ライフサイエンスコーパス: noncytotoxic

1 evaluation indicated that the hydrogels were noncytotoxic.

2 totoxic to eudicot plants and those that are noncytotoxic.

3 lines tested, whereas 2,7-DAM is relatively noncytotoxic.

4 blocks PEA-induced cell lysis and is itself noncytotoxic.

5 lly, compound 3 inhibits BChE ex vivo and is noncytotoxic.

6 rs and degradation products were shown to be noncytotoxic.

7 is not internalized by target cells, and is noncytotoxic.

8 the quinoline compounds were both active and noncytotoxic.

9 s epidermidis at loadings of silver that are noncytotoxic.

10 uNK cells with angiogenic factors keeps them noncytotoxic.

11 h unique physical properties, are inherently noncytotoxic.

12 0(S)-methylenedioxycamptothecin, but not its noncytotoxic 20(R)-stereoisomer, radiosensitized MCF-7 c

13 s and children can show cytotoxic as well as noncytotoxic activity against viral replication.

14 CD8(+) T cells display a noncytotoxic activity that suppresses transcription of h

15 duced by uNK cells, is responsible for their noncytotoxic activity.

16 ry properties for 1a, 1d, and 6d while being noncytotoxic against human colon cancer cells (HCT-116).

17 their ability to inhibit SerB2 enzyme, were noncytotoxic against mammalian cell lines, and inhibited

18 otoxic against several cancer cell lines and noncytotoxic against normal cells.

19 e recently, were multicenter, or evaluated a noncytotoxic agent.

20 ed commitment to treatment is desirable when noncytotoxic agents are administered.

21 Novel noncytotoxic agents are needed to protect men and women

22 Novel noncytotoxic agents are needed to protect women from sex

23 e been translated into therapeutic trials of noncytotoxic agents for this disorder.

24 has provided a stronger rationale for using noncytotoxic agents that influence the mechanisms involv

25 otoxic agents other than methotrexate (MTX), noncytotoxic agents, and glucocorticoids was compared wi

26 The noncytotoxic analog of AAP, 3-hydroxyacetanilide, neithe

27 Furthermore, SQAs were found to be noncytotoxic and demonstrated efficacy in a mouse model

28 TSA concentrations of 250 nM or less were noncytotoxic and did not alter normal HSF morphology or

29 s secreting catalytically inactive ExoU were noncytotoxic and did not cause acute lung injury or deat

30 nd that (a) the targeted (anti-MG1) HNPs are noncytotoxic and have greater than 20% intratumoral accu

31 Most of the mutations made nsp1 noncytotoxic and incapable of inducing translational shu

32 identified nsp1 mutations make this protein noncytotoxic and incapable of inducing translational shu

33 he rat version of the peptide, which is both noncytotoxic and nonamyloidogenic, differs from the huma

34 The biocompatible hybrid is noncytotoxic and presents significant potential for appl

35 Both enzymes were noncytotoxic and protected A549 pulmonary epithelial cel

36 ralis and K. denitrificans, were found to be noncytotoxic and to lack the RTX region, as determined b

37 itory KIR for self-HLA class I were commonly noncytotoxic, and anti-HLA-C2 cytotoxicity was nearly ex

38 c agents that are effective against HCC, are noncytotoxic, and are tolerated by the typical patient w

39 vasive abilities upon normally nonhemolytic, noncytotoxic, and noninvasive strains of Escherichia col

40 s NKp44(+) NK cells were mucosae-restricted, noncytotoxic, and produced IL-22 and IL-17.

41 rtially responsible for CD8+ T cell-mediated noncytotoxic anti-HCV activity in PBMCs.

42 This noncytotoxic anti-HCV activity was confirmed in HCV repl

43 HIV infection, CD8+ cells show cytotoxic and noncytotoxic anti-HIV activity.

44 The CD8+ cell noncytotoxic anti-HIV response (CNAR) is associated with

45 The noncytotoxic anti-HIV response, measured by suppression

46 allografts than those with weak-cytotoxic or noncytotoxic antibodies.

47 SM, in which symptoms are usually managed by noncytotoxic antimediator therapy, cytoreduction is usua

48 I and class II loci) regulates CD8(+) T-cell noncytotoxic antiviral activity against infected CD4(+)

49 T cells, which is a property consistent with noncytotoxic antiviral CTLs.

50 This CD8+ cell noncytotoxic antiviral response (CNAR), observed by cocu

51 individuals demonstrate a strong CD8(+) cell noncytotoxic antiviral response (CNAR).

52 tion is suppressed in vitro by a CD8(+) cell noncytotoxic antiviral response (CNAR).

53 (+)VCAM-1(+) cells show enhanced CD8(+) cell noncytotoxic antiviral response activity that could have

54 infected individuals showing the CD8(+) cell noncytotoxic antiviral response unexpectedly revealed mR

55 Its inhibition is regarded as a promising, noncytotoxic approach in cancer therapy by blocking grow

56 row and thymic niches, and provides a novel, noncytotoxic approach to accomplish engraftment after st

57 ix metalloproteinases (MMP) is an attractive noncytotoxic approach to cancer therapy.

58 e that MEK inhibitors represent a promising, noncytotoxic approach to the clinical management of colo

59 ity suggest the encouraging possibility of a noncytotoxic approach to the treatment of melanoma.

60 RSV-induced chemokine and MPO release was noncytotoxic as assessed by trypan blue exclusion.

61 new antimalarial lead which was found to be noncytotoxic as compared to the natural product lead tha

62 Many compounds were noncytotoxic at 100 muM, leading to high antiviral selec

63 ance (MDR) reversal agents (C-seco-TRAs) are noncytotoxic at the upper limit of solubility and detect

64 f CPE produces a fragment that appears to be noncytotoxic because it cannot undergo the post-binding

65 ields ferromagnetic FePt nanomotors that are noncytotoxic, biocompatible, and possess a remanence and

66 BI-9564 (2) is a cell permeable and noncytotoxic BRD9 inhibitor provided to the scientific c

67 The water-soluble, biocompatible, noncytotoxic, bright orange-red emissive, paramagnetic,

68 A noncytotoxic C-terminal fragment of Clostridium perfring

69 (+) T cells that migrate to LT are primarily noncytotoxic, calling into question whether these cells

70 These noncytotoxic cascades are not simply a manifestation of

71 Moreover, the noncytotoxic CD8(+) T cell antiviral response is a prima

72 actor consistent with the hallmarks defining noncytotoxic CD8(+) T-cell suppression of HIV-1.

73 Therefore, the observed strong noncytotoxic CD8(+)-cell anti-HIV responses may be an an

74 tions demonstrate the presence of an unusual noncytotoxic CD8+ T cell in patients with the Hu paraneo

75 Given that noncytotoxic cells and natural killer cells can also rel

76 otoxic cells, 3) allospecific TCR alphabeta+ noncytotoxic cells, 4) TCR alphabeta- nonspecific cytoto

77 tumor-infiltrating NK population enriched in noncytotoxic cells.

78 Finally, the noncytotoxic character and cellular uptake of PMeOzi- gr

79 These novel, noncytotoxic chemosensitizers effectively target CSCs an

80 ns into two classes: cytotoxic (class 1) and noncytotoxic (class 2).

81 were used to prepare stable, biocompatible, noncytotoxic CNT dispersions that were then attached to

82 A screen of structurally diverse, noncytotoxic COEs identified a lead compound, COE-PNH(2)

83 Noncytotoxic compounds with both the ability of disrupti

84 Indeed, exposure to a noncytotoxic concentration of HQ induced both NQO1 and s

85 n (0.1 microM) alone and in combination with noncytotoxic concentration of MSC (10 microM) did not re

86 Similarly, a noncytotoxic concentration of the NO donor S-nitroso-ami

87 ial cell morphology were seen at much lower, noncytotoxic concentrations (0.1 micro M) of ZD6126 and

88 differentiating cells with the NA extract at noncytotoxic concentrations alters expression of various

89 the conclusion that activity against HCMV at noncytotoxic concentrations by benzimidazole ribonucleos

90 C function by chemotherapeutic agents in low noncytotoxic concentrations has not yet been investigate

91 was inhibited by equol, but not daidzein, at noncytotoxic concentrations in a dose-dependent manner.

92 r to taxol as much as 700-fold at relatively noncytotoxic concentrations in vitro; (ii) as a single a

93 The authors found that these compounds at noncytotoxic concentrations induced differentiation and

94 ys broad-spectrum antiviral activity, and at noncytotoxic concentrations it is shown to inhibit the r

95 ell-based phenotypic screening revealed that noncytotoxic concentrations of (Z)-(+/-)-2-(1-benzenesul

96 Noncytotoxic concentrations of all six alpha-defensins (

97 Chronic exposure of ScN2a cells to low noncytotoxic concentrations of branched polyamines for 1

98 Furthermore, we show that noncytotoxic concentrations of CDDO derivatives in cultu

99 shed by synchronization or by treatment with noncytotoxic concentrations of chemotherapy agents that

100 Moreover, noncytotoxic concentrations of IFN-beta significantly in

101 Exposure to noncytotoxic concentrations of ketamine (</=1 mmol/L) in

102 mRNA decay rates following 24-hr exposure to noncytotoxic concentrations of sodium arsenite, and we c

103 Treatment of cells with noncytotoxic concentrations of Staphylococcus aureus-der

104 Preclinical studies suggest that noncytotoxic concentrations of the DNA methyltransferase

105 Treatment of cells with noncytotoxic concentrations of the functional inhibitors

106 ells were treated with high cytotoxic or low noncytotoxic concentrations of the highly carcinogenic a

107 monkey kidney (Vero) cells, was inhibited by noncytotoxic concentrations of the lysosomotropic agents

108 Noncytotoxic concentrations of these agents acted at an

109 oplastic chemotherapeutic agents used in low noncytotoxic concentrations on the Ag-presenting functio

110 ) macrophages with gedunin (0.01-100 microM, noncytotoxic concentrations) inhibited LPS (50 ng/ml)-in

111 New data demonstrated that in ultralow noncytotoxic concentrations, paclitaxel modulated in imm

112 At noncytotoxic concentrations, protease inhibitors ZnCl2 a

113 At noncytotoxic concentrations, telomestatin suppresses the

114 RS in the human breast cancer MCF-7 cells at noncytotoxic concentrations.

115 selective inhibitors of HCMV replication at noncytotoxic concentrations.

116 nd that PSMs are chemoattractants for DCs at noncytotoxic concentrations.

117 d disrupted capillary-like tube formation at noncytotoxic concentrations.

118 preadipocytes in a dose-dependent manner at noncytotoxic concentrations.

119 e derived ProTides show anti-HIV activity at noncytotoxic concentrations; ester and aryl variation wa

120 tly altered upon isoprene SOA exposure under noncytotoxic conditions (p < 0.05), with the majority (2

121 to the gel indicates that the gel surface is noncytotoxic, conducive to cell adhesion, and allows cel

122 d the biological factors contributing to the noncytotoxic control of HIV replication mediated by prim

123 bstrate binding were identified by selecting noncytotoxic CTF mutants followed by in vitro screening.

124 The interaction of noncytotoxic decidual natural killer cells (dNK) and ext

125 This model was developed by noncytotoxic depletion of bone marrow lineage-positive c

126 n of a dose and schedule of DAC designed for noncytotoxic depletion of DNMT1 suggests a potential rol

127 In addition PMA-activated neutrophils were noncytotoxic, despite the capacity of PMA to generate tw

128 Noncytotoxic DNMT1 depletion was confirmed by serial BM

129 y in a manner that may facilitate accessible noncytotoxic DNMT1-targeted therapy.

130 We demonstrate that when a low, noncytotoxic dose of an optimized 5'triphosphorylated RN

131 Here we demonstrate that in HNSCC cells, a noncytotoxic dose of IB represses mesenchymal-mode migra

132 eous melanoma, we tested effects of ultralow noncytotoxic dose paclitaxel on functions of myeloid-der

133 suggest that the ability of paclitaxel in a noncytotoxic dose to block the immunosuppressive potenti

134 In vitro exposure of the cell models to low, noncytotoxic doses (0.1 and 1 nM) of BaP elicited increa

135 RSV), a plant-derived polyphenol, at low and noncytotoxic doses for immune cells, can efficiently inh

136 Furthermore, prior treatment with noncytotoxic doses of carboplatin sensitized SKOV-3 tumo

137 Luciferase messenger RNA in the presence of noncytotoxic doses of DMA-135.

138 We investigated the effect of noncytotoxic doses of MTX on latency and lytic KSHV repl

139 that inhibited vaccinia virus replication at noncytotoxic doses.

140 lators for cancer invasion and metastasis at noncytotoxic doses.

141 titumor activity was achieved in mice with a noncytotoxic dosing regimen of ethyl pyruvate shown prev

142 e assessed the impact of circulating HLA and noncytotoxic DSA detected before transplant on developme

143 In this review we discuss the noncytotoxic effector functions of NK cells and how they

144 To explore such noncytotoxic effector mechanisms, we tested whether huma

145 In this study, we demonstrate the noncytotoxic effects of ionizing radiation on MHC class

146 a variety of ways in which NK cells mediate noncytotoxic effects.

147 endothelial cells (BMVEC) using a recyclable noncytotoxic endocytic pathway.

148 Therefore, we used a noncytotoxic ExoU variant, designated ExoU(S142A)-Bla, t

149 Entry of noncytotoxic (exoU) P. aeruginosa into human and rabbit

150 cells but also by controlling the virus in a noncytotoxic fashion that leaves the infected cell funct

151 ntial for developing biologically driven and noncytotoxic first-line therapies for DLBCL.

152 om 81 to 106 produced a CPE variant that was noncytotoxic for Caco-2 cells and was unable to form CPE

153 in vivo experiments, one of the peptides was noncytotoxic for ocular surfaces and had comparable anti

154 acids from the C terminus of CPE produces a noncytotoxic fragment lacking receptor binding activity,

155 Further, a noncytotoxic fragment of anti-APO-1 antibody that blocks

156 Focusing on noncytotoxic glioblastoma treatments, we demonstrated th

157 h CD4(+) T cells are primarily classified as noncytotoxic helper T cells, it has become appreciated t

158 Using a CD8(+) T-cell line displaying potent noncytotoxic HIV-1 suppression activity, we have identif

159 = 1 immune response in the form of CD8 cell noncytotoxic HIV-1 suppressive activity, proliferative C

160 We hypothesized that noncytotoxic IgG2 anti-Galalpha1-3Gal was responsible fo

161 Pretreatment of cancer cells with the noncytotoxic imidazoline 1d (10 nM) resulted in a signif

162 The appearance of noncytotoxic immunoregulatory T cell activity after cess

163 Cyclophosphamide was ineffective, but noncytotoxic immunosuppressive agents generally produced

164 Unlike other far-red FPs, E2-Crimson is noncytotoxic in bacterial and mammalian cells.

165 Se2SAP was found to be less photoactive and noncytotoxic in comparison to TMPyP4.

166 und stable in cell culture medium as well as noncytotoxic in HeLa cells, and their spectroscopic and

167 The eluates were noncytotoxic in micro-CDC assays.

168 Most were noncytotoxic in their antiviral concentration range.

169 9 and 10 were weakly active against HCMV and noncytotoxic in their antiviral dose range.

170 tive against HCMV (IC50's = 1-10 microM) and noncytotoxic in their antiviral dose ranges.

171 Microspheres were found to be noncytotoxic in vitro, and noninflammatory in vivo.

172 teasomal activity causes formation of large, noncytotoxic inclusions within the cytoplasm of both neu

173 mune responses, WHV establishes a persistent noncytotoxic infection of woodchuck hepatocytes in uPA/R

174 We observed CD8(+)-cell noncytotoxic inhibition of HIV replication in acutely in

175 strate that at 20 muM shornephine A (1) is a noncytotoxic inhibitor of P-glycoprotein-mediated drug e

176 alin-11-one oxime) was found to be a potent, noncytotoxic inhibitor of pro-inflammatory cytokine [int

177 -compound) chemical library, we identified a noncytotoxic inhibitor of this interaction that impaired

178 icity effects, endogenous amino-acid-derived noncytotoxic inhibitors (from the nocardioazine core) ar

179 )-7H-pyrrolo[2,3-d]pyri midine as potent and noncytotoxic inhibitors of HCV RNA replication.

180 This resulted in the identification of noncytotoxic inhibitors that exhibited single digit nano

181 A total of 24 noncytotoxic invasion inhibitors were identified.

182 can be established across MHC barriers by a noncytotoxic, irradiation-free approach using costimulat

183 The lung instillation of a noncytotoxic, isogenic mutant strain (PA103DeltaUT), whi

184 Since sonication and Glucanex digestion were noncytotoxic, it was also possible to observe the crypto

185 Exposure of 3T3-L1 preadipocytes to noncytotoxic levels of arsenic, including inorganic arse

186 Noncytotoxic levels of oxidative stress downregulate tro

187 that a one-time periadventitial delivery of noncytotoxic levels of PGG inhibits elastin degeneration

188 Fluorescent proteins photoswitchable with noncytotoxic light irradiation and spectrally distinct f

189 the gut mucosa have long been thought to be noncytotoxic lymphocytes that are critical for homeostas

190 We identified a noncytotoxic M. marinum strain with a transposon inserti

191 its HIV transcription in an MHC-independent, noncytotoxic manner and that mediators of this pathway c

192 CSA inhibited, in a dose-dependent and noncytotoxic manner, aggrecanase-mediated proteoglycan c

193 sis and inflammation-associated markers in a noncytotoxic manner.

194 Our data suggest a predominantly noncytotoxic mechanism of action for decitabine, leading

195 reases in HbF and total hemoglobin through a noncytotoxic mechanism of action.

196 rity, consistent with a DNA hypomethylating, noncytotoxic mechanism of action.

197 pecific TCR reduced HCV RNA replication by a noncytotoxic mechanism, the NS3-specific TCR-redirected

198 IV replication in cultured CD4(+) cells by a noncytotoxic mechanism.

199 but not IFN-gamma, elicited IL-4 release by noncytotoxic mechanisms.

200 using challenge with wild-type PAO1 or other noncytotoxic members of the O2/O5 serogroup, there was n

201 , with the ability to discern cytotoxic from noncytotoxic modes of action.

202 Six of the noncytotoxic mutants, however, demonstrated measurable l

203 an increased proportion of more immature and noncytotoxic NK cell subsets in their peripheral blood,

204 ronospora arabidopsidis encodes 10 different noncytotoxic NLPs (HaNLPs) that do not cause necrosis.

205 The function of noncytotoxic NLPs remains enigmatic, but the expansion o

206 We discovered that these noncytotoxic NLPs, however, act as potent activators of

207 rimary isolates of HIV by >90% and did so in noncytotoxic/noncytostatic concentrations and in a beta-

208 Moreover, hits were found noncytotoxic on primary cultures of murine neurons and o

209 gardless of their cytokine phenotype, can be noncytotoxic or lyse target cells via either perforin- o

210 17 to inocula of either cytotoxic (exoU+) or noncytotoxic P. aeruginosa resulted in large reductions

211 ic phenotype on some, but not all, otherwise-noncytotoxic P. aeruginosa strains and, for recombinant

212 Seven phenotypically noncytotoxic P. aeruginosa strains were transformed with

213 ertional mutations in the exoU gene confer a noncytotoxic phenotype on mutant strains and decrease vi

214 uction of apoptosis results in a conditional noncytotoxic phenotype, whereas simultaneous inactivatio

215 IFN-gamma and granzyme B, but they exhibit a noncytotoxic phenotype.

216 iphoton excitation is used to focally excite noncytotoxic photosensitizers that promote protein cross

217 lts show that chronic exposure (3 months) to noncytotoxic, physiological relevant concentration (1 mu

218 influenza virus, we developed an efficient, noncytotoxic, plasmid-based virus-like particle (VLP) sy

219 Using an unacylated, noncytotoxic pro-LKT produced by an DeltalktC mutant of

220 The addition of efaproxiral, a noncytotoxic radiation sensitizer, to WBRT may improve r

221 yl)-5'benzimidazolyl] benzimidazole (DMA) as noncytotoxic radioprotector in mammalian cells.

222 E-induced histologic damage, suggesting that noncytotoxic rCPE variants might be useful for protectin

223 treatment of ileal loops with either of the noncytotoxic rCPE variants produced no visible histologi

224 th of which are cytotoxic, with those of the noncytotoxic rCPE variants rCPE D48A and rCPE(168-319).

225 Noncytotoxic regimens of DAC were evaluated for in vitro

226 This anti-HIV response was noncytotoxic; removal of the CD8+ cells from the infecte

227 results suggest that a part of the CD8+ cell noncytotoxic response involves the activity of a proteas

228 The CD8+ noncytotoxic response is mediated by a novel soluble fac

229 tency in vivo in the induced ODC assay using noncytotoxic rotenoid concentrations with cultured MCF-7

230 and (S)-7 have potent in vitro activity, are noncytotoxic, show no adverse effects in vivo following

231 estricted pathway as well as by secretion of noncytotoxic soluble inhibitory factors.

232 Noncytotoxic steatosis in HepG2 cells affected the secre

233 Using transposon mutagenesis, we isolated a noncytotoxic strain of E. tarda.

234 In contrast, the instillation of the noncytotoxic strains (PA01, PA103exsA::omega) did not le

235 e whether introduction of the exoU gene into noncytotoxic strains of P. aeruginosa lacking this gene

236 ical or basolateral surface to cytotoxic and noncytotoxic strains of P. aeruginosa.

237 Apical addition of either noncytotoxic strains or cytotoxic strains failed to affe

238 Both cytotoxic and noncytotoxic strains were identified among corneal and n

239 anges observed after basolateral addition of noncytotoxic strains.

240 nd on APCs, is primarily responsible for the noncytotoxic suppression of HIV replication in CD4+ cell

241 ficant reduction in the level of CD8(+) cell noncytotoxic suppression of HIV replication was observed

242 alizing antibodies, and secretion of soluble noncytotoxic suppressor factors of SIV replication.

243 duction of apoptotic signaling pathways, the noncytotoxic T cell activation showed extended prolifera

244 Matched, noncytotoxic T cells were similarly generated by culturi

245 lled T cells represent highly proliferative, noncytotoxic T cells with an IL-10 cytokine bias.

246 To study the efficacy of noncytotoxic therapy in this animal model, cohorts of na

247 ch this information might be used to develop noncytotoxic therapy.

248 h regulatory mechanisms may lead to specific noncytotoxic therapy.

249 f 2 and 26 nM, respectively, while remaining noncytotoxic to cells at concentrations exceeding 23 mic

250 Fifteen (65%) of the derivatives were noncytotoxic to host cells (TD(50) > or = 320 microM).

251 Generally, the compounds were noncytotoxic to mammalian cells.

252 Vanilloids were noncytotoxic to the MCs, in contrast to the DRGs.

253 ily infiltrated by CD8(+) T cells, which are noncytotoxic to the renal tissue.

254 otoxic P. aeruginosa strain, and 33 isogenic noncytotoxic transposon mutants for internalization by M

255 on of apoptosis renders serotype Typhimurium noncytotoxic under all conditions tested.

256 Naturally occurring noncytotoxic vacA type s2 strains of Helicobacter pylori

257 A 2017 article reported the development of a noncytotoxic version-a major advance-based on attenuatin

258 ymerase-driven overexpression system, in our noncytotoxic VLP system M1 was not released efficiently

259 ones apoptolidinone A and D were shown to be noncytotoxic when evaluated against human lung cancer ce

260 tent with these data, tempol was found to be noncytotoxic, whereas tempo induced apoptotic cell death

261 l cultures of 0.1 microM and was shown to be noncytotoxic with a CC(50) > 10 microM.