ライフサイエンスコーパス: nuclear import

1 solely accomplished through control of CrzA nuclear import.

2 of the precursor and cleavage, resulting in nuclear import.

3 rane, making it accessible for importins and nuclear import.

4 ce to molecular transport, and increases YAP nuclear import.

5 ction of resting CD4 T cells at the level of nuclear import.

6 postentry steps of reverse transcription and nuclear import.

7 e and is facilitated by both DNA binding and nuclear import.

8 ular trafficking of proteins including their nuclear import.

9 the MRTF-A regulatory RPEL domain, promoting nuclear import.

10 r (karyopherin/importin) complex and disrupt nuclear import.

11 e nuclear membrane, and an overall defect in nuclear import.

12 omain and central region that regulates MDMX nuclear import.

13 itotic NPC disassembly-reassembly or general nuclear import.

14 interaction with Importin-beta for efficient nuclear import.

15 ges that modulate its catalytic activity and nuclear import.

16 nse to apoptotic stimuli by facilitating its nuclear import.

17 onship between the phosphorylation event and nuclear import.

18 on, suggesting IPO11 facilitates betacatenin nuclear import.

19 Progerin did not cause global inhibition of nuclear import.

20 epigenetically by RNA, as well differential nuclear import.

21 nscription or at the nuclear envelope during nuclear import.

22 the capsid protein shell and efficient viral nuclear import.

23 triggers their uncoating and promotes viral nuclear import.

24 organization beyond their canonical role in nuclear import.

25 er-cargo complex is required to modulate p17 nuclear import.

26 er-cargo complex is required to modulate p17 nuclear import.

27 confirmed to mediate TNPO3 binding and CPSF6 nuclear import.

28 h two other lysines also contributing to its nuclear import.

29 cytoplasm to the nucleus via retrograde tRNA nuclear import, a process that is conserved from yeast t

30 lization signals, and that this limits KPNA7 nuclear import activity.

31 The prolyl-3,4-dihydroxylase Ofd1 and nuclear import adaptor Nro1 regulate the hypoxic respons

32 Consistent with this, leptomycin B-induced nuclear import and adrenocorticotropic hormone (ACTH) tr

33 t histones are loaded on HIV-1 DNA after its nuclear import and before its integration in the host ge

34 port rates controlling activated STAT5 dimer nuclear import and beta-casein mRNA export to cytoplasm

35 cascade to increase PLPP3 expression through nuclear import and binding of RelA and RelB transcriptio

36 and H4, modifications that are important for nuclear import and chromatin assembly.

37 ex blockade to monitor the kinetics of HIV-1 nuclear import and define the biochemical staging of the

38 ofactors Nup153 and CPSF6 that mediate viral nuclear import and direct integration into gene-rich reg

39 We find that HERC3 restricts NF-kappaB nuclear import and DNA binding without affecting IkappaB

40 Nuclear import and export are often considered inverse p

41 rs to originate from dual regulation of both nuclear import and export by phosphorylation, as mutants

42 ive nucleocytoplasmic transport, we measured nuclear import and export in poly-GR or poly-PR expressi

43 ecreased in hypoxia, and the use of specific nuclear import and export inhibitors clearly showed that

44 Cofilin and Profilin, which regulate the nuclear import and export of actin, also localize to the

45 lear pore complex is the primary conduit for nuclear import and export of molecules.

46 f the substrate is used to directly modulate nuclear import and export, thereby regulating the report

47 found in Alzheimer's disease brains, delayed nuclear import and furthermore blocked the ability of nu

48 These data provide a mechanism for MeCP2 nuclear import and have implications for the design of t

49 Eukaryotic ribosome biogenesis requires nuclear import and hierarchical incorporation of approxi

50 Our results clarify the mechanism of CPSF6 nuclear import and highlight differential roles for RSLD

51 ose a model that unifies Vpr manipulation of nuclear import and inhibition of innate immune activatio

52 Our data support a model in which HIV nuclear import and integration are concerted steps, and

53 oles in HIV-1 infection, specifically during nuclear import and integration targeting.

54 anscription activity but displays a block in nuclear import and integration, as measured by quantitat

55 ted in later steps of replication, including nuclear import and integration.

56 starvation leads to down-regulation of tRNA nuclear import and nearly complete curtailment of its nu

57 nuclear localization signal to Ala abolished nuclear import and Oxtr-induced gene expression.

58 identify proteins mediating tRNA retrograde nuclear import and re-export using the unique wybutosine

59 lation of a cellular factor necessary for L1 nuclear import and retrotransposition.

60 in geminivirus replication, but its role in nuclear import and SCE1 binding differs depending on the

61 s, Acl4 serves a dual function to facilitate nuclear import and simultaneously protect unassembled Rp

62 hese modifications are important for histone nuclear import and subsequent chromatin assembly.

63 stem into the cytoplasm, allowing subsequent nuclear import and the initiation of gene expression, re

64 as the most important karyopherins for Rrp6 nuclear import and the nuclear localization signals reco

65 How environmental factors influence histone nuclear import and the nucleosome assembly pathway, lead

66 TRN-SR2 protein-protein interaction for HIV nuclear import and validate the IN/TRN-SR2 interaction i

67 TNPO3 is well established to regulate HIV-1 nuclear import and viral replication.

68 ressing TNPO3, a factor that regulates HIV-1 nuclear import and viral; replication of TNPO3 is well e

69 ymerization disrupts nuclear pore integrity, nuclear import, and downstream pathways such as mRNA pos

70 ral events, including reverse transcription, nuclear import, and integration, and enhances viral prod

71 ics and efficiency of reverse transcription, nuclear import, and integration.

72 n infected cells during cytoplasmic transit, nuclear import, and mRNA synthesis.IMPORTANCE The fates

73 anine expansions on the homeodomain-mediated nuclear import, and our data clearly show that the expan

74 lexes (vRNPs), thereby resulting in impaired nuclear import, and that the additional acquired mutatio

75 n, such as uncoating, reverse transcription, nuclear import, and transport to integration sites are i

76 Viral nuclear import antagonists, expressed by several highly

77 By using in vitro nuclear import assays and immuno-cytofluorescence, we di

78 ily conserved process called tRNA retrograde nuclear import, before relocalization back to the cytopl

79 s (NLSs) of cargo proteins not only mediates nuclear import but also, prevents their aberrant phase s

80 ly has the primary role of regulating Dorsal nuclear import, but also has a secondary role in shuttli

81 activities of Ddx19 are dispensable for MKL1 nuclear import, but RNA binding is required.

82 nly composed of Tpr, is not required for HIV nuclear import, but that Nup153 is essential.

83 dditional antiviral blocks exist upstream of nuclear import, but the ISGs that suppress infection, e.

84 ting-is emerging as a critical parameter for nuclear import, but the triggers and mechanisms that orc

85 y, we provide evidence that targeting S100A4 nuclear import by low-dose paclitaxel, a microtubule-sta

86 Consistent with the behavior of normal nuclear import cargoes, HIV-1 IN is released from the co

87 Here we have use genetics to separate HIV-1 nuclear import cofactor dependence from MxB sensitivity.

88 e-assembled on endosome to synchronize their nuclear import, could coordinate genome-wide transcripti

89 mutants, srp1-31 displays the characteristic nuclear import defect of importin-alpha mutants, whereas

90 ed binding of PKCdelta to importin-alpha and nuclear import, demonstrating that tyrosine kinase inhib

91 d assessed its impact on Pol III biogenesis, nuclear import, DNA occupancy, transcription, and protei

92 ure-based assays of proteosomal degradation, nuclear import, enhancer DNA occupancy, and SRY-dependen

93 understanding of the requirements for their nuclear import, especially the role of multivalent bindi

94 shuttling protein, suggesting that balanced nuclear import/export and dendritic spine localization a

95 n of the L1 RNA and by repressing a required nuclear import factor (TNPO1).

96 eukaryotic translation initiation factor 4E nuclear import factor 1 (Eif4enif1), which encodes an eu

97 s as a gp130-sensitive transactivator of the nuclear import factor importin-alpha5 (Impalpha5), and i

98 stable and stoichiometric complex with host nuclear import factor RanBP5 that can be modelled using

99 Here we report that the nuclear import factor Srp1 (also known as importin alpha

100 Karyopherin alpha 2 (KPNA2) is a nuclear import factor that is elevated in multiple cance

101 We found that miR-128 targets the 3' UTR of nuclear import factor transportin 1 (TNPO1) mRNA.

102 We show that Ddx19 is not a general nuclear import factor, and that its specific effect on M

103 and depletion of either Formin-2 or actin's nuclear import factor, importin-9, increases the number

104 ytes, ribosomal proteins that did not engage nuclear import factors were targets for UBE2O.

105 tubule dynamics and 2) postsynaptic Frizzled nuclear import (FNI).

106 We found that both NLS1 and NLS2 possess nuclear import function, with NLS1 responsible for nucle

107 tion of TDP-43 C-terminal fragments and of a nuclear import-impaired mutant.

108 hibitor of cellular Imp-alpha/beta1-mediated nuclear import.IMPORTANCE Human adenoviruses (HAdVs) rep

109 ough etoposide treatment similarly inhibited nuclear import in a mouse embryonic fibroblast model.

110 sc70 is required for the maximal rate of SRY nuclear import in living cells but has no impact upon SR

111 Increased nuclear import in turn drives the expression of a cohere

112 first reported series of constrained peptide nuclear import inhibitors.

113 Nuclear import is an essential step in small nuclear rib

114 The process of nuclear import is considered to be the bottleneck of the

115 Regulation of nuclear import is fundamental to eukaryotic biology.

116 The biological significance of this tRNA nuclear import is not entirely clear.

117 factor, and that its specific effect on MKL1 nuclear import is separate from its role in mRNA export.

118 y of developmental phenotypes increases, but nuclear import is unaffected.

119 Here, we assayed nuclear import kinetics of 30 large cargo models based o

120 ups, ooc-5-mutant embryos displayed impaired nuclear import kinetics, although the nuclear pore-size

121 lasm of infected cells and exploits the host nuclear import machinery to gain access to the nucleus,

122 ermed here escortins-to securely connect the nuclear import machinery with pathways that deposit r-pr

123 a functional NLS that interacts with canonic nuclear import machinery.

124 ospora arabidopsidis co-opts the host cell's nuclear import machinery.

125 Our findings uncover a novel nuclear import mechanism for betacatenin in cells with h

126 This has suggested that nuclear import mechanism may determine MxB sensitivity.

127 Therefore, the nuclear import mechanism of NRF-2 is unique among Ets fa

128 990, involved heat-shock protein 70-mediated nuclear importing mechanism.

129 rovides important support for the model that nuclear import mechanisms have been co-opted for indepen

130 Nuclear import, mediated in part by karyopherin-alpha (K

131 We hypothesized that retrograde tRNA nuclear import might function in proofreading tRNAs to e

132 usively coupled oscillators that account for nuclear import, nuclear positioning determines the pacem

133 ness in a fashion that is independent of the nuclear import/nuclear retention of COP1.

134 Surprisingly, we observe that nuclear import occurs with relatively rapid kinetics (<5

135 ed the activation of importin beta-dependent nuclear import of 53BP1, a large NCT cargo.

136 bellar neurons results in the generation and nuclear import of a 30 kDa fragment comprising most of L

137 participates in mRNA export, translation and nuclear import of a key transcriptional regulator.

138 n of TNPO1 affects L1 retrotransposition and nuclear import of an L1-ribonucleoprotein complex (using

139 a code that determines importin-independent nuclear import of ankyrin repeats (ARs), a structural mo

140 -) cells with a vector encoding APP restored nuclear import of anMan-containing HS.

141 Eukaryotic ribosome biogenesis requires the nuclear import of approximately 80 nascent ribosomal pro

142 ain and are critical for the recognition and nuclear import of ASF/SF2.

143 In addition, TRN-1 promotes the efficient nuclear import of both viral DNA and capsid protein.

144 Four compounds were found to inhibit nuclear import of C in transfected cells, with one able

145 ive in primary human macrophages, indicating nuclear import of capsids or capsid-like structures.

146 n nuclear pore formation and is required for nuclear import of CRABP2 and for transcriptional activat

147 This export occurs after the nuclear import of cyclin B-Cdk1 complexes, requires the

148 is capable of disrupting the CDK4-dependent nuclear import of Cyclin D1.

149 ) and APOL1(G1/G2) transgenic mice displayed nuclear import of dendrin indicating destabilization of

150 DPDG1s/G2s displayed nuclear import of dendrin, indicating an occurrence of d

151 Nuclear import of ErbB3 occurs via importin beta1, which

152 , we show that the MA region is required for nuclear import of Gag through the TNPO3 pathway.

153 Blocking the nuclear import of GAPDH by suppressing Src signaling or

154 Nap1 is a histone chaperone involved in the nuclear import of H2A-H2B and nucleosome assembly.

155 tablish that PKB/Akt activation promotes the nuclear import of HDAC4 and is thereby required for epig

156 o reversed Abeta oligomer- and ApoE4-induced nuclear import of HDACs, preventing the loss in BDNF.

157 Whether this interaction mediates the nuclear import of HIV remains controversial.

158 ind that NLRX1 depletion results in impaired nuclear import of HIV-1 DNA in human monocytic cells.

159 PO3) is a cellular karyopherin implicated in nuclear import of HIV-1.

160 The nuclear import of IAV genome is an indispensable step in

161 ated inhibition of Hsp40 resulted in reduced nuclear import of IAV RNPs, diminished viral polymerase

162 only reveal the molecular mechanisms of the nuclear import of IAV vRNP but also provide potential an

163 beta, disrupt its cargo loading, and inhibit nuclear import of importin beta, importin alpha/beta, an

164 ck protein 40 (Hsp40/DnaJB1) facilitates the nuclear import of incoming IAV viral ribonucleoproteins

165 ortin-alpha5), which is known to mediate the nuclear import of ISGF3.

166 fluenza virus infection at the step prior to nuclear import of its ribonucleoproteins.

167 entity is not associated with defects in the nuclear import of key pluripotency factors.

168 CXCL12-dependent nuclear import of LASP-1 could be blocked by CXCR4 antag

169 IMPalpha-1, -2 and -3 are necessary for the nuclear import of LHP1.

170 nal (MNESmut), however, we revealed that the nuclear import of M is ubiquitous, because MNESmut was r

171 ole for the mRNA export factor Ddx19/Dbp5 in nuclear import of MKL1, the signal-responsive transcript

172 pendently inhibiting SRF gene expression and nuclear import of MRTF-A.

173 importin-beta-like protein required for the nuclear import of MYB4, a transcriptional repressor of p

174 calization signal mutant version and induced nuclear import of NEMO in digitonin-permeabilized cells.

175 ifically blocked the importin alpha-mediated nuclear import of NF-kappaB and prevented lipopolysaccha

176 ion significantly increased the CN-dependent nuclear import of NFATc3 in the mDA neurons of transgeni

177 leoprotein (vRNP) complex without disrupting nuclear import of NP alone.

178 ther studies revealed that eEF1D impeded the nuclear import of NP and PA-PB1 heterodimer of IAV, ther

179 at directly interacts with NP1, mediates the nuclear import of NP1, and plays a role in the maturatio

180 ly, we revealed a novel role of CPSF6 in the nuclear import of NP1, in addition to the critical role

181 IMB-2 specifically drives nuclear import of NSY-7 within AWC neurons to transactiv

182 It is known that nuclear import of nuclear factor-kappaB (NF-kappaB) play

183 ne transfer and enhance understanding of the nuclear import of other viral DNA genomes, such as those

184 lasmic translocation of kaiso depends on the nuclear import of p120ctn in complex with MUC1-CT and th

185 data show that KPNB1 is required for timely nuclear import of PER/CRY in the negative feedback regul

186 TCS mutations, in POLR1C impair assembly and nuclear import of POLR3, but not POLR1, leading to decre

187 pathway of nuclear holo-TFIID, regulated by nuclear import of preformed cytoplasmic submodules.

188 tored the binding of hexon at the NE and the nuclear import of protein VII (pVII), indicating that th

189 Nuclear import of proteins was decreased in affected ind

190 t with PS-ASOs in the cytoplasm and that the nuclear import of PS-ASOs is at least partially through

191 ate NCAM ligands leads to the generation and nuclear import of PSA-lacking and -carrying NCAM fragmen

192 determined that specifically preventing the nuclear import of pSMAD3 using the TAT-SNX9 peptide inhi

193 Active nuclear import of Ran exchange factor RCC1 is mediated b

194 one highly conserved lysine is important for nuclear import of Rep from three different begomoviruses

195 onserved lysine independently of its role in nuclear import of Rep.

196 ing the IAV replication by inhibition of the nuclear import of RNP subunits, which not only uncovers

197 Dif1 protein inhibits RNR by promoting nuclear import of Rnr2-Rnr4.

198 omolog of yeast and human proteins linked to nuclear import of selective cargo.

199 3 (Tnpo3, Transportin-SR2) is implicated in nuclear import of splicing factors and HIV-1 replication

200 r results elucidate the structural bases for nuclear import of splicing factors and the Tnpo3-CPSF6 n

201 gs strongly implicate hsc70 in CaM-dependent nuclear import of SRY.

202 tein hsc70 plays a key role in CaM-dependent nuclear import of SRY.

203 TDP2 UBA-Ub binding interface do not affect nuclear import of TDP2, but severely compromise its abil

204 Both in vitro hexon binding and in vivo nuclear import of the AdV genome were strongly reduced i

205 that uncoating is tightly regulated to allow nuclear import of the genome while minimizing the exposu

206 When nuclear import of the HIV-1 reverse transcription comple

207 We show that Nup116 mediates nuclear import of the karyopherin Kap121, and each prote

208 In mammals, the kinase promoting the nuclear import of the key clock component Period 2 (PER2

209 description of a protein factor involved in nuclear import of the L1 element and demonstrates that m

210 urin, which dephosphorylates and induces the nuclear import of the osteogenic transcription regulator

211 We speculate that nuclear import of the PIC may proceed concurrently with

212 ey role in HIV infection by facilitating the nuclear import of the pre-integration complex (PIC) that

213 PARP-1 did not impair reverse transcription, nuclear import of the preintegration complex, or viral D

214 n form of lamin A, causing a major defect in nuclear import of the protein, translocated promoter reg

215 Here, we show that the nuclear import of the PSA-carrying NCAM fragment is medi

216 id core disassembles to allow the subsequent nuclear import of the viral genome.

217 Both prevent nuclear import of the viral ribonucleoprotein (vRNP) com

218 Generation and nuclear import of this fragment in cultured cerebellar n

219 ected or infected cells, thus perturbing the nuclear import of transcription factors of the innate im

220 nstance, gene expression entails coordinated nuclear import of transcriptional regulators to activate

221 by different mechanisms, with eVP24 blocking nuclear import of tyrosine-phosphorylated STAT1 and mVP4

222 1 capsid and interferes with capsid-mediated nuclear import of viral DNA, HIV particle production and

223 efective SIV failed to promote the efficient nuclear import of viral genome and suggests that MAPK/ER

224 of HIV-2/SIV is known to be involved in the nuclear import of viral genome in nondividing cells, but

225 V nucleoprotein (NP) is known to mediate the nuclear import of viral genome via its nuclear localizat

226 DNA production by competitively blocking the nuclear import of viral nucleocapsids.

227 Antiviral VHHs prevented nuclear import of viral ribonucleoproteins or mRNA trans

228 provides new insights into the mechanisms of nuclear import of vRNP proteins.IMPORTANCE Influenza A v

229 on between PB1 and RanBP5, which impeded the nuclear import of vRNP.

230 mmalian nucleotide excision repair (NER) and nuclear import of XPA from the cytoplasm for NER is regu

231 XPA nuclear import, showed no effect on the nuclear import of XPA in our siRNA knockdown analysis.

232 nstimulated ECs and, strikingly, blocked the nuclear import of YAP induced by Ab-induced HLA I activa

233 The nuclear import of YAP was associated with a rapid decrea

234 Mammalian Mask1/2 proteins also promote nuclear import of YAP, as well as stabilising YAP and dr

235 Only depletion of ZO-2 reduced the nuclear import of YAP.

236 Here we show that Mask acts to promote nuclear import of Yki, and that addition of an ectopic N

237 ous report of a dependence of UV-induced XPA nuclear import on ataxia telangiectasia and Rad3-related

238 ypically ascribed to roles in either histone nuclear import or deposition.

239 that Hat1 is not required for either histone nuclear import or deposition.

240 variety of proteins, in some cases affecting nuclear import or export.

241 abundant, suggesting that MX2 inhibits HIV-1 nuclear import, or destabilizes nuclear HIV-1 DNA.

242 ay represents a general importin-independent nuclear import pathway and is frequently used by AR-cont

243 We show that depleting CPSF6 to change nuclear import pathway does not impact MxB sensitivity,

244 assical NLS and importin alpha/beta mediated nuclear import pathway has already been described for be

245 Thus, the IPO3 nuclear import pathway is an early and crucial determina

246 function is inhibiting the classical protein nuclear import pathway mediated by importin-alpha (Imp-a

247 e results suggest that RSV hijacks this host nuclear import pathway using a unique mechanism, potenti

248 Here we show that a nonclassical nuclear import pathway via IPO3 (importin 3, transportin

249 d found that rAAV2 can utilize the classical nuclear import pathway, involving the nuclear pore compl

250 ancer through silencing of components of the nuclear import pathway.

251 tification of a general importin-independent nuclear import pathway.

252 review the structural basis of the principal nuclear import pathways and the molecular basis of their

253 The majority of nuclear import pathways are mediated by importin-cargo i

254 d, demonstrating that HIV-1 can use distinct nuclear import pathways during infection.

255 and immuno-cytofluorescence, we dissect the nuclear import pathways of NRF-2.

256 the capsid protein(1) to engage the cellular nuclear import pathways of the target cell and mediate t

257 n that are known, or suspected, to alter the nuclear import pathways used by HIV-1 confer resistance

258 Several nuclear import pathways, by contrast, were not affected

259 templates for evaluating virus antagonism of nuclear import processes but also can reveal candidate c

260 n signaling by blocking karyopherin-mediated nuclear import processes.

261 cifically and directly interact with IPO5, a nuclear import protein of the importin beta family, via

262 IPO11 (Importin-11) is a nuclear import protein that shuttles cargo from the cyto

263 in myotubes depended on molecular weight and nuclear import rate, as well as on myotube width.

264 ER-CRY repressive complex by controlling the nuclear import rate, whereas FBXL3 separately regulates

265 velopmental program does not correspond with nuclear import rates, but provide evidence that PKC acti

266 hat the Ub-conjugating enzyme UBE2E3 and its nuclear import receptor importin 11 (Imp-11) regulate Nr

267 Strikingly, the nuclear import receptor Karyopherin-beta2 reverses the m

268 This dsRBD-NLS is recognized by the nuclear import receptor transportin 1 (Trn1; also called

269 trongest suppressor was karyopherin-alpha, a nuclear-import receptor; this required nuclear localizat

270 The nuclear import receptors importin beta and transportin p

271 is a member of the Importin-alpha family of nuclear import receptors.

272 Nuclear-import receptors (NIRs) bind nuclear-localizatio

273 iruses to regulate the kinetics of terminase nuclear import, reflecting a mechanism of virus:host ada

274 sms of the IAV-host interactions involved in nuclear import remain poorly understood.

275 ence of this factor(s) was mapped to reduced nuclear import, replication, and translation, as well as

276 l GTPase Ran, which is a master regulator of nuclear import required for nuclear localization of TDP-

277 capsid-destabilizing compound PF74 following nuclear import, revealing that uncoating is completed in

278 These data resolve independent nuclear import routes for Rrp6 and Rrp47, reveal a struc

279 ed to imply the absence of a need for active nuclear import, sequence and structural analysis suggest

280 and IMPalpha2 to impede their normal role in nuclear import, shedding new light on the cellular funct

281 , previously proposed to be required for XPA nuclear import, showed no effect on the nuclear import o

282 we demonstrated that the rate of HIF-1alpha nuclear import substantially influences its stabilizatio

283 This revealed not only further nuclear import substrates such as Ubc9, but also Pil1, L

284 signal (PY-NLS)/karyopherinbeta2 (Kapbeta2) nuclear import system regulates Gli ciliary localization

285 e in CRPC cells utilize distinct pathways of nuclear import that affect the antitumor efficacy of tax

286 TNPO1 binding site is dispensable for CPSF6 nuclear import, the arginine/serine (RS)-like domain (RS

287 A has well-defined domains necessary for its nuclear import, the region responsible for the transloca

288 ggest that the C9orf72-HRE impairs Mitf/TFEB nuclear import, thereby disrupting autophagy and exacerb

289 uit cytoplasmic proteins destined for active nuclear import to the nuclear transport machinery.

290 s and proteins involved in lipid metabolism, nuclear import, translation, and RNA processing.

291 y replication events including mechanisms of nuclear import, uncoating, reverse transcription, integr

292 nome-wide within minutes after controlled TF nuclear import using time-series chromatin immunoprecipi

293 nucleocytoplasmic shuttling due to impaired nuclear import (V60L; mediated by Exportin-4) or export

294 We propose that, rather than promoting HIV-1 nuclear import, Vpr interacts with karyopherins to distu

295 uorescence-based import assay, the defect in nuclear import was corroborated.

296 To clarify the mechanism of MeCP2 nuclear import, we isolated proteins that interact with

297 Both binding and nuclear import were independent of RSLD phosphorylation,

298 BbSre1 transcriptional activity and nuclear import were repressed in DeltaBbOhmm cells and a

299 lpha mutants that impair interactions during nuclear import were used together with cytoplasmic Ran G

300 e immunity by selectively targeting PY-STAT1 nuclear import while leaving the transport of other carg