ライフサイエンスコーパス: noncompetitive inhibitor

1 tion site on the enzyme was identified for a noncompetitive inhibitor.

2 tent 2',5'-dd-3'ATP, a post-transition state noncompetitive inhibitor.

3 ependent manner and that azide is a mixed or noncompetitive inhibitor.

4 allosterically regulated by an agonist or a noncompetitive inhibitor.

5 subtype GluA2 receptor in complex with three noncompetitive inhibitors.

6 r drugs that bind to specific RNA targets as noncompetitive inhibitors.

7 oproteins as a substrate and found both were noncompetitive inhibitors.

8 d the most potent ones were characterized as noncompetitive inhibitors.

9 d P-gp inhibition was due to the presence of noncompetitive inhibitors.

10 as WIN 51,708 and N-desmethylclozapine were noncompetitive inhibitors.

11 effect as compared to other competitive and noncompetitive inhibitors.

12 ner allosterically regulated by agonists and noncompetitive inhibitors.

13 uation that favors the identification of ATP noncompetitive inhibitors.

14 dates the binding site for a series of novel noncompetitive inhibitors.

15 ve inhibitor anakinra (Kineret) and a potent noncompetitive inhibitor 101.10, for efficacy in blockin

16 The products behaved as noncompetitive inhibitors according to studies using the

17 This peptide functioned as a noncompetitive inhibitor against ATP.

18 c analysis suggests that EGCG functions as a noncompetitive inhibitor against ATP.

19 ydrolysis of UDP-2,3-diacylglucosamine, is a noncompetitive inhibitor against both substrates.

20 t the peptide substrate and most likely as a noncompetitive inhibitor against NAD(+).

21 titive inhibitor against R-3-OHC14-ACP and a noncompetitive inhibitor against UDP-3-O-(R-3-OHC14)-Glc

22 oped herein allowed identifying new original noncompetitive inhibitors against cN-II that act in a sy

23 values associated with the formation of the noncompetitive inhibitor-alpha3beta4-nAChR complexes.

24 st that micromolar levels of the more potent noncompetitive inhibitor and corresponding protide are t

25 studies that analogues of this chemotype are noncompetitive inhibitors, and by using a crystal struct

26 rs from compound library screens because ATP-noncompetitive inhibitors are often weaker and commonly

27 Varying AcCoA, citrate is a noncompetitive inhibitor as predicted, but CoA is noncom

28 we have discovered that SNAP-5114 acts as a noncompetitive inhibitor at GAT3.

29 hat the kinetics are accounted for best by a noncompetitive inhibitor binding model.

30 ucleotides known to be either competitive or noncompetitive inhibitors but not by agents known not to

31 inase 4 (CDK4) and the identification of ATP-noncompetitive inhibitors by high-throughput screening a

32 hibition of the muscle-type nAChR (1) by the noncompetitive inhibitors cocaine and MK-801 [(+)-dizoci

33 nique to glutathione reductase suggests that noncompetitive inhibitors could also serve as lead compo

34 ge, MA, USA) is a small-molecule, selective, noncompetitive inhibitor directed against human IMPDH.

35 Some noncompetitive inhibitors (e.g., ganglionic blockers) ex

36 Lastly, compounds known to act as noncompetitive inhibitors exhibited parallel concentrati

37 The pharmacological effects of the noncompetitive inhibitors, expressed as percent recovery

38 lalanine and phenylalanylalanine are general noncompetitive inhibitors for E3alpha-catalyzed ubiquiti

39 designing conformation-specific, more potent noncompetitive inhibitors for the GluR2 AMPA receptor.

40 There are challenges to identifying ATP-noncompetitive inhibitors from compound library screens

41 M) consistent with reports that it acts as a noncompetitive inhibitor in the steady state at high con

42 d was found to be a competitive, rather than noncompetitive, inhibitor in both radioligand and functi

43 e present together, coniferyl aldehyde was a noncompetitive inhibitor (K(i) = 0.59 microM) of ferulat

44 e crystal structure of a complex between the noncompetitive inhibitor (Kis = 27 microM, Kii = 48 micr

45 , and adsorption rate constants (ka) for the noncompetitive inhibitors: mecamylamine, ketamine, bupro

46 ess dissociation rate constants (k(d)) of 12 noncompetitive inhibitor-nAChR complexes.

47 cement of dizocilpine radioligand binding by noncompetitive inhibitors (NCIs) and conversely dizocilp

48 The noncompetitive inhibitors (NCIs) of the nAChR (R)- and (

49 A large number of drug substances act as noncompetitive inhibitors (NCIs) of the nicotinic acetyl

50 in part by the cellular concentrations of a noncompetitive inhibitor, nicotinamide, that reacts with

51 Neither the more potent noncompetitive inhibitor nor a neutral protide exhibits

52 P450c17 was competitive, but it was mainly a noncompetitive inhibitor of 3betaHSDII.

53 Cytochalasin B (CB) is a reversible, noncompetitive inhibitor of 3MG uptake with Ki(app) = 0.

54 theta-Defensin RTD-1 is a noncompetitive inhibitor of anthrax lethal factor (LF) p

55 tive inhibitor of poly(Glu,Tyr) and a linear noncompetitive inhibitor of ATP.

56 the viscosity of the medium using PEG-400, a noncompetitive inhibitor of ATPase activity.

57 e of 20 mM azide, consistent with CO being a noncompetitive inhibitor of azide reduction and with azi

58 were treated with eosin-5-maleimide (EM), a noncompetitive inhibitor of chloride exchange.

59 cate that phenamacril is a species-specific, noncompetitive inhibitor of class I myosin in susceptibl

60 Additionally, the compound is a noncompetitive inhibitor of daunorubicin (MRP1), calcein

61 e substrate, we demonstrate that E acts as a noncompetitive inhibitor of detergent-solubilized MraY,

62 ation of S-adenosyl-L-homocysteine (a potent noncompetitive inhibitor of DNMTs) during the catechol-O

63 action surface of SUMO1 with DPP9, acts as a noncompetitive inhibitor of DPP9.

64 f migrating neurons with Dynasore, a soluble noncompetitive inhibitor of Dynamin, rapidly arrests the

65 eplication assays, indicating that TBPc is a noncompetitive inhibitor of E1 binding.

66 s substrates demonstrated that I3C acts as a noncompetitive inhibitor of elastase activity with an in

67 ells and characterized as a slow, tight, and noncompetitive inhibitor of factor (F) XIa by a mechanis

68 In contrast, pAB acted as a noncompetitive inhibitor of factor X activation.

69 a lines are growth inhibited by cerulenin, a noncompetitive inhibitor of fatty acid synthase.

70 nt form of vitamin E present in humans, is a noncompetitive inhibitor of glutathione S-transferase pi

71 phosphorylation was inhibited by lithium, a noncompetitive inhibitor of glycogen synthase kinase-3be

72 ibition experiments indicate that As2O3 is a noncompetitive inhibitor of GTP binding to tubulin.

73 s more accurately described as a reversible, noncompetitive inhibitor of LPL.

74 bistatin is a small-molecule, high-affinity, noncompetitive inhibitor of myosin II.

75 rons of NAD(+) with FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosylt

76 Nitrous oxide (N(2)O) is a noncompetitive inhibitor of NMDA receptors that appears

77 transport substrate clotrimazole, which is a noncompetitive inhibitor of Pdr5 ATPase activity, has a

78 preincubation, we find that darbufelone is a noncompetitive inhibitor of PGHS-2 (K(i) = 10 +/- 5 micr

79 Kinetic analyses revealed that AP4' is a noncompetitive inhibitor of prothrombinase with respect

80 containing residues 1-14 of GRK2 served as a noncompetitive inhibitor of receptor phosphorylation by

81 coralloides synthesizes corallopyronin A, a noncompetitive inhibitor of RNA polymerase ineffective a

82 e (3MG) uptake with Ki(app) = 6 mum but is a noncompetitive inhibitor of sugar exit.

83 ysis characterized NSC48300 as a reversible, noncompetitive inhibitor of Taspase1 (K(i) = 4.22 mumol/

84 re, we found that GMP binds as a reversible, noncompetitive inhibitor of TGase 3 transamidation activ

85 ABCB1-mediated transport of calcein AM, and noncompetitive inhibitor of the ABCG2-mediated pheophorb

86 In contrast, PAB was found to be a noncompetitive inhibitor of the activation of the macrom

87 Etoposide is a hyperbolic noncompetitive inhibitor of the ATPase activity with a K

88 idinyl)-2,4-dichlorobenzamide 5 (BPDBA) is a noncompetitive inhibitor of the betaine/GABA transporter

89 CP1, like D10, was a noncompetitive inhibitor of the binding of [3H]vinblasti

90 vered in the screen, GW4869, functioned as a noncompetitive inhibitor of the enzyme in vitro with an

91 hosphatidylinositol 4,5-bisphosphate, a pure noncompetitive inhibitor of the enzyme.

92 yl farnesyl methyl cysteine is shown to be a noncompetitive inhibitor of the enzyme.

93 lso used to evaluate two competitive and one noncompetitive inhibitor of the HIV-1 protease.

94 ucture of psi-conotoxin Piiie (psi-Piiie), a noncompetitive inhibitor of the nicotinic acetylcholine

95 as a competitive inhibitor and cyanide was a noncompetitive inhibitor of the nitrate reductase activi

96 observations imply that DPA is behaving as a noncompetitive inhibitor of the QO site.

97 We have previously shown that TriCHQ is a noncompetitive inhibitor of the thiol-disulfide exchange

98 TriCHQ acts as a noncompetitive inhibitor of the thiol-disulfide exchange

99 vator of the wild-type enzymes and a partial noncompetitive inhibitor of the truncated mutants.

100 psi-conotoxin Piiie, a previously identified noncompetitive inhibitor of Torpedo electroplax nAChR, a

101 yclopropylmethylamine was found to be a weak noncompetitive inhibitor of tyramine oxidase.

102 enation of arachidonic acid (AA) but potent, noncompetitive inhibitors of 2-arachidonoylglycerol (2-A

103 PAR1-wt exodomain and P4 and P3 mutants were noncompetitive inhibitors of alpha-thrombin hydrolyzing

104 e, highly potent, and conformation-selective noncompetitive inhibitors of AMPA receptors.

105 wild type enzyme, CO and acetylene are both noncompetitive inhibitors of dinitrogen reduction.

106 ysis revealed that methoxyestrogens acted as noncompetitive inhibitors of E2 oxidation with K(i) rang

107 reas both compounds behaved as tight-binding noncompetitive inhibitors of FabI.

108 thyl thiohistidines of marine origin, act as noncompetitive inhibitors of GGT, with an apparent K(i)

109 port, are consistent with barbiturates being noncompetitive inhibitors of Glc translocation and prefe

110 protease inhibitors (PIs) act as reversible noncompetitive inhibitors of GLUT4 with binding affiniti

111 inhibitor of Klenow fragment and two strong noncompetitive inhibitors of HIV-1 reverse transcriptase

112 trophenols which proved to be very effective noncompetitive inhibitors of mammalian complex II, parti

113 ternate amino acids act as rapid equilibrium noncompetitive inhibitors of MtIPMS failing to display b

114 I proteins indicated that soybean CysPIs are noncompetitive inhibitors of papain.

115 mbranoids are naturally occurring, uncharged noncompetitive inhibitors of peripheral and neuronal ACh

116 hat these aryl diketoacid derivatives act as noncompetitive inhibitors of PTP1B.

117 Noncompetitive inhibitors of sarco- and endoplasmic reti

118 well as 3'-end-truncated tRNA(Val) are mixed noncompetitive inhibitors of the aminoacylation reaction

119 Compounds active against agr were noncompetitive inhibitors of the autoinducing peptide (A

120 mustine in a dose-dependent fashion and were noncompetitive inhibitors of the binding of estramustine

121 ucleotide exchange on beta-tubulin, and were noncompetitive inhibitors of the binding of radiolabeled

122 cid esters have recently been reported to be noncompetitive inhibitors of the N-acylethanolamine acid

123 Noncompetitive inhibitors of the nicotinic acetylcholine

124 analysis indicates that these compounds are noncompetitive inhibitors of the p-hydroxyphenylpyruvate

125 anesthetics which can also act as uncharged noncompetitive inhibitors of the peripheral nicotinic ac

126 idine ([3H]TCP), an analogue of the cationic noncompetitive inhibitor phencyclidine (PCP), was used t

127 bly also overlaps the sites for the cationic noncompetitive inhibitors, procaine and quinacrine.

128 t analog (p'Tide) behaved as competitive and noncompetitive inhibitors, respectively; on varying Tide

129 Complete inhibition of aromatase with ATD, a noncompetitive inhibitor, significantly and similarly re

130 cated in the channel pore and equates with a noncompetitive inhibitor site found in many pLGICs.

131 ion can be exploited to overcome blockade by noncompetitive inhibitors such as beta-amyloid peptide.

132 line agent to treat hypertension, and by the noncompetitive inhibitor tetrabenazine, presently in use

133 netic studies reveal that neomycin acts as a noncompetitive inhibitor that can bind to the Tat-TAR co

134 ir2 activity is regulated by nicotinamide, a noncompetitive inhibitor that promotes a base-exchange r

135 Our results show that the aptamer is a noncompetitive inhibitor that selectively inhibits the G

136 sults show that the aptamer we isolated is a noncompetitive inhibitor that selectively inhibits the o

137 tion of the inhibitor revealed that it was a noncompetitive inhibitor that showed a time-dependent on

138 NNRTIs are noncompetitive inhibitors that bind in a hydrophobic poc

139 K-3 inhibitor, CHIR99021 (CHIR), and the ATP noncompetitive inhibitor, Tideglusib (TG), can equally e

140 CO is also converted from a noncompetitive inhibitor to a competitive inhibitor of a

141 n growing interest in the development of ATP-noncompetitive inhibitors to overcome these problems.

142 ompetitive inhibitor versus S6 peptide and a noncompetitive inhibitor versus ATP.

143 intermediate analog 25-azacycloartanol was a noncompetitive inhibitor versus cycloartenol and an unco

144 s a competitive inhibitor versus urate and a noncompetitive inhibitor versus O2, which suggests that

145 -Acetyltryptamine, a reaction product, was a noncompetitive inhibitor versus tryptamine and uncompeti

146 r versus variable peptide substrate and as a noncompetitive inhibitor versus variable ATP.

147 Acetaldehyde and butyraldehyde are noncompetitive inhibitors versus nitroethane due to form

148 petitive inhibitors AMP-PCP and Y-27632 were noncompetitive inhibitors versus S6 peptide, and the S6

149 Kinetic studies showed that PDPA is a mixed (noncompetitive) inhibitor versus dUMP.

150 HGA, is a competitive inhibitor vs 4PE and a noncompetitive inhibitor vs alpha-ketoglutarate.

151 grative data indicate that thioridazine is a noncompetitive inhibitor, while benzamidine presents a m

152 The most potent compound behaves as a noncompetitive inhibitor with a Ki of 0.7 microM and sho

153 We found that BDZ-f is a noncompetitive inhibitor with a slight preference for th

154 TY720 is therefore an S1P-GPCR-selective and noncompetitive inhibitor with a unique mechanism of acti

155 gh the screen was further characterized as a noncompetitive inhibitor with both ATP and PLK-peptide a

156 )-activated dGTP hydrolysis, 8-oxo-dGMP is a noncompetitive inhibitor with K(I)(sl)(o)(pe) = 49 nM, w

157 o the isoprenylated cysteine substrate and a noncompetitive inhibitor with respect to AdoMet, the met

158 wed that a Zn-L-DTT solution functioned as a noncompetitive inhibitor with respect to ATP in the rho

159 ive with respect to pyrophosphate (PP(i)), a noncompetitive inhibitor with respect to ATP, but at >10

160 ated bis(dihydroxyalkylbenzene) 5 was a pure noncompetitive inhibitor with respect to both substrates

161 concentrations, Li+ was found to be a linear noncompetitive inhibitor with respect to Mg2+.

162 ability to activate the enzyme and became a noncompetitive inhibitor with respect to Mg2+.

163 During turnover, it is found that azide is a noncompetitive inhibitor with respect to O(2), most cons

164 respect to N-methyl-L-tryptophan, acts as a noncompetitive inhibitor with respect to oxygen.

165 ion kinetic analysis indicates that they are noncompetitive inhibitors with respect to androstenedion

166 059 demonstrates that U0126 and PD098059 are noncompetitive inhibitors with respect to both MEK subst

167 sites: one that equilibrates with the tested noncompetitive inhibitors within approximately 50 ms, an