ライフサイエンスコーパス: nonnative

1 r reinvasion of sites when treating dominant nonnatives.

2 onnative led to competitive release of other nonnatives.

3 transition state of Protein L is found to be nonnative, a significant result that agrees with our Pro

4 vity at the price of protein instability and nonnative aggregation.

5 Results suggest that nonnatives also use a facultative C(4) -like photosynthe

6 etones on the side chain of the incorporated nonnative amino acid and hydroxylamine functionalized mo

7 The ribosomal incorporation of nonnative amino acids into polypeptides in living cells

8 This example illustrates the utility of nonnative amino acids to optimize protein therapeutics i

9 tibodies with site-specifically incorporated nonnative amino acids were produced in stable cell lines

10 m), to determine the solution structure of a nonnative amyloidogenic intermediate at high resolution.

11 ould affect the phenological overlap between nonnative and native competitors, with potentially large

12 the Rosetta energy discriminate between the nonnative and native-like structures significantly bette

13 d infants and tested the discrimination of a nonnative, and hence never-before-experienced, speech so

14 management that assumes negative effects of nonnatives, and emphasize the need to consider context-d

15 genic activities--particularly the spread of nonnative annual grasslands--has led to a breakdown in t

16 concomitant increase in cover and biomass of nonnative annuals, particularly under high levels of exp

17 expanded forms of the capsids, which possess nonnative antigenicity, are now well understood, but hig

18 Interactions among nonnatives are relatively understudied, though the likel

19 se the misfolded state is characterized by a nonnative arrangement of aromatic side chains.

20 hat two key bound intermediates, each with a nonnative arrangement of hydrophobic residues in the MDM

21 Experimental infection with nonnative bacteria reveals that--despite successful colo

22 ies under the US Endangered Species Act, and nonnative barred owls (S. varia) in western Oregon, USA

23 Structural contacts in the core, including a nonnative base pair, help to stabilize the intermediate

24 le to anticipate positive interactions among nonnatives based upon traits of the co-occurring invader

25 in a protein's dynamics, and we discuss the nonnative, beta-sheet-rich states that play a distinct r

26 patterns and potential drivers of native vs nonnative biodiversity.

27 , relative abundance decreased with age when nonnative biomass was high and soil moisture was low.

28 Habitat for nonnative brook trout Salvelinus fontinalis and brown tr

29 ERQC substrates may be recognized as nonnative by the presence of exposed hydrophobic surface

30 -terminal beta-hairpin and alpha-helix and a nonnative C-terminal alpha-helix.

31 HIV drugs based on the concept of trapping a nonnative capsid protein conformation.

32 e in amplitude of the mismatch response to a nonnative change of phoneme at the end of the first year

33 The nonnative character partially explains the failure of ac

34 cluding large-bodied snook, mojarra species, nonnative cichlids, and striped mullet, while having lit

35 d productivity: positive selection effect in nonnative communities and positive complementarity effec

36 ersity-productivity mechanisms in native and nonnative communities differ and are the first to show t

37 did monoculture communities, but native and nonnative communities diverged in root : shoot ratios an

38 of interactions differed between native and nonnative communities.

39 one FkpA contributes to LacZ folding in this nonnative compartment.

40 d a meta-analysis of experiments that tested nonnative competition intensity.

41 atchy, marginal habitats unsuitable to their nonnative competitors.

42 Starting from a nonnative conformation held by an aromatic disulfide bon

43 The resulting nonnative conformation is competent for translocation, w

44 tous metabolite interacts selectively with a nonnative conformation of a protein and facilitates prot

45 increased risk of undergoing transitions to nonnative conformational states or will persist within s

46 Hyperglycosylated GRP94 forms have nonnative conformations and are less active.

47 s in transthyretin tend to unfold and sample nonnative conformations and that the edge strands in one

48 turn interfaces traps the protein in compact nonnative conformations.

49 ation of the P3 pseudoknot, and refolding of nonnative conformers, respectively.

50 ticulators impeded their discrimination of a nonnative consonant contrast but only when the relevant

51 he transition state (DeltaF) correlates with nonnative-contact variation (DeltaA), and the simulated

52 contacts, suggesting that for some peptides, nonnative contacts can lead to productive folding events

53 ined in terms of folding of either native or nonnative contacts from a common compact disordered stat

54 g rate depending on the amount of native and nonnative contacts made in those subspaces.

55 ng on the stability of the unbound monomers, nonnative contacts play different roles in the associati

56 d protein alpha3D being a notable exception, nonnative contacts play no significant part in determini

57 nd metal-binding sites, and stabilization of nonnative contacts that leads to a misfolded state.

58 r-shifted sheet, which is composed of solely nonnative contacts, suggesting that for some peptides, n

59 hanisms of protein folding are not biased by nonnative contacts, typically argued to be a consequence

60 cts and partially extended in urea with many nonnative contacts.

61 after training with a Hindi dental-retroflex nonnative contrast.

62 Nonnative cues for synthetically regulating kinases are

63 attachment of a Ru(II) photosensitizer to a nonnative cysteine near the heme (RuIIK97C-FeIIIP450), i

64 scopy has required site-specific labeling of nonnative cysteines, a labor-intensive process occasiona

65 Disrupting the nonnative DBD-DBD interaction or transiently inhibiting

66 f the Trp91/Arg174 packing presumably allows nonnative DBD-DBD interactions that both nucleate aggreg

67 the structures determined thus far are in a nonnative detergent environment.

68 consistent with the formation of interchain, nonnative disulfide bridges and the establishment of mol

69 e to reducing agents due to the formation of nonnative disulfide bridges.

70 pinal cord, contained abundant misfolded and nonnative disulfide-cross-linked aggregated SOD1.

71 iants selectively catalyzed recombination of nonnative DNA sequences > 10,000-fold more effectively t

72 lect on how the cultural horizon, containing nonnative ecofacts, may relate to indigenous or Norse ac

73 relative to native, whereas such a prominent nonnative effect is not observed for H1-H4 packing.

74 ecular recognition, and suggest further that nonnative effects in H1-H2 packing may be largely avoide

75 of the myristoyl with the protein as well as nonnative electrostatic interactions have a pronounced e

76 th a pseudohelical turn; and 2), less stable nonnative ensembles of conformers characterized by sever

77 omatography (SEC) to isolate NL trimers from nonnative Env species.

78 ould potentially contribute to adaptation to nonnative environments despite the founder population be

79 imers and inconsistent with profiles seen in nonnative Envs.

80 e also predicted that N addition would favor nonnatives, especially annual grasses, leading to higher

81 d CzrA mutants are characterized by distinct nonnative fast internal dynamics "fingerprints" upon Zn

82 The disappearance of nonnative fish from numerous water bodies after cessatio

83 mes and the abundance of multiple native and nonnative fish species over 18 years in a large, dryland

84 gnificant opportunities to favor native over nonnative fishes while rarely, if ever, encroaching on h

85 enefiting native fishes while disadvantaging nonnative fishes.

86 n infrared experiment that could observe the nonnative folding nucleus.

87 l antibodies was used to determine native or nonnative folding of N1922S-fVIII.

88 cterizing misfolding directly by mapping out nonnative folding pathways.

89 ull free energy landscape, including all the nonnative folds.

90 rtality rates caused by the 15 most damaging nonnative forest pests.

91 is usually conferred by the acquisition of a nonnative gene encoding a penicillin-binding protein (PB

92 ant species in the United States belonged to nonnative genera, he concluded that the lack of competit

93 ation of glutamatergic local neurons using a nonnative genetically encoded cation channel.

94 nist, we tested several native JHs and their nonnative geometric and optical isomers for the ability

95 evisiae strains whose growth depended on two nonnative glycolytic pathways: a complete glycolysis fro

96 ific mannosidase that preferentially targets nonnative glycoproteins trapped in partially structured

97 However, in contrast to the favored nonnative H1-H2 packing in isolation, the native H1-H2 p

98 We manipulated the abundance of the nonnative, habitat-forming seaweed Gracilaria vermiculop

99 Nonnatives had significantly higher Chl, carotene, and a

100 experiments and leads us to assign a compact nonnative helical trap as the reason for slower P-jump-i

101 We hypothesize that nonnative helix at helix-turn interfaces traps the prote

102 hetic biology approach to reconstitute, in a nonnative heterologous host, a minimal machinery capable

103 me pocket by the native E7 histidine and two nonnative histidine residues.

104 eplication of human influenza A viruses in a nonnative host drives the evolution of new variants and

105 mics pathway suggests that several transient nonnative hydrogen bonds may facilitate the transition.

106 role of encounter complex intermediates and nonnative hydrophobic interactions for other SH3 domains

107 ne-binding protein hisactophilin reveal that nonnative hydrophobic interactions of the myristoyl with

108 ldwide, forests are increasingly affected by nonnative insects and diseases, some of which cause subs

109 Despite phytosanitary measures, nonnative insects arrive at United States (U.S.) ports o

110 t invasions, the establishment and spread of nonnative insects in new regions, can have extensive eco

111 Interestingly, the simulation also shows a nonnative interaction between Asp(8) and Glu(48) in the

112 atured state of wild-type, which is due to a nonnative interaction between Asp(8) and Lys(12).

113 e revealed that the compact state involves a nonnative interaction between the disordered N terminus

114 traps (>20 k(B)T) that result from multiple nonnative interactions and are sufficient for trapping o

115 e native-like interactions are developed and nonnative interactions are rearranged.

116 ble of structural intermediates that include nonnative interactions at low Mg(2+) concentration.

117 monomers, thermodynamic states stabilized by nonnative interactions correspond to productive, on-path

118 iased energetics needed to select native vs. nonnative interactions during folding.

119 monomers, in contrast, states stabilized by nonnative interactions generally correspond to traps tha

120 It also illuminates the important role of nonnative interactions in defining folding pathways.

121 hich are sometimes taken to be indicative of nonnative interactions in the transition state.

122 se lengths, folding is drastically slowed by nonnative interactions involving C-terminal residues.

123 Predicting positive nonnative interactions is an important tool for determin

124 and atomistic simulations indicate that the nonnative interactions of the myristoyl group in the fol

125 t extended conformations due to short-range, nonnative interactions rather than generic electrostatic

126 states and discrimination against potential nonnative interactions that favor alternate stable confi

127 and another in the RNA, that weaken specific nonnative interactions that stabilize one of the interme

128 uch prefactor differences is the presence of nonnative interactions that stabilize the TSE but need t

129 ational folding due to a lack of significant nonnative interactions, and indeed these proteins' seque

130 re formed at the transition state, including nonnative interactions, and most of the folding occurs a

131 ntermediate is stabilized by both native and nonnative interactions, friction in the folding transiti

132 ate is profoundly insensitive to omission of nonnative interactions, provided that native contact het

133 inding of charged peptides can be steered by nonnative interactions, which might be a general mechani

134 ncluding secondary structures and native and nonnative interactions.

135 otein ubiquitin (Ub), which is known to form nonnative intermediate states under a variety of mildly

136 rtance of monomer geometry, flexibility, and nonnative intermonomeric contacts in the association pro

137 sible this variant leads to the formation of nonnative intra- or intermolecular disulfide bonds.

138 This nonnative intramolecular structure could serve as a prec

139 uggesting that they misfold and/or stabilize nonnative intronic structures.

140 thropogenic changes in available habitat and nonnative invasion eliminate the role of evolutionary pr

141 However, nonnative invasion may overwhelm the effect of immigrati

142 esource-use efficiencies in 14 native and 18 nonnative invasive species of common genera found in Eas

143 Nonnative, invasive feral pigs (Sus scrofa) modify habit

144 Here, we quantify the effects of 12 nonnative, invasive grasses on fire occurrence, size, an

145 viruses and virus-like particles (VLPs) bear nonnative "junk" forms of envelope (Env) glycoprotein th

146 ifornia grassland plants in competition with nonnative Lactuca serriola, a species that flowers earli

147 Infants listening to German, a nonnative language that shares key rhythmic and prosodic

148 dies reported that the removal of a dominant nonnative led to competitive release of other nonnatives

149 from multiple Candida species and identified nonnative ligands that can induce self-mating and biofil

150 proposed for distinguishing native-like from nonnative-like membrane protein structures.

151 ed to replicase proteins, but expressed from nonnative locations, mostly late-transcribed subgenomic

152 By using a set of nonnative low-energy structures found by our extensive s

153 erm AGPase remains unsolved, structures of a nonnative, low-activity form of the potato tuber (Solanu

154 When introduced to nonnative mosquito hosts, Wolbachia induce resistance to

155 y prior but remained at low densities until nonnative Mysis became established.

156 The TL circles contain nonnative nucleotides resulting from the 3' end created

157 ssociate with Northern Hemisphere hosts also nonnative, or are some native fungi compatible with nonn

158 The reactivities of nonnative organic peroxide cosubstrates effectively excl

159 Introductions or invasions of nonnative organisms can mediate major changes in the tro

160 a factor in the establishment and spread of nonnative organisms, the colonization of undefended reso

161 n alternative pathway becomes dominant, with nonnative P5abc binding the core and then undergoing an

162 ation is detected in H1-H2 packing in that a nonnative packing orientation is significantly stabilize

163 g of the hydrophobic core to accommodate the nonnative peptidyl-prolyl trans-isomer at Pro32.

164 le of native species diversity in regulating nonnative pest invasions.

165 Nonnative pests often cause cascading ecological impacts

166 ponse to a change of phoneme at a native and nonnative phonetic boundary in full-term and preterm hum

167 ts show a decline in their discrimination of nonnative phonetic contrasts between 9 and 12 months of

168 Nonnative Phragmites australis (common reed) is one of t

169 t this assumption, estimating the effects of nonnative Phragmites australis on a native amphibian.

170 e created phylogenetically paired native and nonnative plant communities in a glasshouse experiment t

171 as anthropogenic nitrogen (N) deposition and nonnative plant invasion.

172 Until now, nonnative plant species were rarely found at high elevat

173 (based on the relatedness between native and nonnative plant species), with insect generalists coloni

174 h N availability also often favors invasive, nonnative plant species, and the loss of woody vegetatio

175 lorida to become the state's most widespread nonnative plant species.

176 onal fires, erosion, and the introduction of nonnative plant species.

177 se expression, the highest yet measured in a nonnative plant.

178 and describe the types of interactions among nonnative plants and determine what factors affect inter

179 Our experiment showed, however, that nonnative plants can establish, grow, and flower well ab

180 Despite reduced per-plant diversity, nonnative plants can support distinctive insect communit

181 Here we propose that nonnative plants introduced to Great Britain may functio

182 tegies centered on monocultural plantings of nonnative plants, largely excluding native species from

183 ve, or are some native fungi compatible with nonnative plants?

184 the functional essentiality of all possible nonnative point mutants in the entire hMC4R protein (332

185 can induce conformational changes and expose nonnative polar domains/residues to the lipid environmen

186 ay in E. coli results in accumulation of the nonnative polyamines diaminopropane and sym-norspermidin

187 e physiological order of addition of ATP and nonnative polypeptide, typically to the open trans ring

188 exert an action of forceful unfolding on the nonnative polypeptide.

189 ain movements, followed by slower binding of nonnative polypeptide.

190 TP-dependent ring-shaped complexes that bind nonnative polypeptides and facilitate protein folding in

191 e molecular mechanism for the recognition of nonnative polypeptides by Type I Hsp40s such as yeast Yd

192 Chaperonins are cage-like complexes in which nonnative polypeptides prone to aggregation are thought

193 ies lined with hydrophobic binding sites for nonnative polypeptides.

194 In contrast, nonnative populations had weaker spatial genetic structu

195 research network comprising 35 native and 18 nonnative populations of Plantago lanceolata Species-spe

196 utants with a single tryptophan residue at a nonnative position 170 (Trp-170) or a native position 7

197 nimal in evolved biological systems although nonnative possibilities are intuitively abundant.

198 ation to the Channel Islands, but native and nonnative prey sources that were important for bald eagl

199 sion of spo0A in the DeltasigK mutant from a nonnative promoter restored solventogenesis and the prod

200 reduce the number and frequency of entering nonnative propagules.

201 e that is characterized by the appearance of nonnative protein aggregates in various tissues.

202 haracterization of structure and dynamics of nonnative protein states is important for understanding

203 ample of tunable boron chemistry in a folded nonnative protein, which offers wide implications in des

204 We show that EDEM1 specifically binds nonnative proteins in a glycan-independent manner.

205 ables cells to cope with the accumulation of nonnative proteins under stress and complete development

206 CP22 results in (i) nuclear sequestration of nonnative proteins, (ii) reduction of cytoplasmic aggres

207 n of apoptosis, prevention of aggregation of nonnative proteins, and the recruitment of a cellular he

208 endering the NTD a conformational sensor for nonnative proteins.

209 eir HSP70 partners to prevent aggregation of nonnative proteins.

210 r chaperones that prevent the aggregation of nonnative proteins.

211 species that flowers earlier in parts of its nonnative range that are drier than its putative Europea

212 There was no evidence that any of the nonnative rDNA units were transcribed; some showed indic

213 ic methodologies provide clear evidence that nonnative RNA can mistakenly map to reference genomes, e

214 of stable virus-like particles encapsidating nonnative RNAs or other cargoes.

215 Here, nonnative rRNA gene [ribosomal DNA (rDNA)] copies were i

216 the inverse sequence of events with the same nonnative salt bridges in the encounter complex.

217 The simulations show that nonnative salt bridges stabilize kinetically the encount

218 ons in which the protein did not fully fold, nonnative salt bridges trapped the protein, which explai

219 * Results show nonnative SAPs are functionally dissimilar to native SAP

220 erences in plant functionality indicate that nonnative SAPs have a competitive advantage over native

221 inguishably from CYT-19 to resolve different nonnative secondary and/or tertiary structures in the Te

222 and alcohol-denatured states with native and nonnative secondary elements supports a hierarchical mec

223 entromeric histone protein CENH3, suggesting nonnative sequences can also function as diatom centrome

224 netic, and genomic analyses implied that the nonnative sequences were acquired between 1 and 5 Mya af

225 onologue either in their native (English) or nonnative (Spanish) language.

226 eness is the phylogenetic distance between a nonnative species and species in the recipient community

227 distribution and abundance, particularly for nonnative species because interactions may influence the

228 w that LCV can immortalize B cells from some nonnative species but that growth transformation is rest

229 eneracy with these properties, as native and nonnative species can overlap.

230 ive phenotypic divergence between native and nonnative species can provide critical insight into the

231 He initially posited that nonnative species closely related to native species woul

232 ively understudied, though the likelihood of nonnative species co-occurrence is high.

233 However, native and nonnative species did not differ systematically in leaf

234 igating ecological and economic impacts once nonnative species establish and spread.

235 Habitat alterations, nonnative species invasion, and water withdrawals during

236 * Nonnative species may change ecosystem functionality at

237 Further, native and nonnative species tended to be less related in warm, hum

238 and those of fine roots for 23 native and 25 nonnative species that occur in temperate deciduous fore

239 ed the impact of the invasion of two noxious nonnative species, Polygonum cuspidatum, which produces

240 ny plant communities are invaded by multiple nonnative species, we have limited information on how a

241 excluded from much of its potential range by nonnative species, will lose a further 58% of habitat du

242 ange, and few ecosystems remain uninvaded by nonnative species.

243 l the northern range limits of many invasive nonnative species.

244 s was random or 84% greater if there were no nonnative species.

245 to a greater degree than nonnative, whereas nonnative speech activates motor brain areas to a greate

246 narrowing make it more difficult to process nonnative speech and require them to continue to access

247 mination task and at 6 and 10 mo of age on a nonnative speech and visual language discrimination task

248 shift attention to the eyes when exposed to nonnative speech because increasing native-language expe

249 eyes at 12 mo in response to native but not nonnative speech.

250 sembly at pH 6.4 results in the formation of nonnative spherical oligomers that disrupt synthetic mem

251 The challenge posed by the competition of nonnative stabilization against native-centric forces is

252 Characterization of nonnative states is critical for the understanding of th

253 tion of D76N-beta(2)m, suggesting that other nonnative states must cause its high aggregation rate.

254 However, metastability and a web of nonnative states slow the average folding rate.

255 Two of the force fields yield compact nonnative states with misplaced alpha-helix content with

256 hub that can facilitate transitions between nonnative states.

257 stence of a folding intermediate of GB3 with nonnative structural elements.

258 ulation characterized by a higher content of nonnative structure (NNS).

259 tifies regions that unfold or rearrange into nonnative structure during the N --> MG transition.

260 reconstructed the energy landscape governing nonnative structure formation.

261 based coarse-grained models do not allow for nonnative structure formation.

262 We recently observed the formation of a nonnative structure in a peptide model of the C-terminus

263 ms that uncleaved gp140 proteins may adopt a nonnative structure with three gp120 moieties "dangling"

264 work at an early stage of folding suppresses nonnative structures and guides the search for the nativ

265 the polypeptide chain to transiently sample nonnative structures before the formation of the product

266 e state generally has lower free energy than nonnative structures but is exceedingly difficult to loc

267 imulation studies, we note the occurrence of nonnative structures intermediates, which may yield a na

268 rmed conformers, some of which have aberrant nonnative structures.

269 hat this pathway is the least likely to form nonnative structures.

270 imilarity of functional traits of native and nonnative submersed aquatic plants (SAP) in an aquatic e

271 as much Rubisco activity was recovered when nonnative substrate protein was added after ATP compared

272 lypeptide, enables more efficient capture of nonnative substrate proteins, and thus allows greater re

273 ivation, during discrimination of native and nonnative syllables in infants at two ages that straddle

274 e to speech, and equivalently for native and nonnative syllables.

275 phylogenetic relatedness between native and nonnative taxa across thousands of nested locations rang

276 Our results suggest high invasion risk for nonnative taxa including Saccharum spontaneum L., a list

277 the relative importance of nativelike versus nonnative tertiary contacts for the folding transition.

278 Seedling establishment was 46% lower in nonnative than in native communities and was correlated

279 Our study proves the black francolin was nonnative to the western Mediterranean, and we document

280 We find that nonnative topologies (arrangement of helices) occur freq

281 major determinant of whether the RNA adopts nonnative topology during folding.

282 intermediates as we investigate the role of nonnative topology in dictating the lifetime of the inte

283 merization of Pro32 from its native cis to a nonnative trans conformation is thought to trigger beta2

284 m, known as the I(T)-state, which contains a nonnative trans Pro-32, has been shown to be a key precu

285 ultiple pathways, facilitated by a number of nonnative transient hydrogen bonds, thus lowering the tr

286 on the northern range limits of an invasive nonnative tree-Schinus terebinthifolius (Brazilian peppe

287 associated with SOD1 aggregation in ALS to a nonnative trimeric SOD1 species.

288 The reason for this paradox is that past nonnative trout invasions and habitat loss have restrict

289 he Upper Colorado River Basin, owing to past nonnative trout invasions and habitat loss.

290 method to map the disulfide bonds present in nonnative uncleaved gp140 proteins and native-like SOSIP

291 ction, but the responses of soil microbes to nonnative ungulate removal remains poorly studied.

292 To assess the energetic favorability of nonnative versus native interactions, we compute free en

293 Nonnative viral glycoproteins, including Friend murine l

294 erse viral families can be incorporated into nonnative viral particles in a process termed pseudotypi

295 three times more frequent when a neighboring nonnative was a nitrogen fixer and 3.5 times lower when

296 fixer and 3.5 times lower when a neighboring nonnative was an annual.

297 itly includes all misfolded microstates with nonnative Watson-Crick (WC) and non-WC contacts.

298 uditory brain areas to a greater degree than nonnative, whereas nonnative speech activates motor brai

299 invasion and for prioritizing management of nonnatives with a higher likelihood of positive interact

300 osition rates of leaves for 42 native and 36 nonnative woody species, and those of fine roots for 23

301 Therefore, these results suggest why these nonnative zinc ligands in the CH1(1) motif are conserved