ライフサイエンスコーパス: novelty

1 esting improved conscious access to auditory novelty.

2 ts bred for distinct behavioral responses to novelty.

3 omeostasis in the evolution of morphological novelty.

4 urons emit brief signals that reflect object novelty.

5 l behavior and alter behavioral responses to novelty.

6 ed groups produce higher rates of scientific novelty.

7 e repetitive behaviors and defects in social novelty.

8 served as a repeated source of morphological novelty.

9 ntributor to genome evolution and phenotypic novelty.

10 ikeness, structural diversity and scientific novelty.

11 regulatory networks can generate phenotypic novelty.

12 evolutionary mechanisms leading to metabolic novelty.

13 orted the evolution of a major morphological novelty.

14 partments is concomitant with vast proteomic novelty.

15 ect on sociability and preference for social novelty.

16 new bibliometric statistics: Importance and Novelty.

17 ants, followed by filtering to confirm their novelty.

18 stepwise evolution of a defining vertebrate novelty.

19 -devo studies on morphological evolution and novelty.

20 reduction of gene complement, alongside gene novelty.

21 re, prioritizing structural fit and chemical novelty.

22 sent a major source of genetic variation and novelty.

23 ternal representation, relies on information novelty.

24 GRNs) indeed underlies numerous evolutionary novelties.

25 in the evolutionary origin of developmental novelties.

26 tomes and protostomes also show large genome novelties.

27 lds, two major lophotrochozoan morphological novelties.

28 ajor driver in the emergence of evolutionary novelties.

29 ral attention network's role in attention to novelty, a key feature of behavioral inhibition.

30 Emergence of novelty accelerated during the past 1000 years.

31 o a new level of understanding of phenotypic novelty accompanying polyploidy.

32 vestigate the expression patterns of genetic novelties across cell types, we performed single-cell RN

33 By elucidating the distribution of genetic novelties across spermatogenesis, this study provides a

34 with different combinations of high and low novelty across the three metrics.

35 relationship to past experiences ('distinct novelty') activate the LC to trigger strong initial memo

36 are some commonality with past ones ('common novelty') activate the VTA and promote semantic memory f

37 Considering how novelty acts throughout the predation sequence could imp

38 s rather than the origination of morphologic novelty alone.

39 racterized in early childhood by distress to novelty and avoidance of unfamiliar people, and it is on

40 campal norepinephrine (NE), are activated by novelty and changes in environmental contingencies.

41 nent genetic systems accumulate evolutionary novelty and diversify in the course of evolution is a fu

42 With its novelty and enabling features including downscaled analy

43 ined the neural and behavioral correlates of novelty and familiarity in the olfactory system of Droso

44 depend critically on the balance between the novelty and familiarity of the microbial communities the

45 e, which is in part governed by evolutionary novelty and functional specialization.

46 rich reservoir for generating morphological novelty and highlights a yet unseen role for aECM in reg

47 O solid-solution catalysts and overstate the novelty and importance of the Mo-doped Ni/MgO catalysts

48 and antagonists, to both introduce chemical novelty and improve drug-like properties.

49 us-evoked dopamine responses are enhanced by novelty and increase the rate at which animals acquire c

50 ertion near a gene can contribute to genetic novelty and phenotypic plasticity.

51 n this regard, the co-occurrence of striatal novelty and retrieval success effects in independent stu

52 ation environments for both plausibility and novelty and shows that several routes would have been av

53 led in a watermaze that placed the impact of novelty and sleep in opposition.

54 s a major role in the behavioral response to novelty and stress.

55 tation is the ultimate source of all genetic novelty and the cause of heritable genetic disorders.

56 ofauna attract much attention owing to their novelty and the insights they provide into life under ex

57 people mistakenly associate creativity (the novelty and usefulness of an idea) with idea production

58 ethods implemented in this research show the novelty and usefulness of FT-MIR as a simple, fast, and

59 iew article aims to strike a balance between novelty and validity by focusing on recent large sample-

60 LC is implicated in arousal, response to novelty, and cognitive functions, including decision-mak

61 flexibly regulate their initial reactions to novelty, and in turn, decrease risk for social anxiety.

62 nsights into the emergence of plant chemical novelty, and offers a template for investigating the 300

63 The genetic origins of novelty are a central interest of evolutionary biology.

64 to gain information) and neophobia (avoiding novelty) are considered independent traits shaped by the

65 stion in evolutionary biology is how genetic novelty arises.

66 ty foundation on which complex immunological novelties arose.

67 tal systems tend to respond to environmental novelty as they do to genetic mutation.

68 d the likelihood that an animal would choose novelty at different stages of its training and found ev

69 iosity that unifies previously contradictory novelty-based and complexity accounts.

70 by recommending that our current emphasis on novelty be replaced by a renewed emphasis on predictive

71 reted as "novel" genes, representing genetic novelty born anew within that lineage.

72 ained in the hippocampus in association with novelty but in the cortex in association with sleep.

73 d the role of gene duplication in functional novelty, but its potential has not been fully realized.

74 Gene and genome duplication fosters genetic novelty, but redundant gene copies would undergo mutatio

75 a framework to assess how multiple forms of novelty can act, alone or in concert, on components shar

76 investigated whether behavioral tagging with novelty can be used to tackle memory problems observed i

77 Our ability to anticipate how novelty changes predator-prey interactions will likely h

78 m genomes, which otherwise does not hold big novelties compared to genomes of non-staurosiroid diatom

79 I conclude that placing too much value on novelty could have counterproductive effects on both the

80 ly implemented vulnerability paradigms-niche novelty (decline in modeled suitability), temporal novel

81 tions with CellCognition Explorer, a generic novelty detection and deep learning framework.

82 l subiculum and dispensable for both spatial novelty detection and reward seeking.

83 under haloperidol was reflected by enhanced novelty detection in the hippocampus and increased activ

84 Overall, we demonstrate the potential for novelty detection to yield biologically relevant niches

85 opose a semi-supervised Bayesian approach to novelty detection, allowing the discovery of additional,

86 e human spatial discriminability and spatial novelty detection.

87 cal cultural landscapes experienced a faster novelty development due to the contribution from anthrop

88 ds providing the three important elements of novelty, diversity, and complexity, yet MCR pathways to

89 solved a task that required them to balance novelty-driven exploration with exploitation of what the

90 viously unrecognized involvement for Rap1 in novelty-driven PFC engagement.

91 elty, rather than a focus on single forms of novelty (e.g., invasive predators or climate change).

92 e identification of causal variants based on novelty, effect and annotation information.

93 network while excluding alternative task and novelty effects.

94 events while ruling out alternative task and novelty effects.SIGNIFICANCE STATEMENT This is the first

95 In particular, memory retrieval and novelty encoding were considered in independent studies,

96 utionary mechanisms that generate phenotypic novelty: exaptation and co-opting of the ancestral baupl

97 e developed TIN-X, the Target Importance and Novelty eXplorer, to visualize the association between p

98 t (W = 4) or wake enforced during the day by novelty exposure (EW = 4; males/females balanced).

99 ss and exploration responses to experimental novelty exposure [3, 4, 6-15].

100 Sleep deprivation studies using novelty exposure as a means to keep animals awake sugges

101 , we investigate how different approaches to novelty (fast or slow) determine the time at which explo

102 even while evolving at a constant rate in a novelty-free manner, have merely become undetectable by

103 n both clades are not well explained by this novelty-free model.

104 Although novelty generally increases as a function of time, clima

105 arly-onset seasons associated with antigenic novelty had particularly localized modes of spread, sugg

106 , how the average natural product structural novelty has changed as a function of time, whether explo

107 of this pathway alone can explain the effect novelty has on "flashbulb" memories, and it can become d

108 state-of-the-art methods, FullMeSH has three novelties: (i) Instead of using a full text as a whole,

109 of secondary metabolite biology and network novelties in fungi.

110 There are two main novelties in our method: the use of change point detecti

111 ously been possible and to recognize genomic novelties in particular bird lineages.

112 d emphasize the importance of conserved gene novelties in plant diversification.

113 n unprecedented level of fundamental genomic novelties in two nodes related to the origin of land pla

114 Dopamine neurons are thought to encode novelty in addition to reward prediction error (the disc

115 o overcome a proteinous barrier represents a novelty in ATP-fueled biochemistry, because normally, AT

116 We reconstruct the emergence of novelty in Europe for a set of baseline conditions over

117 abolites and demonstrate its use to evaluate novelty in marine microbial and sponge extracts.

118 s measure can effectively score molecules by novelty in terms of their cumulative sp(3) complexity.

119 in acrodont dentitions probably represents a novelty in the Acrodonta clade.

120 ronment - dolphin gums - uncovers surprising novelty in the bacterial tree of life, underscoring the

121 the isolation-induced serotonin response to novelty in the level of the whole brain and the forebrai

122 These findings represent a great novelty in the study of central orexinergic and NPY-ergi

123 elopment in V. carteri, and of developmental novelty in the volvocine algae.

124 tion are an important source of evolutionary novelty in this highly diversified receptor-ligand syste

125 novelty (standardized anomaly), and spatial novelty (inbound climate velocity)-each of which uses a

126 tomated image processing pipeline whose main novelties include an innovative module for cell detectio

127 Novelties include not only a more user-friendly web inte

128 halopod mollusks evolved numerous anatomical novelties, including arms and tentacles, but little is k

129 us to directly test the relationship between novelty-induced acetylcholine release and later contextu

130 bsequent pairing with shock, suggesting that novelty-induced acetylcholine release primes future cont

131 eprivation studies using approaches avoiding novelty-induced arousal (i.e., gentle handling) suggest

132 rotonin reuptake inhibitors (SSRIs) leads to novelty-induced exploration deficits in adulthood, poten

133 mission, revealing the basis for the reduced novelty-induced exploration in adulthood due to postnata

134 nvolved in emotional regulation, relative to novelty-induced exploration.

135 or cannabimimetic effects, but it decreased novelty-induced hyperactivity, exaggerated stereotypy, a

136 ronic mild stress, chronic forced swim test, novelty-induced hypophagia (NIH), novelty-suppressed fee

137 nced negative affective-like behavior in the novelty-induced hypophagia test following restraint stre

138 l testing measured anxiety levels, using the Novelty-Induced Hypophagia test, and cognition, using a

139 hdrawal-induced anxiety-like behavior in the Novelty-Induced Hypophagia test.

140 Conditional RIM1 KO mice show heightened novelty-induced locomotion and impaired motor learning o

141 eta4 knock-out (KO) male mice show increased novelty-induced locomotor activity, lower baseline anxie

142 NRG2 KOs exhibit hyperactivity in a novelty-induced open field, deficits in prepulse inhibit

143 phenotype characterized by low anxiety, high novelty-induced response, lack of sensitivity to palatab

144 on, and defects in motor learning and social novelty interactions.

145 l as repetitive behaviors and impairments in novelty interest in the social preference test as adults

146 Establishing a timeline for the evolution of novelties is a common, unifying goal at the intersection

147 Understanding the origin of novelty is a key question in evolutionary developmental

148 The molecular and cellular basis of novelty is an active area of research in evolutionary bi

149 The emergence of novelty is baseline specific and, during the early-Holoc

150 Evolutionary novelty is difficult to define.

151 To understand how this novelty is generated, we investigated the evolution of t

152 Comparison of the GRNs identifies how novelty is incorporated in early development.

153 A key novelty is our reporting of the impact of individual KCN

154 ties are not stable over time and biological novelty is predicted to emerge due to climate change, th

155 Overall, the important novelty is speed: where the lightning-fast HHblits neede

156 The main novelty is that the friction factor of vegetated flow ca

157 A second major novelty is the discovery of numerous derived CRISPR-Cas

158 ggest that major substrates for evolutionary novelty lie in the alterations of dendritic structures a

159 Further, the method's novelty lies in the manner in which isofunctional groups

160 of the Capsella genus comprise an anatomical novelty, making it particularly well suited for studies

161 a reinforcement-learning task encompassing a novelty manipulation to disentangle the molecular system

162 However, the rate at which this novelty may arise over longer time periods has so far re

163 nt applications - words such as incremental, novelty, mechanism, descriptive and impact - have lost t

164 rinsic motives such as curiosity or need for novelty, mediated through dopaminergic valuation systems

165 nd impaired performance in Y-maze and social novelty memory tests.

166 rstand how important an explicit emphasis on novelty might be for scientific progress.

167 ogy of science to anticipate how emphasizing novelty might impact the structure and function of the s

168 cal analyses, will help to target functional novelty more efficiently.

169 idered in independent studies, implying that novelty (new > old) and retrieval success (old > new) ef

170 lent iodine reagent, are the most remarkable novelties of this synthetic strategy.

171 These results highlight the increasing novelty of annual climatic conditions viewed through a m

172 etwork meta-analysis (NMA) that includes the novelty of assessing time on root coverage outcomes whil

173 The novelty of BINGO lies in a nonparametric approach featur

174 A key novelty of CAGm is the ability to aggregate microsatelli

175 The breadth and evolutionary novelty of candidate virulence factors that we discover

176 To evaluate the novelty of compounds in a challenging way, we chose the

177 Due to the novelty of e-cigarettes (e-cigs) and e-cigarette liquids

178 We show that the extent of novelty of expressed transcripts decreases significantly

179 The novelty of JDINAC lies in its potential to capture non-l

180 Our study demonstrates the novelty of modeling the human tongue as a porous materia

181 Our study supports eco-evolutionary novelty of non-natives as a driver of their outsized imp

182 The novelty of our approach is that we (a) recognise the sim

183 The novelty of our approach is to design an integrated proce

184 The novelty of our approach lies in (1) representing cell-sc

185 The novelty of our approach resides in the combination of th

186 The novelty of our method is that the contribution of each d

187 The novelty of our new DNN method is its modular architectur

188 Here we develop a framework to test the novelty of population-level findings against simpler fea

189 The novelty of QFT-Plus is that it elicits a response from C

190 us exemplifies the plasticity, dynamics, and novelty of regulatory networks mediated by WGD.

191 The novelty of Strawberry is that the two modules use differ

192 his photochemical process and the structural novelty of the (hetero)aryl-fused 1-aminonorbornane prod

193 The novelty of the instrument lies in its ability to monitor

194 xpression in cancer cells and highlights the novelty of the mda-7/IL-24-miR-221-beclin-1 loop in medi

195 The novelty of the mitogenomic structure in Ceriantharia hig

196 This sort of correction is indeed the main novelty of the paper, being crucial toward reliable meas

197 attract widespread attention due to both the novelty of the phenomena observed and the ability to rel

198 The novelty of the procedure is the production of glass bead

199 The novelty of the synthesis lies in the intermediacy of an

200 development sites, further compounded by the novelty of the technology and inherent difficulty of con

201 The novelty of the work lies in the application of MW radiat

202 Interpreting the function and novelty of these predicted BGCs requires comparison with

203 Regarding the allergy workup, the main novelty of this document is the fact that in some low-ri

204 The novelty of this methodology comes from two main contribu

205 The novelty of this study consists in the combination of the

206 Novelty of this study includes a new method to predict o

207 The novelty of this study is in demonstrating that methods o

208 The novelty of this study is that the metabolic state, expre

209 The novelty of this study lies on both the development of a

210 The novelty of this study was based on the application of li

211 The novelty of this study was to brewed beers containing com

212 The novelty of this suspect screening workflow is to combine

213 The novelty of this technique lies in its feasibility to det

214 The novelty of this work arises from the new synthesis metho

215 The novelty of this work is the first incorporation of NKA i

216 The variation and novelty of various desirable traits seen in these previo

217 Developmental novelties often underlie the evolutionary origins of key

218 d mice to exhibit behaviours associated with novelty or anxiety.

219 ractical way to test individual responses to novelty or challenge.

220 nd interference associated with postencoding novelty or sleep.

221 I is associated with heightened detection of novelty or threat.

222 termine whether resegmentation is a tetrapod novelty, or an ancestral feature of jawed vertebrates, w

223 ciated with increased disparity, morphologic novelty, or the radiation of a single subclade.

224 e signatures across locations, and the three novelty paradigms diverge widely in their climate change

225 gs partially validate results from great ape novelty paradigms in captivity [7, 8].

226 We propose that considering these three novelty paradigms in combination could help improve our

227 ring criteria based on cellular location and novelty parameters to select 5 top lead candidate target

228 Novelty preference (NP) is an evolutionarily conserved,

229 s in VNS and sham rats performing a multiday novelty preference (NP) task.

230 We show that VNS enhances novelty preference (NP); alters the hippocampal, cortica

231 e-art silicon-based immunoFET structures and novelty, principles of operation and sensing performance

232 the explicit evaluation of multiple forms of novelty, rather than a focus on single forms of novelty

233 established as playing an important role in novelty related modulation of hippocampal memory.

234 was uniquely associated with a gradual, goal novelty-related reorganization of place cell assemblies

235 depressive-like behavior compared with high novelty responder (HR) rats.

236 Rats bred for low novelty response (low responder [LR]) exhibit high level

237 luding familiarity with humans, best explain novelty responses of wild great apes.

238 tion with familiar stimuli without affecting novelty responses, whereas photoactivation of the same n

239 and restores oxytocin signalling and social novelty responses.

240 Ts) and completely novel transcripts (CNTs) (novelty score >/= 70%) revealed that the PNTs are both h

241 Novelty seeking did not change markedly until middle age

242 ls through unique IPN circuitry that opposes novelty seeking to control NP.

243 re we use a longitudinal design to track 144 novelty-seeking adolescents at age 14 and 16 to determin

244 d neural responses to anticipated rewards in novelty-seeking adolescents may increase vulnerability t

245 Novelty-seeking tendencies in adolescents may promote in

246 e initial propensity to take drugs; whereas "novelty-seeking" predicts compulsive drug-seeking behavi

247 ce, increased social interaction, and social novelty-seeking).

248 (EL), a behavioral phenotype correlated with novelty-seeking, impulsive response to reward, and vulne

249 ensitivity to alcohol-aversion and increased novelty-seeking, which may be relevant to excessive drin

250 ubsequently tested for sensation-seeking and novelty-seeking.

251 T Burst activation of the broadly projecting novelty signaling system of the locus coeruleus initiate

252 Silencing this novelty signaling system prevented the appearance of new

253 her, these results demonstrate that dopamine novelty signals are localized in TS along with general s

254 y the IPN depends on familiarity signals and novelty signals arising from excitatory habenula and dop

255 nt on task attributes, such as complexity or novelty.SIGNIFICANCE STATEMENT In comparison with other

256 These results highlight the novelty, simplicity and effectiveness of this biomateria

257 netic material that facilitates evolutionary novelty, species adaptation, and crop domestication.

258 y (decline in modeled suitability), temporal novelty (standardized anomaly), and spatial novelty (inb

259 1, gabra2, gabrd, & gabrg2) in response to a novelty stressor.

260 des a hotspot for the origination of genetic novelties such as de novo genes, duplications and mutati

261 sion test (TST), forced swimming test (FST), novelty suppressed feeding (NSF) test, and open field te

262 s, as well as reduced latency to feed in the novelty suppressed feeding test.

263 ntidepressant effects in the forced swim and novelty suppressed feeding tests, and increased synaptic

264 using the forced swim, tail suspension, and novelty suppressed feeding tests.

265 tic ACC stimulation and were evaluated using novelty suppressed feeding, splash, and forced swim test

266 swim test, novelty-induced hypophagia (NIH), novelty-suppressed feeding (NSF), social defeat stress,

267 nd sustained antidepressant responses in the novelty-suppressed feeding test (NSFT), a measure of anx

268 the elevated-plus maze, light-dark box, and novelty-suppressed feeding test revealed no differences

269 using the open-field, elevated plus maze and novelty-suppressed feeding tests.

270 idepressant-like effects in the forced swim, novelty-suppressed feeding, female urine sniffing, and c

271 can be salient for multiple reasons-such as novelty, surprise, or reward prediction errors [20-24]-a

272 d in altered behavioural responses to social novelty tests in mice.

273 her cephalopods offer a wealth of biological novelties that could spur discovery.

274 , cranial placodes are considered ectodermal novelties that drove evolution of the vertebrate head.

275 The nature of the evolutionary novelty that accompanies speciation in a morphospecies i

276 ers of the Capsella genus is a morphological novelty that has evolved after Capsella diverged from Ar

277 A key novelty that makes the presented terahertz detector supe

278 ace receptors has evolved from somewhat of a novelty that was treated with skepticism to purinergic t

279 ion capabilities, rather than any perceptual novelty, that determined whether adult observers' reacti

280 elopment of a recently evolved morphological novelty, the posterior lobe of D. melanogaster.

281 Accurately dating GRN novelties, thereby establishing a timeline for GRN evolu

282 Despite their novelty, these platforms usually rely on optical labels,

283 volutionary origin of insect wings (that is, novelty through a merger of two distinct tissues).

284 Our methodology introduces several technical novelties to tackle the OCT frame misalignment, correct

285 roviruses contribute an abundance of genetic novelty to host genomes, including unique protein-coding

286 rget - altering an individual's mood or task novelty - to improve learning.

287 all three of convergence, conservation, and novelty underlie the modular architecture of Heliconius

288 ive of both number of compounds and compound novelty using a dataset of all published microbial and m

289 igural processing, regardless of an object's novelty, was strongly predicted by alERC volume, but not

290 Of particular novelty, we identified the PRC2-associated protein, ASXL

291 Considering the structural novelty, we propose that lugdunomycin represents a novel

292 Hippocampal memory traces followed by novelty were more dominant by default but liable to inte

293 e whether there are risks to overemphasizing novelty when deciding what constitutes good science.

294 Ecological novelty, when conditions deviate from a historical basel

295 such as opinion formation or the adoption of novelties, where complex mechanisms of influence and rei

296 ity lies in determining how GRNs incorporate novelty while preserving the overall stability of the ne

297 d to a non-linear post-glacial trajectory of novelty with jumps corresponding to periods of rapid cha

298 o identify, and ultimately elucidate, atomic novelty within a complex mixture of small molecules.

299 To illustrate novelty within the dataset, we surveyed the genomic land

300 base rates of failure, persuasion words, or novelty words like "remarkable" or "unexpected." We did