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1 methylase fusion protein appears to nick DNA nonspecifically.
2 in enhanced affinity modestly and presumably nonspecifically.
3 of the ring-forming group bind to the motor nonspecifically.
4 ity that Toxoplasma may disrupt all of these nonspecifically.
5 dency to attract fluorescently labeled bases nonspecifically.
6 s those lacking the peptide bound weakly and nonspecifically.
7 lly at AT-rich sites; the remainder bind DNA nonspecifically.
8 spectral data show that Cu(II) binds to NfoR nonspecifically.
9 pansion of polyclonal autoreactive responses nonspecifically.
10 t to the Dnmt3b PWWP domain, which binds DNA nonspecifically.
11 is achieved after DNA binding, which occurs nonspecifically.
12 their ability to bind to double-stranded DNA nonspecifically.
13 e of DES while PC-SPES affects this promoter nonspecifically.
14 e-specific manner and two others that cleave nonspecifically.
15 4 and PSD-95 were disrupted, Kv1.4 localized nonspecifically.
16 p" structure that binds to substrate helices nonspecifically.
17 analog and thereby increase binding affinity nonspecifically.
18 f heparin, suggesting that it bound the bait nonspecifically.
19 ecific antibodies to bind cellular membranes nonspecifically.
20 Our results indicate that DGCR8 binds RNA nonspecifically.
21 for an intercalating compound that binds RNA nonspecifically.
22 eption is due to loss of the circadian clock nonspecifically.
24 rements indicate that LPS interacts with Skp nonspecifically, accompanied by destabilization of the S
26 tivation, as existing stimulation techniques nonspecifically activate/inhibit all cell types (neurons
29 I:C)-induced protective effect, since siRNAs nonspecifically activated the DCs, inducing the appearan
30 ammaHV68 elicits virus-specific Ab, and also nonspecifically activates B cells to Ab production throu
32 ve, specifically active against bacteria, or nonspecifically active against bacteria and eukaryotic c
33 threshold ratio of DOPE:DOPC = 4:1, and the nonspecifically active AMO requires a drastically lower
34 specifically active in neuroblastoma cells, nonspecifically active in neuroblastoma cells, and nonac
37 ogical fluids is challenging as biomolecules nonspecifically adsorb on the electrode surface and adve
38 these results suggest that the nanoparticles nonspecifically adsorb polymerase, thus effectively redu
39 d with a solution of short thiols to release nonspecifically adsorbed DNA before hybridization with c
40 xplanation of this fact is that proteins are nonspecifically adsorbed on DNA, and sliding along DNA p
41 To validate the technique, crude serum was nonspecifically adsorbed on four self-assembled monolaye
42 nd endocytosis of a virus particle initially nonspecifically adsorbed on the host cell membrane are c
45 introduced for binding, and the membrane and nonspecifically adsorbed proteins on the membrane were s
47 moved from the microarray surface along with nonspecifically adsorbed proteins, resulting in extremel
48 s, thus allowing the complete washing of the nonspecifically adsorbed salts and biomolecules, while s
53 demonstrated that only four transcripts were nonspecifically affected by RNAi, whereas approximately
54 een put forward suggesting that Cyt1A rather nonspecifically aggregates on the membrane surface and a
55 sence of negatively charged DNA or RNA could nonspecifically aid in association of these proteins.
56 ds us to propose that MutS: (i) binds to DNA nonspecifically and bends it in search of a mismatch; (i
59 IE62 is capable of associating with DNA both nonspecifically and in a sequence-specific manner via a
60 rs showed that BAF binds double-stranded DNA nonspecifically and is a host component of preintegratio
61 cess IgG, suggesting IgG transcytosis occurs nonspecifically and originates from fluid-phase endocyto
62 ue indicating that these clusters are formed nonspecifically and that any differences in ion detectio
63 o found that purified UBR1 and CUP9 interact nonspecifically and that specific binding (which involve
64 t the N-terminal domain of SF3b155 binds RNA nonspecifically and that the sites for U2AF65 binding an
65 the complex first binds to a dsDNA molecule nonspecifically and then linearly diffuses, or slides, a
66 desmata permit solutes to move between cells nonspecifically and without having to cross a membrane.
67 d short double-stranded DNA oligonucleotides nonspecifically, and a deletion mutant affecting the N-t
68 d by influenza A and B viruses often present nonspecifically, and a rapid, high-throughput laboratory
69 ents, classified numerous compounds that act nonspecifically, and identified compounds that cause cel
70 tivity depends on the ability to bind to DNA nonspecifically, and in its absence, T antigen is unable
71 -dependent public goods that act broadly and nonspecifically, and whose need cannot always be accurat
72 present in the extracellular medium that may nonspecifically associate with virions, we also analyzed
74 t can be specifically primed by trypsin, and nonspecifically associated VP4 that is degraded by tryps
75 l molecule aggregates, which inhibit enzymes nonspecifically at micromolar concentrations in aqueous
77 ing site and were inactive in vivo bound Rev nonspecifically at these concentrations, the real stoich
79 d domains such as p53 TAD bind their targets nonspecifically before folding to a tightly associated c
80 r the two forms, suggesting cationic GrB may nonspecifically bind cytosolic proteins, leading to redu
82 that are ubiquitous in eukaryotic cells and nonspecifically bind to DNA, inducing large-angle DNA be
87 mon resonance analysis show that PKCalpha-C2 nonspecifically binds phosphoinositides, including PtdIn
89 mor, together with fast renal elimination of nonspecifically bound activity, resulted in specific ima
91 degrees C was reduced by the amount that was nonspecifically bound at 4 degrees C to yield the amount
94 ood with enrichment factors (specifically vs nonspecifically bound cells) of up to about 3000 compare
95 assigned as a rapidly exchanging mixture of nonspecifically bound copies (fns) and copies undergoing
98 hat we measure by single-molecule imaging of nonspecifically bound fluorescently labeled LacI in livi
100 blocking effect but minimizing the amount of nonspecifically bound iron cations, supports this conclu
103 e amount of background signal arising due to nonspecifically bound probes and fluorescence that is in
105 a heterogeneous polymer, before exposing the nonspecifically bound protein to immobilized oligomeric
106 when the specificity ratio is low, multiple nonspecifically bound proteins may occupy the region of
108 populated (<1%), transient states involving nonspecifically bound Sox2 in rapid exchange with specif
109 was used to represent tracer in the free and nonspecifically bound state, and equilibrium receptor eq
111 c repressor spends approximately 90% of time nonspecifically bound to and diffusing along DNA with a
113 f the DNA-scanning process in which Egr-1 is nonspecifically bound to DNA and perpetually changes its
114 cribing mRNA and ribosomal RNA (rRNA), RNAPs nonspecifically bound to DNA, free RNAP, and immature RN
115 SEP-7 was used as a carrier to remove FM1-43 nonspecifically bound to the outer leaflet of the plasma
116 en the cyclo[n]pyrroles were intercalated or nonspecifically bound to the quadruplex, or if conformat
117 that most of the ions are territorially and nonspecifically bound to the RNA, as predicted by the co
118 um between total tissue concentration (free, nonspecifically bound, and specifically bound) and the f
121 fic sites on DNA, via a mechanism in which a nonspecifically-bound protein can switch between two con
123 omplex ubiquitylates free histone substrates nonspecifically but is highly specific for histone H2A l
124 high levels of CD25 and LAG-3 when expanding nonspecifically, but FoxP3 after activation by the autoa
125 DbpA binds group I and group II intron RNAs nonspecifically, but its ATPase activity is activated sp
126 until recently thought to allow IgG movement nonspecifically by constitutive transcytosis in caveolae
131 t, that uses both the targeted reads and the nonspecifically captured off-target reads to infer copy
132 whenever their morphology or composition are nonspecifically changed without any surface treatment.
134 initiation of plus-strand DNA synthesis and nonspecifically cleaves the viral genome to facilitate s
135 This finding indicates that the RNA forms a nonspecifically collapsed intermediate and then searches
136 ith greater sensitivity and specificity than nonspecifically coupled fragments, and can detect extrem
138 The purified endonuclease domain of RdRp nonspecifically degraded RNA in vitro It is puzzling how
139 polyclonal agents are most widely used; they nonspecifically deplete the T-cell pool and are thus ass
140 -directed therapy (rituximab, two patients), nonspecifically depleted T-cells and was associated with
142 s an aminoglycoside molecule that binds RNAs nonspecifically did not preferentially stabilize the ES
143 ctrometry revealed that this enzyme pair can nonspecifically digest oligonucleotides and DNA into fra
146 ns are scavenger cells that continuously and nonspecifically endocytose fluid from the pseudocoelom (
150 specifically within the IL-1 family but also nonspecifically for TLR ligands and the innate immune re
151 he trilobite neuron phenotype does not arise nonspecifically from aberrant gastrulation-associated mo
153 ere numerous permissive substitutions, which nonspecifically improved cooperativity and affinity of D
154 er cytosolic material, including organelles, nonspecifically in a process called nonselective macroau
155 om a multicopy plasmid, HetR-GFP accumulated nonspecifically in all cells under nitrogen-replete cond
156 ion of the high affinity binding sites found nonspecifically in conventional microtiter well assays.
158 e other hand, haloduracin beta was localized nonspecifically in the absence of haloduracin alpha, but
161 that the gp3 ring binds double-stranded DNA nonspecifically in vitro via electrostatic interactions
163 strate that both viral and cellular RNAs are nonspecifically incorporated into HCMV, potentially thro
165 lished approach to prevent or treat PVAN but nonspecifically increasing host immune competence also a
166 valent salts, which stabilize the folded RNA nonspecifically, induce states that fold in less than 30
167 tic model revealed that most genetic factors nonspecifically influence risk for either all 11 symptom
170 -responsive gene, with tungstate or vanadate nonspecifically inhibited NaPi-2b mRNA expression and Pi
171 measure, geminivirus proteins reverse TGS by nonspecifically inhibiting cellular transmethylation rea
172 portantly, this effect was not reproduced by nonspecifically inhibiting mPFC neurons in VPA-exposed m
174 model of protein and DNA in the presence of nonspecifically interacting bulk and DNA-bound crowders
175 e of cellular environment that contains many nonspecifically interacting proteins and other biomolecu
179 selenomethionine, and these are incorporated nonspecifically into proteins in place of cysteine and m
180 traditionally seen as proteins packaging RNA nonspecifically into ribonucleoprotein particles (RNPs),
181 ibute to the early innate immune response by nonspecifically killing pathogens, virus-infected cells,
183 wn on macrophages as "garbage men" that act "nonspecifically." Last fall's Nobel Prizes honored two o
184 gle bridges formed by proteins that bind DNA nonspecifically, like H-NS dimers, are expected to fail
185 e groups: (I) four genes were down-regulated nonspecifically, likely involving both parental ortholog
186 that TCZ suppresses Ig production in B cells nonspecifically, likely through inhibition of interleuki
187 ectively, the data indicate the Vsa proteins nonspecifically mediate M. pulmonis surface interactions
189 ches and DNA ligase to reseal incorrectly or nonspecifically nicked sites was previously developed in
190 hat K(+) ions bind transiently (</=5 ns) and nonspecifically (nine different positions) to the two tr
191 ipid compositions tested, SNARE-mediated and nonspecifically nucleated pores had similar openness, su
193 ubstantial quantities of VP22 and UL11 bound nonspecifically onto or were precipitated with gE and gD
194 , autophagy can degrade cytoplasmic contents nonspecifically or can target the degradation of specifi
195 ile favoring growth arrest and apoptosis for nonspecifically or inappropriately activated B cells.
196 hown to significantly decrease the amount of nonspecifically or noncovalently bound probe, creating b
197 observation that retroviral particles adhere nonspecifically, or 'hitchhike,' to the surface of T cel
198 obtained after 12 days of incubation, killed nonspecifically pig, human, and mouse normal and maligna
199 nto homomultimers, binds single-stranded RNA nonspecifically, possesses a Mg2+-dependent nucleoside t
200 cule, other ions bind to the protein surface nonspecifically, presumably because the electrostatic at
202 ce, in combination with CD8 T cells that can nonspecifically produce IFN-gamma, leads to transient co
203 nce of TCR ligation, the pathogen is able to nonspecifically promote Th1 responses against nonparasit
204 site destabilize pol beta when bound to DNA nonspecifically, promoting DNA scanning and providing bi
206 eociliary ankle links or pillar cells, which nonspecifically react with two antisera raised against T
207 ng various potential interfering substances, nonspecifically reacting substances (including mRNA from
208 d at the head domain of CCHFV N protein that nonspecifically recognizes the single strand RNA (ssRNA)
211 er cell cultures with DNase I to degrade DNA nonspecifically reduced metastatic characters associated
213 ensitivity to vancomycin and SDS but did not nonspecifically release periplasmic proteins or VirE2 tr
215 e possibility that the Hsp70.1/70.3 mice are nonspecifically sensitized to all protein misfolding dis
216 nd transcriptome sequencing (RNA-Seq), which nonspecifically sequences all RNA, including host and ba
217 half of S phase, to ask whether all origins nonspecifically show decreased firing (as expected for d
218 ssible inorganic arsenic associated with (1) nonspecifically sorbed phases, (2) specifically sorbed p
219 us, certain fluorophore-containing compounds nonspecifically stain degenerating neuronal tissue in hi
221 egulated in allogeneic T cells compared with nonspecifically stimulated T cells were validated in vit
222 hanism by which an HIV-specific response can nonspecifically suppress both HIV-specific and unrelated
224 cult because existing stimulation techniques nonspecifically target all cell types near the stimulate
225 , which targets the human telomeric sequence nonspecifically, the platinum-intercalator technology ha
226 heir target sequence by first binding to DNA nonspecifically, then by linearly diffusing or hopping a
227 egulate synaptic weights homeostatically and nonspecifically, thereby improving the signal:noise rati
228 ntly in the on-state; when these bind to DNA nonspecifically, they form clusters that grow indefinite
229 nuclei (MITN) were long believed to project "nonspecifically," they are now known from rat studies to
231 that mast cells influence T-cell activation nonspecifically through the release of inflammatory medi
232 es not activate arrestin, but acts, probably nonspecifically, through some other part of the transduc
233 ion by structure: 30S subunits bind sequence-nonspecifically to a single-stranded region and, on brea
234 othesis that magnesium ions bind loosely and nonspecifically to actin filaments, and thus show a beha
236 xpress HA-specific Abs, but it does not bind nonspecifically to B cells, and this mutation has no eff
238 projections from midbrain DA neurons target nonspecifically to both the dorsolateral striatum and th
239 ior through sex-specific transcripts and sex-nonspecifically to control the development of imaginal d
240 monoclonal antibodies of the IgM class bind nonspecifically to CSA-selected iRBC, an important consi
242 py suppressor for dnaJ mutations and to bind nonspecifically to DNA and preferentially to curved DNA.
243 e DNA-ACTD interaction; ACTD initially binds nonspecifically to DNA but exerts its activity by dissoc
245 phase in a sigma(S)-dependent fashion, bind nonspecifically to DNA, and form a crystalline structure
247 , both with and without thioredoxin, binding nonspecifically to double-stranded DNA and diffusing alo
249 minal protein fragment (residues 1-70) binds nonspecifically to DRE in a Ca(2+)-independent manner, w
250 ed that Escherichia coli HU(alphabeta) binds nonspecifically to duplex DNA in three different binding
254 tribute to RNA-chaperone activity by binding nonspecifically to large RNA substrates and flexibly tet
258 , UL11, and VP16 are highly prone to binding nonspecifically to other proteins, and this did not repr
259 show that if ParB complexes bind weakly and nonspecifically to ParA filaments, then they can closely
261 contact with pathogen compounds and respond nonspecifically to reinfection, a phenomenon called inna
262 rs have shown that basic residues in NC bind nonspecifically to RNA, which in turn scaffolds or nucle
263 gp120s from CXCR4-using HIV-1 strains bound nonspecifically to several cell lines lacking human CXCR
266 g inverted repeat sequences (i.e., IR-1) and nonspecifically to single-stranded DNA, and related gene
268 remarkable ability to adhere tenaciously and nonspecifically to solid surfaces such as glass, plastic
270 Interference from matrix components adhering nonspecifically to the column was minimized by the inser
272 serum components, that otherwise would bind nonspecifically to the HPIAC column, but allowed the flu
274 cent protein (YFP) and 29/31KT Gag-YFP bound nonspecifically to the PM and intracellular membranes, p
276 ns ruled out variables that might contribute nonspecifically to this result such as differences in ac
277 ductase DsbA, a soluble periplasmic protein, nonspecifically transfers a disulfide to a substrate pro
278 ally, irregularly shaped sickle cells become nonspecifically trapped, resulting in vaso-occlusion.
279 dicate that yRad6 has an in vitro ability to nonspecifically ubiquitylate all core histones in the ab
280 mer bridges and compacts double-stranded DNA nonspecifically via two symmetry-related DNA binding sit
282 rged to hydrolyze the backbone of xyloglucan nonspecifically with a dissociative mode of action and r
283 e C1a domain, most notably Arg(77), interact nonspecifically with anionic phospholipids prior to the
284 anding how gene regulatory proteins interact nonspecifically with DNA in terms of both structure and
285 y in which the chaperone initially interacts nonspecifically with hydrophobic regions of the partiall
288 binding domain of the LacI protein interacts nonspecifically with nonoperator DNA adjacent to the ope
293 e membrane which had been covalently labeled nonspecifically with the hapten p-diazoniumphenyl-beta-D
294 We thus establish that serotonin interacts nonspecifically with the membrane at physiologically rel
295 l operator with a long spacer that interacts nonspecifically with the receptor TPR domain, while the
296 on the tentacles themselves likely interact nonspecifically with the substrate's transmembrane helic
298 ly (with high affinity) to A2RE sequences or nonspecifically (with lower affinity) to other RNA seque
299 that the cytoplasm interacts favorably, but nonspecifically, with CI2, and these interactions overco