ライフサイエンスコーパス: noncoding

1 ing RNAs (lncRNAs) have been misannotated as noncoding.

2 The CCVs are predominantly noncoding and enriched in regulatory elements.

3 AD-associated BIN1 variants are generally noncoding and likely change expression.

4 parts: an early region, a late region, and a noncoding control region (NCCR).

5 We show that noncoding de novo mutations near genes co-expressed in m

6 We conclude that, in the inner ear, the noncoding del10 mutation in Hgf leads to developmental d

7 ximately 90% of such structural variants are noncoding deletions (mean 19.1 per genome).

8 ARF) Here, we report that the damage-induced noncoding (DINO) lncRNA (DINOL) is the "missing link" be

9 s little is known about somatic mutations in noncoding DNA and their role in driving tumors remains c

10 MRX restricts transcription of coding and noncoding DNA by a mechanism that does not require the n

11 a contain fewer genes and substantially less noncoding DNA than those of eukaryotes, and as a result,

12 (nORFs) with coding potential may arise from noncoding DNA.

13 ichment of potentially disruptive regulatory noncoding DNVs in a fraction of CHD at least as high as

14 To assess the contribution of noncoding DNVs to CHD, we compared genome sequences from

15 uccessfully identified well-known coding and noncoding drivers, such as TP53 and the TERT promoter.

16 protein-truncating SVs was stronger than all noncoding effects.

17 ural lineages, transcriptional dynamics, and noncoding element activity between fetal brain and organ

18 onserved NFAT binding site within the distal noncoding element hHS-8 coordinately controls TNF and LT

19 we infer the dosage sensitivity of genes and noncoding elements, and reveal trends that relate to ele

20 Exon-level analysis (including noncoding exons) revealed decreased 5' UTR usage of Hnrn

21 nd several circular RNAs believed to perform noncoding functions during virus replication, although a

22 st derivatives expressed 2 antisense RNA1, a noncoding gene related to cardiovascular function) and r

23 Although the coding and noncoding gene sets are associated with similar pathways

24 onversely most studies of protein-coding and noncoding genes frequently ignore any intron-derived miR

25 oss thirteen cancer types, identifying novel noncoding genes potentially involved in tumor pathogenes

26 profiles for distinct classes of coding and noncoding genes, (b) perform differential expression ana

27 iptome, inclusive of over 109,000 coding and noncoding genes, as described in the FANTOM CAGE-Associa

28 Here, we captured noncoding genetic variants by performing epigenetic prof

29 ly improve our ability to assign function to noncoding genetic variants, by measuring allelic effects

30 Predicting the impact of noncoding genetic variation requires interpreting it in

31 for defining regulatory conservation in the noncoding genome beyond classic sequence-level conservat

32 We generated a model of the LA noncoding genome by profiling 7 histone post-translation

33 Annotation of the noncoding genome in human LA is limited, as are effects

34 The noncoding genome may harbor further mechanisms involved

35 Profiling the noncoding genome provides new insights into the gene exp

36 cers work will improve the interpretation of noncoding genome variation and empower the generation of

37 We also examined the noncoding genome, and found deletions in regulatory regi

38 ysis of gene regulation, WGS analysis of the noncoding genome, and machine learning have begun to suc

39 RNAs (lncRNAs) are a major component of the noncoding genome, but their biological impacts are not f

40 ed our view of somatic mutations in the vast noncoding genome, uncovered novel genes in localized pro

41 enome-wide association studies reside in the noncoding genome, which makes deciphering biological mec

42 enotypic negative regulatory elements in the noncoding genome.

43 Noncoding genomic sequences-for which molecular function

44 identification of functional regions in the noncoding human genome is difficult but critical in orde

45 data to identify a novel long noncoding RNA Noncoding Intergenic Co-Induced transcript (NICI) on chr

46 afness using a mouse model engineered with a noncoding intronic 10 bp deletion (del10) in Hgf Male an

47 ted ORFs and from RNAs previously considered noncoding, it is becoming clear that these initial assum

48 Genes, associated eGene types (e.g., coding, noncoding, level of evolutionary constraint), effect siz

49 temically migrating Ya transcripts as a long noncoding (lnc) RNA.

50 Long noncoding (lnc) RNAs are emerging regulators of inflamma

51 ecent iScience paper by Fan et al., the long noncoding (lnc)RNA CISAL is shown to form a DNA-RNA trip

52 Long noncoding (lnc)RNAs potently regulate gene expression pr

53 heer number of targets and their predominant noncoding localization, as well as pervasive pleiotropy

54 ent diversifying selection on our identified noncoding loci in Darwin finch populations further sugge

55 l-related phenotype associations specific to noncoding loci.

56 Our results suggest a novel noncoding mechanism of ASD, describe a powerful method t

57 ssion in 2CLCs and identified miR-344 as the noncoding molecule that positively controls 2CLC potency

58 Overlaying more than 700 noncoding mutations from patients with developmental dis

59 nnot directly identify individual pathogenic noncoding mutations from personal cancer genomes.

60 Our understanding of noncoding mutations in cancer genomes has been derived p

61 rtant contribution to the list of functional noncoding mutations in cancer.

62 scribe a functional role for these recurrent noncoding mutations in disrupting an autoregulatory feed

63 eep learning framework to capture pathogenic noncoding mutations in personal cancer genomes, which pe

64 UTR binding, and raise the possibility that noncoding mutations in the ATXN1 locus may act as risk f

65 Noncoding mutations require more work.

66 Our sequencing revealed novel recurrent noncoding mutations surrounding a single exon of the HNR

67 Coding and noncoding mutations, as well as epimutations, converged

68 iation, elongation, and termination, several noncoding (nc)RNAs also function as global transcription

69 highlights ASoC as a functional mechanism of noncoding neuropsychiatric risk variants, providing a po

70 2013 and PRVABC59 differ by an additional 31 noncoding or silent nucleotide changes.

71 ights the critical importance of identifying noncoding polymorphisms as disease risk factors.

72 y, which was originally located in the HU-14 noncoding region between dnaG (DNA primase) and rpoD (si

73 to cytosine (C) at nucleotide 472 in the 5' noncoding region of type 3 OPV.

74 homozygous 221-kb and 338-kb deletions in a noncoding region on chromosome 8 with an approximately 2

75 mozygous deletion of the mouse ortholog of a noncoding region with candidate pacemaker-specific REs i

76 s genes in close proximity to the identified noncoding regions are involved in craniofacial embryo de

77 phrenia have demonstrated that variations in noncoding regions are responsible for most of the common

78 Many of these noncoding regions contain important regulatory sequences

79 dentify 1434 protein-coding genes and 39,806 noncoding regions for which molecular rates were signifi

80 ribe a powerful method to identify important noncoding regions in the human genome, and emphasize the

81 ied for neuropsychiatric disorders reside in noncoding regions of the genome and are therefore likely

82 These variants are located mainly in noncoding regions of the genome and likely include varia

83 ity of the AF-associated variants lie within noncoding regions of the genome where causal variants af

84 nsive sets of orthologous protein-coding and noncoding regions of the genome, and identified a basal

85 at positive epistasis between the coding and noncoding regions of the viral genome combined to elicit

86 ost tumor-associated sites, predominantly in noncoding regions, have unknown functional relevance.

87 le-nucleotide polymorphisms (SNPs) reside in noncoding regions.

88 utrality across the locus in both coding and noncoding regions.

89 ousand years on de novo mutations, mainly in noncoding regions.

90 any AF-associated genetic variants reside in noncoding regions; this knowledge gap impairs efforts to

91 mmunity-associated SNPs in the genome map to noncoding regulatory regions in T cells, but the nature

92 ASD genetic risk variants in hyperacetylated noncoding regulatory regions linked to neuronal genes.

93 effect and to identify functional alleles in noncoding regulatory regions.

94 leads to a dramatic induction of a class of noncoding retrotransposons called B2 SINEs in multiple c

95 ), its translocation and binding to the long noncoding RNA (lncRNA) BACE1-antisense transcript (BACE1

96 Here, we identified the nuclear long noncoding RNA (lncRNA) H19X as a master regulator of TGF

97 ing evidence highlights the role of the long noncoding RNA (lncRNA) KCNQ1OT1 in fracture healing.

98 y Pvt1b, a p53-dependent isoform of the long noncoding RNA (lncRNA) Pvt1, expressed 50 kb downstream

99 ntify a group of Y chromosome-expressed long noncoding RNA (lncRNA) that are involved in male non-sma

100 as a novel KSHV reactivation-activated long noncoding RNA (lncRNA) that interacts with HIV Tat.

101 rn was negatively controlled by a novel long noncoding RNA (lncRNA) that we named Stem Cell Inhibitor

102 timulated non-coding RNA 1 (INCR1) as a long noncoding RNA (lncRNA) transcribed from the PD-L1 locus

103 we identified and characterized a novel long noncoding RNA (lncRNA), acting as a regulator of the mon

104 We report that a long noncoding RNA (lncRNA), H19, associates with dystrophin

105 a micropeptide produced from a putative long noncoding RNA (lncRNAs) that is important in controlling

106 III (RNAPIII)-transcribed, retrotransposable noncoding RNA (ncRNA) elements ubiquitously spread throu

107 the Set3 complex to both protein-coding and noncoding RNA (ncRNA) genes via a SUMO-interacting motif

108 s (sRNAs), including microRNAs (miRNAs), are noncoding RNA (ncRNA) molecules involved in gene regulat

109 ave revealed the enormous diversity of small noncoding RNA (sRNA) classes in mammalian cells.

110 of the active VSG is transcribed into a long-noncoding RNA (TERRA), which forms RNA:DNA hybrids (R-lo

111 we identified a hypermethylation in the long noncoding RNA 299 (LINC00299) gene in blood-derived DNA

112 ed mechanism for 5' tRNA fragment control of noncoding RNA biogenesis and, consequently, global chrom

113 results show for the first time that a long noncoding RNA can regulate A-to-I RNA editing, further e

114 The pro-oncogenic long noncoding RNA colon cancer-associated transcript 1 (CCAT

115 Our study demonstrates that the long noncoding RNA DINO is the long-sought missing link betwe

116 DRAIC is a 1.7 kb spliced long noncoding RNA downregulated in castration-resistant adva

117 BC200 is a noncoding RNA elevated in a broad spectrum of tumor cell

118 ed genome-wide methylation profile: the long noncoding RNA ephemeron, whose rapid upregulation is cru

119 neuropeptides, neurotransmitters, mRNA, and noncoding RNA expression signatures, while we do not rev

120 tone modification, chromatin remodeling, and noncoding RNA expression, and elucidates potential strat

121 The FTX locus, comprising of a long noncoding RNA FTX and multiple intronic miRNA, was highl

122 uggest that this troublesome gene region has noncoding RNA functions, possibly related to conflict be

123 Reduced long noncoding RNA Gas5 and increased miR-222 expression in M

124 Circular and long noncoding RNA genes were the most strongly methylated re

125 yme 1A (DCP1A) as a key regulator of Tsix, a noncoding RNA implicated in allelic choice through X-chr

126 consensus on the current state of the art in noncoding RNA in cardiovascular disease.

127 ncludes messenger RNA and diverse classes of noncoding RNA in human cells.

128 nt frequency, supporting a role for the long noncoding RNA in the etiology of ASD.

129 tional activities, likely operating via long noncoding RNA in this region.

130 dvanced web server, the plant-specific small noncoding RNA interference tool pssRNAit, which can be u

131 Noncoding RNA molecules have been implicated in critical

132 transcriptomic data to identify a novel long noncoding RNA Noncoding Intergenic Co-Induced transcript

133 The long noncoding RNA nuclear paraspeckle assembly transcript 1

134 Noncoding RNA plays essential roles in transcriptional c

135 that encompasses PTCHD1, DDX53, and the long noncoding RNA PTCHD1-AS is frequently disrupted in male

136 the human telomerase RNA component (hTR), a noncoding RNA required for telomere elongation.

137 turn, reduced the levels of HAS2-AS1, a long-noncoding RNA that epigenetically controls HAS2 mRNA exp

138 The previously characterized noncoding RNA that regulates expression of the key seed

139 ator recruitment, histone modifications, and noncoding RNA transcription.

140 e identification of a considerable amount of noncoding RNA transcripts, which are increasingly recogn

141 sm, possibly mediated or regulated by a long noncoding RNA, that supports latency III critical for th

142 targeting mRNAs and discuss the progress of noncoding RNA-based drugs in clinical trials.

143 o significant progress in the development of noncoding RNA-based next-generation therapeutics for car

144 In this review, we focus on noncoding RNA-based studies conducted mainly in large-an

145 The emerging field of noncoding RNA-based therapies has now come to the attent

146 nt modified base in eukaryotic mRNA and long noncoding RNA.

147 expanding the functional repertoire of long noncoding RNA.

148 s, reactive species, biogenic volatiles, and noncoding RNA.

149 , which has been thus far mainly confined to noncoding RNA.

150 ompounds, treatment-dependent changes in the noncoding RNAome in primary human cardiac fibroblasts we

151 Long noncoding RNAs (lncRNA) have been implicated in many dis

152 Of the thousands of long noncoding RNAs (lncRNA) identified in lymphocytes, very

153 Hypoxia induces a vast array of long noncoding RNAs (lncRNA) in breast cancer cells, but thei

154 classes have been identified, including long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs).

155 We investigated the potential of long noncoding RNAs (lncRNAs) and corresponding predictive mo

156 uently used to functionally interrogate long noncoding RNAs (lncRNAs) and discriminate lncRNA loci th

157 Long noncoding RNAs (lncRNAs) and promoter- or enhancer-assoc

158 injury, including up- and downregulated long noncoding RNAs (lncRNAs) and transcriptional regulators,

159 Long noncoding RNAs (lncRNAs) are a class of transcribed RNA

160 Long noncoding RNAs (lncRNAs) are a heterogenous group of RNA

161 Long noncoding RNAs (lncRNAs) are a major component of the no

162 Long noncoding RNAs (lncRNAs) are crucial in many cellular pr

163 onses to the environment, since several long noncoding RNAs (lncRNAs) are known to quantitatively reg

164 Long noncoding RNAs (lncRNAs) are often associated with polys

165 tes mellitus are global emergencies and long noncoding RNAs (lncRNAs) are regulatory transcripts with

166 We have known for decades that long noncoding RNAs (lncRNAs) can play essential functions ac

167 Long noncoding RNAs (lncRNAs) evolve more rapidly than mRNAs.

168 commonly cause the dysregulation of the long noncoding RNAs (lncRNAs) expression.

169 Long noncoding RNAs (lncRNAs) have been demonstrated to play

170 Long noncoding RNAs (lncRNAs) have been identified in all euk

171 Specifically, some putative long noncoding RNAs (lncRNAs) have been misannotated as nonco

172 Long noncoding RNAs (lncRNAs) have been revealed to play crit

173 Several long noncoding RNAs (lncRNAs) have been shown to function as

174 Long noncoding RNAs (lncRNAs) have emerged as key coordinator

175 Long noncoding RNAs (lncRNAs) have emerged as key regulators

176 Long noncoding RNAs (lncRNAs) have emerged as putative biomar

177 The roles of long noncoding RNAs (lncRNAs) in musculoskeletal development,

178 Long noncoding RNAs (lncRNAs) localize in the cell nucleus an

179 involves many transcription factors and long noncoding RNAs (lncRNAs) that regulate gene expression.

180 ethylation, transcriptional elongation, long noncoding RNAs (lncRNAs), and CCCTC-binding factor (CTCF

181 undreds of regulated protein-coding and long noncoding RNAs (lncRNAs), some of which are regulated in

182 s the transcription of large numbers of long noncoding RNAs (lncRNAs).

183 e in breast cancer metastasis including long noncoding RNAs (lncRNAs).

184 Gene expression is also regulated by long noncoding RNAs (LncRNAs).

185 These RNA molecules are named noncoding RNAs (ncRNA).

186 Small noncoding RNAs (ncRNAs) are involved in many important p

187 Among a subset of noncoding RNAs (ncRNAs) cosedimenting with the ubiquitin

188 discovery, via deep sequencing, of numerous noncoding RNAs (ncRNAs) derived from both EBOV and MARV

189 Noncoding RNAs (ncRNAs) direct a remarkable number of di

190 Noncoding RNAs (ncRNAs) have been assessed as biomarkers

191 Noncoding RNAs (ncRNAs) longer than 200 nucleotides are

192 Small noncoding RNAs (ncRNAs) play a vital role in a broad ran

193 TE-containing noncoding RNAs (ncRNAs) show considerable tissue specifi

194 MicroRNAs are small (~ 22nt long) noncoding RNAs (ncRNAs) that regulate gene expression at

195 Small noncoding RNAs (sncRNA) are recognized as important acto

196 Small noncoding RNAs (sncRNA), including microRNA (miR), are e

197 th host cellular components, including small noncoding RNAs (sncRNAs).

198 MicroRNAs (miRNAS) are small noncoding RNAs and are important regulatory molecules th

199 The obstacles and promises of targeting long noncoding RNAs and circRNAs as therapeutic modalities in

200 EBV-encoded proteins, along with noncoding RNAs and microRNAs, hijack cellular proteins a

201 ion of protein-coding genes, long intergenic noncoding RNAs and microRNAs.

202 Here we review recent progress involving noncoding RNAs and their functions in the Apicomplexa, w

203 g RNAs such as circular RNAs, YRNAs, or long noncoding RNAs are currently gaining increasing attentio

204 Long noncoding RNAs are thought to regulate gene expression b

205 In recent years, the emergence of small noncoding RNAs as a mega controller of gene expression h

206 the ring-shaped Ro 60-kDa (Ro60) protein and noncoding RNAs called Y RNAs, are present in all three d

207 rovide an overview of the different types of noncoding RNAs controlling the vasculature and focus on

208 By contrast, noncoding RNAs evolve rapidly between ecotypes and may c

209 Furthermore, identifying noncoding RNAs for targeted therapeutics to treat cardio

210 piRNAs comprise the largest group of small noncoding RNAs found in humans, and they are distinct fr

211 echnologies to investigate the role of these noncoding RNAs in cardiovascular health.

212 ranscribes all protein-coding genes and many noncoding RNAs in eukaryotic genomes.

213 and sensitive measurement of both coding and noncoding RNAs in the blood transcriptome.

214 Noncoding RNAs in the course of RNA surveillance and pro

215 ach other and are transcribed from divergent noncoding RNAs in the latency-associated transcript (LAT

216 ious studies have identified the presence of noncoding RNAs in the major zoonotic pathogen Campylobac

217 anosine (m(7)G) "capping" of coding and some noncoding RNAs is critical for their maturation and subs

218 hyladenosine (m(6)A) into various coding and noncoding RNAs of the plant transcriptome.

219 n mESCs affected the levels of several small noncoding RNAs originating from TET2-bound tRNAs that we

220 asses the cellular mechanisms by which short-noncoding RNAs posttranscriptionally modulate gene expre

221 NA quality control given the large number of noncoding RNAs processed by DEDD deadenylases.

222 Circular RNAs (circRNAs) are a class of noncoding RNAs produced by a noncanonical form of altern

223 eIF4E's association with noncoding RNAs strongly positions it to act beyond trans

224 Other noncoding RNAs such as circular RNAs, YRNAs, or long non

225 MicroRNAs (miRNAs) are small noncoding RNAs that act as master regulators in many bio

226 Similarly, the identification of long noncoding RNAs that appear to play an important role in

227 microRNAs are short, noncoding RNAs that can regulate hundreds of targets and

228 describe transcription factor-adjacent long noncoding RNAs that define each subclass and validate th

229 MicroRNAs (miRNAs, miRs) are small noncoding RNAs that modulate gene expression by negative

230 miRNAs are small noncoding RNAs that posttranscriptionally reduce gene ex

231 Argonautes (AGOs) associate with noncoding RNAs to regulate gene expression during develo

232 MicroRNAs (miRNAs) are short noncoding RNAs which each cause repression of many targe

233 wn about the molecular role of lncRNAs (long noncoding RNAs) in cell-cycle progression.

234 onal role of messenger RNAs, microRNAs, long noncoding RNAs, and circular RNAs (ie, regRNAs) in heart

235 disease-associated disruption of nucleoli by noncoding RNAs, and establish locus-targeted R-loop modu

236 nd technologies currently available to study noncoding RNAs, and identify areas of unmet need.

237 Circular RNAs (circRNAs), a class of long noncoding RNAs, are known to be enriched in mammalian ne

238 NA, can include both protein-coding RNAs and noncoding RNAs, as long as they contribute, directly or

239 igenetic control mechanisms, including small noncoding RNAs, DNA methylation, and histone modificatio

240 Noncoding RNAs, including small nucleolar RNAs (snoRNAs)

241 Among various noncoding RNAs, microRNAs (miRNAs) are the most studied

242 as far reaching implications in the study of noncoding RNAs, particularly within the context of trans

243 Among these noncoding RNAs, regulation of the U7 snRNA by tRF-GG mod

244 oding capacity of the transcriptome and, for noncoding RNAs, to regulate their activities.

245 ys a role in production of a wide variety of noncoding RNAs-snoRNAs, scaRNAs, and snRNAs-that are dep

246 control of gene expression via this class of noncoding RNAs.

247 reased capping efficiency of ~100 coding and noncoding RNAs.

248 ammalian genomes encode tens of thousands of noncoding RNAs.

249 d in messenger (mRNA), ribosomal (rRNA), and noncoding RNAs.

250 re and focus on the developing field of long noncoding RNAs.

251 cription termination of upstream interfering noncoding RNAs.

252 les cells to selectively regulate coding and noncoding RNAs.

253 hers lacking protein-coding potential, named noncoding RNAs.

254 ability and, hence, expression of coding and noncoding RNAs.

255 evidence that nucleotides have been used in noncoding roles for even longer than RNA has been used a

256 blueprint for dissection of their coding and noncoding roles.

257 CpG-rich Foxp3 intronic enhancer, conserved noncoding sequence 2 (CNS2), is activated via DNA demeth

258 proaches can reveal the phenotypic impact of noncoding sequence changes.

259 europsychiatric disease risk variants are in noncoding sequences and lack functional interpretation.

260 al genes and mutations, including at distant noncoding sites.

261 Noncoding small RNA is a signaling molecule that is graf

262 The regulatory noncoding small RNAs (sRNAs) of bacteria are key element

263 However, a synthetic noncoding snoU1RNA was only capable of increasing adhesi

264 However, noncoding SNPs remain understudied, partly because they

265 y variants in neuroblastoma and suggest that noncoding somatic mutations have relevant implications i

266 to interpret the functional significance of noncoding somatic mutations in promoting tumorigenesis.

267 Noncoding somatic mutations of 151 neuroblastomas were i

268 ting biological and clinical consequences of noncoding splice-inducing mutations that were previously

269 We also uncovered modest selection against noncoding SVs in cis-regulatory elements, although selec

270 A vital role for noncoding transcription and/or transcripts emerges as th

271 This exploration of the noncoding transcriptome identified ecotype-specific lncR

272 cholerae Our work revealed 603 coding and 85 noncoding transcripts associated with Hfq, including 44

273 luding novel and as yet uncharacterized long noncoding transcripts with unknown function.

274 ability of lncRNAs to function as regulatory noncoding transcripts, there is growing evidence that ln

275 ranscripts and 24 728 as high confident long noncoding transcripts.

276 genome than coding exons; nevertheless, most noncoding variant prioritization methods only focus on t

277 10 bp deletion recapitulating a human DFNB39 noncoding variant, we demonstrate that neural crest cell

278 Two ACE2 noncoding variants (rs4646118 and rs143185769) present i

279 ciation studies have implicated thousands of noncoding variants across common human phenotypes.

280 Whether these noncoding variants affect expression of TBX3 or neighbor

281 der may be influenced by myriad small-effect noncoding variants and/or by rare but severe coding vari

282 meta-analysis dataset to unravel functional noncoding variants associated with ALS based on their ep

283 DFNB39 However, the mechanism by which these noncoding variants causes deafness was unknown.

284 overy and provide insights into relevance of noncoding variants for cell-specific gene regulation and

285 putational method for discovering regulatory noncoding variants in cancer by integrating whole-genome

286 In humans, noncoding variants in HGF are associated with nonsyndrom

287 s, cis-X enables the discovery of regulatory noncoding variants in individual cancer genomes.

288 c approach to interpret phenotype-associated noncoding variants in proper cell types and relevant dyn

289 hat human deafness DFNB39 is associated with noncoding variants in the 3'UTR of a short isoform of HG

290 enabling integrative analyses of regulatory noncoding variants in the context of large population-le

291 e deleted the orthologue of an RE containing noncoding variants in the Hcn4 (potassium/sodium hyperpo

292 s support the regulatory roles for inherited noncoding variants in the pathogenesis of CLL.

293 ome-wide association studies have identified noncoding variants near TBX3 that are associated with PR

294 It then searches for causal noncoding variants that may introduce aberrant transcrip

295 demonstrating the functional consequences of noncoding variation in gene regulatory networks that sta

296 l in order to gain understanding of the role noncoding variation plays in gene regulation in human he

297 ci for five genes, involving both coding and noncoding variation.

298 (Arabidopsis thaliana) and we show here that noncoding variations of the brassinosteroid (BR) biosynt

299 em by limiting protein expression; producing noncoding viral RNAs (including microRNAs) to suppress l

300 Noncoding Y RNAs are abundant in animal cells and presen