms of noncanonical signaling by IL6 in human ovarian clear cel

247 tant role for Wnt5a acting via canonical and noncanonical signaling in spinal processing of nocicepti

248 ream of the TGFbeta receptor involved in the noncanonical signaling is unknown.

249 is expressed presynaptically and recruits a noncanonical signaling mechanism to reduce glutamatergic

250 o inhibition of BMP signaling, several other noncanonical signaling modalities of GREM1 have been pos

251 rated that Wnt3a is able to recruit multiple noncanonical signaling pathways to alter peripheral sens

252 Thus, pursuing TGFbeta noncanonical signaling, we identified how TGFbeta recept

253 We find that vPK, through a noncanonical site phosphorylation, activates the cellula

254 SMCHD1 is a noncanonical SMC family protein and implicated in epigen

255 further suggesting biological importance of noncanonical Smoothened-dependent pathways.

256 The contribution of noncanonical Smoothened-independent signaling to the ove

257 n PacBio Iso-seq dataset, and rescues 39% of noncanonical splice junctions.

258 e estimate 35%-40% of pathogenic variants in noncanonical splice site positions are missing from publ

259 al proteins that are known for their role as noncanonical splicing regulators were greatly increased,

260 The disruption of the noncanonical Src homology 3 recognition motif by P366L r

261 It is now clear that noncanonical structures are present in genomic DNA and h

262 RNA sequences rich in guanine can fold into noncanonical structures called G-quadruplexes (GQs), whi

263 onal components; Petasis-type reactions with noncanonical substrates, mechanism, and products; new as

264 Klentaq variants, complexed with natural or noncanonical substrates.

265 of UBA(Cez) with ubiquitin is mediated via a noncanonical surface and that hydroxylation of Asn(35) i

266 This approach revealed noncanonical target sites specific to each miRNA, miRNA-

267 73A localizes to mitochondria, mediated by a noncanonical targeting sequence that is partially retain

268 gested to have diverse activities, including noncanonical template-dependent polymerase activities.

269 Noncanonical tetrahelical nucleic acids, G-quadruplexes

270 Next, the role of several noncanonical TGF-beta pathways were tested.

271 -CD48(-) CD150(+) fraction for canonical and noncanonical TGF-beta signaling, as indicated by decreas

272 mical inhibitors, revealed a requirement for noncanonical TGFbetaR signaling through p38MAPK.

273 induces allosterically a rearrangement of a noncanonical toggle switch and the opening of the intrac

274 g from a canonical mode (myeloid cells) to a noncanonical trans-signaling mode (adipocytes and muscle

275 from primary amines, this method enables the noncanonical transformation of NH(2) groups into a wide

276 Noncanonical transforming growth factor-beta signaling a

277 at-associated non-AUG (RAN) translation is a noncanonical translation initiation event that occurs at

278 sequence 1 (MCT-1/MCTS1) oncoprotein support noncanonical translation initiation, promote translation

279 In this study, we demonstrate that TRIM14, a noncanonical TRIM that lacks an E3 ubiquitin ligase RING

280 fferential expression of tRNA genes regulate noncanonical tRNA functions performed by tRFs.

281 ir differential expression may be related to noncanonical tRNA functions.

282 into a hydrophobic pocket in Bcl-xL via its noncanonical Trp120 residue and conserved Leu123 residue

283 Here, we report that a noncanonical tumor suppressor activity of p53 prevents c

284 Unexpectedly, we also identified a series of noncanonical, unsaturated bile acids that were depleted

285 This defect coincides with the noncanonical up-regulation of so-called don't eat me mol

286 ion and were associated with activation of a noncanonical UPR(mt) pathway; the quality-control protea

287 Given the increased potency, noncanonical uptake, and off-target effects that we iden

288 romeres are ectopic centromeres that form at noncanonical, usually nonrepetitive, genomic locations.

289 from next subunit S4 residues is key for the noncanonical VSD-to-PD coupling.

290 We found SHTN1 contains a noncanonical WH2 domain and an upstream proline-rich reg

291 s with beta-catenin activation relied on the noncanonical WNT ligand WNT5a for sustained growth.

292 The noncanonical Wnt ligand Wnt5a is found in high concentra

293 which WNT secretion is reduced suggest that noncanonical WNT signaling establishes or maintains PCP

294 that combining an epigenetic therapy with a noncanonical WNT signaling pathway inhibitor has the pot

295 (planar cell polarity) signaling, one of the noncanonical Wnt signaling pathways, mediates collective

296 ein array further demonstrated activation of noncanonical WNT signaling via C-JUN as a downstream tar

297 umorigenicity and a switch from canonical to noncanonical Wnt signaling.

298 SC symmetric self-renewal divisions via the noncanonical WNT/planar cell polarity pathway, to modify

299 seen in Sfrp4 (-/-) mice is a consequence of noncanonical Wnt/Ror2/Jnk signaling activation in OCs ov

300 activation of canonical Wnt/beta-catenin and noncanonical Wnt/Ror2/Jnk signaling cascades.