ライフサイエンスコーパス: nonself

1 e immune system distinguish between self and nonself.

2 tem is its ability to discriminate self from nonself.

3 trategies to distinguish self from microbial nonself.

4 the ability to discriminate between self and nonself.

5 ed on self-peptide-MHCs and primed to detect nonself.

6 al processes to distinguish between self and nonself.

7 s a means of discriminating between self and nonself.

8 h B cells, yet discriminate between self and nonself.

9 ine to methionine substitution at p2 defines nonself.

10 based on the recognition of self rather than nonself.

11 ons by making a distinction between self and nonself.

12 igens to change the specificity from self to nonself.

13 rather than simply to distinguish self from nonself.

14 ) in islet beta cells, some recognize Tag as nonself.

15 hology, and ability to distinguish self from nonself.

16 y relies on the differentiation of self from nonself.

17 s a molecular ruler to distinguish self from nonself.

18 ms of the same species distinguish self from nonself.

19 urites readily discriminate between self and nonself.

20 and readily recognize and reject allogeneic nonself.

21 ity of P. mirabilis to distinguish self from nonself.

22 hat monocytes mount a response to allogeneic nonself, a function not previously attributed to them, a

23 act on the host immune system of exposure to nonself ABH antigens during early life in human heart ve

24 ific IgM, IgG, and IgA isotype antibodies to nonself ABH subtypes were detected in control participan

25 toimmune diseases, yet little is known about nonself Ag-induced tolerance.

26 e intraocular administration of low doses of nonself Ag.

27 ent mice conserved the ability to respond to nonself Ags and mitogens.

28 T(Reg)) control immune responses to self and nonself Ags.

29 uced, nondeletional tolerance to extrathymic nonself Ags.

30 lesion, in response to unidentified self- or nonself Ags.

31 tor reveals that T cell-mediated immunity to nonself-Ags in the liver is self-limiting.

32 (self-HLA-restricted) and HLA-A*02-negative [nonself (allogeneic) HLA [allo-HLA]-restricted] individu

33 of infectious organisms mediate awareness of nonself and are integral to host defense in plants and a

34 aboratory mice, male tissue is recognized as nonself and destroyed by the female immune system via re

35 e identified a single gene that encodes self-nonself and determines "graft" outcomes in this organism

36 by a foreign DNA, the REase recognizes it as nonself and subjects it to restriction.

37 ights into the peptide universe that defines nonself and the basis of histoincompatibility.

38 delicate balance between the recognition of nonself and the prevention of autoimmunity.

39 nses that are poised to recognize viruses as nonself and to activate antiviral pathways.

40 Their ability to distinguish "self" from "nonself" and lyse virally infected and tumorigenic cells

41 vely present at the portals between self and nonself, and contain a large and diverse complement of p

42 2-type immune response against an exogenous, nonself antigen, keyhole limpet hemocyanin (KLH), by rel

43 Nonself antigen-presenting molecules typically contain p

44 n reject normal grafts that express the same nonself-antigen.

45 which allow discrimination between self and nonself antigens as well as the recognition of potential

46 zonulin up-regulation, the excessive flow of nonself antigens in the intestinal submucosa can cause b

47 ch year, yet formation of antibodies against nonself antigens remains a significant problem, particul

48 We conclude that exogenous, nonself antigens that can induce Th2 responses, can modi

49 tireactive, binding to a variety of self and nonself antigens, including dsDNA (albeit at reduced aff

50 ntracellular discrimination between self and nonself antigens, resulting in the preferential presenta

51 quilibrium between tolerance and immunity to nonself antigens.

52 mental in limiting inflammatory responses to nonself antigens.

53 entation of peptides derived from opsonized, nonself antigens.

54 erally cross-reactive, besides responding to nonself-antigens, they also maintain significant respons

55 ated host immune responses against self- and nonself-antigens; however, the impact of CD4(+) Tregs on

56 the absence of eTh and that persist, whereas nonself are those Ags encountered in the presence of eTh

57 of molecular patterns demarcating infectious nonself, as well as normal and abnormal self.

58 mmune systems in differentiating "self" and "nonself," as well as lay the foundation for resolving th

59 s have any capacity to distinguish self from nonself at the molecular level is an outstanding questio

60 g the particular viral ligands recognized as nonself by cytosolic PRRs, and on defining the nature of

61 cular patterns (PAMPs/MAMPs) are detected as nonself by host pattern recognition receptors (PRRs) and

62 eas microbial pathogens can be recognized as nonself by immune receptors, misfolded protein assemblie

63 ion that RNA genomes are first recognized as nonself by the immune system.

64 role in the distinction between "self" and "nonself" by the cellular immune system.

65 g infection by certain viruses that possess "nonself" cap0-mRNAs.

66 mplement becomes activated on the surface of nonself cells by one of three initiating mechanisms know

67 This led us to suggest that nonself cells may play a role in the disease process.

68 c genes to distinguish self from conspecific nonself cells or tissues.

69 lticellular state and to tell apart self and nonself cells.

70 tations were retrieved, with an overall self/nonself-citation ratio of 0.17 (53/304).

71 same TCR has the potential to interact with nonself class I complexed with nonself peptides.

72 Activation of NK cells by nonself class I molecules was not predicted by the missi

73 lleles are present in the population and all nonself combinations of Y and Z alleles are equally func

74 r, we determine the coupling constants for a nonself-complementary 11-mer A-tract DNA duplex from 2D

75 7BL/6 model whether providing the infectious nonself context in a tumor-by injecting CpG-oligodeoxynu

76 immune responses are modified along the self-nonself continuum may offer more effective opportunities

77 clarify how molecular mimicry can drive self/nonself cross-reactivity and illustrate how low peptide-

78 The core idea is to exploit the self versus nonself differentiation by natural bacterial DNA methyla

79 However, the competing demands of nonself discrimination and self-recognition place limita

80 r efforts to understand the "rules" for self-nonself discrimination are constantly evolving.

81 sors raises fundamental questions about self/nonself discrimination because of the abundance of self-

82 While PAMs play an essential role in self/nonself discrimination by CRISPR-Cas immune systems, thi

83 into a host cell, sperm-egg fusion, and self/nonself discrimination by the immune system.

84 largely responsible for reliable self versus nonself discrimination by these receptors.

85 Instead, self-nonself discrimination depends on the intron that progra

86 -peptide-specific T(reg) cells promoted self-nonself discrimination during infection by selectively c

87 PRR distribution form a basis of self versus nonself discrimination during the antiviral response.

88 Here we defined the molecular basis of self-nonself discrimination for the murine chromosome 7 encod

89 A link between immunoregulation and self-nonself discrimination has emerged from experiments show

90 ism underpins an important mechanism of self/nonself discrimination in bacteria.

91 e being exploited by T cells to advance self-nonself discrimination in early T cell activation.

92 understanding the molecular details of self-nonself discrimination in P. mirabilis.

93 As the major site of self-nonself discrimination in the immune system, the thymus,

94 ermediate-avidity T cells to accomplish self-nonself discrimination in the periphery.

95 es and differences between SI and other self/nonself discrimination systems are discussed.

96 ne system evolved several strategies of self/nonself discrimination that are based on the recognition

97 eostasis and pathogen encounter (self versus nonself discrimination), as well as poised states for su

98 llular introns provide a novel means of self-nonself discrimination, allowing HUSH to recognize and t

99 in no way challenges the need to make a self-nonself discrimination, nor, for that matter, does it ch

100 lax that likewise enable genomic self versus nonself discrimination, this time by specifying self seq

101 rferonopathies relate to a breakdown of self/nonself discrimination, with the associated mutant genot

102 quence of Hsp60 (Hsp60sp) contribute to self/nonself discrimination.

103 p, which was associated with failure of self/nonself discrimination.

104 ity of peripheral immune regulation and self-nonself discrimination.

105 ne receptor as a mechanism that governs self-nonself discrimination.

106 es of their guide RNAs at the center of self/nonself discrimination.

107 ly inseparable relationship between self and nonself discrimination.

108 ne system is often said to function by "self-nonself" discrimination.

109 c protein HET-S causes cell death in a self-/nonself-discrimination process.

110 ellular immunity requires accurate self- vs. nonself-discrimination to protect against infections and

111 s support a role for siglecs in B cell self-/nonself-discrimination, namely suppressing responses to

112 elp explain their function in neuronal self-/nonself-discrimination.

113 rate neurons and a molecular basis for self-/nonself-discrimination.

114 In addition to nonself DNA and RNA from microorganisms, nucleic acid se

115 fic features to distinguish between self and nonself DNA, cGAS-STING immunity requires precise regula

116 ted from these loci to target complementary "nonself" DNA sequences for destruction, while avoiding b

117 g, their expression is not limited to these 'nonself' DNA elements.

118 rly phase of IBV infection, the signaling of nonself dsRNA through both MDA5 and TLR3 remains intact

119 ly dynamics to discriminate between self vs. nonself dsRNA.

120 RNAs that are endogenous Dicer products, and nonself dsRNAs such as by-products of viral replication.

121 annot always distinguish between "self" and "nonself" dsRNAs.

122 s of cells must distinguish between self and nonself during the construction of neural circuits.

123 s, the immune system discriminates self from nonself, during adaptive immunity in the periphery, not

124 he potential for T-cell immunity to self and nonself dystrophin epitopes should be considered in desi

125 vey an epigenetic memory of genomic self and nonself elements.

126 t among vertebrates, is the rejection of the nonself-embryo.

127 or editing to accommodate the recognition of nonself-eplets, the driving force of the humoral allores

128 to efficiently distinguish between self and nonself even within three-component mixtures in CDCl3.

129 ferent mating types recognize one another as nonself, form a complex and activate development.

130 the immune system to distinguish infectious nonself from noninfectious self.

131 Discrimination by the host defense system of nonself from self can prevent invasion of pathogens, but

132 s routinely transport antigen (both self and nonself) from the periphery to the thymus, where they po

133 To distinguish self from nonself genomic DNA, HUSH recognizes long single-exon (i

134 t the basis of TCRs to distinguish self from nonself H13 peptides is their ability to distinguish a s

135 GW and implanted into experimentally induced nonself healing calvarial defects, GW treatment substant

136 In contrast, NK cells expressing self- and nonself-HLA class I-binding inhibitory killer cell Ig-li

137 Unwanted alloantibodies to nonself human leukocyte antigens (HLAs) on donor cells i

138 mammalian transcription-as arbiters of self-nonself identity.

139 C)-mediated antigen presentation in self and nonself immune recognition was derived from immunologica

140 to HSC isolation and its importance in self-nonself immune recognition.

141 l self-tolerance by discriminating self from nonself in humans.

142 that enables them to discriminate self from nonself in the periphery is one of the central issues of

143 T cell regulation to discriminate self from nonself in the periphery to maintain self-tolerance.

144 s, discrimination against, and exclusion of, nonself is critical.

145 une system's ability to distinguish self and nonself is essential for both host defense against forei

146 Differentiation of self from nonself is indispensable for maintaining B cell toleranc

147 ther members of the same species (allogeneic nonself) is less clear.

148 the ability to discriminate between self and nonself, is ubiquitous among colonial metazoans and wide

149 to efficiently distinguish between self and nonself-is common in nature but is still relatively rare

150 by the loss of distinction between self and nonself, leading to excessive antiviral responses mediat

151 reactive T cells of activation with a potent nonself ligand, we have generated a TCR transgenic mouse

152 tially autoreactive T cells by high-affinity nonself ligands may be important in breaking self-tolera

153 system by playing a pivotal role in sensing "nonself" ligands.

154 vaey et al. explore the molecular details of nonself lipid discrimination and self-recognition.

155 The symmetry in self- and nonself-lipid detection mechanisms enabled us to enginee

156 ate groups and long acyl chains of self- and nonself-lipids.

157 s govern caspase interactions with self- and nonself-lipids.

158 e ligand, but does not impact recognition of nonself MHC class II molecules.

159 models suggest that T cell affinity toward a nonself MHC molecule would be lower than that toward a s

160 t limited by a lower affinity of T cells for nonself MHC molecules.

161 T cells recognize determinants expressed on nonself MHC molecules.

162 ts had greater inhibitory neuroactivity than nonself-MHC I molecules, regardless of the nature of the

163 understanding of the immune system, the self-nonself model continues to dominate the field.

164 mmunotherapy is fully influenced by the self-nonself model of immunity.

165 Recognition of nonself molecular patterns such as those seen with viral

166 d by microbial patterns that are detected as nonself molecules.

167 s (PRRs) of the host cell recognize specific nonself-motifs within viral products (known as a pathoge

168 ally synergistic role for it in self- versus nonself-mRNA discernment.

169 sults which elucidate the mechanism by which nonself mRNAs are silenced, and have implications for pi

170 elf also had HLA-C2, indicating that neither nonself nor missing-self discrimination was operative.

171 critical in discriminating between self and nonself nucleic acid.

172 ge Piwi proteins to suppress transposons and nonself nucleic acids and maintain genome integrity and

173 liably differentiate self-nucleic acids from nonself nucleic acids.

174 a variety of means, including recognition of nonself nucleic acids.

175 mechanisms used to distinguish "self" from "nonself" nucleic acids remain mysterious.

176 invaders that is based on the perception of nonself or modified-self molecules.

177 ch signals can originate from the infectious nonself or the damaged self, the latter termed damage-as

178 g safeguards against aberrantly replicating, nonself or virally infected cells.

179 he ER stress pathway senses influenza HA as "nonself" or misfolded protein and sorts HA to ERAD for d

180 s to and enhances macrophage uptake of other nonself particles, specifically apoptotic polymorphonucl

181 nding of how plants recognize and respond to nonself patterns, a process from which the seemingly cha

182 n is given to the search for viral and tumor nonself peptide epitopes, yet the question remains, "Wha

183 ating between wild-type and mutated self and nonself peptide ligands presented by host cells.

184 ls requires differentiation between self and nonself peptide-class I major histocompatibility complex

185 T cell activation by nonself peptide-major histocompatibility complex (MHC) a

186 on of peripheral T cells can also respond to nonself peptide-MHC (pMHC) complexes in the context of t

187 t MHC I heavy chains with a defined self- or nonself-peptide presented, on cultured embryonic retinas

188 could explain the nonresponsiveness to many nonself peptides and could improve the understanding of

189 Mature T cells respond to antigenic nonself peptides bound to self-MHC molecules, but a size

190 eir clonotypic receptor, the TCR, recognizes nonself peptides displayed by MHC class I molecules.

191 ntogeny and with self class I complexed with nonself peptides to initiate Ag-specific responses.

192 interact with nonself class I complexed with nonself peptides.

193 dicted to bind large repertoires of self and nonself peptides.

194 e permitting those against pathogen-derived "nonself" peptides.

195 direct or indirect presentation of self and nonself phosphoantigens (pAg).

196 S-RNases interact more with nonself Pi SLFs than with self Pi SLFs, and Pi SLFs also

197 mpatibility, discrimination between self and nonself pollen by the pistil is controlled by the highly

198 Approaching swarms of nonself populations led to increased ids expression and

199 is crucial for elimination of cells bearing "nonself" proteins.

200 What limits this second layer of self- and nonself-reactive Treg production in physiological condit

201 improved strategies to select effective, yet nonself-reactive, TCRs.

202 atibility with het-c) was required for het-c nonself recognition and heterokaryon incompatibility (HI

203 hich may implicate mitochondria in N. crassa nonself recognition and PCD.

204 lly with a transcription factor vib-1 during nonself recognition and programmed cell death (PCD).

205 D)-like receptors that were found to control nonself recognition and programmed cell death processes.

206 efficient mechanism to leverage the limited nonself recognition capacity of their innate immune syst

207 Nonself recognition during vegetative growth in filament

208 ns in vib-1 (Deltavib-1) suppress PCD due to nonself recognition events; however, a Deltavib-1 Deltai

209 y in particular-shifted the emphasis of self-nonself recognition from lymphocytes functioning in the

210 similar transmembrane proteins mediate self/nonself recognition in both ciliates, the mechanisms of

211 nonallelic interactions may be important in nonself recognition in filamentous fungi and that protei

212 Nonself recognition in filamentous fungi is conferred by

213 Using epitope-tagged HET-C, we show that nonself recognition is mediated by the presence of a het

214 Our finding is a step towards understanding nonself recognition mechanisms that operate during veget

215 ich, in the prion state, is active in a self/nonself recognition process called heterokaryon incompat

216 rch into understanding the evolution of self-nonself recognition systems and the functional integrati

217 atibility (SI) systems are unique among self/nonself recognition systems in being based on the recogn

218 Genetic nonself recognition systems such as vegetative incompati

219 signaling, and may carry out a form of self-nonself recognition that is independent of microbial pat

220 extant animals but nevertheless possess self-nonself recognition that rivals the specificity of the v

221 okaryon and transformation tests showed that nonself recognition was mediated by synergistic nonallel

222 an important factor involved in sponge self/nonself recognition.

223 ion, consistent with the role of het loci in nonself recognition.

224 genetic polymorphism for specificity in self/nonself recognition.

225 PRR-PAMP interactions lead to PRR-dependent nonself-recognition and the downstream induction of type

226 ng the diversity of molecules functioning in nonself-recognition in an invertebrate.

227 ys involved in detecting DNA viruses through nonself-recognition of viral DNA are also being elucidat

228 the context of both immune response and self/nonself-recognition.

229 Exposure to nonself red blood cell (RBC) antigens, either from trans

230 duals, activity in the DMN is reduced during nonself-referential goal-directed tasks, in keeping with

231 ts (49.8%) had obstructive CAD compared with nonself-referral patients (53.5%), with an odds ratio of

232 st innate immunity to discriminate self from nonself RNA and that this novel biological function of v

233 response to infection with RNA viruses, host nonself RNA sensors recognize virus-derived dsRNA as dan

234 interact with MDA5, a cytoplasmic sensor of nonself RNA that induces type I IFN.

235 ioned in the endolysosome to detect incoming nonself RNA.

236 us replication triggered upon recognition of nonself RNAs by the cytoplasmic sensors encoded by retin

237 zinc finger antiviral protein (ZAP) depletes nonself RNAs through recognition of their elevated CpG d

238 serve as epigenetic memories of "self" and "nonself" RNAs.

239 ted this hypothesis in the context of native nonself-RNAs.

240 an SCF complex mediating the degradation of nonself S-RNase but not self S-RNase.

241 Pi SLFs, and Pi SLFs also interact more with nonself S-RNases than with self S-RNases.

242 ediate ubiquitination and degradation of all nonself S-RNases, but not self S-RNase, resulting in cro

243 eptor (BCR) plays a central role in the self/nonself selection of B lymphocytes and in their activati

244 eleterious mutations, and the acquisition of nonself sequences influencing the phylogenetics of viral

245 RNAs, C. elegans is able to target arbitrary nonself sequences with high probability.

246 d salicylic acid (SA) are induced by general nonself signals and pathogen signals, respectively, in A

247 esis genes by general pathogen elicitors and nonself signals, thereby functioning as a feedback contr

248 Recognition of these nonself structures results in peptide-dependent alloimmu

249 fter transplantation, T cells may react with nonself structures, contributing to graft-versus-host di

250 immune surveillance machinery to recognize "nonself", such as the presence of pathogenic RNA.

251 Exposure of nonself surfaces such as those of biomaterials or transp

252 t importantly, also, a regulatory penalty on nonself surfaces, yielding a selectivity factor of ~2.4

253 cific for a self (MUC.1) and the other for a nonself T cell determinant.

254 es of Abeta(1-11) fused with the promiscuous nonself T cell epitope, PADRE (pan human leukocyte antig

255 protein subunit of Cascade, is required for nonself target recognition and binding.

256 d three base pair motif that is required for nonself target selection.

257 surfaces that determine specificity for the nonself target.

258 ation of an endogenous immunologic signal of nonself that can provoke a sterile inflammatory response

259 ystem uses to distinguish between infectious nonself (that is to be attacked) and noninfectious self

260 vation, and differentiation between self and nonself through a complex array of pathways and mechanis

261 barcodes to exquisitely discriminate against nonself to ensure populations are genetically homogenous

262 Immune systems distinguish "self" from "nonself" to maintain homeostasis and must differentially

263 ne system from a narrative of "self" versus "nonself" to one in which immune function is critical for

264 to recognize "self" from "altered self" or "nonself." To escape the host immune system, some bacteri

265 case proteins that can identify viral RNA as nonself via binding to pathogen associated molecular pat

266 tion of ADAR1 editing of self (cellular) and nonself (viral) dsRNAs.

267 a programmed suicide pathway in uninfected (nonself) yeast.