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2 solute reliance developing myofibers have on nuclear accrual to establish size, and the limits of ada
3 ith the NFAT blocker A-285222 reduced NFATc3 nuclear accumulation and NFAT-luciferase transcriptional
5 1 is not only positively correlated with the nuclear accumulation of SREBP1 in samples from patients
9 Further mechanistic dissection suggests that nuclear Akt activity mediates growth factor-induced nucl
11 chromosome arms, yet how the cell regulates nuclear and chromatin-associated RNAs after chromosome c
14 Mitochondrial disorders are the result of nuclear and mitochondrial DNA mutations that affect mult
15 evisiae, the Pif1 helicase functions in both nuclear and mitochondrial DNA replication and repair pro
16 f a multitude of membranous, cytoplasmic and nuclear antigens in whole mouse organs and embryos, huma
18 Here, we describe an approach to large-scale nuclear architecture in metazoans that incorporates cell
21 nderground at the Laboratory for Underground Nuclear Astrophysics (LUNA) of the Laboratori Nazionali
23 the range of transcriptional return on a per nuclear basis in myofibers diminishes, which accounts fo
25 ligomerization promote the assembly of large nuclear bodies, which sequester SRSF7 transcripts at the
30 al GABAergic interneurons in the basolateral nuclear complex (BNC) of the amygdala are critical for t
31 e cochlear nuclear complex, superior olivary nuclear complex, lateral lemniscus, inferior colliculus,
34 ned, which were modified into the definitive nuclear configuration through the metamorphic climax.
36 ally, we observed an altered distribution of nuclear cyclic guanosine monophosphate-adenosine monopho
37 Compared to FF, FFPE transcripts coding for nuclear/cytoplasmic proteins involved in DNA packaging,
39 perones for cytoskeletal maintenance in post-nuclear degradation lens fiber cells, perturbation of wh
40 Glucose conjugation nevertheless increases nuclear delivery ca 2.5-fold, and a non-destructive inte
41 chromosomal abnormalities and the release of nuclear DNA into the cytoplasm, activating the cGAS-STIN
44 rovide insights into both the electronic and nuclear dynamics of this fundamental class of reactions.
47 e impact of transcriptional reprogramming of nuclear-encoded chloroplast genes during disease and def
49 synthetic riboswitches for the regulation of nuclear-encoded genes in planta remains to be explored.
50 of 72 chloroplast genes and 7621 homologous nuclear-encoded proteins, for 157 and 76 taxa, respectiv
51 contrast, the protein abundance of specific nuclear-encoded subunits in oxidative phosphorylation co
52 lly diverse organelles that are dependent on nuclear-encoded, plastid-targeted proteins for all bioch
54 ox and TF, cytotoxicity of CDT resulted from nuclear entry by Dox, promoting double-stranded DNA brea
57 lines are induced by stretch stimulation and nuclear envelope (NE) proteins including nesprins, SUN2,
58 Comparisons of shape and integrity of the nuclear envelope and its resistance to stresses found th
59 cytoplasmic components are displaced before nuclear envelope assembly by the movement of chromosomes
63 alculations support the possibility that the nuclear envelope may balance significant mechanical stre
64 found that both mutations result in similar nuclear envelope perturbations that were reversed in the
67 Poly(ADP-ribose) polymerase 1 (PARP-1) is a nuclear enzyme involved in DNA repair and transcription
68 gical activation of the transcription factor nuclear erythroid 2-related factor 2 (Nrf2) enables ideb
71 osphatase activation leading to Akt-mediated nuclear exclusion of FoxO1 and concomitant beta-catenin
72 factor that is specifically required for the nuclear export of intronless and intron-poor mRNAs and l
75 kinase C (aPKC) at the contact-free domain, nuclear expression of Hippo signalling pathway effectors
79 entified that aging alters Sirtuin-1-hepatic nuclear factor 4alpha circuit in hepatocytes to downregu
80 imary cultures of rat enteric neurons and in nuclear factor erythroid 2-related factor (Nrf2) knockou
82 alyses across technologies demonstrated that nuclear factor kappa B (NF-kappaB) and cholesterol biosy
85 insulin receptor, which in turn activates a nuclear factor kappa B-dependent metabolic pathway, lead
86 dly induces co-occupancy of KDM7A and UTX at nuclear factor kappa-B (NF-kappaB)-associated elements i
87 nducible expression of receptor-activator of nuclear factor kappa-Beta ligand (Rankl) leads to ectopi
88 ntrols whether the cell undergoes NF-kappaB (nuclear factor kappa-light-chain-enhancer of activated B
89 e (MAPK), Jun NH2-terminal kinase (JNK), and nuclear factor kappa-light-chain-enhancer of activated B
90 antagonist; or parthenolide, a caspase-1 and nuclear factor kappa-light-chain-enhancer of activated B
91 tion of EGLN3, a known negative regulator of nuclear factor kappaB (NF-kappaB), as a direct target of
94 Genetic faults in several components of the nuclear factor-kappaB pathway cause immunodeficiency.
96 e that SETD6 is necessary for memory-related nuclear factor-kappaB RELA methylation at lysine 310 and
97 ypothesis, we resequenced two 3-4 generation nuclear families (totaling 29 individuals) of olive babo
102 onses, including transcriptional rewiring of nuclear gene expression, return to levels, such as, or e
103 us to retrieve the plastome, 57 single copy nuclear genes, and the nuclear ribosomal ITS from 29 spe
106 mitochondrial DNA are also reflected in the nuclear genome or, alternatively, are the product of lim
107 s local pool at each cell division modulates nuclear growth kinetics and dictates size scaling throug
108 st known as a scaffolding protein within the nuclear hetero-hexameric transcriptional Elongator prote
111 in aggregate followed by modality (CT, MRI, nuclear imaging, echocardiography, US, radiography).
112 ex blockade to monitor the kinetics of HIV-1 nuclear import and define the biochemical staging of the
116 ggest that the C9orf72-HRE impairs Mitf/TFEB nuclear import, thereby disrupting autophagy and exacerb
117 ng, RNA processing, translation, metabolism, nuclear integrity, protein trafficking, and cytoskeletal
119 Src family kinase biosensors showed that the nuclear kinase activities are much suppressed compared t
121 ndent downregulation of lamin B1, one of the nuclear lamins in adult neural stem/progenitor cells (AN
122 ly the GCL, inner plexiform layer, and inner nuclear layer thickness with rates of -0.11 mum/year, -0
123 or resolved PAMM lesion was defined as inner nuclear layer thinning with outer plexiform layer (OPL)
124 ression model showed that SSPiM in the inner nuclear layer was related to treatment response (P = 0.0
125 tive EYS secretory vesicles within the outer nuclear layer, and diminished EYS protein near the conne
126 s, and thinned the outer plexiform and inner nuclear layers of both WT and hWtEPOR 8-week-old mice.
130 In this study, we manipulated three putative nuclear localization (NLS1 to -3) and two potential nucl
131 d that the ring component anillin contains a nuclear localization signal (NLS) that binds to importin
132 at CRWN4 is coimported into the nucleus with nuclear localization signal (NLS)-bearing paralogues in
133 These features include enhancement of the nuclear localization signals in the nucleocapsid protein
136 re, we show that an AT-hook motif-containing nuclear localized (AHL) protein regulates lipid mobiliza
140 iology techniques are X-ray crystallography, nuclear magnetic resonance (NMR) imaging, and cryogenic
144 ando synchrotron X-ray diffraction (XRD) and nuclear magnetic resonance (NMR) spectroscopy to demonst
145 on reaction mechanism was examined employing nuclear magnetic resonance (NMR) spectroscopy to determi
153 ctures elucidated by one and two-dimensional nuclear magnetic resonance spectroscopy (1D and 2D NMR)
154 17 wines of Czech origin were analysed using nuclear magnetic resonance spectroscopy (NMR) with the a
156 d de-N-acetylated by mono- and bidimensional Nuclear Magnetic Resonance spectroscopy and mass spectro
157 e spectroscopic analysis performed by proton-nuclear magnetic resonance spectroscopy showed that the
158 ng circular dichroism, thermal denaturation, nuclear magnetic resonance spectroscopy, analytical ultr
159 , electrospray ionization mass spectrometry, nuclear magnetic resonance spectroscopy, and density fun
160 omplex at polymer chain ends is evidenced by nuclear magnetic resonance spectroscopy, end group analy
165 ty classes has been evaluated by time domain Nuclear Magnetic Resonance, Thermogravimetric analysis a
169 ting, localizing, and characterizing special nuclear material (e.g. highly-enriched uranium, plutoniu
170 y, American College of Radiology, Society of Nuclear Medicine and Molecular Imaging, American Urologi
172 onstructed images were blindly reviewed by 3 nuclear medicine physicians and scored (using a Likert s
173 Conclusion: Both diagnostic and therapeutic nuclear medicine procedures declined precipitously, with
174 f the predicted PET images was assessed by 2 nuclear medicine specialists using a 5-point grading sch
177 ne encompassing the acentrics fuses with the nuclear membrane, facilitating integration of the acentr
180 cues that pattern cortical Galphai, LGN, and nuclear mitotic apparatus protein (NuMA) [3, 7-18].
182 ural development is the origin of stochastic nuclear movement between apical and basal surfaces of ne
183 lization of Raptor to the nucleus results in nuclear mTORC1 activity in the absence of growth factor
185 nd presents dynamic crowding within the bulk nuclear nanoenvironment as a novel regulatory framework
186 ving force for the effort is in the realm of nuclear nonproliferation efforts, the ubiquitous use of
190 emonstrated that A2AR ligation increased the nuclear P-SMAD2/3/P-SMAD1/5/8 ratio, a change associated
191 ive uptake, and those that measure cytosolic/nuclear penetration, which represents only productive up
194 growth of rice shoots, likely to be through nuclear phosphoinositide signals, and provides insights
195 perimental results settle the most uncertain nuclear physics input to BBN calculations and substantia
196 of important systems in condensed matter and nuclear physics, as well as the study of many-body state
197 e ambitious room temperature in situ dynamic nuclear polarisation studies of batteries and the select
200 is activity is also important for interphase nuclear pore complex insertion into growing germline nuc
201 subset of 8, including key components of the nuclear pore complex scaffold and the transmembrane nucl
204 intuiting which molecular forces govern the nuclear positioning; we therefore used computational scr
205 does not rely on a physical rearrangement of nuclear positions, material constraints are lifted, thus
206 on in freshwater systems after the Chernobyl Nuclear Power Plant (NPP) accident in 1986 and in freshw
207 ntamination caused by the Fukushima Dai-ichi Nuclear Power Plant accident has aroused great concern r
209 leukemia protein (PML) bodies, sites of many nuclear processes including protein quality control of n
213 poptotic markers and increased expression of nuclear protein 1 and tribbles related protein-3 compare
214 syltransferase that modifies cytoplasmic and nuclear protein by transfer of N-acetylglucosamine (O-Gl
222 tein activator receptor gamma (PPARgamma), a nuclear receptor involved in inflammatory responses.
223 t directs the biodistribution of parent drug nuclear receptor modulators into the CNS while masking t
225 cells, PD-L1 expression was regulated by the nuclear receptor NR4A1/Sp1 complex bound to the proximal
227 These lipids are endogenous ligands for the nuclear receptor PPARalpha, and we demonstrate that Ppar
230 how that liver X receptors (LXRs)-a class of nuclear receptors and transcription factors with diverse
231 ol metabolism and energy balance via several nuclear receptors and/or G-protein-coupled receptors(3,4
233 roperties of druggability and actionability, nuclear receptors have demonstrated much promise as nove
234 liminarily been identified as a modulator of nuclear receptors involved in beta-amyloid (Abeta) metab
235 Consequently, EP300 is redirected away from nuclear receptors that promote differentiation towards b
236 ndrome, as RXR heterodimerizes with multiple nuclear receptors that regulate genes involved in metabo
239 ing the circumstances of the undeclared 2017 nuclear release of ruthenium that led to widespread dete
241 example, they describe how long interspersed nuclear repeat (LINE1) transcripts are recruited togethe
242 uggest that the initial clustering is due to nuclear repulsion from the cell poles, while the third,
243 e mutants can rescue iMEF survival and small nuclear ribonucleoprotein (snRNP) assembly, demonstratin
245 -type spliceosomes, large complexes of small nuclear ribonucleoprotein particles and associated prote
248 stome, 57 single copy nuclear genes, and the nuclear ribosomal ITS from 29 species representing all b
249 tin-beta1, nucleoporin 98 and nucleoporin 62 nuclear rim staining are observed in Purkinje cells of A
250 ding sites of TRAMP components with multiple nuclear RNA binding proteins, revealing preferential col
251 ost abundant non-coding (spliceosomal) small nuclear RNA, silences proximal PASs and its inhibition w
254 Site is highly desirable for the purpose of nuclear safety and environmental protection, but current
257 Despite the correlation between abnormal nuclear shape and human pathologies, the mechanism by wh
258 eographing proper chromatin decompaction and nuclear shape by directly associating with the DNA.
262 relocation were connected by a novel synapto-nuclear signaling pathway that surprisingly invoked mech
264 se TOE1 in distinguishing the fates of small nuclear (sn)RNAs of the spliceosome from unstable genome
267 ession correlates inversely with distance to nuclear speckles, with chromosome regions of unusually h
269 anging the coherent superposition of initial nuclear spin states with an external magnetic field.
270 action with the nanoscale ensemble of atomic nuclear spins, which is particularly problematic in stra
271 arkably, after this cytoplasmic passage, the nuclear stability of telomerase RNA no longer depends on
272 or 2 (RTF2) restricts influenza virus at the nuclear stage (and perhaps other stages) of the viral li
274 il to capture the viscoelastic modulation of nuclear stress-strain relationships by the physiological
276 Removal of (99)TcO(4)(-) from legacy defense nuclear tank waste at Savannah River Site is highly desi
277 osphorylated N-terminus that interacted with nuclear TCF-4 resulting in luciferase reporter activity
278 lly, these data bring a new dimension to the nuclear theranostic model by showing a requirement for i
280 rylation of PHB1 at Thr258, resulting in its nuclear translocation and binding to the Axin1 promoter.
281 RT1) repression and stimulates NF-kappaB p65 nuclear translocation and transactivation of NF-kappaB t
282 ctivation, enhanced spine Ca(2+) transients, nuclear translocation of a CaM shuttle, and nuclear CaMK
283 ular activation of c-Jun was demonstrated by nuclear translocation of c-Jun, enhanced phosphorylation
284 between CLOCK and BMAL1 and interferes with nuclear translocation of CLOCK both in vivo and in vitro
286 STING-mediated IFN production is mediated by nuclear translocation of IRF3 whereas TLR9-mediated acti
287 t maternal piRNAs, which prevents precocious nuclear translocation of NRDE-3 in the early embryo.
288 Akt activity mediates growth factor-induced nuclear translocation of Raptor, a regulatory scaffoldin
289 c study showed the inhibition of EGFR caused nuclear translocation of S6K1 for binding with MDM2 in r
292 esenchymal transition (EMT) and beta-catenin nuclear translocation to promote cell migration and inva
293 on 6 to 9 (ARM6-9) of KAP3, required for its nuclear translocation, is also necessary and sufficient
296 ble to host a geological repository in every nuclear waste-generating country, but carbonate rocks ma
298 is it that someone would approve of using a nuclear weapon to kill millions of enemy civilians in th
300 mics, we show that a cycle of fast exodus of nuclear YAP to the cytoplasm followed by fast reentry to