ライフサイエンスコーパス: nonselective

1 ossible structures should be inactive and/or nonselective.

2 in production but is generally thought to be nonselective.

3 in degradation, however, is considered to be nonselective.

4 e integrating into host chromosomes is locus nonselective.

5 l of A(3)R in complex with two agonists, the nonselective 1-(6-amino-9H-purin-9-yl)-1-deoxy-N-ethyl-b

6 ons in 5alphaR1 activity in obesity and with nonselective 5alpha-reductase inhibition in men with pro

7 The nonselective 5alpha-reductase inhibitor finasteride indu

8 pha-blockers preoperatively (selective, 587; nonselective, 627; both, 40).

9 the leak channel NALCN (sodium leak channel, nonselective), ablating AITC detection by nociceptors.

10 ned antidepressant effects of scopolamine, a nonselective acetylcholine muscarinic receptor antagonis

11 as the dose-limiting toxicity caused by the nonselective action on normal tissues by such drugs.

12 btypes, i.e., many antagonists considered as nonselective actually are beta3-sparing, including propr

13 g A2A and A2B receptor transcripts, only the nonselective adenosine agonist NECA (5'-N-ethylcarboxami

14 lays the desired profile in vitro with high, nonselective affinity for the MOP, KOP, and DOP receptor

15 izations of 1,2-bis(2-nitroaryl)ethenes were nonselective, affording mixtures of monocyclized indoles

16 ere we report fluorescent derivatives of the nonselective agent asenapine which were designed, synthe

17 h cox-2>cox-1 inhibition (eg, naproxen), and nonselective agents with cox-1>cox-2 inhibition (eg, ibu

18 Nonselective agents with cox-1>cox-2 inhibition were not

19 selective cox-2 inhibitors (eg, celecoxib), nonselective agents with cox-2>cox-1 inhibition (eg, nap

20 Nonselective alpha- and beta-adrenergic antagonists or s

21 IS in all groups (those taking selective and nonselective alpha-antagonists and also those not taking

22 Nonselective alpha-antagonists caused IFIS at a higher p

23 The use of either selective or nonselective alpha-antagonists preoperatively demonstrat

24 Inspired by the discovery of the nonselective aminotransferase inactivator (1R,3S,4S)-3-a

25 TPC1 is selective for Ca(2+) over Na(+), but nonselective among monovalent cations (Li(+), Na(+), and

26 ase chain reaction (TOP-PCR) for full-length nonselective amplification of minute quantity of DNA fra

27 olving this pathway, but current methods are nonselective and are not applicable to measurement of th

28 al transient receptor potential 6 (TRPC6), a nonselective and Ca(2+)-permeable cation channel, mediat

29 = 5) and omega-agatoxin-IVA (100 nM, n = 3), nonselective and Cav2.1 Ca(2+) channel blockers, respect

30 This role of BACE2 implies that nonselective and chronic inhibition of BACE1 may cause s

31 f HDAC8 in therapeutic adaptation, with both nonselective and HDAC8-specific inhibitors enhancing the

32 have found that the RHOGAP domain itself is nonselective and in some cases rather inefficient under

33 gy, resulting in a robust protocol which was nonselective and reproducible (the overall success ident

34 Notably, the Sq dye in solution state is nonselective and responds to any thiol-containing protei

35 y protein kinases C and A, we used different nonselective and selective kinase inhibitors and activat

36 S. aureus was isolated using nonselective and selective media.

37 How is cargo sequestration regulated under nonselective and selective types of autophagy?

38 at lateralis synaptogenesis is intrinsically nonselective and that interaxonal interactions continuou

39 such electrophilic fragments were considered nonselective and were rarely screened.

40 n administered in the presence of estradiol (nonselective) and genistein (ERbeta-selective), respecti

41 tes to thionated NDIs are generally lengthy, nonselective, and low yielding and their polymeric analo

42 Because many fishing gears are nonselective, and the costs of making gear selective can

43 A neutralizing antiserum against AnxA1 and a nonselective antagonist of AnxA1 receptor abolished the

44 reatment of dystonia is pharmacotherapy with nonselective antagonists of muscarinic acetylcholine rec

45 Nonselective antagonists of voltage-gated sodium (Na(V))

46 xA1 pathway (by using N-t-Boc-Met-Leu-Phe, a nonselective AnxA1 receptor antagonist, or by using an a

47 these discrepancies can be explained by the nonselective application of relative perfusion threshold

48 Unlike nonselective approaches targeting the entire T cell popu

49 We showed that injection of mice with a nonselective AR agonist, 5'-N-ethylcarboxamidoadenosine

50 the alpha7 subtype of nAchRs, similar to the nonselective AR antagonist caffeine, taken as the refere

51 Although previous, nonselective attenuation of CRH production or action, ge

52 some fusion events controlling selective and nonselective autophagy pathways.

53 nt knowledge derives mostly from settings of nonselective autophagy, recent work also indicates that

54 critical role in the efficient induction of nonselective autophagy.

55 ying the onset of AD and could be safer than nonselective BACE inhibitor drugs.

56 Na(+), which is reminiscent of the SF in the nonselective bacterial NaK channel.

57 und to be RAN-preferring, SEQ-preferring, or nonselective based on total firing rate.

58 ant antihyperalgesia cannot be achieved with nonselective BDZs.

59 Nonselective beta blockers (NSBBs) reduce portal pressur

60 ophylaxis of esophageal variceal bleeding is nonselective beta blockers.

61 Propranolol is a nonselective beta-adrenergic receptor antagonist that is

62 Carvedilol, a currently prescribed nonselective beta-blocker, has been classified as a beta

63 Carvedilol, a nonselective beta-blocker, may be more effective than th

64 Nonselective beta-blockers (NSBB) are widely used becaus

65 Nonselective beta-blockers (NSBB), isosorbide-mononitrat

66 At these earlier stages, nonselective beta-blockers (NSBBs) have been ineffective

67 The safety of nonselective beta-blockers (NSBBs) in advanced cirrhosis

68 mainstay of such therapy has been the use of nonselective beta-blockers (NSBBs) that act by reducing

69 Nonselective beta-blockers are useful to prevent bleedin

70 nsity, and increased survival of patients on nonselective beta-blockers.

71 (ADC) manufacturing methods are based on the nonselective bioconjugation of cytotoxic drugs to lysine

72 1 was identified as a mechanically-activated nonselective Ca(2+) permeable cationic channel in a rang

73 nt receptor potential channel 5 (TRPC5) is a nonselective, Ca(2+)-permeable cation channel that belon

74 ient receptor potential channel family, is a nonselective calcium channel.

75 However, the choice between targeted and nonselective campaigns should be context specific, achie

76 larization-activated cyclic nucleotide-gated nonselective cation (HCN) channels in rat layer 5B pyram

77 TRPM8 is a polymodal, nonselective cation channel activated by cold temperatur

78 TRPM8, a nonselective cation channel activated by cold, voltage,

79 al Canonical 3 (TRPC3), a calcium-permeable, nonselective cation channel endowed with high constituti

80 receptor potential melastatin 8 (TRPM8) is a nonselective cation channel expressed in a subpopulation

81 ining fluid homeostasis, AQP1 also acts as a nonselective cation channel gated by cGMP, a property sh

82 channel, and under permissive conditions, a nonselective cation channel gated by cGMP.

83 P2X4 is an ATP-gated nonselective cation channel highly permeable to calcium.

84 cation channel, subfamily M, member 2) is a nonselective cation channel involved in the response to

85 otential mucolipin 1) is a Ca(2+)-permeable, nonselective cation channel localized to the membranes o

86 Plant TPC1 functions as a nonselective cation channel on the vacuole membrane, whe

87 hodopsin 2 (ChR-2), a direct light-activated nonselective cation channel originally discovered in Chl

88 We found that the mechanically activated nonselective cation channel Piezo2 was expressed in sens

89 nt receptor potential vanilloid 1 (TRPV1), a nonselective cation channel present on most afferents.

90 The P2X7 receptor (P2X7R) is an ATP-gated nonselective cation channel that induces inflammatory re

91 melastatin 3 (TRPM3) is a calcium-permeable nonselective cation channel that is expressed in a subse

92 TRPA1 is a nonselective cation channel that is expressed in peptide

93 receptor potential melastatin 3 (TRPM3) is a nonselective cation channel that is inhibited by Gbetaga

94 ember 1 (TRPV1) or vanilloid receptor 1 is a nonselective cation channel that is involved in the dete

95 nsient receptor potential channel TRPP2 is a nonselective cation channel that is mutated in autosomal

96 otential mucolipin 1) is a Ca(2+)-permeable, nonselective cation channel that is predominantly locali

97 nt receptor potential channel 1 (TRPC1) is a nonselective cation channel that is required for Ca(2+)

98 Here, we evaluated the nonselective cation channel transient receptor potential

99 ansient receptor potential superfamily, is a nonselective cation channel with Ca(2+) permeability.

100 cellular constriction point in the bacterial nonselective cation channel, NaK.

101 r has been coupled to hyperactivation of the nonselective cation channel, transient receptor potentia

102 ubfamily C, member 6 (TRPC6) gene encoding a nonselective cation channel.

103 ief exposure to ATP induces the opening of a nonselective cation channel; while repeated or prolonged

104 tute Ca2+ -activated, but Ca2+ -impermeable, nonselective cation channels and are expressed both in a

105 tor Potential Canonical (TRPC) proteins form nonselective cation channels commonly known to be activa

106 P2X7 receptors are nonselective cation channels gated by high extracellular

107 Nonselective cation channels promote persistent spiking

108 tential (TRPC) channels are Ca(2+)-permeable nonselective cation channels that are activated by a wid

109 lipid bilayers at acidic pH to form pH-gated nonselective cation channels that are opened upon pH neu

110 nical (TRPC) channels are highly homologous, nonselective cation channels that form many homo- and he

111 tor potential canonical (TRPC) proteins form nonselective cation channels that play physiological rol

112 clic nucleotide-gated (CNG) ion channels are nonselective cation channels, essential for visual and o

113 he opening of cyclic-nucleotide-gated (CNG), nonselective cation channels.

114 ial vanilloid 1) proteins are heat-activated nonselective cation channels.

115 t receptor potential (TRP) channel family of nonselective cation channels.

116 r finding new pharmacological modulators for nonselective cation channels.

117 of inward and outward currents mediated by a nonselective cation conductance and a calcium-activated

118 a S2 cells induces an L-canavanine-activated nonselective cation conductance.

119 ciated Ca(2+) influx via the mGluR1-mediated nonselective cation conductance.

120 hat blue light (470 nm) elicited the typical nonselective cation current of ChR-2 with reversal poten

121 PV4 agonist GSK1016790A (GSK101) activated a nonselective cation current, robustly elevated [Ca(2+) ]

122 T-type Ca(2+) currents and Ca(2+)-activated nonselective cation currents (I(CAN)).

123 r potential vanilloid subtype 1 (TRPV1) is a nonselective cationic channel activated by painful stimu

124 melastatin 4 (TRPM4) is a Ca(2+) -activated nonselective cationic channel that regulates cell migrat

125 resting K(+) conductance and activation of a nonselective cationic conductance primarily mediated by

126 ve fuels was consistent with a decrease in a nonselective cationic conductance.

127 ed the reversal potential, consistent with a nonselective cationic conductance.

128 eurons that express calcium (Ca2+)-activated nonselective cationic current (ICAN) to generate robust

129 e-activated calcium channels (CaV) using the nonselective CaV blocker Cd(2+) or the specific N-type b

130 Paradoxically, the nonselective CB1/CB2 receptor agonist WIN55212 inhibited

131 ne-reconstituted SDBC disclosed that it is a nonselective channel that has some peculiar gating prope

132 ane channels; an open (hemi)channel is not a nonselective channel.

133 M induction via stretch-activation of cation-nonselective channels, with VF induction requiring PVEM

134 acological block of stretch-activated cation-nonselective channels.

135 ivated potassium or stretch-activated cation-nonselective channels.

136 Nonselective clonotypic expansion was caused by relative

137 ionization with data-independent multiplexed nonselective collision induced dissociation (CID) on a t

138 oxylic acid (NTRC-739, 7b) starting from the nonselective compound 5a.

139 Eliminating the nonselective compounds did not change the clustering of

140 suppress a latent state of unrestricted and nonselective consumption.

141 bition of PGE2 production with diclofenac, a nonselective COX inhibitor, resulted in reduced tumor gr

142 pholipase A2 (PLA2) inhibitor], ibuprofen [a nonselective COX inhibitor], neomycine [a phospholipase

143 of therapeutic desensitization to aspirin by nonselective COX inhibitors in patients with AERD.

144 cells (MCs) in response to administration of nonselective COX inhibitors is a cardinal feature of asp

145 Because patients with AERD react to all nonselective COX inhibitors regardless of their chemical

146 th ICV and intra-dmPFC administration of the nonselective CRF antagonist, D-Phe-CRF, dose-dependently

147 ) or ventricular (1000 ng) injections of the nonselective CRF receptor antagonist D-Phe-CRF(12-41) de

148 d that an intracerebroventricularly injected nonselective CRF-R antagonist enhances, whereas an agoni

149 tive sodium current and inhibits the outward nonselective current.

150 le(4)-c[Asp(5),D-Nal(2')(7),Lys(10)]-NH2), a nonselective cyclic peptide antagonist at hMC3R and hMC4

151 MCs), and bronchoconstriction in response to nonselective cyclooxygenase inhibitors that deplete home

152 Current inv(16) AML treatment with nonselective cytotoxic chemotherapy results in a good in

153 at produced by selective D(2)R antagonism or nonselective D(2)-like receptor antagonists, and is like

154 However, nonselective depletion of ECM has led to poor patient ou

155 e the cardiovascular safety of alogliptin, a nonselective dipeptidyl peptidase 4 inhibitor.

156 as in absence of Mg(2+), CorA is essentially nonselective, displaying only mild preference against ot

157 f DNA fragmentation indicates a low level of nonselective DNA cleavage.

158 ects of intra-accumbens core flupenthixol, a nonselective dopamine receptor antagonist, on context re

159 tively augment pulmonary vascular effects of nonselective drugs without the potentially problematic c

160 BET BD inhibitors (BETis) that are nonselective for BD1 or BD2 have recognized anti-inflamm

161 ced lung fibrosis similar to that of a known nonselective galectin-1/galectin-3 inhibitor, which stro

162 iquid membrane contactor generally used as a nonselective gas absorption enhancement device is innova

163 to few others with heterogeneous strength), nonselective (glomeruli connect to most others with hete

164 The nonselective glucocorticoid receptor (GR) antagonist mif

165 ntrol conditions and following selective and nonselective glutamate transporter blockade.

166 vely correlated with LTP magnitude following nonselective glutamate transporter inhibition but not fo

167 rior efficacy had previously been noted with nonselective group II antagonists.

168 r)) isolates showed reduced resistance after nonselective growth, suggesting that mechanisms other th

169 of the resistance phenotype was scored after nonselective growth.

170 Many ion channels, both selective and nonselective, have reentrant pore loops that contribute

171 His bundle (HB) electrograms, selective, and nonselective HB capture sites were tagged.

172 echnologies have allowed the use of existing nonselective herbicides to be extended into crops.

173 During permanent nonselective His bundle (ns-HB) pacing, it is crucial to

174 y of anti-CD20 antibodies and confirmed with nonselective histone deacetylase inhibitors (HDACis).

175 hienopyrimidine amino acids as promising but nonselective hits that were optimized using nuclear magn

176 ily, TRPM8 is the cold receptor that forms a nonselective homotetrameric cation channel.

177 ng use of alpha-blockers (both selective and nonselective), IFIS, intraoperative iris trauma, intraop

178 Controls were screened from nonselective imaging and ECG databases.

179 tence of a rapid subcortical pathway that is nonselective in terms of the spatial frequency or emotio

180 Importantly, nonselective inactivation of infralimbic neurons, using

181 cZ transgenic rats for activity-dependent or nonselective inactivation of neurons, respectively, whic

182 methanogenic community dynamics pointed to a nonselective influence of the different operational cond

183 ents due to lack of potency, high doses, and nonselective inhibition mechanisms.

184 We found that nonselective inhibition of Ca(2+) signaling strongly imp

185 he lead HL16 demonstrated improved, however, nonselective inhibition on the NLRP3 inflammasome.

186 Isoxicam is a nonselective inhibitor of COX-1 and COX-2 whereas meloxi

187 , similar to the effects of the PDE4 subtype nonselective inhibitor rolipram.

188 onyl DKA derivatives were first described as nonselective inhibitors of 3'-processing (3'-P) and stra

189 PDE4 subtype nonselective inhibitors produce potent antidepressant-li

190 ted by retinal horizontal cells that receive nonselective input from L and M cones.

191 rs and confirm that the majority of them are nonselective interference compounds.

192 We found that both selective and nonselective interglomerular networks could mediate hete

193 utside the typical spectral bandwidth of the nonselective inversion pulse used in conventional LGE, w

194 pulse sequence was modified by replacing the nonselective inversion pulse with a wideband inversion p

195 scramblase (CaPLSase) and Ca(2+)-activated, nonselective ion channel (CAN) activities.

196 mportant in enabling the transition from the nonselective ion channel mode to a membrane pore allowin

197 The TRPV1 cation nonselective ion channel plays an essential role in ther

198 (CALHMs) are voltage-gated, Ca(2+)-inhibited nonselective ion channels that act as major ATP release

199 hat is also dependent on the activity of TRP nonselective ion channels.

200 , transient receptor potential channels, and nonselective ion channels.

201 otential of biocatalysis relative to mature (nonselective ion exchange, selective ion exchange, and w

202 higher in cost and environmental impact than nonselective ion exchange.

203 The effects of lidocaine (a nonselective ion-channel inhibitor), P2X-purinoceptor an

204 d currents composed of enhanced ICRAC plus a nonselective ISOC mediated by TRPC1.

205 necycloalkanones structurally related to the nonselective isopeptidase inhibitor G5 were synthesized

206 Nonselective (ketorolac tromethamine, ibuprofen, indomet

207 are accommodated, as illustrated through the nonselective labeling of the human kinesin Eg5 with phot

208 receptor potential vanilloid 1 (TRPV1) is a nonselective ligand-gated cation channel responding to n

209 r potential TRPV1 or vanilloid receptor is a nonselective ligand-gated channel highly expressed in pr

210 tion in solution and gas phases by comparing nonselective lipid binding with soluble and membrane pro

211 We have previously reported doxycycline, a nonselective matrix metalloproteinases (MMPs) inhibitor,

212 Doxycycline, a nonselective matrix metalloproteinases inhibitor, was re

213 lance sample screening, culture on selective/nonselective media for recovery of C. auris and other ye

214 lysis of Rheb lipidation revealed that weak, nonselective, membrane interactions support Rheb-depende

215 petitor oxo-anions to sorb on commonly used, nonselective, metal (hydr)oxide materials is presented,

216 e, we evaluated the effect of doxycycline, a nonselective MMP inhibitor on CAVD progression in the mo

217 Pretreatment with FTY720, an S1P-R1 nonselective modulator significantly reduced migration a

218 ial melastatin member 4 (TRPM4) channels are nonselective monovalent cationic channels found in human

219 , tasimelteon and TIK-301, are high-affinity nonselective MT1/MT2 agonists.

220 rking in concert with megalin and cubilin, a nonselective multireceptor complex that predominantly di

221 al reports have revealed that scopolamine, a nonselective muscarinic acetylcholine receptor antagonis

222 ical studies demonstrate that scopolamine, a nonselective muscarinic acetylcholine receptor antagonis

223 g the cholinergic side effects observed with nonselective muscarinic orthosteric agonists.

224 Here, we find that nonselective muscarinic receptor antagonism in mice as w

225 atio (PR) performance was facilitated by the nonselective muscarinic receptor antagonist scopolamine

226 inding pockets identified previously for the nonselective nAChR PAMs galantamine and physostigmine at

227 Comparison of NMR spectra of the nonselective NaK and potassium-selective NaK2K indicates

228 e-gated (SCN) Na(+) and Na(+) leak channels, nonselective (NALCN) channels, the Na K-ATPase, and hype

229 As a result of the nonselective nature of these multikinase inhibitors, pat

230 ries, we obtained atomistic evidence for the nonselective nature of TRPV1.

231 The utility of nonselective Nav blockers is often limited due to advers

232 KB-R7943, a nonselective NCX3 blocker, reduced [Ca(2+)]r in both swi

233 ecause of technical limitations (anesthesia, nonselective neuronal actuators).

234 tracranial microinfusions of mecamylamine, a nonselective nicotinic receptor antagonist, highlight a

235 Ms, CP101,606 and BMT-108908, along with the nonselective NMDA antagonists, ketamine and AZD6765, in

236 The nonselective NMDA receptor antagonist d,l-2-amino-5-phos

237 patial working memory deficits caused by the nonselective NMDAR antagonist ketamine.

238 who take warfarin with antiplatelet drugs or nonselective nonsteroidal anti-inflammatory drugs (NSAID

239 scular safety of celecoxib, as compared with nonselective nonsteroidal antiinflammatory drugs (NSAIDs

240 study of cyclooxygenase 2 inhibitors versus nonselective nonsteroidal antiinflammatory medications i

241 re retained in tumors for over 1 wk, whereas nonselective NPs were cleared within hours.

242 dard to differentiate between selective (S), nonselective (NS) His bundle pacing (HBP), and right ven

243 d the risk of UGIB during concomitant use of nonselective (ns)NSAIDs, cyclooxygenase -2 selective inh

244 tients with general asthma unwilling to risk nonselective NSAID exposure when oral challenge tests ar

245 All nonselective NSAIDs significantly accelerated mortality

246 egular use of selective cox-2 inhibitors and nonselective NSAIDs with cox-2>cox-1 inhibition showed a

247 Use of nonselective NSAIDs, either alone or as adjuncts to anti

248 nd N-phenylpropyl substituted compounds were nonselective opioid antagonists (2) all N-phenylpropyl a

249 Naltrexone is a nonselective opioid receptor antagonist used as a treatm

250 , whereas past extinction events were either nonselective or preferentially removed smaller-bodied ta

251 discovered the structural basis for turning nonselective or promiscuous Bcl-2 family ligands into se

252 of prostaglandin (PG) production with either nonselective or selective inhibitors of cyclooxygenase-2

253 The nonselective orexin receptor antagonist suvorexant has b

254 ysis reveals that the SCN5A variant mediates nonselective outward currents and a small, but detectabl

255 Accessible to varying degrees by direct and nonselective oxidations of porphyrins, the rational synt

256 l four FDA-approved HDAC-targeting drugs are nonselective, pan-HDAC inhibitors, exhibiting adverse si

257 4B should retain the therapeutic benefits of nonselective PDE4 inhibitors.

258 The poor and nonselective penetration of current chemotherapeutics ac

259 on has been explained by the activation of a nonselective permeation pathway by the P2X7 receptor, a

260 ith the presence of extrachromosomal DNA and nonselective persistence of plasmids in mammalian models

261 xpression through siRNA derepression or with nonselective pharmacologic inducers, including the CNS-p

262 vation during murine CMV (MCMV) infection: a nonselective phase mediated by proinflammatory cytokines

263 analysis of Tf1 integration events from the nonselective phase of the retrotransposition assay.

264 Ibudilast, a nonselective phosphodiesterase inhibitor, is used clinic

265 performed between rats to test the impact of nonselective (Piroxicam), preferential (Meloxicam), and

266 ct on RGS2 protein levels was blocked by the nonselective PKC inhibitor Go6983 (3-[1-[3-(dimethylamin

267 udden cardiac death, but data on the role of nonselective post-mortem CIED (pacemaker or defibrillato

268 perennial race, recent climate conditions or nonselective processes, such as dispersal limitation or

269 Nonselective product formation was also observed from re

270 tosolic or extraneuronal DA can give rise to nonselective protein modifications.

271 sis and ubiquitin recycling while preventing nonselective proteolysis, and the regulation of proteaso

272 d conjugate addition of a nickel hydride and nonselective protonation to release the substrate.

273 he probe was optimized from a weakly potent, nonselective pyridazinone hit to deliver high potency fo

274 on of As(III) by PMS avoids the formation of nonselective reactive radicals, thus minimizing the adve

275 e disease without the pleiotropic effects of nonselective reagents and, thus, could be applicable to

276 r K(+) for Cs(+) is nearly thermodynamically nonselective, recent experiments show that direct, anhyd

277 ptor potential canonical type 6 (TRPC6) is a nonselective receptor-operated cation channel that regul

278 related resting activity in the striatum and nonselective reduction in striatal inhibition synchroniz

279 tion (based on stereoselective oxidation and nonselective reduction).

280 Finally, pharmacologic treatment with the nonselective S1P receptor agonist FTY720 causes increase

281 d metabolite of fingolimod was found to be a nonselective S1P receptor agonist, agonism specifically

282 ing MH pathophysiology by demonstrating that nonselective sarcolemmal cation channel activity plays a

283 ults on preclinical testing of selective and nonselective single compounds in orthotopic mouse models

284 bound to the receptors in both selective and nonselective SiNWs.

285 sirtuin activity, we previously identified a nonselective sirtuin inhibitor called cambinol (IC50 app

286 nediol, monodihydrogen phosphate ester) is a nonselective sphingosine-1-phosphate (S1P) receptor agon

287 metals is prevented by chemical blocking of nonselective surface adsorption sites.

288 the inhibition of AA or 2-AG oxygenation by nonselective time-dependent inhibitors.

289 Similarly, DNCB activated nonselective TRPA1 current in patch clamp studies.

290 The nonselective TrpC channel inhibitors SKF96365 and 2-APB

291 However, the inefficient and nonselective uptake of these agents by tumor cells compr

292 esulted from off-target actions of Cd(2+), a nonselective VACC blocker, or other variations in experi

293 in mouse neocortical neurons, selective and nonselective VACC blockers inhibit spontaneous release a

294 ed, afterdischarge-like bursting by gating a nonselective voltage-dependent cationic current.

295 ty antagonist of the prokaryotic NaVs NsVBa (nonselective voltage-gated Bacillus alcalophilus) and Na

296 However, nonselective, widespread PSA-testing followed by liberal

297 the widely used KCC2 inhibitor furosemide is nonselective with antiseizure efficacy in slices and in

298 n campaigns in measles outbreak response are nonselective with respect to the immune status of indivi

299 molecular design and synthesis of potent but nonselective zinc-chelating MMP inhibitors (e.g., 10a an

300 ontrast to the Notch cofactor Maml, which is nonselective, Zmiz1 was selective.