ライフサイエンスコーパス: nuclear pore

1 ation of Notch signaling at the level of the nuclear pore.

2 semi-disrupted capsid while traveling to the nuclear pore.

3 he genome once the capsid interacts with the nuclear pore.

4 ent NPC module, forms the outer rings of the nuclear pore.

5 nuclear speckles and properly dock with the nuclear pore.

6 sing the viral genome from capsids docked at nuclear pores.

7 otherwise arrest CRM1 transport complexes at nuclear pores.

8 or increasing flux of molecules through the nuclear pores.

9 G-nucleoporins to facilitate passage through nuclear pores.

10 -nucleoporins to facilitate movement through nuclear pores.

11 rferon-responsive promoter to associate with nuclear pores.

12 romatin and hindrance of mRNPs from engaging nuclear pores.

13 yolk sac (ELYS) is a constituent protein of nuclear pores.

14 trols the exchange of macromolecules through nuclear pores(2).

15 cleus by receptor-mediated transport through nuclear pores(2).

16 long the nuclear periphery, likely to find a nuclear pore allowing export.

17 ells prime the virus for passage through the nuclear pore and drive the establishment of a productive

18 is (ALS) binds to the central channel of the nuclear pore and inhibits the movement of macromolecules

19 nd, at the cellular level, to defects in the nuclear pore and nuclear lamina assembly.

20 nces HIV-1 complexes are retained inside the nuclear pore and undergo CA-multimer dependent CPSF6 clu

21 s are located at the cytoplasmic site of the nuclear pores and contain most cytoplasmic RNA-binding p

22 rization of actin to propel nucleocapsids to nuclear pores and entry into the nucleus.

23 act viral cores are too large to fit through nuclear pores and uncoating occurs in the cytoplasm in c

24 to the cytoplasm, docking of the capsid at a nuclear pore, and release of the viral genome into the n

25 Interestingly, nuclear pores are maintained by piecemeal replacement of

26 stent with the Mlp1/2 role in gene gating to nuclear pores, artificial tethering to the nuclear perip

27 orts a model in which animal genomes use the nuclear pore as an organizing scaffold for inducible poi

28 ents with C9orf72 ALS/FTD by chaperoning the nuclear pore assembly and sponging away deleterious (G4C

29 centrics pass through membrane-, lamin-, and nuclear pore-based channels in the nuclear envelope that

30 In this study, we show that the nuclear pore basket component Alm1 is required to mainta

31 Here, we investigate the role of the major nuclear pore basket protein, TPR, in regulating mRNA and

32 enes were found to be stably associated with nuclear pores before and after activation.

33 Our findings lend to a model where different nuclear pores bind different types of chromatin via inte

34 e dynamics of blebbing and the connection to nuclear pore biogenesis remain poorly understood.

35 embrane nucleoporin essential for interphase nuclear pore biogenesis.

36 We report a novel role for torsin in nuclear pore biology.

37 Transport of macromolecules through the nuclear pore by importins and exportins plays a critical

38 argoes may be delayed in passage through the nuclear pore channel, affecting its selective barrier fu

39 central particles (known as "plugs") in the nuclear pore channels of affected cells.

40 architectures ranging from bacteriophages to nuclear pores, cilia, and synaptonemal complexes in larg

41 exerts its function and whether it modulates nuclear pore complex (NPC) activity remain unknown.

42 Multiple components of the nuclear pore complex (NPC) and a second coiled-coil prot

43 uncover two metformin response elements: the nuclear pore complex (NPC) and acyl-CoA dehydrogenase fa

44 found that SARS-CoV-2 Orf6 localizes at the nuclear pore complex (NPC) and directly interacts with N

45 NUP188 encodes a scaffold component of the nuclear pore complex (NPC) and has been implicated as a

46 ding yeast, targeting of active genes to the nuclear pore complex (NPC) and interchromosomal clusteri

47 Nuclear transport is facilitated by the Nuclear Pore Complex (NPC) and is essential for life in

48 generated nanobodies against the vertebrate nuclear pore complex (NPC) and used them in STORM imagin

49 The nuclear pore complex (NPC) arose in evolution as the cel

50 However, how nuclear pore complex (NPC) barrier selectivity, Kap traf

51 The intricacy of nuclear pore complex (NPC) biogenesis imposes risks of f

52 Nup358, a late marker for interphase nuclear pore complex (NPC) biogenesis, is underrepresent

53 elusive mechanism of membrane fusion during nuclear pore complex (NPC) biogenesis.

54 ing; here we show that it is targeted to the nuclear pore complex (NPC) by binding an acidic face of

55 show that PfSR1 is localized adjacent to the Nuclear Pore Complex (NPC) clusters in the nucleus of ea

56 Here, we show that nuclear pore complex (NPC) components Nup93 and Nup153 b

57 The nuclear pore complex (NPC) constitutes the sole gateway

58 While the static structure of the nuclear pore complex (NPC) continues to be refined with

59 The key component of the nuclear pore complex (NPC) controlling permeability, sel

60 The nuclear pore complex (NPC) controls the transport of mac

61 mechanism to explain how a component of the nuclear pore complex (NPC) could cause Htx/CHD was undef

62 These findings are attributed to nuclear pore complex (NPC) disintegration by nsp1beta, r

63 The nuclear pore complex (NPC) employs the intrinsically dis

64 Here we tested if the nuclear pore complex (NPC) facilitates the targeting of

65 /RanGAP1*SUMO1/Ubc9 localizes at cytoplasmic nuclear pore complex (NPC) filaments and is a docking si

66 nterest and represents a central paradigm to nuclear pore complex (NPC) function, where nuclear trans

67 nucleocytoplasmic information transfer, the nuclear pore complex (NPC) has been studied in great det

68 In recent years, the nuclear pore complex (NPC) has emerged as a key player i

69 The Nuclear Pore Complex (NPC) has emerged as an important h

70 Interactions between the genome and the nuclear pore complex (NPC) have been implicated in multi

71 ential for the transport of mRNA through the nuclear pore complex (NPC) in yeast, but the molecular m

72 oporin 62 (Nup62), and as a consequence, the nuclear pore complex (NPC) is disintegrated and the nucl

73 Binding of the capsid to the nuclear pore complex (NPC) is mediated by the capsid pro

74 The nuclear pore complex (NPC) is responsible for nucleocyto

75 The nuclear pore complex (NPC) is the gate for transport bet

76 The nuclear pore complex (NPC) is the principal gateway for

77 The prevailing model poses that the nuclear pore complex (NPC) is the sole gatekeeper for tr

78 The nuclear pore complex (NPC) mediates nucleocytoplasmic tr

79 iated Esc1, the SUMO E3 ligase Siz2, and the nuclear pore complex (NPC) protein Nup170-physically and

80 enterovirus 2A protease directly cleaves the nuclear pore complex (NPC) protein, Nup98, at amino acid

81 ring Aspergillus nidulans mitosis peripheral nuclear pore complex (NPC) proteins (Nups) disperse from

82 Enteroviruses proteolyze nuclear pore complex (NPC) proteins (Nups) during infect

83 Loss of nuclear pore complex (NPC) proteins, transcription facto

84 SLiM-dependent proximity to centrosomal and nuclear pore complex (NPC) proteins-structures where Ca(

85 his process is regulated at the level of the nuclear pore complex (NPC) remains unclear.

86 Translocation of mRNA through the nuclear pore complex (NPC) requires interactions with di

87 The nuclear pore complex (NPC) selectively gates the transpo

88 The nuclear pore complex (NPC) serves as both the unique gat

89 The nuclear pore complex (NPC) serves as the sole bidirectio

90 The nuclear pore complex (NPC) solely mediates molecular tra

91 es for some ER proteins in the NE for proper nuclear pore complex (NPC) structure and function.

92 The nuclear pore complex (NPC) tethers chromatin to create a

93 We propose that NUP153 links the nuclear pore complex (NPC) to chromatin architecture all

94 novirus (AdV) to the cytoplasmic face of the nuclear pore complex (NPC), a key step during delivery o

95 the nuclear envelope (NE) is mediated by the nuclear pore complex (NPC), a massive ~100-MDa assembly

96 One such assembly is the nuclear pore complex (NPC), an ~50 MDa assembly comprise

97 tether transcriptionally active loci to the nuclear pore complex (NPC), and it also promotes large-s

98 etic modifiers that encode components of the nuclear pore complex (NPC), as well as the machinery tha

99 ls involves regulatory interactions with the nuclear pore complex (NPC), followed by translocation to

100 Nuclear pore complex (NPC)-mediated nucleocytoplasmic tr

101 cleocytoplasmic transport events through the nuclear pore complex (NPC).

102 5, a core component of the inner ring of the nuclear pore complex (NPC).

103 of a non-dividing cell, is exclusive to the nuclear pore complex (NPC).

104 Nucleoporins are essential components of the nuclear pore complex (NPC).

105 mammalian nucleoporin 98, a component of the nuclear pore complex (NPC).

106 rved assembly at the cytoplasmic face of the nuclear pore complex (NPC).

107 repeats that fill the central channel of the nuclear pore complex (NPC).

108 hat localizes to the cytoplasmic side of the nuclear pore complex (NPC).

109 king site for protein-cargo complexes at the nuclear pore complex (NPC).

110 to and out of the nucleus occurs through the nuclear pore complex (NPC).

111 lasmic transport is tightly regulated by the nuclear pore complex (NPC).

112 Grima et al. (2017) describe defects in the nuclear pore complex and impaired nucleocytoplasmic tran

113 t of nucleoporins (Nups) can detach from the nuclear pore complex and move into the nuclear interior

114 mbrane-less organelles such as nucleoli, the nuclear pore complex and stress granules.

115 rallel CC of the dynein stalk region and the nuclear pore complex and suggests that this one-dimensio

116 tosol by employing anti-beta-tubulin or anti-nuclear pore complex antibody as cargo.

117 e nuclear periphery and interaction with the nuclear pore complex are prerequisites for gene clusteri

118 included in developing models and using the nuclear pore complex as an example to illustrate the pra

119 e stereotypic arrangement of proteins in the nuclear pore complex as in situ reference structures to

120 lar or identical to those needed for de novo nuclear pore complex assembly.

121 Moreover, we provide evidence that a nuclear pore complex associates with the duplicating SPB

122 nk between the Torsin/cofactor system and NE/nuclear pore complex biogenesis or homeostasis and estab

123 mutants are insensitive to a Nup62-mediated nuclear pore complex blockade in cells that potently blo

124 Here, we use an inducible nuclear pore complex blockade to monitor the kinetics of

125 Nuclear pore complex components (Nups) have been implica

126 of studies have reported the involvement of nuclear pore complex components in embryogenesis, cell d

127 The nuclear pore complex controls the passage of molecules v

128 e provide insight into how compartmentalized nuclear pore complex disassembly allows cells that under

129 process occurs for the core subunits of the nuclear pore complex in both young and aged cells.

130 Our study also unveils a role for the nuclear pore complex in resolving replication defects at

131 is activity is also important for interphase nuclear pore complex insertion into growing germline nuc

132 , thereby inhibiting mRNA export through the nuclear pore complex into the cytoplasm for translation.

133 The nuclear pore complex is the primary conduit for nuclear

134 The nuclear pore complex mediates nucleocytoplasmic transpor

135 rins implicated in maintaining the selective nuclear pore complex permeability barrier.

136 The nuclear pore complex protein NUP88 is frequently elevate

137 that the Arabidopsis (Arabidopsis thaliana) nuclear pore complex protein Nup88/MOS7 is essential for

138 itionally revealed interactions with several nuclear pore complex proteins by proteomics analysis.

139 subset of 8, including key components of the nuclear pore complex scaffold and the transmembrane nucl

140 Depletion of nuclear pore complex subunits in the context of POT1 dys

141 rate complicated molecular gates such as the nuclear pore complex to control the transport of biologi

142 mprehensive architectural model of the human nuclear pore complex to date.

143 onsiderations when studying the mechanism of nuclear pore complex transport in vivo.

144 entary studies that Plk1 is recruited to the nuclear pore complex upon mitotic entry, where it acts w

145 cking and translocation of mRNAs through the nuclear pore complex via interactions with nucleoporins(

146 lear translocation through components of the nuclear pore complex(2-4).

147 s membranes, by shuttling cargos through the nuclear pore complex, and by triggering the formation of

148 nteracts with both RNA polymerase II and the nuclear pore complex, and its deletion reverts the nucle

149 NUP107 is a component of the nuclear pore complex, and the NUP107-associated protein

150 ous intracellular compartments including the nuclear pore complex, COPII-coated vesicles, and inside

151 omolecular complexes with an emphasis on the nuclear pore complex, holding great potential for applic

152 , which is shared by several proteins of the nuclear pore complex, including those in the central cha

153 uding capsid transport, decapsidation at the nuclear pore complex, particle assembly, and secondary e

154 Here we review transport through the nuclear pore complex, pointing out vulnerabilities that

155 eraction partners of VAPB at the INM and the nuclear pore complex, respectively.

156 ld-type full-length NUP98 is a member of the nuclear pore complex, the chromosomal translocations lea

157 the cellular substrates, particularly in the nuclear pore complex, used by these proteases were indee

158 are stacked ER-derived membranes containing nuclear pore complex-like structures whose fate and func

159 Analysis of a large dynamic structure-the nuclear pore complex-revealed variations detectable at t

160 of cells lacking Pom152, a component of the nuclear pore complex.

161 tified as the protein that disintegrates the nuclear pore complex.

162 ckade of the phenylalanine-glycine (FG)-rich nuclear pore complex.

163 oplasmic reticulum (ER) that is gated by the nuclear pore complex.

164 sically interacts with key components of the nuclear pore complex.

165 clear periphery through interaction with the nuclear pore complex.

166 beta1, which drives the receptor through the nuclear pore complex.

167 Nup35 gene, which encodes a component of the nuclear pore complex.

168 ed promoter region (TPR), a component of the nuclear pore complex.

169 cleus, including several constituents of the nuclear pore complex.

170 gel using protein fragments derived from the nuclear pore complex.

171 ins (NUPs) are an essential component of the nuclear-pore complex, which regulates nucleocytoplasmic

172 smic transport and accumulations of specific nuclear-pore-complex-associated proteins have been repor

173 ontaining nucleoporin proteins (Nups) within nuclear pore complexes (NPC).

174 Nuclear pore complexes (NPCs) accumulate at TAN lines pr

175 Nuclear Pore complexes (NPCs) act as docking sites to an

176 Nuclear pore complexes (NPCs) allow selective import and

177 lasmic reticulum (ER), translocation through nuclear pore complexes (NPCs) and retention on nuclear p

178 Nuclear pore complexes (NPCs) are 110-megadalton assembl

179 Nuclear pore complexes (NPCs) are approximately 100 MDa

180 Nuclear pore complexes (NPCs) are composed of several co

181 embranes coupled to the selective barrier of nuclear pore complexes (NPCs) are essential for the segr

182 Nuclear pore complexes (NPCs) are important for cellular

183 Nuclear Pore Complexes (NPCs) are key cellular transport

184 Nuclear pore complexes (NPCs) are multiprotein channels

185 Nuclear pore complexes (NPCs) are the main conduits for

186 e nucleus, possibly due to delocalization of nuclear pore complexes (NPCs) at the nuclear envelope.

187 Nuclear pore complexes (NPCs) conduct selective, bidirec

188 The permeability barrier of nuclear pore complexes (NPCs) controls bulk nucleocytopl

189 Transport through nuclear pore complexes (NPCs) during interphase is facil

190 es but also on its binding to Megator/Tpr at nuclear pore complexes (NPCs) during interphase.

191 Nuclear pore complexes (NPCs) emerged as nuclear transpo

192 Oocytes stockpile nuclear pore complexes (NPCs) in cytoplasmic membrane sh

193 The interior of nuclear pore complexes (NPCs) is densely filled with FG-

194 Passive macromolecular diffusion through nuclear pore complexes (NPCs) is thought to decrease dra

195 cleus and cytoplasm, is tightly regulated by nuclear pore complexes (NPCs) made up of nucleoporins (N

196 Nuclear pore complexes (NPCs) mediate nucleocytoplasmic

197 Nuclear pore complexes (NPCs) perforate the nuclear enve

198 Nuclear pore complexes (NPCs) regulate all cargo traffic

199 nuclear envelope (NE) is densely packed with nuclear pore complexes (NPCs) that are stockpiled for em

200 Chromatin and nuclear pore complexes (NPCs) undergo dramatic changes d

201 known as the constituent building blocks of nuclear pore complexes (NPCs), membrane-embedded channel

202 selective and efficient biomachines known as nuclear pore complexes (NPCs).

203 nuclei showed a round shape and presence of nuclear pore complexes (NPCs).

204 ar envelope, so Mad1 does not anchor them to nuclear pore complexes (NPCs).

205 nucleocytoplasmic transport (NCT) to bypass nuclear pore complexes (NPCs).

206 les and contribute to the quality control of nuclear pore complexes (NPCs); whether these processes a

207 ess the ability to enter the nucleus through nuclear pore complexes and can infect interphase cells,

208 compaction that facilitates movement through nuclear pore complexes and the length of transcript poly

209 olecule exchange, it has become evident that nuclear pore complexes and their components also have mu

210 indings that highlight the dynamic nature of nuclear pore complexes and their roles in many cell type

211 Nuclear pore complexes are multiprotein channels that sp

212 Increasing evidence points to nuclear pore complexes as important regulators of cell f

213 Nuclear pore complexes have emerged in recent years as c

214 fission yeast, and surveillance of defective nuclear pore complexes in budding yeast.

215 ith nuclear membrane but devoid of lamin and nuclear pore complexes in Drosophila melanogaster.

216 tructured substrates and the distribution of nuclear pore complexes in myoblasts differentiated on a

217 Recording nanobody-labeled nuclear pore complexes in Xenopus laevis cells showed th

218 that an increase (decrease) in the number of nuclear pore complexes increases (decreases) the number

219 It initiates assembly of nuclear pore complexes into functional nuclear pores tow

220 f HIV-1 replication complexes through intact nuclear pore complexes is critical for successful infect

221 duals, while the total number and density of nuclear pore complexes remained normal.

222 RNAs from the nucleus to the cytosol through nuclear pore complexes represents an important step in t

223 Nuclear pore complexes tightly regulate nucleo-cytoplasm

224 ants, and 3) transcripts being enriched near nuclear pore complexes when components of the mRNA expor

225 Tpr, a component of the NPCs (nuclear pore complexes), facilitates the formation of th

226 The opening lacks nuclear lamina, nuclear pore complexes, and nuclear membrane, but it is

227 Most models propose transport through the nuclear pore complexes, but a central outstanding questi

228 ddition to its well-defined interaction with nuclear pore complexes, here we find that Gle1 is enrich

229 lo-like kinase 1 (PLK-1) is recruited to the nuclear pore complexes, just prior to NEBD, through its

230 Beyond their role at nuclear pore complexes, some nucleoporins function in th

231 oscopy (AFM) to the nuclear envelope and the nuclear pore complexes, we demonstrate that disposition

232 ery and requires Nup2, suggesting a role for nuclear pore complexes.

233 of the AAL signal localizes in proximity to nuclear pore complexes.

234 al properties of the permeability barrier of nuclear pore complexes.

235 a functional role and mechanism for specific nuclear pore components in promoting an open chromatin s

236 In summary, the nuclear pore components Nup88/214 suppress Notch signali

237 ins and exportins, Ran-GTP cycle regulators, nuclear pore components, and arginine methylases in medi

238 ng them to receptor clustering in platelets, nuclear pore components, endocytic proteins and microtub

239 pecific transcription complexes and show how nuclear pore composition changes can be exploited to reg

240 including alternative splicing, RNA editing, nuclear pore composition, RNA-binding protein motif enri

241 scission delay upon checkpoint activation by nuclear pore defects also depends on MsrB2.

242 ficient to promote TDP-43 granule formation, nuclear pore defects and cell death in excitatory neuron

243 scission in response to lagging chromosomes, nuclear pore defects, and tension forces at the midbody.

244 nuclear and cytoplasmic TDP-43 granules and nuclear pore defects.

245 echanosensing mechanism mediated directly by nuclear pores, demonstrated for YAP but with potential g

246 We show that an increased nuclear pore density during OIS is responsible for SAHF

247 tein Nup1 reduces telomere relocalization to nuclear pores early after telomerase inactivation.

248 , which is gated at the inner surface of the nuclear pore for cytoplasmic export of processed transcr

249 ses, the molecular mechanisms modulating the nuclear pore function are still largely unknown.

250 e identified SLP-76 as a direct regulator of nuclear pore function in T cells.

251 at proximity of transcribed chromatin to the nuclear pore helps restrain pathological R loops.

252 CRT-dependent surveillance system that seals nuclear pores: how these pores are sensed and sealed is

253 rast, nondividing quiescent cells remove old nuclear pores in an ESCRT-dependent manner.

254 results uncover a previously unknown role of nuclear pores in heterochromatin reorganization in mamma

255 chitectures, from mitochondrial networks and nuclear pores in mammalian cells to amyloid-beta plaques

256 t modulation of actin homeostasis can rescue nuclear pore instability and dysfunction caused by mutan

257 modulation of actin polymerization disrupts nuclear pore integrity, nuclear import, and downstream p

258 st rapidly evolving human-ape gene families, nuclear pore interacting protein (NPIP).

259 The journey from plasma membrane to nuclear pore is a critical step in the lifecycle of DNA

260 Knowing the configuration of the nuclear pore is essential for appreciating the underlyin

261 des evidence by direct imaging at the single nuclear pore level of functional changes linked to a hum

262 envelope (NE) specifically during G2 via two nuclear pore-mediated mechanisms involving RanBP2-BicD2

263 high-resolution structure of the cytoplasmic nuclear pore-mRNA export holo-complex, challenging our t

264 Prior to export through the nuclear pore, mRNPs undergo several obligatory remodelin

265 s dependent on F-actin stress fiber mediated nuclear pore opening, however the protein mediators of Y

266 us and exit it either by passing through the nuclear pores or by rupturing the nuclear envelope.

267 and reversed PRn-mediated enhancement of the nuclear pore permeability barrier.

268 y confirmed that the relocation of damage to nuclear pores plays an important role in a naturally occ

269 In this study, we show that the nuclear pore protein ALADIN is a novel spatial regulator

270 dundant mechanism of acidic patch binding by nuclear pore protein ELYS.

271 sential for the association of Rph1 with the nuclear pore protein Nup1.

272 We found that the nuclear pore protein Nup214 (nucleoporin 214) and its in

273 The Sig-1R colocalizes with RanGAP and nuclear pore proteins (Nups) and stabilizes the latter.

274 Nuclear pore proteins (Nups) interact with chromosomes t

275 assembly composed of multiple copies of ~30 nuclear pore proteins (Nups).

276 Nuclear pore proteins at the base of cilia were thought

277 t from its ability to lock the FG repeats of nuclear pore proteins in the polymerized state.

278 lasses of proteins in the nucleus, including nuclear pore proteins, adaptor proteins such as FAK and

279 tained in the nucleoplasm, requires distinct nuclear pore proteins, and is regulated differently thro

280 e NPC and depends critically on unstructured nuclear pore proteins, and is therefore not well underst

281 brils also induces cytoplasmic aggregates of nuclear pore proteins.

282 nal memory often relies on interactions with nuclear pore proteins.

283 rdered phenylalanine-glycine-rich repeats of nuclear pore proteins.

284 signaling and programmed cell death require nuclear pore rearrangement and release of sequestered cy

285 leads to nuclear flattening, which stretches nuclear pores, reduces their mechanical resistance to mo

286 o the Ran-activating protein (RanGAP) at the nuclear pore, resulting in nucleocytoplasmic transport d

287 e of nucleocytoplasmic transport through the nuclear pore, revealing a novel mechanism of neurodegene

288 lease of MAD1 from the embrace of TPR at the nuclear pore so that it can be recruited to kinetochores

289 lates the nuclear entry rates of YAP/TAZ via nuclear pore stretching, clarifying how forces affect ge

290 hese results on a molecular chaperone at the nuclear pore suggest that Sig-1Rs may benefit patients w

291 n microscopy revealed capsids accumulated at nuclear pores that retained the viral genome for at leas

292 hey are also found in the central channel of nuclear pores, the nexus points of intermediate filament

293 by decreasing the mechanical restriction of nuclear pores to molecular transport.

294 t cold-stress responses, associates with the nuclear pores to regulate mRNA export, and regulates the

295 export factors mediate mRNA transit through nuclear pores to the cytoplasm, after which these factor

296 ly of nuclear pore complexes into functional nuclear pores toward the end of mitosis.

297 Both restricted nuclear pore transit and upregulation of ACAD10 are requ

298 teins too large to passively diffuse through nuclear pores were readily imported into the nucleus thr

299 mutations caused a depletion of hGle1 at the nuclear pore where it carries out an essential role in n

300 fission is achieved via local disassembly of nuclear pores within the narrow bridge that links segreg