ライフサイエンスコーパス: nonreceptor tyrosine kinase

1 ABL2, also known as ARG, a membrane-anchored nonreceptor tyrosine kinase.

2 ndependent of the Smad proteins is the c-Abl nonreceptor tyrosine kinase.

3 ing the interaction of a P-type ATPase and a nonreceptor tyrosine kinase.

4 or through phosphorylation of Abl by the Src nonreceptor tyrosine kinase.

5 al consequence of expression of an activated nonreceptor tyrosine kinase.

6 v-Abl is an oncogenic form of the c-Abl nonreceptor tyrosine kinase.

7 ells, demonstrating its ability to inhibit a nonreceptor tyrosine kinase.

8 The v-src oncogene encodes a nonreceptor tyrosine kinase.

9 n kinase C, or herbimycin A, an inhibitor of nonreceptor tyrosine kinase.

10 f activated Cdc42-associated kinase (Ack), a nonreceptor tyrosine kinase.

11 strate of the Abl and Abl-related gene (Arg) nonreceptor tyrosine kinases.

12 ional molecule such as CD44, which activates nonreceptor tyrosine kinases.

13 ation by p210bcr/abl as well as receptor and nonreceptor tyrosine kinases.

14 rosine kinases or proteasomal degradation of nonreceptor tyrosine kinases.

15 rged as a negative regulator of receptor and nonreceptor tyrosine kinases.

16 ers of this family associate with Jak family nonreceptor tyrosine kinases.

17 h factor, nerve growth factor receptors, and nonreceptor tyrosine kinases.

18 f neuronal potassium current by receptor and nonreceptor tyrosine kinases.

19 o-related GTP-binding proteins, PKC-zeta and nonreceptor tyrosine kinases.

20 d, which encodes a phosphoprotein that binds nonreceptor tyrosine kinases.

21 sponse to activation of various receptor and nonreceptor tyrosine kinases.

22 ignaling adaptor that regulates receptor and nonreceptor tyrosine kinases.

23 e kinase 1) is a member of the Ack family of nonreceptor tyrosine kinases.

24 own as Etk, is a member of the Tec family of nonreceptor tyrosine kinases.

25 Activation of the nonreceptor tyrosine kinase Abelson (Abl) contributes to

26 Using MEDUSA, we find that the conserved nonreceptor tyrosine kinase Abelson (Abl) contributes to

27 nt proteomic analysis has predicted that the nonreceptor tyrosine kinase Abelson murine leukemia vira

28 Nonreceptor tyrosine kinase Abl is an actin-binding prot

29 ABL1 gene encodes the ubiquitously expressed nonreceptor tyrosine kinase ABL.

30 yrosine 88 of p27 for phosphorylation by the nonreceptor tyrosine kinase Abl.

31 onsensus sequence for phosphorylation by the nonreceptor tyrosine kinases Abl and Arg.

32 C-abl oncogene 1, nonreceptor tyrosine kinase (ABL1) kinase inhibitors suc

33 he SH3-binding site of ABL proto-oncogene 1, nonreceptor tyrosine kinase (ABL1), so we investigated t

34 Here, we report that the cdc42-activated, nonreceptor tyrosine kinase, Ack1, is a DAT endocytic br

35 Many receptor and nonreceptor tyrosine kinases activate phosphoinositide 3

36 Abl family kinases are nonreceptor tyrosine kinases activated by diverse cellul

37 signaling pathways required for receptor and nonreceptor tyrosine kinase activation by H2O2 involving

38 sis.SIGNIFICANCE STATEMENT The Src family of nonreceptor tyrosine kinases acts in signaling pathways

39 Expression of the receptor and nonreceptor tyrosine kinases, alpha platelet-derived gro

40 pp60(c-src) is a prototypical nonreceptor tyrosine kinase and may play a role in disea

41 Bruton's tyrosine kinase (BTK), a nonreceptor tyrosine kinase and member of the TEC family

42 and Fc gamma RIIIb required activation of a nonreceptor tyrosine kinase and phosphatidylinositol 3-k

43 vation such as BMX and STS (encoding for Bmx nonreceptor tyrosine kinase and steroid sulfatase, respe

44 The c-Abl nonreceptor tyrosine kinase and the c-Jun NH2-terminal k

45 1 (activated Cdc42-associated kinase 1) is a nonreceptor tyrosine kinase and the only tyrosine kinase

46 lization, down-regulation, and signaling via nonreceptor tyrosine kinases and mitogen-activated prote

47 ne kinase (BTK) belongs to the TEC family of nonreceptor tyrosine kinases and plays a critical role i

48 -containing proteins, including receptor and nonreceptor tyrosine kinases and their phosphorylated su

49 onal responses to cytokines, growth factors, nonreceptor tyrosine kinases, and a variety of oncogenic

50 Both Arp2/3 complex and the Abl2/Arg nonreceptor tyrosine kinase are essential to form and ma

51 Src family nonreceptor tyrosine kinases are an integral component o

52 Jak (Janus kinase) family nonreceptor tyrosine kinases are central mediators of cy

53 The Src family of nonreceptor tyrosine kinases are important regulators of

54 The activities of the related Abl and Arg nonreceptor tyrosine kinases are kept under tight contro

55 Tec family nonreceptor tyrosine kinases are key immunological enzym

56 sponse to ligand-receptor interaction, these nonreceptor tyrosine kinases are rapidly phosphorylated

57 the Abelson (Abl) and Abl-related gene (Arg) nonreceptor tyrosine kinases are required for maintenanc

58 dy, we provide evidence that the Abl-related nonreceptor tyrosine kinase Arg mediates epidermal growt

59 Extracellular cues stimulate the Abl family nonreceptor tyrosine kinase Arg to promote actin-based c

60 The Abl family nonreceptor tyrosine kinase Arg/Abl2 interacts with cort

61 dc42-associated kinase (ACK) is an oncogenic nonreceptor tyrosine kinase associated with poor prognos

62 point cluster region - ABL proto-oncogene 1, nonreceptor tyrosine kinase (BCR-ABL1) antagonist inhibi

63 factor receptors EGFR, VEGFR, and FGFR) and nonreceptor tyrosine kinases (Bcr-Abl), where advances h

64 Cbl and the Abl nonreceptor tyrosine kinase both bind to SH3 domains fro

65 ch then sequentially bound and activated the nonreceptor tyrosine kinases Bruton's tyrosine kinase (B

66 Mutations in the nonreceptor tyrosine kinase Btk result in the B cell imm

67 ctivation of G(alphaq) and both receptor and nonreceptor tyrosine kinases but that is independent of

68 a in bone marrow, expression of receptor and nonreceptor tyrosine kinases by androgen-independent PCa

69 transduces promitogenic signals from various nonreceptor tyrosine kinases by orchestrating its own ph

70 Expression of the nonreceptor tyrosine kinase c-Abl and Smad1 was blocked

71 (IR) treatment results in activation of the nonreceptor tyrosine kinase c-Abl because of phosphoryla

72 Oligomerization of the nonreceptor tyrosine kinase c-Abl can activate its trans

73 The ubiquitously expressed nonreceptor tyrosine kinase c-Abl contains three nuclear

74 Here, we report that hyperactivity of the nonreceptor tyrosine kinase c-Abl critically regulates a

75 The requirement for the nonreceptor tyrosine kinase c-abl in the pathogenesis of

76 The nonreceptor tyrosine kinase c-Abl is tightly regulated i

77 Here we show that the nonreceptor tyrosine kinase c-Abl phosphorylates tyrosin

78 The ubiquitously expressed nonreceptor tyrosine kinase c-Abl regulates stress respo

79 en NRP-1, the scaffold protein GIPC, and the nonreceptor tyrosine kinase c-Abl that augmented alpha5b

80 We show that the nonreceptor tyrosine kinase c-SRC (SRC) is a key modulat

81 tigen (PyMT) oncogene activates the cellular nonreceptor tyrosine kinase c-Src and recruits the Hippo

82 n kinase Calpha (PKCalpha) activation of the nonreceptor tyrosine kinase c-Src and the subsequent for

83 The localization of the nonreceptor tyrosine kinase c-Src appeared disrupted in

84 The function of the nonreceptor tyrosine kinase c-Src as a plasma membrane-a

85 have investigated the role of the ubiquitous nonreceptor tyrosine kinase c-Src in activation of the M

86 dermal growth factor receptor (EGFR) and the nonreceptor tyrosine kinase c-Src may contribute to an a

87 The catalytic activity of the nonreceptor tyrosine kinase c-Src, but not the epidermal

88 tablished a complex consisting of MerTK, the nonreceptor tyrosine kinase c-Src, the transcription fac

89 trates its utility in activity assays of the nonreceptor tyrosine kinase c-Src.

90 e demonstrated that bradykinin activates the nonreceptor tyrosine kinase c-src.

91 study that occludin was colocalized with the nonreceptor tyrosine kinase c-Yes at cell junction areas

92 In addition, we show that the nonreceptor tyrosine kinase c-Yes is contained within EB

93 formation in epithelial cells, and that the nonreceptor tyrosine kinase c-Yes is involved in the reg

94 ical EBP50 protein complexes, containing the nonreceptor tyrosine kinase c-Yes, may regulate apical s

95 proteins have been identified, including the nonreceptor tyrosine kinases c-Abl and Arg, and the guan

96 ed kinase-2 (PAK2) and activation of abelson nonreceptor tyrosine kinase (c-abl) have been shown rece

97 We previously identified SRC proto-oncogene, nonreceptor tyrosine kinase (c-Src), as an essential hos

98 cle and is modulated by endogenous levels of nonreceptor tyrosine kinase, c-src.

99 ma subunit-mediated activation of Src family nonreceptor tyrosine kinases can account for the Gi-coup

100 The 32 nonreceptor tyrosine kinases can be placed in 10 subfami

101 ta pathways results in the activation of the nonreceptor tyrosine kinase cellular Abelson (c-Abl), an

102 dies have demonstrated a requirement for the nonreceptor tyrosine kinase, cellular Src (c-Src), in ep

103 The Abl family nonreceptor tyrosine kinases, consisting of closely rela

104 The Abl family of mammalian nonreceptor tyrosine kinases consists of c-Abl and ARG (

105 The Abl family of nonreceptor tyrosine kinases consists of two related pro

106 ation of a single C-terminal tyrosine by the nonreceptor tyrosine kinase Csk.

107 Here we report that the nonreceptor-tyrosine-kinase Csk is an essential componen

108 Here we identify CaMKII and the nonreceptor tyrosine kinase DFak as critical intermediat

109 The nonreceptor tyrosine kinase encoded by the c-Abl gene ha

110 The nonreceptor tyrosine kinase, encoded by the v-Abl oncoge

111 wth by modulating the expression of PEAK1, a nonreceptor tyrosine kinase essential for PDAC cell grow

112 Janus kinase 3 (Jak3) is a nonreceptor tyrosine kinase essential for signaling via

113 Janus kinase 3 (Jak3) is a nonreceptor tyrosine kinase expressed in both hematopoie

114 The nonreceptor tyrosine kinase FAK ("focal adhesion kinase"

115 on-independent activation of MET through the nonreceptor tyrosine kinase feline sarcoma-related (FER)

116 cells with JMP results in the release of the nonreceptor tyrosine kinase Fer from the cadherin comple

117 Previous characterization of the nonreceptor tyrosine kinase FER identified a tight physi

118 Here, we demonstrated the role of the nonreceptor tyrosine kinase Fes, abundantly expressed in

119 The c-fes protooncogene encodes a nonreceptor tyrosine kinase (Fes) implicated in cytokine

120 The c-fes protooncogene encodes a nonreceptor tyrosine kinase (Fes) implicated in cytokine

121 The nonreceptor tyrosine kinase focal adhesion kinase (FAK)

122 The activity of the nonreceptor tyrosine kinase, focal adhesion kinase (FAK)

123 We found that three nonreceptor tyrosine kinases, focal adhesion kinase (FAK

124 ar focal adhesions is the interaction of two nonreceptor tyrosine kinases, focal adhesion kinase (FAK

125 The product of the c-abl protooncogene is a nonreceptor tyrosine kinase found in both the cytoplasm

126 e Caenorhabditis elegans ortholog of the Fer nonreceptor tyrosine kinase, FRK-1, limits Wnt signaling

127 , we found that activation of the Src family nonreceptor tyrosine kinase Fyn in oligodendrocytes lead

128 ng pathway elucidated to date, converging on nonreceptor tyrosine kinase Fyn.

129 Bmx nonreceptor tyrosine kinase has an established role in e

130 The SH3-SH2-kinase domain arrangement in nonreceptor tyrosine kinases has been conserved througho

131 The Src family of nonreceptor tyrosine kinases has been implicated in many

132 ow kinase in chromosome X (Bmx), an arterial nonreceptor tyrosine kinase, has been shown to inhibit c

133 Etk/Bmx, a member of the Tec family of nonreceptor tyrosine kinases, has been implicated in the

134 The SH3 domains of src and other nonreceptor tyrosine kinases have been shown to associat

135 Inhibitors of the JAK family of nonreceptor tyrosine kinases have demonstrated clinical

136 duction by transforming variants of c-Fes, a nonreceptor tyrosine kinase implicated in cytokine signa

137 c-Src is an extensively studied nonreceptor tyrosine kinase implicated in mammary tumori

138 Furthermore, focal adhesion kinase (FAK), a nonreceptor tyrosine kinase important for regulating cel

139 t little is known about the function of this nonreceptor tyrosine kinase in chronic lymphocytic leuke

140 rk has shown that disruption of the Abl2/Arg nonreceptor tyrosine kinase in mice compromises spine st

141 We have studied the role of Src family nonreceptor tyrosine kinases in G protein-coupled recept

142 s most likely the scm gene, thus implicating nonreceptor tyrosine kinases in neuronal migration and l

143 We have examined the role of the nonreceptor tyrosine kinases in the signaling mechanism(

144 iating cytokine signaling, the role of other nonreceptor tyrosine kinases in this process remains unc

145 s a role for Arg, a member of the Abl family nonreceptor tyrosine kinases, in the regulation of adhes

146 n to increase the kinase activity of several nonreceptor tyrosine kinases including Jak2 and c-Src.

147 Caveolin-1 is a substrate for nonreceptor tyrosine kinases including Src, Fyn, and Abl

148 urn, may through integrin signaling activate nonreceptor tyrosine kinases, including p72Syk, and late

149 The Tec family nonreceptor tyrosine kinase inducible T cell kinase (ITK

150 Pretreatment of OK cells with the nonreceptor tyrosine kinase inhibitors genistein and her

151 c-Abl, a conserved nonreceptor tyrosine kinase, integrates genotoxic stress

152 hose activity is stimulated by I-R. c-Abl, a nonreceptor tyrosine kinase, interacts with ATM and is a

153 Focal adhesion kinase (FAK) is a nonreceptor tyrosine kinase involved in development and

154 The c-abl proto-oncogene encodes a nonreceptor tyrosine kinase involved in many cellular pr

155 he c-Abl protein is a ubiquitously expressed nonreceptor tyrosine kinase involved in the development

156 The c-Abl nonreceptor tyrosine kinase is activated by growth facto

157 The Abl nonreceptor tyrosine kinase is activated by ligand-stimu

158 demonstrate that the Abl-related gene (Arg) nonreceptor tyrosine kinase is required for dynamic lame

159 Signaling by a variety of receptor and nonreceptor tyrosine kinases is mediated by Ras, a membr

160 functions of the Src homology 2 sequences of nonreceptor tyrosine kinases is to provide a binding sit

161 Bruton tyrosine kinase (BTK), a nonreceptor tyrosine kinase, is a major therapeutic targ

162 Bruton's tyrosine kinase (BTK), a nonreceptor tyrosine kinase, is a member of the Tec fami

163 Here we show that Src, a nonreceptor tyrosine kinase, is overexpressed in androge

164 e that c-Fes, unlike c-Src, c-Abl, and other nonreceptor tyrosine kinases, is constitutively oligomer

165 The nonreceptor tyrosine kinases Jak1 and Jak3, which bind t

166 recurrent somatic activating mutation in the nonreceptor tyrosine kinase JAK2 (JAK2V617F) occurs in t

167 nvolve members of the Janus kinase family of nonreceptor tyrosine kinases JAK2, TYK2, and signal tran

168 5, a somatic activating mutation in the JAK2 nonreceptor tyrosine kinase (JAK2V617F) was identified i

169 dy is that contrary to previous reports, the nonreceptor tyrosine kinase, Jak3 (Janus kinase 3), does

170 s are thought to involve the Janus family of nonreceptor tyrosine kinases (JAKs) and the signal trans

171 M140, the focal adhesion kinase p125(fak), a nonreceptor tyrosine kinase known to mediate integrin-de

172 Cbl associates with the lymphoid-restricted nonreceptor tyrosine kinase Lck, but the functional rele

173 hsp90-dependent protein, the T cell-specific nonreceptor tyrosine kinase lck.

174 toplasmic tail and forward signaling via the nonreceptor tyrosine kinases Lck and Zap70.

175 Here, we present the first evidence that the nonreceptor tyrosine kinase, Matk/CHK, is an important m

176 phatidylinositol (GPI)-anchored proteins and nonreceptor tyrosine kinases may preferentially partitio

177 hibition of inducible T-cell kinase (ITK), a nonreceptor tyrosine kinase, may represent a novel treat

178 We have cloned, expressed, and purified the nonreceptor tyrosine kinase MbSrc1 from the choanoflagel

179 These studies identify a regulated nonreceptor tyrosine kinase-mediated pathway for targeti

180 Here, we report that the c-Abl nonreceptor tyrosine kinase negatively regulates the rep

181 binding to LFA-1 results in activation of a nonreceptor tyrosine kinase (NRTK) signaling cascade.

182 Focal adhesion kinase (FAK) is a nonreceptor tyrosine kinase (NRTK) with key roles in int

183 -1 by other Src homology 2 domain-containing nonreceptor tyrosine kinases (NRTKs).

184 human leukemias, whose protein product is a nonreceptor tyrosine kinase of unknown function.

185 Nonreceptor tyrosine kinases of the Src family are large

186 We found that BLK--a nonreceptor tyrosine-kinase of the src family of proto-o

187 The nonreceptor tyrosine kinase (p60src) is implicated in L1

188 The integrin-signaling nonreceptor tyrosine kinase, p72Syk, was activated in PM

189 Members of the JAK family of nonreceptor tyrosine kinases play a critical role in the

190 In attempts to determine whether nonreceptor tyrosine kinases play a fundamental role in

191 The Jak (Janus) family of nonreceptor tyrosine kinases plays a critical role in cy

192 The nonreceptor tyrosine kinase pp60(c-src) was required for

193 isolate the src homology (SH2) domain of the nonreceptor tyrosine kinase pp60c-src and beta-lactamase

194 rylation also required the activation of Src nonreceptor tyrosine kinase: pretreatment of cells with

195 inhibit the kinase activity of a receptor or nonreceptor tyrosine kinase, preventing downstream signa

196 Src, a nonreceptor tyrosine kinase proto-oncogene, reportedly m

197 The nonreceptor tyrosine kinase, proto-oncogene cAbl is a su

198 been previously demonstrated, e.g., via the nonreceptor tyrosine kinase PYK2 and by Ca(2+)/calmoduli

199 e alpha5beta1 integrin and activation of the nonreceptor tyrosine kinase PYK2 by PKC, most likely PKC

200 this study, we investigated the role of the nonreceptor tyrosine kinase Pyk2 during HPV16 pseudoviri

201 this study, we investigated the role of the nonreceptor tyrosine kinase Pyk2 during human papillomav

202 The nonreceptor tyrosine kinase Pyk2 is highly expressed in

203 In this study, we demonstrate that the nonreceptor tyrosine kinase Pyk2 phosphorylates tyrosine

204 KC), intracellular Ca(2+) ([Ca(2+)](i)), and nonreceptor tyrosine kinases Pyk2 and Src play in the ac

205 w that concomitant targeting of EGFR and the nonreceptor tyrosine kinases PYK2/FAK synergistically in

206 n 120 (gp120) induces phosphorylation of the nonreceptor tyrosine kinase, Pyk2.

207 Abl family nonreceptor tyrosine kinases regulate cellular morphogen

208 The c-Abl nonreceptor tyrosine kinase regulates actin responses in

209 Focal adhesion kinase (FAK) is an essential nonreceptor tyrosine kinase regulating cell migration, a

210 pyrimidine (PP1), suggesting that Src family nonreceptor tyrosine kinases represent a point of conver

211 ncentrate on Spleen tyrosine kinase (Syk), a nonreceptor tyrosine kinase required to transduce BCR-de

212 in ligase activity that targets receptor and nonreceptor tyrosine kinases, resulting in their ubiquit

213 Expression of v-Src, a transforming nonreceptor tyrosine kinase, results in Ras activation,

214 Hck, a Src family nonreceptor tyrosine kinase (SFK), has recently been est

215 the expression pattern of the Src family of nonreceptor tyrosine kinases (SFK) in mouse embryonic st

216 RY)2 as a negative regulator of receptor and nonreceptor tyrosine kinase signaling in the pathogenesi

217 2, adaptors that normally integrate receptor/nonreceptor tyrosine kinase signaling into PI3K/AKT, rev

218 hese mice and discovered a central role of a nonreceptor tyrosine kinase, spleen tyrosine kinase (SYK

219 uld significantly decrease activation of the nonreceptor tyrosine kinase Src and activation of cAbl i

220 In the case of the membrane-bound nonreceptor tyrosine kinase Src from Rous sarcoma virus,

221 The nonreceptor tyrosine kinase Src has been implicated in t

222 Previously, we established a role for the nonreceptor tyrosine kinase Src in signaling cardiac myo

223 The nonreceptor tyrosine kinase Src is expressed at a high l

224 We report that the nonreceptor tyrosine kinase Src phosphorylates botulinum

225 cogenic potential of Ras is dependent on the nonreceptor tyrosine kinase Src to promote the Ras/Raf/M

226 t Tyr-67 by the FGF15/19 signaling-activated nonreceptor tyrosine kinase Src was shown to be importan

227 to lipid rafts, where it interacts with the nonreceptor tyrosine kinase Src, is a prerequisite for f

228 ere, we show that PC1-p30 interacts with the nonreceptor tyrosine kinase Src, resulting in Src-depend

229 The nonreceptor tyrosine kinase Src, which has been associat

230 s the tyrosine phosphorylation of Akt by the nonreceptor tyrosine kinase Src, which is critical for A

231 t post-VEGF receptor levels and involves the nonreceptor tyrosine kinase Src.

232 e inhibitors, and specific inhibitors of the nonreceptor tyrosine kinase Src.

233 lly activate downstream targets, such as the nonreceptor tyrosine kinase Src.

234 l membrane targeting domain, mediated by the nonreceptor tyrosine kinase Src.

235 The nonreceptor tyrosine kinases Src and FAK regulate focal-

236 rectly phosphorylated by SRC proto-oncogene, nonreceptor tyrosine kinase (SRC) at Tyr(198) We demonst

237 Here, we show that SRC proto-oncogene, nonreceptor tyrosine kinase (SRC) is an important driver

238 somes allows delivery of SRC proto-oncogene, nonreceptor tyrosine kinase (SRC) to the plasma membrane

239 CA1 AuAbs also activated SRC proto-oncogene, nonreceptor tyrosine kinase (SRC).

240 Here we provided evidence on the role of nonreceptor tyrosine kinase, Src, in hyperoxia-induced t

241 udies with genistein and PP2 showed that the nonreceptor tyrosine kinase, Src, is an upstream stimula

242 tified as an SH3/SH2 binding partner for the nonreceptor tyrosine kinase, Src.

243 hosphorylated mammalian Disabled can recruit nonreceptor tyrosine kinases, such as src and abl, to th

244 al growth factor receptor (EGF-R) as well as nonreceptor tyrosine kinases, such as Src, have been imp

245 We have identified the nonreceptor tyrosine kinase syk as a marker of different

246 The nonreceptor tyrosine kinase SYK has recently received a

247 rosine-based activation motif (ITAM) and the nonreceptor tyrosine kinase Syk.

248 es TNFalpha and IL1-beta was mediated by the nonreceptor tyrosine kinase, Syk.

249 tion that encodes a constitutively activated nonreceptor tyrosine kinase termed P210(BCR-ABL).

250 Jak2 is a nonreceptor tyrosine kinase that acts in numerous cellul

251 ACK1 is a nonreceptor tyrosine kinase that associates specifically

252 Tyrosine kinase 2 (TYK2) is a nonreceptor tyrosine kinase that belongs to the JAK fami

253 Src is a nonreceptor tyrosine kinase that coordinates responses t

254 ted Cdc42-associated tyrosine kinase-2) is a nonreceptor tyrosine kinase that is a specific target/ef

255 c-Abl is a nonreceptor tyrosine kinase that is activated by certain

256 Focal adhesion kinase (FAK) is a nonreceptor tyrosine kinase that is activated by integri

257 p56lck is a nonreceptor tyrosine kinase that is essential for signal

258 Spleen tyrosine kinase (Syk) is a nonreceptor tyrosine kinase that is expressed primarily

259 Brk (breast tumor kinase) is a nonreceptor tyrosine kinase that is most closely related

260 Breast tumor kinase (Brk) is a nonreceptor tyrosine kinase that is overexpressed in a h

261 C-Abl is a nonreceptor tyrosine kinase that is tightly regulated in

262 PEAK1 is a 190-kDa nonreceptor tyrosine kinase that localizes to actin fila

263 e H2O2-dependent phosphorylation of c-Abl, a nonreceptor tyrosine kinase that modulates the actin cyt

264 Focal adhesion kinase (FAK) is a nonreceptor tyrosine kinase that on activation generates

265 Ack1 is a nonreceptor tyrosine kinase that participates in tumorig

266 Focal adhesion kinase (FAK) is a nonreceptor tyrosine kinase that plays a critical role i

267 Focal adhesion kinase (FAK) is a nonreceptor tyrosine kinase that plays an important role

268 Y245 phosphorylation of endogenous c-Abl, a nonreceptor tyrosine kinase that reciprocally regulates

269 Focal adhesion kinase (FAK) is a nonreceptor tyrosine kinase that regulates cell signalin

270 In this study, we focused on JAK3, the nonreceptor tyrosine kinase that signals from the IL-2R,

271 c-Abl is a nonreceptor tyrosine kinase that we have recently linked

272 longs to a new group of structurally related nonreceptor tyrosine kinases that also includes Btk and

273 Src family kinases (SFKs) are a group of nonreceptor tyrosine kinases that are characterized by t

274 Syk and ZAP-70 form a subfamily of nonreceptor tyrosine kinases that contain tandem SH2 dom

275 and Arg proteins comprise a unique family of nonreceptor tyrosine kinases that have been implicated i

276 inase (Brk) is a member of the Frk family of nonreceptor tyrosine kinases that is overexpressed in a

277 ndocytosis of cell-surface receptors and Abl nonreceptor tyrosine kinases that participate in actin c

278 Abl and Arg define a family of nonreceptor tyrosine kinases that regulate actin-depende

279 l and the Abl-related gene product (Arg) are nonreceptor tyrosine kinases that regulate the actin cyt

280 g in transgenic mice deficient in a specific nonreceptor tyrosine kinase (the fyn mutant).

281 n alpha3 interacts functionally with the Arg nonreceptor tyrosine kinase to activate p190RhoGAP, whic

282 gnal through the Abl2/Arg (Abl-related gene) nonreceptor tyrosine kinase to control fibroblast cell m

283 to-oncogene (MET) through SRC proto-oncogene nonreceptor tyrosine kinase to maximize cellular invasio

284 s are responsible for the attachment of this nonreceptor tyrosine kinase to the membrane-solution int

285 ons show that TNFR1 associates with and uses nonreceptor tyrosine kinases to engage signaling pathway

286 ransduction from growth factor receptors and nonreceptor tyrosine kinases to Ras.

287 As a member of the Janus (JAK) family of nonreceptor tyrosine kinases, TYK2 plays an important ro

288 e SH2 domains are positive regulators of the nonreceptor tyrosine kinases, we tested whether this put

289 The Crk SH2/SH3 adaptor and the Abl nonreceptor tyrosine kinase were first identified as onc

290 kinase (c-Abl) is a ubiquitously expressed, nonreceptor tyrosine kinase which plays a key role in ce

291 the role of spleen tyrosine kinase (SYK), a nonreceptor tyrosine kinase, which has a central modulat

292 en tyrosine kinase (Syk) is an intracellular nonreceptor tyrosine kinase, which has been implicated a

293 Jak (Janus kinase) is a nonreceptor tyrosine kinase, which plays important roles

294 e inhibitor p27Kip1 on a tyrosine residue by nonreceptor tyrosine kinases, which decreases p27 stabil

295 ism of STAT3 activation by the Src family of nonreceptor tyrosine kinases, which have been linked to

296 is coupled either directly or indirectly to nonreceptor tyrosine kinases, which phosphorylate and th

297 The protooncogene c-abl encodes a nonreceptor tyrosine kinase whose cellular function is u

298 Focal adhesion kinase (FAK) is a nonreceptor tyrosine kinase whose focal adhesion targeti

299 SRC is a nonreceptor tyrosine kinase with key roles in breast can

300 Janus kinases (JAKs) are nonreceptor tyrosine kinases with a tandem pseudokinase-