ライフサイエンスコーパス: nonselective cation channel

1 The membrane form of TRPV1 functions as a nonselective cation channel.

2 wever, membrane stretch can activate a 21-pS nonselective cation channel.

3 ndependent Ca(2+) entry in TRPC6 cells via a nonselective cation channel.

4 ubfamily C, member 6 (TRPC6) gene encoding a nonselective cation channel.

5 m), which is compatible with activation of a nonselective cation channel.

6 lyzes cGMP, and that cGMP directly gates the nonselective cation channel.

7 family and can function as a homotetrameric nonselective cation channel.

8 scribe the semisynthesis of NaK, a bacterial nonselective cation channel.

9 otein expression of TRPM2, a Ca2+-permeable, nonselective cation channel.

10 members, NALCN forms a voltage-independent, nonselective cation channel.

11 and by flufenamic acid, a blocker of Cl- and nonselective cation channels.

12 sure rapid and efficient activation of these nonselective cation channels.

13 of the vanilloid type of TRP superfamily of nonselective cation channels.

14 or internal Ca2+, features typical of Na+/K+ nonselective cation channels.

15 ral gene with the genes encoding the related nonselective cation channels.

16 otential near 0 mV suggesting involvement of nonselective cation channels.

17 low-affinity receptors also associated with nonselective cation channels.

18 olar cell transmitter glutamate, which opens nonselective cation channels.

19 he opening of cyclic-nucleotide-gated (CNG), nonselective cation channels.

20 ial vanilloid 1) proteins are heat-activated nonselective cation channels.

21 t receptor potential (TRP) channel family of nonselective cation channels.

22 sequence identity and form Ca(2+)-permeable nonselective cation channels.

23 ls TRPML2 and TRPML3 (MCOLN2 and MCOLN3) are nonselective cation channels.

24 r finding new pharmacological modulators for nonselective cation channels.

25 um/calcium exchanger and possibly opening of nonselective cation channels.

26 TRPM8 is a polymodal, nonselective cation channel activated by cold temperatur

27 TRPM8, a nonselective cation channel activated by cold, voltage,

28 TRP) subfamily, TRPA1, is a Ca(2+)-permeable nonselective cation channel activated by electrophilic c

29 ssed in skin keratinocytes, where it forms a nonselective cation channel activated by hot temperature

30 receptor potential vanilloid 1 (TRPV1) is a nonselective cation channel activated by multiple stimul

31 n cyclic nucleotide-gated (CNG) channels are nonselective cation channels activated by cGMP or cAMP a

32 TRPC5 channels are Ca(2+)-permeable nonselective cation channels activated by G-protein-coup

33 Cyclic nucleotide-gated channels are nonselective cation channels activated by intracellular

34 K(Ca) and Cl(-) currents in macrophages, but nonselective cation channel activation was unique to gp1

35 , hyperpolarizes On bipolar cells by closing nonselective cation channels, an effect mediated by the

36 uired the cytoskeleton and the activity of a nonselective cation channel and the epithelial sodium ch

37 uces the activity of PC2, a Ca(2+)-permeable nonselective cation channel and, thus, limits the amplit

38 tute Ca2+ -activated, but Ca2+ -impermeable, nonselective cation channels and are expressed both in a

39 e data suggest two mechanisms, activation of nonselective cation channels and the sodium/calcium exch

40 ical properties of neurons expressing TRPV4 (nonselective cation channel) and transmembrane member 16

41 ), IP(3) receptors, diacylglycerol-activated nonselective cation channels, and Ca(2+)-activated chlor

42 nonical transient receptor potential (TRPC3) nonselective cation channels are effectors of G-protein-

43 These nonselective cation channels are inhibited by local anes

44 These nonselective cation channels are permeable to Na(+) and

45 Thus, 3-pS nonselective cation channels are present and activated b

46 nsing receptor (CaSR) which in turn inhibits nonselective cation channels at the majority of cortical

47 t Ca(2+) chelator, and Gd(3+) and SKF-96365, nonselective cation channel blockers.

48 Ca2+ stores, and maitotoxin, an activator of nonselective cation channels, both converted the glucose

49 tor Potential Canonical (TRPC) proteins form nonselective cation channels commonly known to be activa

50 Several different nonselective cation channels contribute to pressure-indu

51 In this study, we tested whether TRPC nonselective cation channels contribute to the variable

52 ptors that are part of or closely coupled to nonselective cation channels directly gated by low conce

53 al Canonical 3 (TRPC3), a calcium-permeable, nonselective cation channel endowed with high constituti

54 clic nucleotide-gated (CNG) ion channels are nonselective cation channels, essential for visual and o

55 TRPA1 is a nonselective cation channel expressed by nociceptors.

56 receptor potential melastatin 8 (TRPM8) is a nonselective cation channel expressed in a subpopulation

57 t receptor potential melastatin 8 (TRPM8), a nonselective cation channel expressed on a subset of per

58 TRP vanilloid 2 (TRPV2) is a nonselective cation channel expressed prominently in med

59 TRPC6 is a receptor-activated nonselective cation channel expressed widely in vascular

60 Thus, NALCN, a nonselective cation channel, forms the background Na(+)

61 opus oocytes provides a voltage-insensitive, nonselective cation channel function with permeability t

62 Unlike the other four members which are nonselective cation channels functioning as heat or osmo

63 ining fluid homeostasis, AQP1 also acts as a nonselective cation channel gated by cGMP, a property sh

64 channel, and under permissive conditions, a nonselective cation channel gated by cGMP.

65 ons express the vanilloid receptor, TRPV1, a nonselective cation channel gated by vanilloid ligands s

66 P2X7 receptors are nonselective cation channels gated by high extracellular

67 ansient receptor potential ankyrin 1 (TRPA1) nonselective cation channel has a conserved function as

68 Cyclic-nucleotide-activated, nonselective cation channels have a central role in sens

69 To understand how, we focus on TRPV4, a nonselective cation channel highly expressed in epitheli

70 P2X4 is an ATP-gated nonselective cation channel highly permeable to calcium.

71 , CG6504), which encodes a Ca(2+)-activated, nonselective cation channel homologous to the human Pkd2

72 Hyperpolarization-activated nonselective cation channels (Ih channels) play an impor

73 cystin-2 (PC2, TRPP2) is a Ca(2+)-permeable, nonselective cation channel implicated in Ca(2+) transpo

74 TRPA1 is an excitatory, nonselective cation channel implicated in somatosensory

75 nonical (TRPC) channels are Ca(2+)-permeable nonselective cation channels implicated in diverse physi

76 annels in cultured neocortical neurons and a nonselective cation channel in Jurkat T cells that is ac

77 We previously identified a novel, nonselective cation channel in native reactive (type R1)

78 erfamily and has been shown to function as a nonselective cation channel in the plasma membrane.

79 annel in the endoplasmic reticulum, and/or a nonselective cation channel in the plasma membrane.

80 sium (K(Ca)), chloride, and calcium-permeant nonselective cation channels in macrophages.

81 ediates M2 receptor coupling to metabotropic nonselective cation channels in mammalian smooth muscle

82 C heteromers form diverse receptor-regulated nonselective cation channels in the mammalian brain.

83 ole of a polycystin-1 protein (components of nonselective cation channels) in a specific cellular pro

84 The authors identified mutations in TRPM4--a nonselective cation channel--in a large family with prog

85 cation channel, subfamily M, member 2) is a nonselective cation channel involved in the response to

86 ial canonical (TRPC) channels are a group of nonselective cation channels involved in many physiologi

87 by glutamate released from photoreceptors, a nonselective cation channel is inhibited, causing these

88 Patch-clamp experiments show that a nonselective cation channel is stimulated by H(2)O(2) an

89 f its members, TRPM8 (CMR1), a ligand-gated, nonselective cation channel, is activated by both cold a

90 denosine 5'-diphosphoribose (ADPR)-activated nonselective cation channel, is also expressed in human

91 otential mucolipin 1) is a Ca(2+)-permeable, nonselective cation channel localized to the membranes o

92 Nonselective cation channels may play a role in insulin

93 m, whereby gating of TRPM7, a Ca2+-permeable nonselective cation channel, mediates Ca2+ overload and

94 TRPC3 is a nonselective cation channel member of the "canonical" tr

95 These channels seem to be nonselective cation channels; monovalent cations are the

96 cellular constriction point in the bacterial nonselective cation channel, NaK.

97 on channels, such as outward K+ channels and nonselective cation channels (NCC).

98 des evidence for a novel, voltage-dependent, nonselective cation channel (NSCC) in the heart.

99 n the activation of novel (calcium-permeant) nonselective cation channels (NSCCs) and calcium release

100 y murine B cells reveal that Ca(2+)-permeant nonselective cation channels (NSCCs) operate in a cooper

101 ives, is a candidate for the store-operated, nonselective cation channels observed in smooth muscle c

102 Plant TPC1 functions as a nonselective cation channel on the vacuole membrane, whe

103 hodopsin 2 (ChR-2), a direct light-activated nonselective cation channel originally discovered in Chl

104 Activation of a nonselective cation channel, Pcat, was considered the ke

105 or no effects on TRPV1 and no effect on the nonselective cation channel PIEZO1.

106 We find that loss of the force-gated nonselective cation channel PIEZO2 in cells of renin lin

107 We found that the mechanically activated nonselective cation channel Piezo2 was expressed in sens

108 toxin, palytoxin, converts Na+/K+ pumps into nonselective cation channels, possibly by disrupting the

109 Transient Receptor Potential A1 (TRPA1) is a nonselective cation channel, preferentially expressed on

110 nt receptor potential vanilloid 1 (TRPV1), a nonselective cation channel present on most afferents.

111 tor potential melastatin type 8 (TRPM8) is a nonselective cation channel primarily expressed in a sub

112 Nonselective cation channels promote persistent spiking

113 the swelling-activated and stretch-activated nonselective cation channel response to strain.

114 tive strain by activating stretch-activated, nonselective cation channels (SA-CAT) and increasing mat

115 B and a small-conductance, Ca(2+)-activated, nonselective cation channel (SCAN), TMEM16F.

116 nsient receptor potential (TRP) channels are nonselective cation channels, several of which are expre

117 to its behavior as an outwardly rectifying, nonselective cation channel, shares many functional and

118 otential channel (TRPC)-related genes encode nonselective cation channels, some of which are similar

119 by which a local Ca(2+) signal generated by nonselective cation channels stimulates TMEM16A channels

120 channel, subfamily V, member 1 (TRPV1) is a nonselective cation channel that can be activated by a w

121 ignated TRPC7 or LTRPC2) is a Ca2+-permeable nonselective cation channel that contains a C-terminal e

122 The P2X7 receptor (P2X7R) is an ATP-gated nonselective cation channel that induces inflammatory re

123 The capsaicin receptor (TRPV1) is a nonselective cation channel that integrates multiple pai

124 The vanilloid receptor (VR1) is a nonselective cation channel that is activated by capsaic

125 In heterologous cell types it forms a nonselective cation channel that is activated by intrace

126 ry receptor neurons in the lobster express a nonselective cation channel that is activated by intrace

127 nsient receptor potential channel TRPV3 is a nonselective cation channel that is activated by warm te

128 The capsaicin receptor (TRPV1) is a nonselective cation channel that is activated in nocicep

129 id receptor type 1 (TRPV1) is a ligand-gated nonselective cation channel that is considered to be an

130 , also known as TRPV1) is a thermosensitive, nonselective cation channel that is expressed by capsaic

131 melastatin 3 (TRPM3) is a calcium-permeable nonselective cation channel that is expressed in a subse

132 TRPA1 is a nonselective cation channel that is expressed in peptide

133 Vanilloid receptor subtype-1 (VR1) is a nonselective cation channel that is expressed in sensory

134 annelrhodopsin-2 (ChR2) is a light-activated nonselective cation channel that is found in the eyespot

135 in excised patches showed that TRPM5 forms a nonselective cation channel that is half-activated by 8

136 receptor potential melastatin 3 (TRPM3) is a nonselective cation channel that is inhibited by Gbetaga

137 ial channel 2 (TRPM2) is a Ca(2+)-permeable, nonselective cation channel that is involved in oxidativ

138 ember 1 (TRPV1) or vanilloid receptor 1 is a nonselective cation channel that is involved in the dete

139 e cells have a second type of Ca2+-activated nonselective cation channel that is less sensitive to in

140 The vanilloid receptor VR1 is a nonselective cation channel that is most abundant in per

141 nsient receptor potential channel TRPP2 is a nonselective cation channel that is mutated in autosomal

142 how that polycystin-L is a calcium-modulated nonselective cation channel that is permeable to sodium,

143 ceptor-1 (VR1 or TRPV1) is a membrane-bound, nonselective cation channel that is predominantly expres

144 otential mucolipin 1) is a Ca(2+)-permeable, nonselective cation channel that is predominantly locali

145 nt receptor potential channel 1 (TRPC1) is a nonselective cation channel that is required for Ca(2+)

146 canonical-1) channel is a constituent of the nonselective cation channel that mediates Ca2+ entry thr

147 ily M member 4 (TRPM4) is a Ca(2+)-activated nonselective cation channel that mediates membrane depol

148 The transient receptor potential TRPV1 is a nonselective cation channel that mediates pain sensation

149 It is a nonselective cation channel that prefers Ca2+ over Na+.

150 TRPM4 is a Ca(2+)-activated nonselective cation channel that regulates membrane pote

151 tential (TRPC) channels are Ca(2+)-permeable nonselective cation channels that are activated by a wid

152 P2X7 receptors are nonselective cation channels that are activated by extra

153 lipid bilayers at acidic pH to form pH-gated nonselective cation channels that are opened upon pH neu

154 tor potential (TRP) ion channel subtypes are nonselective cation channels that can be activated by in

155 The nonselective cation channels that carry this current hav

156 Piezo1 forms mechanically activated nonselective cation channels that contribute to endothel

157 Animal CNGCs are nonselective cation channels that do not discriminate be

158 nical (TRPC) channels are highly homologous, nonselective cation channels that form many homo- and he

159 sists of a family of seven membrane-spanning nonselective cation channels that have been implicated i

160 Capsaicin receptor channels (TRPV1) are nonselective cation channels that integrate multiple nox

161 een defined as heat-sensitive, ligand-gated, nonselective cation channels that integrate nociceptive

162 tor potential canonical (TRPC) proteins form nonselective cation channels that play physiological rol

163 TRPM7 channels are nonselective cation channels that possess a functional a

164 In a second example, expression of a nonselective cation channel, the influenza virus M2 prot

165 We recently identified a nonselective cation channel, the NC(Ca-ATP) channel, in

166 at sulfonylurea receptor 1 (SUR 1) regulated nonselective cation channel, the NC(Ca-ATP) channel, is

167 y, and a small-conductance calcium-activated nonselective cation channel, TMEM16F, linked to Scott sy

168 Here, we evaluated the nonselective cation channel transient receptor potential

169 The nonselective cation channel transient receptor potential

170 r has been coupled to hyperactivation of the nonselective cation channel, transient receptor potentia

171 The nonselective cation channel TRPA1 (ANKTM1, p120) is a po

172 mucolipin 1 (TRPML1) is a Ca(2+)-permeable, nonselective cation channel ubiquitously expressed in th

173 These nonselective cation channels, underlying the I(f), I(h)

174 id not detect ENaC activity but did detect a nonselective cation channel upregulated by pioglitazone.

175 with the genes encoding the closely related, nonselective cation channels VR1, VRL-1, OTRPC4 (also kn

176 as a receptor-activated, calcium-permeable, nonselective cation channel when expressed in cell lines

177 y of proteins, functions as a Ca2+-modulated nonselective cation channel when expressed in Xenopus oo

178 This receptor incorporates a nonselective cation channel, which is opened by the bind

179 5 is a member of the P2X family of ATP-gated nonselective cation channels, which exist as trimeric as

180 ief exposure to ATP induces the opening of a nonselective cation channel; while repeated or prolonged

181 al melastatin-related channel 2 (TRPM2) is a nonselective cation channel, whose prolonged activation

182 nd TRPC5 in HEK293 cells resulted in a novel nonselective cation channel with a voltage dependence si

183 ansient receptor potential superfamily, is a nonselective cation channel with Ca(2+) permeability.

184 TRPM7 encodes a Ca2+-permeable nonselective cation channel with kinase activity.

185 TRPC are Ca(2+)-permeable, nonselective cation channels with a variety of physiolog

186 ces express both highly selective cation and nonselective cation channels with average conductances o

187 ptor potential vanilloid 4 (TRPV4) channels--nonselective cation channels with considerable Ca(2+) co

188 A separate class of nonselective cation channels, with a conductance of 50-6