ライフサイエンスコーパス: nuclear RNA

1 nical mechanisms of base pairing to U1 small nuclear RNA.

2 ynamic deposition on mRNA and other types of nuclear RNA.

3 and H/ACA small nucleolar RNAs and U4 small nuclear RNA.

4 ated by changes in short lived heterogeneous nuclear RNA.

5 esis of the complete Ighm/Ighd heterogeneous nuclear RNA.

6 ts association with the inhibitory 7SK small nuclear RNA.

7 en-induced expression of CYP1A heterogeneous nuclear RNA.

8 NAs have not been optimized for the study of nuclear RNAs.

9 28S rRNAs and levels of the U-class of small nuclear RNAs.

10 plex required for 3'-end processing of small nuclear RNAs.

11 ylguanosine (TMG) caps on spliceosomal small nuclear RNAs.

12 s, which share some of the features of small nuclear RNAs.

13 t not that of RESCUE-S, can efficiently edit nuclear RNAs.

14 also generates the spliceosomal U-rich small nuclear RNAs.

15 ctural features with cellular Sm-class small nuclear RNAs.

16 of the large inactive P-TEFb:7SK RNP (small nuclear RNA 7SK ribonucleoprotein) complex and the relea

17 , which prevented the destabilization of the nuclear RNA 7SK, a process normally associated with adul

18 t LARP7, BCDIN3, and the noncoding 7SK small nuclear RNA (7SK) are vital for the formation and stabil

19 thyl phosphate capping enzyme, and 7SK small nuclear RNA (7SK).

20 cRNAs implicated in RNA processing: U1 small nuclear RNA, a component of the spliceosome, and Malat1,

21 talysis by unwinding base-paired U4/U6 small nuclear RNAs, a step that must be precisely timed.

22 e of changes in nascent transcript and total nuclear RNA abundance for the transcription factors STAT

23 of cytoplasmic ORF59 RNA, ORF57 offsets the nuclear RNA accumulation mediated by RBM15 by preventing

24 quence element (PSE) recognized by the small nuclear RNA activating protein complex (SNAPc).

25 he Myb-like DNA-binding subunit of the small nuclear RNA activating protein complex, binds piRNA clus

26 We identified a zebrafish snapc4 (small nuclear RNA-activating complex polypeptide 4) mutant in

27 ique transcription factor known as the small nuclear RNA-activating protein complex (SNAPc).

28 The small nuclear RNA-activating protein complex SNAP(c) is requir

29 IB, and TFIIH which, together with the small nuclear RNA-activating protein complex, form a transcrip

30 t-long RNAs, including spliceosomal U6 small nuclear RNA and a cyclic-di-AMP binding riboswitch RNA.

31 The SL RNA is a small nuclear RNA and a trans splicing substrate for the matur

32 The splicing factor SC35/SRSF2 binds to nuclear RNA and facilitates the incorporation of exon 10

33 ntalization by fluorophore-labeling U1 small nuclear RNA and observing its distribution in the nucleu

34 f uridine residues to pseudouridine in small nuclear RNA and ribosomal RNA.

35 articles (snRNPs), which consist of U1 small nuclear RNA and ten proteins, recognize the 5' splice si

36 the machinery that coordinates the export of nuclear RNA and the import of nuclear proteins.

37 ases the levels of spliceosomal and U7 small-nuclear RNAs and corrects RNA processing defects induced

38 that is crucial for the biogenesis of small nuclear RNAs and enhancer RNAs.

39 ial interactions of pre-mRNA with five small nuclear RNAs and many proteins.

40 lexes Nrd1/Nab3 and TRAMP4, targets aberrant nuclear RNAs and processes snoRNAs.

41 thin snatched fragments and found that small nuclear RNAs and small nucleolar RNAs contributed the mo

42 s in the misexpression of a variety of small nuclear RNAs and small nucleolar RNAs, an effect that is

43 to noncoding RNAs such as rRNA, tRNA, small nuclear RNA, and small nucleolar RNA is likely to affect

44 lar RNA, natural antisense transcript, small nuclear RNA, and small RNA using published datasets and

45 ricate network formed by U5, U2 and U6 small nuclear RNAs, and a pre-messenger-RNA substrate.

46 We further found that nuclear RNAs are critical to its oligomerization.

47 rcoma-associated herpes virus polyadenylated nuclear RNA) are not efficiently processed to precursor

48 liceosome, a macromolecule composed of small nuclear RNAs associated with proteins.

49 on of IRAK4-L is mediated by mutant U2 small nuclear RNA auxiliary factor 1 (U2AF1) and is associated

50 U2 Small Nuclear RNA Auxiliary Factor 1 (U2AF1) forms a heterodim

51 of all placental mammals express an ancient nuclear RNA binding protein of unknown function called R

52 r neurons exhibit aberrant localization of a nuclear RNA binding protein, TDP-43, into cytoplasmic ag

53 Enteroviruses are dependent upon host nuclear RNA binding proteins for efficient replication.

54 ding sites of TRAMP components with multiple nuclear RNA binding proteins, revealing preferential col

55 ate ubiquitously expressed and predominantly nuclear RNA binding proteins, which form pathological cy

56 Finally, we determined the nuclear RNA-binding profile of Ago-2, found it bound to

57 Cytosolic aggregation of the nuclear RNA-binding protein (RBP) TDP-43 (43 kDa TAR DNA

58 nderlie ribonucleoprotein (RNP) granules and nuclear RNA-binding protein assemblies that may nucleate

59 Reinduction of a nuclear RNA-binding protein CELF1 (CUGBP Elav-like famil

60 f-function cytoplasmic aggregates or loss of nuclear RNA-binding protein function.

61 Heterogeneous nuclear RNA-binding protein LL (hnRNPLL) is specifically

62 ar ribonucleoprotein C (HNRNPC), an abundant nuclear RNA-binding protein responsible for pre-mRNA pro

63 Cytosolic aggregation of the nuclear RNA-binding protein TDP-43 is a histopathologic

64 TDP-43 is a predominantly nuclear RNA-binding protein that forms inclusion bodies

65 SART3 is a spliceosome recycling factor and nuclear RNA-binding protein with no previously reported

66 FUS is a nuclear RNA-binding protein, and its cytoplasmic aggrega

67 A predominantly nuclear RNA-binding protein, HuR translocates to the cyt

68 with the survival factor p54nrb/Nono (54-kDa nuclear RNA-binding protein, non-POU-domain-containing o

69 FUS, a nuclear RNA-binding protein, plays multiple roles in RNA

70 ation initiation factor 2alpha, shuttling of nuclear RNA-binding proteins such as TIA-1 to the cytopl

71 that the three UBA2 genes encode hnRNP-type nuclear RNA-binding proteins that function in a novel wo

72 We identify two, primarily nuclear RNA-binding proteins, hnRNP L and NF90, with pre

73 nally responsive and interacts with abundant nuclear RNA-binding proteins.

74 Here we identify a component of the nuclear RNA cap-binding complex (CBC), Ars2, that is imp

75 sistant protein 2 (ARS2), a component of the nuclear RNA CAP-binding complex that is crucial for biog

76 ular spliceosome components, including small nuclear RNAs, cause reproducible uniquely distributed ph

77 and a 'U1 domain' that binds to the U1 small nuclear RNA component of the U1 small nuclear ribonucleo

78 ladenosine (m(6)A) methylation of eukaryotic nuclear RNA controls post-transcriptional gene expressio

79 he 3UTR of nuclear-retained Cat2 transcribed nuclear RNA (Ctn RNA).

80 Nudt16p is a nuclear RNA decapping protein initially identified in Xe

81 While vertebrate Nudt16p is a nuclear RNA decapping protein, Syndesmos is associated w

82 (RNase) that contributes to cytoplasmic and nuclear RNA decay and quality control.

83 BP2 is synthetic lethal with deletion of the nuclear RNA decay factor, RRP6, pointing to a global rol

84 state RNA sequencing in mutants defective in nuclear RNA decay including the exosome to reassess the

85 rus both protects from and exploits the host nuclear RNA decay machinery for proper expression of its

86 ts in exposure to at least two host-mediated nuclear RNA decay pathways, the PABPN1- and PAPalpha/gam

87 to degradation by at least two host-mediated nuclear RNA decay pathways, the PABPN1- and poly(A) poly

88 hether RNA cleavage is sufficient to trigger nuclear RNA degradation and transcription termination or

89 s of different cofactors associated with the nuclear RNA degradation machinery.

90 uggesting the existence and maintenance of a nuclear RNA degradation pathway in metazoans.

91 bonucleolytic exosome complex is central for nuclear RNA degradation, primarily targeting non-coding

92 e to obtain useful sequencing libraries from nuclear RNA derived from cultured human cells after cros

93 post-transcriptional modification and small nuclear RNA duplexes for splicing.

94 is known about the mechanisms that regulate nuclear RNA editing activity.

95 clear import of specific ADARs and, in turn, nuclear RNA editing.

96 cterized 247 liver lincRNAs, with many being nuclear RNA enriched and regulated by growth hormone.

97 The viral polymerase complex co-opts the nuclear RNA exosome complex and cellular RNAs en route t

98 DIS3 encodes a catalytic subunit of the nuclear RNA exosome complex that mediates RNA processing

99 Mechanistically, the nuclear RNA exosome coordinates the initial steps of vir

100 The nuclear RNA exosome includes a 9-subunit non-catalytic c

101 The nuclear RNA exosome is an essential multi-subunit comple

102 Rrp6 is a key catalytic subunit of the nuclear RNA exosome that plays a pivotal role in the pro

103 CHC8 in mediating TR 3' end targeting to the nuclear RNA exosome.

104 hysically interacts with the ribonucleolytic nuclear RNA exosome.

105 Nuclear RNA exosomes catalyze a range of RNA processing

106 of NS1 as the mRNA export receptor complex, nuclear RNA export factor 1-nuclear transport factor 2-r

107 ted from nucleus to cytoplasm by a family of nuclear RNA export factors (NXF).

108 -1 and EBER-2, are highly abundant noncoding nuclear RNAs expressed during all forms of EBV latency.

109 presence of m(6)A on transcripts can impact nuclear RNA fates, a reader of this mark that mediates p

110 al sequestration of MBNL1 splicing factor by nuclear RNA foci and consequently MBNL1 functional loss,

111 Mutant DMPK mRNAs are toxic, present in nuclear RNA foci and correlated with a plethora of RNA s

112 of muscleblindlike 1 (MBNL1) protein within nuclear RNA foci and increased CUGBP, ELAV-like family m

113 Thus, nuclear RNA foci are neutral intermediates or possibly n

114 licing factor MBNL1, which is sequestered in nuclear RNA foci by C(C)UG microsatellite expansions in

115 Here, we identify nuclear RNA foci containing the hexanucleotide expansion

116 By contrast, siRNAs fail to reduce nuclear RNA foci despite marked reduction in overall C9o

117 Brains of 6-month-old mice contained nuclear RNA foci, inclusions of poly(Gly-Pro), poly(Gly-

118 liced C9ORF72 transcript and to formation of nuclear RNA foci, suggesting multiple disease mechanisms

119 e identified by biochemical fractionation of nuclear RNA followed by RNA sequencing, but until now, a

120 tionally acquired oligo(A) tails that target nuclear RNAs for degradation.

121 h to compare APA profiles of cytoplasmic and nuclear RNA fractions from human cell lines.

122 Here, we describe the purification of nuclear RNA from early stage Arabidopsis thaliana embryo

123 Loss of repeat-rich, stable nuclear RNAs from euchromatin corresponds to aberrant ch

124 Vectors should be useful in conditions where nuclear RNA function is studied or where export to the c

125 hemical modifications of ribosomal and small nuclear RNAs, functions that are carried out in the nucl

126 RMRP was the first non-coding nuclear RNA gene implicated in a disease.

127 AP(c) is required for transcription of small nuclear RNA genes and binds to a proximal sequence eleme

128 ted, RNAPII-dependent, uridylate-rich, small nuclear RNA genes.

129 tor that is required for expression of small nuclear RNA genes.

130 structural and RBP interaction landscape of nuclear RNAs has yet to be compiled for any organism.

131 Nuclear RNA helicase A (DHX9/RHA) is necessary for the t

132 ommon global breakdown in RNA metabolism and nuclear RNA homeostasis.

133 We demonstrate the canonical nuclear RNA [human telomerase RNA (hTR)] is not present

134 RNA, small Cajal body RNA (scaRNA) and small nuclear RNA in human and mouse cells by conventional tra

135 ides at the 3' end of the catalytic U6 small nuclear RNA in splicing termination.

136 n a biological function to a large noncoding nuclear RNA in the regulation of mRNA export.

137 However, functionalizing these nuclear RNAs in mammalian cells remains challenging, due

138 interactions between unspliced RNA and small nuclear RNAs in spliceosomal intermediates.

139 ovalent modifications of ribosomal and small nuclear RNAs in the nucleus.

140 hat a base-paired complex of U6 and U2 small nuclear RNAs, in the absence of the approximately 200 ot

141 at the Gemin5-containing subunits bind small nuclear RNA independently of the SMN complex and without

142 hese studies show that REF/Aly can stabilize nuclear RNAs independently of their export and support a

143 sters the 5'ss residues involved in U1 small nuclear RNA interactions, thereby inhibiting excision of

144 e U6 ACAGAGA stem-pre-mRNA and Brr2-U4 small nuclear RNA interactions.

145 Nuclear RNA interference (RNAi) is mediated by the canon

146 acting RNA (piRNA) function and the germline nuclear RNA interference (RNAi) pathway, as well as MET-

147 Nuclear RNA interference (RNAi) pathways work together w

148 The Caenorhabditis elegans nuclear RNA interference defective (Nrde) mutants were i

149 leoprotein (U1-snRNP) that includes U1-small nuclear RNA is a highly conserved intranuclear molecular

150 The 7SK small nuclear RNA is a highly conserved non-coding RNA that re

151 protein La recognizes UUU-3'OH on its small nuclear RNA ligands and stabilizes them against 3'-end-m

152 ed previously unknown regulatory factors for nuclear RNA localization.

153 an Ago/Piwi protein and 3' tRNA fragments in nuclear RNA metabolism.

154 the SLA1 snoRNP but does not affect U1 small nuclear RNA methylation.

155 increased by 2- to 10-fold the heterogeneous nuclear RNA, mRNA, protein, and activity levels of GLUT5

156 owed that several viral RNAs (polyadenylated nuclear RNA, open reading frame 58 [ORF58], ORF59, T0.7,

157 Lytic KSHV expresses polyadenylated nuclear RNA (PAN RNA), a long noncoding RNA (lncRNA).

158 ing transcript referred to as polyadenylated nuclear RNA (PAN RNA).

159 erpesvirus (KSHV) expresses a polyadenylated nuclear RNA (PAN RNA).

160 ions in chromatin transcription by all three nuclear RNA Pols.

161 owed that loss of the RNA polymerase IV gene NUCLEAR RNA POLYMERASE D1 (NRPD1) in tetraploid fathers

162 nation and UPS-dependent degradation of rice NUCLEAR RNA POLYMERASE D1a (OsNRPD1a), one of two orthol

163 RNA (dicer-like2 dicer-like3 dicer-like4 and nuclear RNA polymerase d2a nuclear RNA polymerase d2b) d

164 3 dicer-like4 and nuclear RNA polymerase d2a nuclear RNA polymerase d2b) do not exhibit inherited res

165 on is thus very similar to that described in nuclear RNA polymerase II-dependent transcription, in wh

166 24 nt siRNA biogenesis requires nuclear RNA polymerase IV (Pol IV), RNA-dependent RNA po

167 ss begins with template DNA transcription by NUCLEAR RNA POLYMERASE IV (Pol IV), whose atypical termi

168 Nuclear RNA polymerase V (Pol V) is an RNA silencing enz

169 ukaryotes express three or more multisubunit nuclear RNA polymerases (Pols) referred to as Pols I, II

170 transcription factor, is broadly required by nuclear RNA polymerases for the initiation of transcript

171 The landmark 1969 discovery of nuclear RNA polymerases I, II and III in diverse eukaryo

172 The discovery of the three eukaryotic nuclear RNA polymerases paved the way for serious bioche

173 and transcriptional silencing involves three nuclear RNA polymerases that are biochemically undefined

174 n all eukaryotes, plants have two additional nuclear RNA polymerases, abbreviated as Pol IV and Pol V

175 oadly promotes transcription mediated by all nuclear RNA polymerases, thereby acting as a positive mo

176 ) is critical for transcription by all three nuclear RNA polymerases.

177 otor neuron (SMN) complex delivers pre-small nuclear RNAs (pre-snRNAs) to the heptameric Sm ring for

178 oan TREX complex is recruited to mRNA during nuclear RNA processing and functions in exporting mRNA t

179 creasing alleles, and could therefore affect nuclear RNA processing and/or decay.

180 strates its potential function in regulating nuclear RNA processing, as well as a novel gain-of-funct

181 Many steps in nuclear RNA processing, surveillance, and degradation re

182 Strains with mutations in nuclear RNA-processing exosome components, including Rrp

183 We describe a nuclear RNA-processing network in fission yeast with a c

184 nthesis, the 7SK snRNP is a key regulator of nuclear RNA production by RNAPII.

185 luorescent protein 1 (mRFP1), polyadenylated nuclear RNA promoter (pPAN)-enhanced green fluorescent p

186 uide RNAs that are expressed from a U6 small nuclear RNA promoter.

187 rr2 RNA helicase disrupts the U4/U6 di-small nuclear RNA-protein complex (di-snRNP) during spliceosom

188 technologies that profile total cellular and nuclear RNA, respectively, during a time course experime

189 leotides in ribosomal and spliceosomal small nuclear RNAs, respectively.

190 Deep sequencing of nuclear RNA revealed a major fraction of nascent, unspli

191 HiChIRP of three nuclear RNAs reveals insights into promoter interactions

192 al identity requires upregulation of a small nuclear RNA, RN7SK, which induces accessibilities of chr

193 we survey four computational strategies for nuclear RNA-seq data analysis and develop a new pipeline

194 we collect ATAC-seq, Hi-C, Capture Hi-C and nuclear RNA-seq data in stimulated CD4+ T cells over 24

195 until now, a rigorous analytic pipeline for nuclear RNA-seq has been lacking.

196 Differential expression analysis following nuclear RNA-seq of neutrophil active transcriptomes reve

197 apping of transcriptional readthrough, using nuclear RNA-Seq, comparing heat shock, osmotic stress, a

198 gain new molecular insights, we used single nuclear RNA sequencing (snRNA-seq) and translating ribos

199 Using nuclear RNA sequencing of mouse enteric neurons that rep

200 ion and barcoding was used to perform single nuclear RNA sequencing with samples from 7 human donors,

201 idant response genes (immunofluorescence and nuclear RNA sequencing) were investigated in retinal end

202 nic ncRNAs, small cytoplasmic RNAs and small nuclear RNAs show less consistent patterns.

203 ost abundant non-coding (spliceosomal) small nuclear RNA, silences proximal PASs and its inhibition w

204 ndant small, noncoding RNAs, including small nuclear RNAs, small nucleolar RNAs (snoRNAs), cryptic un

205 The small nuclear RNA (snRNA) activating protein complex (SNAPc) i

206 Thus, these data suggest that U6 small nuclear RNA (snRNA) and RtcB participate in the formatio

207 The human small nuclear RNA (snRNA) and small cytoplasmic RNA (scRNA) ge

208 U1 and U2 gene loci, which produce the small nuclear RNA (snRNA) component of the respective snRNP.

209 The small nuclear RNA (snRNA) components of the spliceosome underg

210 Promoters for vertebrate small nuclear RNA (snRNA) genes contain a relatively simple ar

211 The small nuclear RNA (snRNA) genes have been widely used as a mod

212 hly enriched at RNA Pol II-transcribed small nuclear RNA (snRNA) genes, and the loss of LEC results i

213 the transcription of Pol II-dependent small nuclear RNA (snRNA) genes.

214 oding genes including c-myc and LEC to small nuclear RNA (snRNA) genes.

215 obe the structure of low-abundance U12 small nuclear RNA (snRNA) in Arabidopsis thaliana and provide

216 Yeast U2 small nuclear RNA (snRNA) nucleotides that form base pairs wit

217 it of a protein complex that regulates small nuclear RNA (snRNA) transcription.

218 he endonucleolytic cleavage of primary small nuclear RNA (snRNA) transcripts within the nucleus.

219 the catalytic Mg(2+) site in the U2/U6 small nuclear RNA (snRNA) triplex, and the 5'-phosphate of the

220 association between coilin and rRNA, U small nuclear RNA (snRNA), and human telomerase RNA, which is

221 des from the 3' end of spliceosomal U6 small nuclear RNA (snRNA), directly catalyzing terminal 2', 3'

222 led spliceosomal complex comprising U5 small nuclear RNA (snRNA), extensively base-paired U4/U6 snRNA

223 clear RNP (snRNP), composed of the 7SK small nuclear RNA (snRNA), MePCE, and Larp7, regulates the mRN

224 I-transcribed cellular RNAs, including small nuclear RNA (snRNA), small nucleolar RNA (snoRNA), and t

225 ch sequence called the Sm site in each small nuclear RNA (snRNA), to form the core domain of the resp

226 urvival motor neuron (SMN) protein, U2 small nuclear RNA (snRNA), U5 snRNA, and the small CB-specific

227 The small nuclear RNA (snRNA)-activating protein complex (SNAPc) i

228 The small nuclear RNA (snRNA)-activating protein complex (SNAPc) i

229 ein is essential for the biogenesis of small nuclear RNA (snRNA)-ribonucleoproteins (snRNPs), the maj

230 to bind RNA stemloops in U1 and/or U2 small nuclear RNA (snRNA).

231 nical base-pairing to the 5' end of U1 small nuclear RNA (snRNA).

232 between the authentic pre-mRNA and U7 small nuclear RNA (snRNA).

233 hyltransferase for the U6 spliceosomal small nuclear RNA (snRNA).

234 at a single catalytic metal site in U6 small nuclear RNA (snRNA).

235 Expression of modified U1 small nuclear RNAs (snRNA) complementary to the splice donor s

236 pins immediately downstream from viral small nuclear RNAs (snRNA).

237 ly dependent on a functional U2 snRNP (small nuclear RNA [snRNA] plus associated proteins), as H2A.Z

238 gonucleotide [MO] and an engineered U7 small nuclear RNA [snRNA]) to correct this splicing defect.

239 [miRNA], small nucleolar RNA [snoRNA], small nuclear RNA [snRNA], small Cajal body-specific RNA [scaR

240 itional production of 3'-extensions of small nuclear RNAs (snRNAs) and biogenesis of novel transcript

241 It assembles from five U-rich small nuclear RNAs (snRNAs) and over 200 proteins in a highly

242 Small nuclear RNAs (snRNAs) are essential factors in messenger

243 Uridine-rich small nuclear RNAs (snRNAs) are the basal components of the sp

244 es requiring RNAPII for transcription, small nuclear RNAs (snRNAs) display a further requirement for

245 mutations (r.3A>G) of U1 spliceosomal small nuclear RNAs (snRNAs) in about 50% of Sonic hedgehog (SH

246 ly, we found that TOE1 associated with small nuclear RNAs (snRNAs) incompletely processed spliceosoma

247 Transcription of genes coding for the small nuclear RNAs (snRNAs) is dependent upon a unique transcr

248 ross-links identified in the U4 and U6 small nuclear RNAs (snRNAs) suggest U4/U6 stem I as a Brr2p su

249 f ubiquitously expressed, uridine-rich small nuclear RNAs (snRNAs) transcribed by RNA polymerase II (

250 olves effects of SmD3 on the levels of small nuclear RNAs (snRNAs) U4 and U5.

251 During their biogenesis small nuclear RNAs (snRNAs) undergo multiple covalent modifica

252 ng of numerous host RNAs, particularly small nuclear RNAs (snRNAs), and avoidance of host transcripts

253 l RNAs (rRNAs), transfer RNAs (tRNAs), small nuclear RNAs (snRNAs), and RMRP.

254 toplasm, precursors to specific tRNAs, small nuclear RNAs (snRNAs), and small nucleolar RNAs (snoRNAs

255 tablished role in 3' end processing of small nuclear RNAs (snRNAs), attenuates MtnA transcription dur

256 ons, we previously proposed the use of small nuclear RNAs (snRNAs), especially U7snRNA to shuttle the

257 RNAs), small nucleolar RNAs (snoRNAs), small nuclear RNAs (snRNAs), piwi-associated RNAs (piRNAs) and

258 mediate 2'-O-methylation of rRNAs and small nuclear RNAs (snRNAs), respectively.

259 Although these small nuclear RNAs (snRNAs), termed U1, U2, U4, U5, and U6 snR

260 mbly of heptameric Sm protein rings on small nuclear RNAs (snRNAs), which are essential for snRNP fun

261 udouridines (Psis) on the spliceosomal small nuclear RNAs (snRNAs), which may enable growth at the ve

262 s)-subnuclear compartments enriched in small nuclear RNAs (snRNAs)-and promotes efficient spliceosoma

263 machine composed of both proteins and small nuclear RNAs (snRNAs).

264 mprising 30 proteins plus U4/U6 and U5 small nuclear RNAs (snRNAs).

265 suggested to play roles in transcription and nuclear RNA stability in addition to its more broadly ch

266 of PAN RNA, suggesting that REF/Aly promotes nuclear RNA stability.

267 for precursor mRNA splicing through U6 small nuclear RNA stabilization.

268 target sequences within different classes of nuclear RNA substrates.

269 an one copy per cell, even in the absence of nuclear RNA surveillance and during late meiosis.

270 activates exosome-mediated 3'-5' turnover in nuclear RNA surveillance and processing pathways.

271 Unexpectedly, the TRAMP and exosome nuclear RNA surveillance complexes are also implicated i

272 his, we identified in vivo binding sites for nuclear RNA surveillance factors, Nrd1, Nab3 and the Trf

273 A key question in nuclear RNA surveillance is how target RNAs are recogniz

274 roducts of SMD are primarily degraded by the nuclear RNA surveillance machinery.

275 In budding yeast, the nuclear RNA surveillance system is active on all pre-mRN

276 3' oligo(A) tails that are characteristic of nuclear RNA surveillance targets.

277 Rrp6-mediated nuclear RNA surveillance tunes eukaryotic transcriptomes

278 Most lncRNAs are targeted for nuclear RNA surveillance, but a subset with 3' cleavage

279 splicing errors that are actively removed by nuclear RNA surveillance.

280 berrant splicing events that are targeted by nuclear RNA surveillance.

281 ous reports linking poly(A) tail length with nuclear RNA surveillance.

282 Levels of heterogeneous nuclear RNA synthesis demonstrated that edn1 mRNA stimul

283 The shift from cytoplasmic to nuclear RNA targets was accompanied by a dramatic transl

284 g various previous versions on both mRNA and nuclear RNA targets.

285 ly any RNA (e.g., mRNA, ribosomal RNA, small nuclear RNA, telomerase RNA and so on).

286 s and a revised model for CTD-mediated small nuclear RNA termination.

287 method, we generated CLIP-Seq libraries from nuclear RNA that had been UV-crosslinked and immunopreci

288 without the association of 7SK RNA, a small nuclear RNA that is bound to approximately 50% of total

289 cellular factor PA28gamma in the control of nuclear RNA trafficking and HTLV-1-induced latency.

290 rmally encode IgM and IgD from heterogeneous nuclear RNA transcripts via alternative splicing, lack i

291 within pc-genes and imply a direct role for nuclear RNA turnover in the regulation of a subset of pc

292 Although uridine-rich small nuclear RNAs (U-snRNAs) are essential for pre-mRNA splic

293 The auxiliary factor of U2 small nuclear RNA (U2AF) is a heterodimer consisting of 65- an

294 oding RNAs, including the uridine-rich small nuclear RNA (UsnRNA) and enhancer RNA (eRNA), and in the

295 Historically, nuclear RNA was thought to interact with proteins to for

296 of the mutants on the synthesis of U5 small nuclear RNA were analyzed.

297 suppression of 3' end formation by U1 small nuclear RNA, which is known to bind pre-mRNA at the earl

298 g one of its essential components, U11 small nuclear RNA, which resulted in micromelia.

299 with RNA-Seq is more predictable than PolyA+ nuclear RNA, while the opposite is true for PolyA- RNA.

300 as evidenced by RNAPII binding and increased nuclear RNA, with polyadenylated RNA levels only elevate