ライフサイエンスコーパス: nonstructural protein

1 Vs, except for an SF3 helicase domain in its nonstructural protein.

2 1b region and provide alternative sources of nonstructural proteins.

3 ural DENV infection and were more focused on nonstructural proteins.

4 a, virus shedding or antibodies against FMDV nonstructural proteins.

5 me of rotavirus expresses 6 structural and 6 nonstructural proteins.

6 ied as a novel inducer of apoptosis, as were nonstructural proteins.

7 o be inhibited through interference of viral nonstructural proteins.

8 llular defenses using various structural and nonstructural proteins.

9 The flavivirus nonstructural protein 1 (NS1) alters glycosaminoglycans

10 e of an RDT that detects dengue virus (DENV) nonstructural protein 1 (NS1) and anti-DENV IgM during s

11 y spliced to express two viral proteins, the nonstructural protein 1 (NS1) and the nuclear export pro

12 rbent assays (ELISAs), for detection of DENV nonstructural protein 1 (NS1) antigen and anti-DENV IgM.

13 ctivity, IgG and IgA antibodies against ZIKV nonstructural protein 1 (NS1) antigen were specific to Z

14 The influenza A virus (IAV) nonstructural protein 1 (NS1) contributes to disease pat

15 DENV nonstructural protein 1 (NS1) has long been considered a

16 e pursuit of subunit vaccine approaches, and nonstructural protein 1 (NS1) has recently emerged as a

17 Antibodies directed against the flavivirus nonstructural protein 1 (NS1) have been proposed as sero

18 uated influenza vaccines with truncations in nonstructural protein 1 (NS1) have shown broad protectiv

19 say for the detection of dengue virus (DENV) nonstructural protein 1 (NS1) in serum.

20 (wt) virus-like particles (VLPs) and soluble nonstructural protein 1 (NS1) in the standard immunoglob

21 DENV nonstructural protein 1 (NS1) induces human endothelial

22 Nonstructural protein 1 (NS1) is a membrane-associated a

23 in the replication and pathogenesis of IAV, nonstructural protein 1 (NS1) is a potential target for

24 Flavivirus nonstructural protein 1 (NS1) is a unique secreted nonst

25 Influenza A virus (IAV) nonstructural protein 1 (NS1) is a virulence factor esse

26 The viral nonstructural protein 1 (NS1) is essential in this proce

27 The multifunctional nonstructural protein 1 (NS1) is the main viral factor c

28 A critical role of influenza A virus nonstructural protein 1 (NS1) is to antagonize the host

29 d immunosorbent assays (ELISAs) based on the nonstructural protein 1 (NS1) of DENV serotype 1 (DENV1)

30 DDX41-dependent innate immune responses, the nonstructural protein 1 (NS1) of influenza virus associa

31 Interestingly, nonstructural protein 1 (NS1) of RSV promoted proteasome

32 The nonstructural protein 1 (NS1) of several flaviviruses, i

33 In this study, we demonstrated that the nonstructural protein 1 (NS1) of WNV antagonizes IFN-bet

34 This study demonstrated that the nonstructural protein 1 (NS1) of WNV antagonizes the ind

35 has the ability to track secreted flaviviral nonstructural protein 1 (NS1) over a broad diagnostic an

36 ZIKV nonstructural protein 1 (NS1) plays an essential role in

37 Nonstructural protein 1 (NS1) proteins from avian influe

38 notransferase (AST) level, positivity in the nonstructural protein 1 (NS1) rapid test, and viremia ma

39 rbent assays (ELISAs) based on ZIKV and DENV nonstructural protein 1 (NS1) were established to test a

40 Antibodies to nonstructural protein 1 (NS1) were largely ZIKV-specific

41 of epitopes in the C-terminal region of DENV nonstructural protein 1 (NS1) which are cross-reactive w

42 Influenza A virus (IAV) nonstructural protein 1 (NS1), a potent antagonist of th

43 2), PB1, PB1-F2, Polymerase Acidic-X (PA-X), Nonstructural Protein 1 (NS1), and Nuclear Export Protei

44 uenza virus encodes both the multifunctional nonstructural protein 1 (NS1), essential for innate immu

45 We previously generated a ZIKV nonstructural protein 1 (NS1)-specific human monoclonal

46 tudy, we applied a previously developed anti-nonstructural protein 1 (NS1)-specific MAC-ELISA (NS1-MA

47 antibodies for rapid detection of the dengue nonstructural protein 1 (NS1).

48 tigens, including membrane, envelope (E) and nonstructural protein 1 (NS1).

49 re directly triggered by dengue virus (DENV) nonstructural protein 1 (NS1).

50 ied M segment and the open reading frames of nonstructural protein 1 (NS1)/nuclear export protein (NE

51 toantibodies elicited by dengue virus (DENV) nonstructural protein 1 (NS1; anti-NS1 Igs) induce plasm

52 The nonstructural protein 1 (nsp1) of CoVs is one such prote

53 Similar to the nonstructural protein 1 (nsp1) of SARS-CoV that inhibits

54 the COVID-19 pandemic, SARS-CoV-2, uses its nonstructural protein 1 (Nsp1) to suppress cellular, but

55 h inactive versions of interferon antagonist nonstructural protein 1 (nsp1), nsp15, and nsp16 individ

56 oV genome: the papain-like protease (PLPro), nonstructural protein 1 (nsp1), ORF6, and ORF7a.

57 (SARS-CoV), establish host shutoff via their nonstructural protein 1 (nsp1).

58 c 5' untranslated region and 186 nt from the nonstructural protein 1 [nsp1]-coding region) not found

59 during different stages of infection (viral nonstructural protein 1 and immunoglobulin M) has greatl

60 odes were determined to be VCD by means of a nonstructural protein 1 antigen immunoassay and reverse-

61 st mRNA nuclear export to the cytoplasm, and nonstructural protein 1 beta (nsp1beta) of PRRSV has bee

62 Moreover, rotavirus NSP1 (nonstructural protein 1) employs a pLxIS motif to target

63 dance proteins like the matrix protein 2 and nonstructural protein 1, with a similar impurity level o

64 ring persistent infection requires the viral nonstructural protein 1/2 (NS1/2).

65 Our data are consistent with RSV nonstructural proteins 1 and/or 2 perturbing the Jak-STA

66 sions of three viral interferon antagonists, nonstructural proteins 1, 15, and 16, results in a highl

67 Here, we report that flavivirus nonstructural protein-1 (NS1), which is abundantly secre

68 In addition, PRRSV nonstructural protein 11 (nsp11) was identified to inter

69 CoV nonstructural protein 14 (nsp14) encodes 3'-to-5' exorib

70 The coronavirus (CoV) nonstructural protein 14 (nsp14) is a multifunctional pr

71 lated at the guanine-N-7 (G-N-7) position by nonstructural protein 14 (nsp14), which facilitates and

72 '-to-5' exoribonuclease in coronavirus (CoV) nonstructural protein 14 (nsp14-ExoN) mediates RNA proof

73 in encoding a 3'-->5' exoribonuclease within nonstructural protein 14 (nsp14-ExoN) that is required f

74 CoVs encode a proofreading exonuclease in nonstructural protein 14 (nsp14-ExoN), which confers a g

75 Here we report that coronavirus nonstructural protein 15 (nsp15), an endoribonuclease, i

76 ein 3 or the endoribonuclease (EndoU) within nonstructural protein 15.

77 are stimulated by the interactions of PRRSV nonstructural protein 1beta (nsp1beta) and host protein

78 ctive and respiratory syndrome virus (PRRSV) nonstructural protein 1beta (nsp1beta) is a multifunctio

79 ne coronavirus (mouse hepatitis virus [MHV]) nonstructural protein 2 (ns2) is a 2',5'-phosphodiestera

80 The RSV nonstructural protein 2 (NS2) is a multifunctional prote

81 Hepatitis C virus (HCV) nonstructural protein 2 (NS2) is a multifunctional prote

82 s (BTV) forms VIBs in infected cells through nonstructural protein 2 (NS2), a phosphoprotein.

83 rus with a single phosphomimetic mutation in nonstructural protein 2 (NSP2 S313D) that exhibits delay

84 Nonstructural protein 2 (nsP2) exhibits the protease and

85 athogenic alphavirus representative, and its nonstructural protein 2 (nsP2) plays critical roles in b

86 in of murine hepatitis virus as fusions with nonstructural protein 2 or 3 and whether such reporters

87 Here, we show that dengue nonstructural protein 2A (NS2A protein) recruits viral R

88 Flavivirus nonstructural protein 2B (NS2B) is a transmembrane prote

89 M1404I, in the ZIKV polyprotein, located in nonstructural protein 2B (NS2B).

90 n an interaction between capsid proteins and nonstructural protein 2C(ATPase) In particular, residue

91 of capsid proteins with the multifunctional nonstructural protein 2C(ATPase) In this study, we have

92 The conserved nonstructural protein 2C, which is an AAA+ ATPase, is a

93 ranslation of two additional viral proteins, nonstructural protein 2TF (nsp2TF) and nsp2N.

94 turally occurring polymorphism, Q80K, in the nonstructural protein 3 (NS3) gene encoding the viral pr

95 ng activity is achieved by the ATP-dependent nonstructural protein 3 (NS3) helicase.

96 The viral nonstructural protein 3 (NS3) plays a key role in mediat

97 The capsid protein followed by nonstructural protein 3 (NS3), NS2A, and NS5 were the mo

98 V replication complex is a helicase known as nonstructural protein 3 (NS3).

99 d by the C-terminal helicase domain of viral nonstructural protein 3 (NS3).

100 licase contained in the C-terminal domain of nonstructural protein 3 (NS3).

101 was subsequently shown to recognize the HCV nonstructural protein 3 (NS3):1406-1415 epitope with hig

102 1.5-kb segment 7 dsRNA encoding full-length nonstructural protein 3 (NSP3) fused to UnaG, a 139-amin

103 sion of the reporter protein in frame within nonstructural protein 3 (nsP3) or insertion of the repor

104 One determinant of alphavirus virulence is nonstructural protein 3 (nsP3) that contains a highly co

105 the papain-like protease 2 (PLP2) domain of nonstructural protein 3 (nsp3), a component of the viral

106 his phenotypic difference is associated with nonstructural protein 3 (nsP3).

107 ase (ADRP) activity within the N terminus of nonstructural protein 3 (nsp3).

108 ssential for viral replication and assembly (nonstructural protein 3 [NS3]).

109 enesis and mosquito transmission through the nonstructural protein 3 helicase.

110 antagonists, the deubiquitinase (DUB) within nonstructural protein 3 or the endoribonuclease (EndoU)

111 Based upon nonstructural protein 3 sequence analysis, no compartmen

112 to strengthen interaction between RCHY1 and nonstructural protein 3, leading to a further increase i

113 ithin the Ubl domain, residues 785 to 787 of nonstructural protein 3, which negatively affect proteas

114 -like protease is encoded next to SUD within nonstructural protein 3.

115 5A inhibitor velpatasvir with or without the nonstructural protein 3/4A protease inhibitor voxilaprev

116 an inhibitor of the hepatitis C virus (HCV) nonstructural protein 3/4A protease; MK-5172 is taken on

117 First, we confirmed the presence of HCV nonstructural proteins 3, 4b, and 5a besides HCV core an

118 The nonstructural protein 3A of poliovirus and related virus

119 Knockdown of nonstructural protein 4 (NSP4) attenuates the [Ca(2+)]cy

120 Rotavirus nonstructural protein 4 (NSP4) is an endoplasmic reticul

121 PgV-2 E2 glycoprotein or bacterium-expressed nonstructural protein 4AB (NS4AB) in detecting past or p

122 Dengue virus nonstructural protein 4B (NS4B) is a membrane protein co

123 n of proline at amino acid 219 (P219) of the nonstructural protein 4B (NS4B) with serine, threonine o

124 The large flavivirus nonstructural protein 5 (NS5) (105 kDa) has RNA methyltr

125 Nonstructural protein 5 (NS5) contains a methyltransfera

126 One RRV construct expressed nonstructural protein 5 (NS5), while a second recombinan

127 Further study showed that nonstructural protein 5 (nsp5) of PRRSV induced the STAT

128 unds inhibiting the interaction between DENV nonstructural protein 5 and host nuclear transport prote

129 Nonstructural protein 5 is essential for capping and rep

130 riments showed that ZIKV RNA replication and nonstructural protein 5 translation were reduced below t

131 etween PI(4,5)P2 and hepatitis C virus (HCV) nonstructural protein 5A (NS5A) and effects on the viral

132 Hepatitis C virus (HCV) nonstructural protein 5A (NS5A) and its interaction with

133 ary structure and long-range interactions in nonstructural protein 5A (NS5A) from hepatitis C virus (

134 The discovery of GSK2818713 (13), a nonstructural protein 5A (NS5A) HCV inhibitor characteri

135 tudy to assess whether adding daclatasvir, a nonstructural protein 5A (NS5A) inhibitor that is active

136 een treated with an HCV regimen containing a nonstructural protein 5A (NS5A) inhibitor; and * genotyp

137 s recommend that patients who have failed on nonstructural protein 5A (NS5A) inhibitors should be ret

138 Hepatitis C virus (HCV) nonstructural protein 5A (NS5A) is a phosphoprotein that

139 The hepatitis C virus (HCV) nonstructural protein 5A (NS5A) plays a key role in vira

140 Direct-acting antivirals that target nonstructural protein 5A (NS5A), such as daclatasvir, ha

141 Here, we studied the disordered domain 2 of nonstructural protein 5A (NS5A-D2) of hepatitis C virus

142 All-oral therapy with daclatasvir (nonstructural protein 5A [NS5A] inhibitor), asunaprevir

143 The nonstructural protein 5A A30K and Y93H substitutions wer

144 ral protein 5B inhibitor sofosbuvir plus the nonstructural protein 5A inhibitor velpatasvir with or w

145 ombination of daclatasvir (DCV; pangenotypic nonstructural protein 5A inhibitor) and sofosbuvir (SOF;

146 may be inherently resistant to all approved nonstructural protein 5A inhibitors for gt3 HCV.

147 ur study reveals high frequencies of RASs to nonstructural protein 5A inhibitors in gt3 HCV; the pair

148 fectiveness and safety of sofosbuvir and the nonstructural protein 5A inhibitors in the treatment of

149 containing regimens, particularly those with nonstructural protein 5A inhibitors, are limited and rem

150 e KT recipient was a nonresponder because of nonstructural protein 5A resistance.

151 rug that targets the hepatitis C virus (HCV) nonstructural protein 5B (NS5B) polymerase and inhibits

152 gimens that included the nucleotide analogue nonstructural protein 5B inhibitor sofosbuvir plus the n

153 A inhibitor) and sofosbuvir (SOF; nucleotide nonstructural protein 5B inhibitor) for 12 weeks previou

154 all HCV DAAs and, in particular, not all HCV nonstructural protein 5B inhibitors may exhibit this car

155 tis C viral genome is catalyzed by the NS5B (nonstructural protein 5B) RNA-dependent RNA polymerase,

156 Finally, we found that nonstructural protein 7 (NS7) of MNV co-localizes with G

157 Coronavirus nonstructural protein 8 (nsp8) has been suggested to hav

158 y of interlineage recombination hot spots in nonstructural protein 9 (NSP9) and in the GP2 to GP3 reg

159 y of interlineage recombination hot spots in nonstructural protein 9 (NSP9) and the GP2 to GP3 region

160 Nonstructural protein 9 (Nsp9) is the RNA-dependent RNA

161 In HCV-infected cells, various HCV nonstructural proteins also interact or colocalize with

162 First, we expressed each individual nonstructural protein and examined their cellular locali

163 y important TM dimer interface within an HCV nonstructural protein and reveal a fundamental role of t

164 Furthermore, these drugs target HCV nonstructural proteins, and with selective pressure, the

165 Viral nonstructural proteins are often important for virus rep

166 HCV nonstructural proteins are shown to colocalize with DDX3

167 sk for HCV infection; viral vectors encoding nonstructural proteins are the only vaccine strategy to

168 Nonstructural proteins are translated from genomic RNA a

169 proteomics led to the identification of HCV nonstructural proteins as well as proteins involved in m

170 e peptide epitopes, from both structural and nonstructural proteins, can prevent adenoviral dissemina

171 Our data indicate that both structural and nonstructural proteins contribute to MHV liver pathogene

172 Using monoclonal antibody fragments against nonstructural protein dengue NS1, an early biomarker for

173 y of immunodominance among structural versus nonstructural proteins differs as a function of the infe

174 h genetic vaccines encoding the HCV NS3-NS5b nonstructural proteins during DAA treatment resulted in

175 studies have suggested that multifunctional nonstructural proteins encoded by flaviviruses antagoniz

176 ell populations specific for variants of the nonstructural protein epitope NS3133 that characterize t

177 e compared to the African lineage, mainly in nonstructural proteins, especially protein NS4B.

178 e, little information is available about the nonstructural proteins essential for viral replication,

179 alysis for the first time of this identified nonstructural protein, expanding the knowledge and under

180 ovides a unique example of how a small viral nonstructural protein facilitates the multifaceted regul

181 ts into the mechanism by which a viral small nonstructural protein facilitates the multiple regulatio

182 the genetic background of codon-deoptimized nonstructural protein genes and a deleted small hydropho

183 DENV T cell epitopes are found primarily in nonstructural proteins.IMPORTANCE The issue of potential

184 eus and is essential for expression of viral nonstructural proteins independent of RNA-activated prot

185 sid proteins (53.7% coverage), but none from nonstructural proteins, indicating capsids are packaged

186 ZIKV virulence is to limit the action of the nonstructural proteins involved in its viral replication

187 Many of the nonstructural proteins involved in replication possess m

188 Among them, we proved that one nonstructural protein is critical to the replication of

189 Viral tegument, envelope, and some nonstructural proteins localize to the cVAC, and cytoske

190 The MRV nonstructural protein muNS comprises the structural matr

191 researchers have focused on visualizing the nonstructural protein muNS, which forms the VF matrix.

192 viruses as well as viruses with only p7 and nonstructural protein mutations.

193 Further analysis identified that the small nonstructural protein NP1 is required for HBoV1 DNA repl

194 In this study, we demonstrated that the nonstructural protein NP1 is required for the expression

195 HBoV1 encodes a small nonstructural protein (NP1) that plays an important role

196 DENV nonstructural protein (NS) 1 has been considered to be a

197 cross-reactive Abs, which can recognize DENV nonstructural protein (NS) 1, have been found in dengue

198 Population sequencing of the nonstructural protein (NS) 3, NS5A, and NS5B genes was p

199 were stratified by their cirrhosis and past nonstructural protein (NS) 5A inhibitor exposure.

200 Here, we show that the HCV protein, nonstructural protein (NS) 5B, directly binds to the tum

201 ing plasmid, pHBoV1NSCap, that harbors HBoV1 nonstructural protein (NS) and capsid protein (Cap) gene

202 y and safety of a combination regimen of the nonstructural protein (NS)5A inhibitor ledipasvir (LDV),

203 CypA binds to HCV's nonstructural protein (NS)5A to promote replication of v

204 addition to NP1, MVC encodes five additional nonstructural proteins (NS) that share an initiation cod

205 ssociated substitutions (RASs) in HCV genes (nonstructural protein [NS]3, NS5A, NS5B) targeted by DAA

206 ek regimen of daclatasvir (DCV; pangenotypic nonstructural protein [NS]5A inhibitor) plus sofosbuvir

207 nd in vitro Mechanistically, the viral large nonstructural protein NS1 activates p38 MAPK, which lead

208 Here, we characterized IAV nonstructural protein NS1 and the cellular factor CPSF4

209 The large viral nonstructural protein NS1 is sufficient to induce the DD

210 p53 and IAV, in particular through the viral nonstructural protein NS1, has been shown to be supporti

211 inst ZIKV structural E protein compared with nonstructural protein NS1.

212 mbined the codon deoptimization of genes for nonstructural proteins NS1 and NS2 (dNS), deletion of th

213 SR regulates the expression of HBoV1-encoded nonstructural proteins NS1, NS2, NS3, and NP1 but not NS

214 nor sites, namely, A1' and D1', in the large nonstructural protein (NS1)-encoding region of the HBoV1

215 By screening MEV nonstructural proteins (NS1 and NS2) and structural prot

216 However, we found that the other four nonstructural proteins (NS1 to -4) are not required for

217 NP1 and other viral nonstructural proteins (NS1 to NS4) colocalized within t

218 During infection, B19V expresses three nonstructural proteins (NS1, 11-kDa, and 7.5-kDa) and tw

219 Parvovirus B19 (B19V) nonstructural protein, NS1, a helicase, covalently modif

220 structural proteins, VP1 and VP2, and three nonstructural proteins, NS1, 11-kDa, and 7.5-kDa.

221 B (GBV-B) chimeric virus carrying the major nonstructural proteins NS2 to NS4A (HCV NS2 to -4A chime

222 HCV nonstructural protein NS3/4A interacts with CHK2 and dow

223 eproducibly detected low levels of the viral nonstructural protein, NS3.

224 In this study, we show that the BTV nonstructural protein NS4 favors viral replication in sh

225 Here, we report that the nonstructural protein NS5 of ZIKV and other flaviviruses

226 otent viral inhibitor of this pathway is the nonstructural protein NS5.

227 ntified a novel cellular target of the viral nonstructural protein NS5A and demonstrated its role in

228 show here that phosphorylation of the viral nonstructural protein NS5A at serine residues is importa

229 es to elucidate host factors involved in HCV nonstructural protein NS5A function and found that MOBKL

230 helical (AH) domain of the hepatitis C virus nonstructural protein NS5A, anchored at the cytoplasmic

231 host response to HCV infection is the viral nonstructural protein NS5A, which, in addition to its ro

232 hipathic peptide resembling a segment of the nonstructural protein (NS5A) of the hepatitis C virus.

233 l structural glycoproteins, Gn and Gc, and a nonstructural protein, NSm.

234 revealed several prominent mutations in the nonstructural protein (nsP) 3 and nsP4 genes that emerge

235 genic, involving at least one gene from both nonstructural protein (nsP) and structural protein (sP)

236 by a replicase-transcriptase composed of 16 nonstructural protein (nsp) subunits.

237 roplasms requires interactions between virus nonstructural proteins NSP2 and NSP5, which are associat

238 The nonstructural protein NSP4 of rotavirus is a multifuncti

239 plasmic reticulum (ER) because the rotavirus nonstructural protein NSP4, which interacts with the imm

240 The nonstructural protein NSP5, which undergoes a complex hy

241 Here, we co-expressed the MERS-CoV nonstructural proteins nsp5, nsp7, nsp8, and nsp12 (RdRp

242 ified active SARS-CoV-2 RdRp composed of the nonstructural proteins nsp8 and nsp12.

243 d complex networks of interactions involving nonstructural proteins (NSPs) 2, 5, and 6 and structural

244 y complex networks of interactions involving nonstructural proteins (NSPs) and structural proteins (V

245 hampered by gaps in our understanding of how nonstructural proteins (nsPs) function to form the viral

246 ion strategy and identified six mutations in nonstructural proteins (nsPs) of Venezuelan equine encep

247 genome that also serves as the mRNA for four nonstructural proteins (nsPs) representing subunits of t

248 tion enzyme complexes (RCs) containing viral nonstructural proteins (nsPs) that mediate the synthesis

249 Three viral nonstructural proteins (nsps), nsp3, nsp4, and nsp6, are

250 Coronaviruses encode 16 nonstructural proteins (nsps), three of which, nsp3, nsp

251 that is unusually complex and composed of 16 nonstructural proteins (nsps).

252 We generated viruses lacking the nonstructural protein NSs and show that UUKV NSs is a we

253 ments through interactions between the viral nonstructural protein NSs and the host general transcrip

254 The nonstructural protein NSs is a major virulence factor kn

255 In this study, we report that the nonstructural protein NSs of the newly described severe

256 ed two recombinant viruses, one in which the nonstructural protein NSs open reading frame was deleted

257 Viral nonstructural protein NSs was inhibitory to the inductio

258 resulting from deletions or mutations in the nonstructural protein NSs.

259 glycoproteins Gn and Gc, as well as putative nonstructural proteins NSs and NSm.

260 iruses, it has been well documented that the nonstructural protein (NSs) enables the virus to counter

261 Here we report that a nonstructural protein (NSs) of severe fever with thrombo

262 V (rHB29NSsKO) that cannot express the viral nonstructural protein (NSs) upon infection of cells in c

263 HBoV1 encodes a small nonstructural protein, nuclear protein 1 (NP1), that pla

264 ese results, for the first time, show that a nonstructural protein of a novel insect reovirus provide

265 In this study, we show that a nonstructural protein of BTV (NS4) is critical to counte

266 fers nuclear trafficking capabilities to the nonstructural protein of the virus and that lysine resid

267 Although it is known that the nonstructural proteins of HEV ORF1 are expressed as a si

268 In this report, we identified three new nonstructural proteins of human bocavirus 1 that are exp

269 virus-based vector system that combines the nonstructural proteins of Semliki Forest virus with the

270 ne is expressed from a replicon encoding the nonstructural proteins of Semliki Forest virus.

271 entification of interactions among the other nonstructural proteins, offers new avenues for antiviral

272 nsgenes, placed either immediately after the nonstructural proteins or at the 3' end of the viral cod

273 ction of antibodies against either the viral nonstructural proteins or the capsid.

274 lication complex formation, the synthesis of nonstructural proteins, or viral RNA synthesis in differ

275 P4 position of the cleavage site between the nonstructural protein P1 (nsP1) and nsP2 regions of the

276 ogical analyses showed that the DcRV-encoded nonstructural protein P10 assembled into a virion-packag

277 t reovirus took advantage of a virus-encoded nonstructural protein, P10, for efficient vertical trans

278 ning the three structural proteins and seven nonstructural proteins present in ZIKV, we found that tw

279 t the Ebola virus delta peptide, a conserved nonstructural protein produced in large quantities by in

280 a novel mechanism of how a parvoviral small nonstructural protein regulates viral DNA replication by

281 Of note, unlike the large nonstructural protein (Rep78/68 or NS1) of other parvovi

282 All nonstructural proteins required for viral replication ar

283 may be facilitated by association of the MRV nonstructural protein sigmaNS with the major SG effector

284 SH3-binding protein 1 (G3BP1), with the MRV nonstructural protein sigmaNS, which localizes to VFs vi

285 ve attenuated vaccines based on deletions of nonstructural proteins since single mutations in the vir

286 We also detected interactions involving nonstructural proteins, such as the DNA-binding protein

287 A virus-encoded nonstructural protein, termed NSs, is a major virulence

288 ons between distantly related structural and nonstructural proteins that are essential for virion pro

289 RNA genome, which encodes 3 structural and 7 nonstructural proteins that are expressed as a single po

290 al 20-kDa 3C-like protease (Pro, NS6) into 6 nonstructural proteins that are necessary for viral repl

291 like their enveloped virus counterparts, are nonstructural proteins that evolved specifically to indu

292 lyprotein is required to generate the mature nonstructural proteins that form the viral replicase.

293 Like RSV, PVM also encodes two nonstructural proteins that have been implicated to supp

294 In addition to many viral nonstructural proteins, the presence of cell nuclear pro

295 share common structures in their capsid and nonstructural proteins, there is often low homology at t

296 n is restricted by the inability of the EILV nonstructural proteins to form functional replicative co

297 l and biophysical characterization of an HEV nonstructural protein using a construct that has partial

298 ral replication by generating structural and nonstructural proteins via the cleavage of the viral pol

299 FMDV structural and nonstructural proteins were localized to follicle-associ

300 to the immunodominance hierarchy of the DENV nonstructural proteins, with NS3, NS5, and NS1 being dom