ライフサイエンスコーパス: nonhomologous end-joining

1 n through the evolutionary loss of classical nonhomologous end joining.

2 imulate DNA double-strand break ligation via nonhomologous end joining.

3 by directly binding and activating DNA-PK in nonhomologous end joining.

4 stant, repairing DNA double-strand breaks by nonhomologous end joining.

5 n DSBs toward accurate and efficient CSR via nonhomologous end joining.

6 that XRCC1 also participates in alternative nonhomologous end joining.

7 ome circularization is mediated primarily by nonhomologous end joining.

8 ith disruptive mutations in genes related to nonhomologous end joining.

9 , originally identified in patients, impedes nonhomologous end joining.

10 ithin a population, which typically arise by nonhomologous end joining.

11 insertions/deletions (indels) via mutagenic nonhomologous end joining.

12 ogical functions in base excision repair and nonhomologous end joining.

13 mage accumulation, with a repair bias toward nonhomologous end joining.

14 akpoint of proteins that promote error-prone nonhomologous end-joining.

15 defects that could be reversed by inhibiting nonhomologous end-joining.

16 ted double-strand-break creation followed by nonhomologous end-joining.

17 subsequently ligated by DNA Ligase IV during Nonhomologous end-joining.

18 rtilization via homologous recombination and nonhomologous end-joining.

19 rom imprecise repair of chromosome breaks by nonhomologous end-joining.

20 ir of DNA double-strand breaks, facilitating nonhomologous end-joining.

21 ays, homology-dependent repair and classical nonhomologous end-joining.

22 d that loss of MSI1 reduces the frequency of nonhomologous end-joining.

23 NA repair, which is accompanied by increased nonhomologous end-joining activity.

24 ated homologous recombination and restrained nonhomologous end joining, affecting cell survival after

25 We now show that knockdown of alt-nonhomologous end joining (alt-NHEJ) components-XRCC1, L

26 ated a poorly defined alternative pathway of nonhomologous end joining (alt-NHEJ) in the generation o

27 PARP1-, LIG3-, and XPF-dependent alternative nonhomologous end joining (alt-NHEJ), which did not gene

28 beta (Pol beta) as mediators of alternative nonhomologous end-joining (Alt-NHEJ) events, including c

29 l components of the error-prone, alternative nonhomologous end-joining (alt-NHEJ) pathway.

30 d DNA double-stranded break (DSB) repair via nonhomologous end joining and homologous recombination.

31 SBs) and stimulates DSB repair, through both nonhomologous end joining and homologous recombination.

32 volved in DNA replication and repair by both nonhomologous end joining and homologous repair is misre

33 s9 to both nuclei, combined with the lack of nonhomologous end joining and markers for positive selec

34 break produced by Ac excision: footprints by nonhomologous end joining and rearrangements by various

35 atures of the fusion fragments indicate that nonhomologous end joining and/or replication-dependent D

36 d with wild-type cells, indicating that both nonhomologous end-joining and homologous recombination D

37 IgD CSR occurred via both alternative nonhomologous end-joining and homologous recombination p

38 ce between the two major DSB repair pathways-nonhomologous end-joining and homologous recombination r

39 se to DNA damage, which suppresses repair by nonhomologous end-joining and homologous recombination.

40 in the repair of DNA double strand breaks by nonhomologous end-joining and in the signaling of DNA da

41 fore, UbcH7-depleted cells display increased nonhomologous end-joining and reduced homologous recombi

42 y, which prevents end resection and promotes nonhomologous end-joining and therefore directly compete

43 lar domain, including Tel1 (ATM) activation, nonhomologous end joining, and DNA double-strand break e

44 bination (HR) and repair efficiency, but not nonhomologous end-joining, and decreased the formation o

45 on and DNA-dependent protein kinase-mediated nonhomologous end-joining, and, when combined with olapa

46 t the level of 10-20% of HR when both HR and nonhomologous end joining are available.

47 While gene conversion and classical nonhomologous end-joining are the most physiologically p

48 tropicalis induced mutations consistent with nonhomologous end joining at the target site, resulting

49 s switch recombination, two events requiring nonhomologous end joining, at levels comparable to Atm(-

50 ombination (HR) and classical or alternative nonhomologous end joining (C-NHEJ versus A-EJ).

51 Classical nonhomologous end joining (C-NHEJ) is a major mammalian

52 Classical nonhomologous end joining (C-NHEJ) is a major mammalian

53 end-joining (EJ) repair pathways [canonical nonhomologous end joining (C-NHEJ) or alternative end jo

54 double-strand break repair via the canonical nonhomologous end joining (c-NHEJ) pathway.

55 most small deletions occur during classical nonhomologous end joining (C-NHEJ).

56 homologous recombination (HR) and classical nonhomologous end joining (C-NHEJ).

57 oining of DSBs within S regions by classical nonhomologous end joining (C-NHEJ).

58 Classical nonhomologous end-joining (C-NHEJ) and alternative end-j

59 The classic nonhomologous end-joining (c-NHEJ) pathway is largely re

60 NA polymerase II (RNAP II) and the classical nonhomologous end-joining (C-NHEJ) proteins, including P

61 many CSR junctions are mediated by classical nonhomologous end-joining (C-NHEJ), which employs the Ku

62 translocations in wild-type versus classical nonhomologous end-joining (C-NHEJ)-deficient NSPCs revea

63 the IDPs RBM14 is required for the canonical nonhomologous end joining (cNHEJ).

64 catalytic subunit (DNA-PKcs), is a classical nonhomologous end-joining (cNHEJ) factor.

65 The classical nonhomologous end-joining (cNHEJ) pathway is a major DNA

66 of CSR is usually mediated by the classical nonhomologous end-joining (cNHEJ) pathway.

67 predominantly by classical, DNA-PK-dependent nonhomologous end joining (D-NHEJ).

68 S-S junctions are joined via a nonhomologous end joining DNA repair process.

69 active cell cycle checkpoints and increased nonhomologous end joining DNA repair, suggesting that pe

70 PAXX was identified recently as a novel nonhomologous end-joining DNA repair factor in human cel

71 DNA-PKcs plays a critical role in the nonhomologous end-joining DNA repair pathway and provide

72 CHO cell lines, which are defective for the nonhomologous end-joining DNA repair pathway, revealed a

73 isruption applications by engaging mutagenic nonhomologous end-joining DNA repair pathways.

74 A damage sites and play a functional role in nonhomologous end-joining DNA repair.

75 uggests that, in addition to its key role in nonhomologous end joining, DNA-PKcs also acts in concert

76 unnos and the paralog of XRCC4 and XLF, PAXX nonhomologous end joining factor (PAXX).

77 nase catalytic subunit (DNA-PKcs), a classic nonhomologous end joining factor, antagonizes double str

78 and breaks in part through antagonism of the nonhomologous end-joining factor 53BP1.

79 One of the major DSBs repair pathways is nonhomologous end joining for which Ku70/80 is essential

80 es four broken DNA ends that are repaired by nonhomologous end joining forming coding and signal join

81 Yet, how XLF binds XRCC4 and impacts nonhomologous end joining functions has been enigmatic.

82 SPR/SpCas9 system was used to knock out, via nonhomologous end-joining genome repair, the 4'OMT2 in o

83 pair, mismatch repair, base excision repair, nonhomologous end joining, homologous recombination, and

84 ir through both homologous recombination and nonhomologous end-joining, implicating FUS as an upstrea

85 was an indirect effect of the repression of nonhomologous end joining in Sir(-) mutants and that the

86 gD, an ATP-dependent DNA ligase dedicated to nonhomologous end joining, in complexes with ATP that hi

87 melphalan sensitivity of the cells, with the nonhomologous end-joining inhibitor SCR7 showing the str

88 ion pattern and a potential microhomology or nonhomologous end joining integration mechanism at the s

89 reaks (DSBs) by homologous recombination and nonhomologous end joining is critical for maintaining ge

90 balance between homology-directed repair and nonhomologous end joining is important for neuronal cell

91 Specifically, nonhomologous end joining is the predominant mechanism u

92 Nonhomologous end joining is the primary deoxyribonuclei

93 Finally, we demonstrate that nonhomologous end joining is uniquely required for the d

94 her, these results indicate that HR, but not nonhomologous end-joining, is the major repair or surviv

95 In nonhomologous end joining, Ku loads onto broken DNA via

96 but LIG4-dependent manner, establishing that nonhomologous end-joining maintains rDNA integrity durin

97 me of these rearrangements appear to involve nonhomologous end-joining, many must have involved mecha

98 uence analysis suggested fundamental role of nonhomologous end joining mechanism during eccDNA format

99 ons by rejoining broken ends, among them the nonhomologous end-joining mechanism that utilizes a DNA

100 Cas9 lesions by homologous recombination or nonhomologous end joining mechanisms can lead to the int

101 nucleus" stage embryos led to high-frequency nonhomologous end-joining-mediated, mutagenic lesions in

102 e Ku heterodimer complex, which functions in nonhomologous end joining, mediates clustering of long t

103 d that, distinct from Ku-dependent classical nonhomologous end joining, MMEJ--even with very limited

104 e/phosphatase-like factor (APLF) facilitates nonhomologous end joining (NHEJ) and associates with the

105 posure, which is indicative of activation of nonhomologous end joining (NHEJ) and homologous recombin

106 nd breaks are repaired by two main pathways: nonhomologous end joining (NHEJ) and homologous recombin

107 How a cell chooses between nonhomologous end joining (NHEJ) and homologous recombin

108 Cells use two major pathways for DSB repair: nonhomologous end joining (NHEJ) and homologous recombin

109 ables the generation of knockout alleles via nonhomologous end joining (NHEJ) and knock-in alleles vi

110 rossovers while alternative pathways such as nonhomologous end joining (NHEJ) are suppressed.

111 Homologous recombination (HR) and nonhomologous end joining (NHEJ) are two distinct DNA do

112 s used to repair DNA double-strand breaks by nonhomologous end joining (NHEJ) are two related family

113 tection of homologous recombination (HR) and nonhomologous end joining (NHEJ) at the same chromosomal

114 Nonhomologous end joining (NHEJ) can effectively resolve

115 We previously showed that the lack of nonhomologous end joining (NHEJ) DNA repair factor ligas

116 between classical (c)- and alternative (alt)-nonhomologous end joining (NHEJ) during DNA double-stran

117 ter assay, we found that COH29 could inhibit nonhomologous end joining (NHEJ) efficiency and that no

118 joining of noncomplementary DNA ends during nonhomologous end joining (NHEJ) for the repair of doubl

119 BRCA1, and deletion of Rif1 suppresses toxic nonhomologous end joining (NHEJ) induced by PARP inhibit

120 Nonhomologous end joining (NHEJ) is a recently described

121 A cell-based assay shows that nonhomologous end joining (NHEJ) is compromised in cells

122 Nonhomologous end joining (NHEJ) is essential for effici

123 by either homology-directed repair (HDR) or nonhomologous end joining (NHEJ) is tightly regulated.

124 Subsequently, nonhomologous end joining (NHEJ) opens, processes, and f

125 double-strand breaks (DSBs) are repaired by nonhomologous end joining (NHEJ) or homologous recombina

126 f tools for Cas9-mediated genome editing via nonhomologous end joining (NHEJ) or homology-directed re

127 Transcriptional up-regulation of major nonhomologous end joining (NHEJ) pathway genes KU80, X-R

128 omyces cerevisiae, the key components of the nonhomologous end joining (NHEJ) pathway that repairs DN

129 DR) mechanisms: the dominant but error-prone nonhomologous end joining (NHEJ) pathway, and the less-f

130 in mre-11(iow1) mutants are repaired by the nonhomologous end joining (NHEJ) pathway, as removing NH

131 A breaks are ultimately resolved through the nonhomologous end joining (NHEJ) pathway.

132 ation repair and antagonizes 53BP1-dependent nonhomologous end joining (NHEJ) pathway.

133 r of double strand breaks (DSBs) through the nonhomologous end joining (NHEJ) pathway.

134 lso suppress inappropriate activation of the nonhomologous end joining (NHEJ) pathway.

135 SET-transposase fusion protein that promotes nonhomologous end joining (NHEJ) repair in humans.

136 primase/polymerase (PolDom) is required for nonhomologous end joining (NHEJ) repair of DNA double-st

137 NA-dependent protein kinase (DNA-PK) and the nonhomologous end joining (NHEJ) repair pathway are intr

138 omote KSHV replication, proteins involved in nonhomologous end joining (NHEJ) repair restrict amplifi

139 of the DNA-PK enzyme, which are involved in nonhomologous end joining (NHEJ) repair, enhance amplifi

140 Nonhomologous end joining (NHEJ) repairs chromosome brea

141 kinase substrates and stimulates error-prone nonhomologous end joining (NHEJ) selectively in HR-defic

142 ylation in homologous recombination (HR) and nonhomologous end joining (NHEJ) through the investigati

143 Many bacteria rely on nonhomologous end joining (NHEJ) when only a single copy

144 Nonhomologous end joining (NHEJ), a major pathway of DNA

145 he efficiency of these methods is limited by nonhomologous end joining (NHEJ), an alternative DNA rep

146 pair systems: homologous recombination (HR), nonhomologous end joining (NHEJ), and single-strand anne

147 ntify DNA-PKcs complex proteins that mediate nonhomologous end joining (NHEJ), as TRIP13-binding part

148 knockout cells and organisms via error-prone nonhomologous end joining (NHEJ), but the efficiency of

149 on, which is almost exclusively dependent on nonhomologous end joining (NHEJ), CSR can occur in NHEJ-

150 ocalized sequence changes through inaccurate nonhomologous end joining (NHEJ), often leading to gene

151 subunit (DNA-PKcs) is a central component of nonhomologous end joining (NHEJ), repairing DNA double-s

152 nation (HR) but can inhibit normal repair by nonhomologous end joining (NHEJ), the main DSB repair pa

153 aired both homologous recombination (HR) and nonhomologous end joining (NHEJ), the two major DSB repa

154 early phosphorylations promote initiation of nonhomologous end joining (NHEJ), whereas ABCDE phosphor

155 ency and decreased accuracy of DSB repair by nonhomologous end joining (NHEJ), which is required for

156 rohomology-mediated end joining (MMEJ)-, and nonhomologous end joining (NHEJ)-based strategies for th

157 Collectively, the data define a nonhomologous end joining (NHEJ)-independent, S-phase-sp

158 outs in the rat and the mouse by introducing nonhomologous end joining (NHEJ)-mediated deletions or i

159 t that TDP-43 is a critical component of the nonhomologous end joining (NHEJ)-mediated DNA double-str

160 Nonhomologous end joining (NHEJ)-mediated repair of DSBs

161 r: the homologous recombination (HR) and the nonhomologous end joining (NHEJ).

162 B by either homologous recombination (HR) or nonhomologous end joining (NHEJ).

163 ct DNA ends from resection and thereby favor nonhomologous end joining (NHEJ).

164 epaired via homologous recombination (HR) or nonhomologous end joining (NHEJ).

165 r, increasing the involvement of error-prone nonhomologous end joining (NHEJ).

166 Bs) and their adequate recombination through nonhomologous end joining (NHEJ).

167 n revealed that OA-NO(2) inhibits HR and not nonhomologous end joining (NHEJ).

168 pathways: homology-directed repair (HDR) or nonhomologous end joining (NHEJ).

169 ed in telomere maintenance and DNA repair by nonhomologous end joining (NHEJ).

170 er a novel role for PARylation in regulating nonhomologous end joining (NHEJ).

171 ) repair for the majority process of precise nonhomologous end joining (NHEJ).

172 tein kinase-catalytic subunit (DNA-PKcs) and nonhomologous end joining (NHEJ).

173 ensitivity is rescued by the inactivation of nonhomologous end joining (NHEJ).

174 capacity for classical, versus alternative, nonhomologous end joining (NHEJ).

175 at are initiated on free DNA ends: classical nonhomologous end-joining (NHEJ) and ATM-dependent DNA d

176 DNA damage, functioning as part of both the nonhomologous end-joining (NHEJ) and base excision repai

177 lved several DSB repair mechanisms, of which nonhomologous end-joining (NHEJ) and homologous recombin

178 choice between two main DSB repair pathways, nonhomologous end-joining (NHEJ) and homologous recombin

179 he HPV16 E7 oncoprotein suppresses canonical nonhomologous end-joining (NHEJ) and promotes error-pron

180 le is a conserved component of the bacterial nonhomologous end-joining (NHEJ) apparatus that performs

181 esection in G1, and thereby favors repair by nonhomologous end-joining (NHEJ) as opposed to homologou

182 DNA damage repair by promoting Ku-dependent nonhomologous end-joining (NHEJ) at the expense of homol

183 ing kinases and that it is not suppressed by nonhomologous end-joining (NHEJ) components, arguing tha

184 ugh conditional deletion of TRF1 and TRF2 in nonhomologous end-joining (NHEJ) deficient cells.

185 gase 4 (LIG4), NHEJ1, and NBS1 involving the nonhomologous end-joining (NHEJ) DNA repair pathway resu

186 53BP1 gene silencing induces defects in the nonhomologous end-joining (NHEJ) DNA repair pathway.

187 Hypomorphic mutations in the nonhomologous end-joining (NHEJ) DNA repair protein DNA

188 B cells from mice and ICF2 patients affects nonhomologous end-joining (NHEJ) during immunoglobulin c

189 Such mutant alleles result presumably from nonhomologous end-joining (NHEJ) events before the segre

190 Ku70, a known nonhomologous end-joining (NHEJ) factor, also functions

191 Disruption of the nonhomologous end-joining (NHEJ) factor, Ku, promotes DN

192 rearrangements by a process dependent on the nonhomologous end-joining (NHEJ) factors 53BP1 and DNA l

193 t DNA ligation in vitro and assembly of core nonhomologous end-joining (NHEJ) factors on damaged chro

194 In the absence of core nonhomologous end-joining (NHEJ) factors, Ab gene class-

195 Somatic mutations in nonhomologous end-joining (NHEJ) genes (DCLRE1C/ARTEMIS,

196 pression of key homologous recombination and nonhomologous end-joining (NHEJ) genes.

197 Nonhomologous end-joining (NHEJ) is a key pathway for ef

198 Nonhomologous end-joining (NHEJ) is a major DNA double-s

199 Nonhomologous end-joining (NHEJ) is a major repair pathw

200 Nonhomologous end-joining (NHEJ) is the major DNA double

201 Furthermore, coexpression the nonhomologous end-joining (NHEJ) machinery from the clos

202 A double strand breaks (DSB) are repaired by nonhomologous end-joining (NHEJ) or homologous recombina

203 Subsequent repair of this break via the nonhomologous end-joining (NHEJ) or homology-directed re

204 ependent large deletions are products of the nonhomologous end-joining (NHEJ) pathway and require Top

205 triggering end resection and inhibiting the nonhomologous end-joining (NHEJ) pathway in G1 phase.

206 i, suggesting that HR is compromised and the nonhomologous end-joining (NHEJ) pathway is elicited to

207 The nonhomologous end-joining (NHEJ) pathway is essential fo

208 The nonhomologous end-joining (NHEJ) pathway is essential fo

209 The nonhomologous end-joining (NHEJ) pathway is the primary

210 y demonstrated that HSCs use the error-prone nonhomologous end-joining (NHEJ) pathway of DNA repair t

211 factor (XLF/Cernunnos) is a component of the nonhomologous end-joining (NHEJ) pathway of double-stran

212 aired DNA ends are joined by proteins of the nonhomologous end-joining (NHEJ) pathway of DSB repair t

213 u (Polmu) participates in DSB repair via the nonhomologous end-joining (NHEJ) pathway, by filling sma

214 d mutability, and abnormal regulation of the nonhomologous end-joining (NHEJ) pathway.

215 Nonhomologous end-joining (NHEJ) pathways repair DNA dou

216 s have proposed the participation of various nonhomologous end-joining (NHEJ) pathways.

217 ither by homologous recombination (HR) or by nonhomologous end-joining (NHEJ) pathways.

218 Cernunnos is involved in the nonhomologous end-joining (NHEJ) process during DNA doub

219 are suppressed by genetically eliminating Ku nonhomologous end-joining (NHEJ) protein, indicating tha

220 Here we show that FBXW7 facilitates nonhomologous end-joining (NHEJ) repair and that FBXW7 d

221 -protein kinase (DNA-PK) phosphorylation and nonhomologous end-joining (NHEJ) repair efficiency and f

222 of mice lacking Lig4, a ligase required for nonhomologous end-joining (NHEJ) repair of DNA double-st

223 lates at DNA double-strand breaks and favors nonhomologous end-joining (NHEJ) repair over ATM-depende

224 Here, we show that Ku70, a core protein of nonhomologous end-joining (NHEJ) repair pathway, can dir

225 ization of homologous recombination (HR) and nonhomologous end-joining (NHEJ) repair pathways but exc

226 d impaired homologous recombination (HR) and nonhomologous end-joining (NHEJ) repair pathways, with d

227 ic subunit (DNA-PKcs), a protein involved in nonhomologous end-joining (NHEJ) repair.

228 Mycobacteria exploit nonhomologous end-joining (NHEJ) to repair DNA double-st

229 and exonuclease activities regulate DSBR by nonhomologous end-joining (NHEJ) versus homologous recom

230 revealed 47 to 58% of reads as repaired via nonhomologous end-joining (NHEJ) with deletions and/or s

231 However, nonhomologous end-joining (NHEJ), an error-prone repair,

232 DSBs, namely homologous recombination (HR), nonhomologous end-joining (NHEJ), and microhomology-medi

233 ways, homologous recombination repair (HRR), nonhomologous end-joining (NHEJ), and single-strand anne

234 cle-invasive bladder tumors are defective in nonhomologous end-joining (NHEJ), and this phenotype may

235 tein TRF2 by promoting their mobility, their nonhomologous end-joining (NHEJ), and, as we show here,

236 ence of DNA damage checkpoint components and nonhomologous end-joining (NHEJ), but not homologous rec

237 ir by both homologous recombination (HR) and nonhomologous end-joining (NHEJ), causes accumulation of

238 ment in the second major DSB repair pathway, nonhomologous end-joining (NHEJ), remains controversial.

239 nstrict the DNA-binding ring of Ku80 disrupt nonhomologous end-joining (NHEJ), telomeric gene silenci

240 nderstood and has been proposed to occur via nonhomologous end-joining (NHEJ)-mediated double-strand

241 occur in human cancers display hallmarks of nonhomologous end-joining (NHEJ).

242 ase (DNA-PK), a critical enzyme required for nonhomologous end-joining (NHEJ).

243 ted an increased number of DSBs processed by nonhomologous end-joining (NHEJ).

244 NA double-strand break repair pathway termed nonhomologous end-joining (NHEJ).

245 RP-3 and APLF accelerate DNA ligation during nonhomologous end-joining (NHEJ).

246 recruited to DNA damage sites to facilitate nonhomologous end-joining (NHEJ).

247 eaks, to recapitulate DSB repair via MMEJ or nonhomologous end-joining (NHEJ).

248 Imprecise nonhomologous-end-joining (NHEJ) DNA repair following re

249 AD50/NBS1 complex and favors the error-prone nonhomologous-end-joining (NHEJ) DNA-repair pathway inst

250 h as KU70 and LIG4 (both involved in classic nonhomologous end-joining, NHEJ) and SMC6B (involved in

251 he integrity of homology-directed repair and nonhomologous end joining of DNA breaks is impaired in K

252 Several of these genes are also involved in nonhomologous end joining of DNA double-strand break rep

253 ress sensor ATR nor DNA-PK, the initiator of nonhomologous end-joining of DSB, was involved in repair

254 breaks (DSBs) are generally repaired through nonhomologous end joining or homologous recombination.

255 ble-strand breaks that stimulate error-prone nonhomologous end joining or homology-directed repair at

256 ts must be removed to allow repair by either nonhomologous end joining or homology-directed repair.

257 ecombination but instead form most often via nonhomologous end joining or microhomology-mediated brea

258 smatch, nucleotide excision, Fanconi anemia, nonhomologous end joining, or translesion synthesis repa

259 sis during DNA double strand break repair by nonhomologous end joining, particularly in nonreplicatin

260 mediates inhibition of the DNA-PK-dependent nonhomologous end joining pathway contributing to the ac

261 Repair of DNA double-strand breaks by the nonhomologous end joining pathway is central for proper

262 genetic disruption strategies relying on the nonhomologous end joining pathway may induce compensator

263 rm of DNA damage, are mainly repaired by the nonhomologous end joining pathway, which relies on DNA-P

264 and an increase in repair by the alternative nonhomologous end joining pathway.

265 nsertions or deletions via DNA repair by the nonhomologous end joining pathway.

266 ologous recombination (HR) and the classical nonhomologous end-joining pathway (cNHEJ).

267 ir of DNA double-strand breaks (DSBs) by the nonhomologous end-joining pathway (NHEJ) is important no

268 d by the DCLRE1C gene, is a component of the nonhomologous end-joining pathway and participates in ha

269 lications of DNA sequence that depend on the nonhomologous end-joining pathway of DSB repair.

270 ely because they mainly used the error-prone nonhomologous end-joining pathway to repair DSBs.

271 Ku70 is a key component of the nonhomologous end-joining pathway, which is the major pa

272 ich was necessary for DSB repair through the nonhomologous end-joining pathway.

273 pair, single strand break repair, and backup nonhomologous end-joining pathway.

274 ouble-stranded breaks (DSBs) mediated by the nonhomologous end-joining pathway.

275 ion-independent frameshifts generated by the nonhomologous end-joining pathway.

276 DNA repair complexes that participate in the nonhomologous end-joining pathway.

277 ubunit, essential DNA repair proteins in the nonhomologous end-joining pathway.

278 these double-strand breaks by the classical nonhomologous end-joining pathway.

279 mble the nuclear, microhomology-mediated and nonhomologous end joining pathways, in terms of the homo

280 NA double strand breaks that are repaired by nonhomologous end-joining pathways.

281 psis but formed in the absence of functional nonhomologous end-joining pathways.

282 thways of homologous recombination and other nonhomologous end-joining processes.

283 ltaAID is impaired in its ability to recruit nonhomologous end joining repair factors, resulting in a

284 , increased expression of DSB initiating and nonhomologous end joining repair machinery in newborn ne

285 n inhibitor of the DNA-PK kinase crucial for nonhomologous end joining repair of DNA DSBs, and BRCA2-

286 Double strand breaks may trigger nonhomologous end joining repair, leading to frameshift

287 s in CML progenitors was mediated by classic nonhomologous end joining repair.

288 re partially disassembled around DSBs during nonhomologous end-joining repair in G1-arrested mammalia

289 can be efficiently ligated by the classical nonhomologous end-joining repair pathway (c-NHEJ), regen

290 nts null for Ku70 or Lig4, components of the nonhomologous end-joining repair pathway.

291 ion and can ultimately become substrates for nonhomologous end-joining repair, leading to large-scale

292 irectly to the DNA break and is required for nonhomologous end-joining repair.

293 HR)-mediated repair and, to a lesser extent, nonhomologous end-joining repair.

294 Nonhomologous end joining repairs DNA double-strand brea

295 ly triggers an activation of the error-prone nonhomologous end joining response.

296 factor (XLF)-XRCC4 complex is essential for nonhomologous end joining, the major repair pathway for

297 also find that MMEJ compensates for loss of nonhomologous end joining to repair rereplication DSBs i

298 s of chromothripsis in TCC-UB is mediated by nonhomologous end-joining using kilobase, rather than me

299 nt protein kinase-mediated (DNA-PK-mediated) nonhomologous end-joining, whereas DNA repair pathways m

300 major pathway for Ku-independent alternative nonhomologous end joining, which contributes to chromoso