ライフサイエンスコーパス: nuclear retention

1 oficiency in TLC1 and Sir4 binding, and TLC1 nuclear retention.

2 s (MEFs), exhibited enhanced DNA binding and nuclear retention.

3 ciation, PABP1 deacetylation, and poly(A)RNA nuclear retention.

4 f degradation is determined by the degree of nuclear retention.

5 denosine-to-inosine editing, involved in its nuclear retention.

6 t nuclear export, whereas low levels reflect nuclear retention.

7 influenced by both Dorsal concentration and nuclear retention.

8 at these complexes play a key role in TDP-43 nuclear retention.

9 on complex, nucleocytoplasmic shuttling, and nuclear retention.

10 cleaves an RNA helicase DDX3X to promote its nuclear retention.

11 xidative stress sensitivity through cyclin C nuclear retention.

12 gion, amino acids 40 to 244, as required for nuclear retention.

13 atus, arguing against the role of editing in nuclear retention.

14 lation, loss of interaction with 14-3-3, and nuclear retention.

15 d with enhanced transcriptional activity and nuclear retention.

16 deacetylated state (KR series) promote FoxO1 nuclear retention.

17 uclear exclusion and deacetylation-dependent nuclear retention.

18 x subunits in regulating the duration of p65 nuclear retention.

19 speckles, nuclear domains implicated in mRNA nuclear retention.

20 mbryonic stem cells (hESCs) does not lead to nuclear retention.

21 nuclear export domains and are required for nuclear retention and co-localization with IN.

22 CAS N-terminus is sufficient to abolish its nuclear retention and coincides with metastatic cellular

23 ulation of Sam68 expression caused exclusive nuclear retention and colocalization of both Rev and CRM

24 rminal portion contributes further to hTAP's nuclear retention and contains a signal(s) for nuclear r

25 reases in RPA32 hyperphosphorylation and RPA nuclear retention and decreases in replication activity,

26 This virus, therefore, has uncoupled the nuclear retention and degradation activities of vhs, pro

27 ucleotide intronic region that increased the nuclear retention and degradation of a reporter mRNA in

28 ing sequence, SAP mutation, prevented L(pro) nuclear retention and degradation of NF-kappaB, resultin

29 ough delayed splicing and nuclear export, or nuclear retention and degradation of specific transcript

30 DNA-PK after virus infection results in its nuclear retention and delayed proteolysis.

31 5 has the opposite effect, decreasing expHTT nuclear retention and increasing expression of expHTT pr

32 n the nucleus which is required for Star-PAP nuclear retention and interaction with PIPKIalpha.

33 Thus, nuclear retention and nucleolar localization are distinc

34 to SMC marker promoter via supporting Smad3 nuclear retention and physically interacting with Smad3.

35 h LPS in vitro also have prolonged NF-kappaB nuclear retention and produce high IL-6 levels.

36 re of vital importance for viruses to ensure nuclear retention and proper segregation of their viral

37 localization region of LIN28A increases its nuclear retention and protein stability.

38 ynamics, with Stat3beta exhibiting prolonged nuclear retention and reduced intranuclear mobility espe

39 ts with a self-cleaving ribozyme can enhance nuclear retention and serve as a tool to decrease specif

40 p107 in the early embryo are crucial for the nuclear retention and subsequent processing of pri-miR42

41 STL associated with MRTF-A and increased its nuclear retention and transcriptional activity.

42 ions: constraining SHORT-ROOT spread through nuclear retention and transcriptional regulation of key

43 Mutations of DNA binding residues relieve nuclear retention and unmask the role of Kap104p in Tfg2

44 functions of WUS-box, which is required for nuclear retention, and EAR-like domain, which participat

45 asmid, association with mitotic chromosomes, nuclear retention, and long-term episome persistence.

46 processes, including cytoplasmic anchorage, nuclear retention, and or nuclear export.

47 ielded a protein with wild-type DNA binding, nuclear retention, and transcriptional and antiviral act

48 perhaps reflecting increased utilization of nuclear retention as a regulatory strategy in adult brai

49 7 domain from Stat3beta eliminated prolonged nuclear retention but did not alter its intranuclear mob

50 Either motif is sufficient for nuclear retention, but disruption of both motifs leads t

51 Prolonged nuclear retention, but not reduced intranuclear mobility

52 The SINE promotes Malat1 nuclear retention by facilitating Malat1 binding to HNRN

53 the full-length protein) and information for nuclear retention contributed to the nuclear localizatio

54 Nuclear retention correlates with adenosine-to-inosine e

55 Such nuclear retention correlates with paraspeckle-associated

56 7 by decreasing its turnover, increasing its nuclear retention, decreasing its DNA binding, and limit

57 t result in dimerization and that facilitate nuclear retention, derepress transactivation, and allow

58 , including a nuclear localization signal, a nuclear retention domain and a nuclear export signal.

59 des as well as the involvement of a dominant nuclear retention domain are novel features that might c

60 ng Mta responsive element and expression and nuclear retention element (1,2).

61 The 79-nucleotide expression and nuclear retention element (ENE) was proposed to adopt a

62 esponse element (MRE) and the expression and nuclear retention element (ENE).

63 erpesvirus is conferred by an expression and nuclear retention element (ENE).

64 Prior data indicate that deletion of a nuclear retention element (NRE) causes nuclear export of

65 ation signal in the extreme C terminus and a nuclear retention element (NRE) in the RNA recognition m

66 nterrupts), and (3) a polyadenylated nuclear-nuclear retention element complex.

67 The element, PAN-ENE (PAN RNA expression and nuclear retention element), increases the efficiency of

68 ons of cis-acting nuclear export elements or nuclear retention elements with trans-acting nuclear tra

69 This facilitates FoxO1 nuclear retention, enhances lipid uptake and lipolysis,

70 F1 or RNA exosome cofactor MTR4 promotes FUS nuclear retention, even when transcription is repressed,

71 e that the RRE is a principal determinant of nuclear retention for envelope transcripts in primate ce

72 trinsically nuclear but the mechanism of its nuclear retention has not been demonstrated, although La

73 of p300 to acetylate E2A and to promote E2A nuclear retention in 293T cells.

74 indicating that the amino terminus mediates nuclear retention in addition to nuclear import.

75 This element provides nuclear retention in cells expressing the EBV protein EB

76 he role of Stat3 in maintenance of NF-kappaB nuclear retention in GBM still remain unknown.

77 eletal regulation, affecting Wnt-independent nuclear retention in syncytial embryos.

78 we demonstrate that Med13p mediates cyclin C nuclear retention in unstressed cells.

79 We find that nuclear retention is dependent on dTCF/Pangolin.

80 ns mediate U6 snRNP localization except that nuclear retention is the likely mechanism for the U6 snR

81 The basis for nuclear retention is unclear and is an important aspect

82 s a nitrate sensor, its nitrate-dependent TF nuclear retention, its "hit-and-run" mode of target gene

83 linked polyubiquitination promotes HIF1alpha nuclear retention leading to an increase in the expressi

84 port does not simply reflect the relief of a nuclear retention mechanism.

85 ional mRNA-specific characteristics, such as nuclear retention motifs or binding sites for cellular p

86 data suggest that conserved elements mediate nuclear retention, nuclear export, and RNA-binding activ

87 t in living cells but has no impact upon SRY nuclear retention/nuclear dynamics.

88 expression of mutant Ltv1 is associated with nuclear retention of 40S subunit marker proteins, RpS2-G

89 required for replication initiation and the nuclear retention of a critical component of the replica

90 Thus, persistent nuclear retention of activated ERK-1/2 may be a critical

91 binding is not a necessary prerequisite for nuclear retention of activated STAT proteins.

92 SIN3A silencing results in a prolonged nuclear retention of activated STAT3 and enhances its re

93 or Ku as a factor required to facilitate the nuclear retention of APLF.

94 nd increases both AR binding of Ku-70/80 and nuclear retention of AR in association with hyperphospho

95 mation, therefore, appears to be the lack of nuclear retention of Arg283His.

96 er levels of REF1/Aly at the c-myc gene, and nuclear retention of bulk HeLa poly(A)+ RNAs in vivo.

97 we demonstrated that Fancd2 was required for nuclear retention of CA-FOXO3a and for maintaining hemat

98 clear RNA export factor-1 (NXF1), leading to nuclear retention of cellular mRNAs.

99 al RNA-protein complexes, and contributes to nuclear retention of certain small RNAs.

100 consensus binding motif and is required for nuclear retention of Chk1 following an hydroxyurea-induc

101 Nuclear retention of CHP1 attenuates the abundance of UB

102 on that is independent of the nuclear import/nuclear retention of COP1.

103 es this intramolecular interaction to induce nuclear retention of COP1.

104 how that while paraspeckles do not influence nuclear retention of Ctn RNA, they modulate its intranuc

105 eckles, suggesting that they do not regulate nuclear retention of Ctn RNA.

106 e show that overexpression of PML results in nuclear retention of cyclin D1 mRNA and that intact PML

107 in at the PML-eIF4E nuclear body, leading to nuclear retention of cyclin D1 transcripts and reduced c

108 Segregation and nuclear retention of DNA is, therefore, a key issue in r

109 mediated transcription activity, and promote nuclear retention of E2A proteins.

110 c adenosine deaminase (ADAR) can lead to the nuclear retention of edited transcripts .

111 These data suggest a model that involves nuclear retention of expansion RNAs by RNA-binding prote

112 factor muscleblind-like 1 (MBNL1) increases nuclear retention of expHTT and decreases the expression

113 enuated Akt signaling, resulting in enhanced nuclear retention of Foxo1, which is indispensable for T

114 We show that nuclear retention of FOXO3a due to serum starvation resu

115 The synergy also enhances nuclear retention of FOXO3a, a crucial factor for HSC ma

116 sequences, which prevent export and mediate nuclear retention of full-length viral RNA.

117 ng non-coding RNA NEAT1; they have a role in nuclear retention of hyperedited transcripts and are ass

118 Inhibition of cdk4 results in nuclear retention of ICP0.

119 These results revealed that the vhs-induced nuclear retention of IE and E transcripts was dependent

120 Nuclear retention of incompletely spliced or mature mRNA

121 ort sequence in the C-terminal tail promotes nuclear retention of IRS2, implicating nuclear export in

122 O-GlcNAc using a dynamic mechanism involving nuclear retention of its fourth intron.

123 significantly increased the NEDDylation and nuclear retention of L11.

124 rns in adult tissue, and we demonstrate that nuclear retention of LMO proteins is enhanced by the nuc

125 Nuclear retention of longer APA isoforms occurs and is p

126 structure associated in some cases with the nuclear retention of molecules involved in transcription

127 l shock in Saccharomyces cerevisiae leads to nuclear retention of most poly(A)+ RNA but heat shock mR

128 a post-transcriptional level by means of the nuclear retention of mRNA containing in their 3'-UTR inv

129 However, nuclear retention of mRNAs containing IRAlus is variable

130 strate that disruption of CARM1 enhances the nuclear retention of mRNAs containing IRAlus.

131 r capable of binding and possibly modulating nuclear retention of mutant DMPK mRNA may prove to be an

132 a myotonica protein kinase (DMPK) causes the nuclear retention of mutant messenger RNA (mRNA).

133 , reduced DMPK protein levels, consequent to nuclear retention of mutant transcripts, are probably a

134 factor (SRF)-mediated transcription through nuclear retention of myocardin-related transcription fac

135 erleukin-6 (IL-6), which is due to prolonged nuclear retention of NF-kappaB.

136 CAR-N removal led to strong nuclear retention of NKILA, and CAR-N insertion promoted

137 EX-TAP pathway components resulted in strong nuclear retention of NKILA.

138 ents, initiation of silencing coincides with nuclear retention of non-polyadenylated RNA derived from

139 Nuclear retention of nucleoplasmic Rb during G(1) phase

140 We show that the nuclear retention of one such transcript, F11R (also kno

141 activity and were associated with extensive nuclear retention of ORF47 and IE62 proteins in vitro.

142 e degradation of some mRNA molecules and the nuclear retention of others.

143 Mutations of these residues causes a nuclear retention of p17.

144 MK2 and HSP27 prevent nuclear retention of p38 by sequestering it in the cytos

145 donors also stimulate rapid and unequivocal nuclear retention of p53 but apparently do not require A

146 Nuclear retention of p53 induced by CRM1 inhibition syne

147 iscuss new studies revealing a mechanism for nuclear retention of p53, and the potential contribution

148 c mobility gel shift assay and prevented the nuclear retention of p65 as shown by immunocytochemistry

149 , our data highlight how the ENE affects the nuclear retention of PAN but ultimately does not play an

150 und that Pak1 activation led to an increased nuclear retention of PCBP1, recruitment to the eukaryoti

151 Lamin promotes nuclear retention of phosphorylated ERK in the CySC line

152 Here we report that acetylation enhances nuclear retention of POP-1, the Caenorhabditis elegans L

153 ibition of CRM1 by leptomycin B leads to the nuclear retention of pp32 and APRIL, their increased ass

154 oplasmic maturation of 40S subunits and that nuclear retention of pre-40S subunits is a downstream co

155 Nuclear retention of pre-mRNA prevents this interaction

156 ng that exon 7 encodes a domain required for nuclear retention of RECQL4.

157 ession of hnRNP H expression by RNAi rescued nuclear retention of RNA with CUG repeat expansions.

158 ar bodies that alter gene expression via the nuclear retention of RNA.

159 unit of replication protein A, and increased nuclear retention of RPA.

160 at the RRE alone plays a crucial role in the nuclear retention of RRE-containing env transcripts in s

161 , dysfunctional p53 strongly correlates with nuclear retention of sequence-verified wt BRCA1.

162 1 binds residues 347-370 of p53 and enhances nuclear retention of Ser315 phosphorylated p53.

163 lation at S47 was critically involved in the nuclear retention of SIRT1 but abolished its association

164 motes breast cancer metastasis by increasing nuclear retention of SMAD3 and identify crosstalk betwee

165 SINE treatment resulted in nuclear retention of snail regulator FBXL5 that was conc

166 way can regulate mRNA export and promote the nuclear retention of some mRNAs.

167 Nuclear retention of Spc1 requires Atf1, a transcription

168 An L-->A mutation within the NES restored nuclear retention of STAT1 in Jak1-deficient cells.

169 Our results explain the selective nuclear retention of tax/rex but not other viral mRNAs b

170 chaperoning the assembly and/or facilitating nuclear retention of telomerase.

171 with RagC eliminated GAP activity and led to nuclear retention of TFE3, with no effect on mTORC1 subs

172 rams the epitranscriptomic landscape through nuclear retention of the ALKBH5 demethylase to protect a

173 ese data suggest that HuR binding results in nuclear retention of the C/EBPbeta mRNA and is consisten

174 Interestingly, LMB treatment led to nuclear retention of the DHOV matrix (M) protein in both

175 trained to a simple molecular switch such as nuclear retention of the DMPK transcript or haploinsuffi

176 erization occludes its NES, thereby ensuring nuclear retention of the DNA-binding form.

177 of the EGFP cDNA led to a rhythmic circadian nuclear retention of the egfp mRNA that was lost when pa

178 Furthermore, nuclear retention of the ER during homogenization proced

179 The IL-12-induced nuclear retention of the IFN-gamma mRNA prevails until a

180 stimulated natural killer (NK) cells through nuclear retention of the IFN-gamma mRNA.

181 eover, knockdown of these factors results in nuclear retention of the intronless mRNAs.

182 V genes in neural cells was characterized by nuclear retention of the major viral transactivating pro

183 Within 10 min after gamma irradiation, nuclear retention of the Mre11 complex in small granular

184 ilencing correlates with A-to-I RNA editing, nuclear retention of the mRNA and its association with t

185 been identified but none can account for the nuclear retention of the mutant transcripts.

186 Tethering of export factors can override the nuclear retention of the PAN-ENE, supporting a mechanism

187 amphipathic alpha-helical structure mediates nuclear retention of the protein.

188 actions with complementary mRNAs, leading to nuclear retention of the targeted mRNA via a mechanism i

189 e suppression of virus replication relies on nuclear retention of the tax/rex mRNA by p30, determinin

190 In contrast, p30 is involved in the nuclear retention of the tax/rex mRNA leading to inhibit

191 s absent in beta1-Delta7p-chimaerin, causing nuclear retention of this truncated variant.

192 vae, suggesting that PER may be required for nuclear retention of TIM.

193 ly stressed to hypertonic conditions reduces nuclear retention of TonEBP, resulting in a substantial

194 f CRM1-mediated nuclear export with aberrant nuclear retention of transcriptional regulators.

195 on is globally comparable between fractions, nuclear retention of transcripts may play an underapprec

196 e canonical length can signal degradation or nuclear retention of transcripts.

197 the cis-acting sequences responsible for the nuclear retention of U3 box C/D snoRNA by analyzing the

198 Furthermore, our results indicate that nuclear retention of U3 RNA does not simply reflect its

199 g of a subset of transcripts and promote the nuclear retention of unspliced pre-mRNAs in yeast.

200 ects in the DNA binding region decreased the nuclear retention of VDR and prevented localization to n

201 sequence also binds histone H4, resulting in nuclear retention of VP22.

202 ays by papaverine may be associated with the nuclear retention of vRNPs and the reduction of influenz

203 The interval of nuclear retention of Whi5, a Swi4 repressor, largely acc

204 Last, knockdown of PTPN14 induces the nuclear retention of YAP and increases the YAP-dependent

205 ll lymphomagenesis and provide evidence that nuclear-retention of cyclin D1 is oncogenic in vivo.

206 E-mediated inhibition did not involve either nuclear retention or degradation of target mRNA, since t

207 finally, (iii) depletion of NXF1 results in nuclear retention or degradation of viral RNAs.

208 nscripts of XMRV and MLV, resulting in their nuclear retention or degradation.

209 s that enhance its stability (p27(T187A)) or nuclear retention (p27(S10A)) attenuate leukemogenesis o

210 CARM1 regulates this nuclear retention pathway at two levels: CARM1 methylate

211 e variant which omits exon 6, containing the nuclear retention PINIT motif.

212 binding to HNRNPK, a protein that drives RNA nuclear retention, potentially through direct interactio

213 ng rotenone-induced G2/M arrest, whereas its nuclear retention protects against mitotic DNA damage an

214 important for snoRNA processing, stability, nuclear retention, protein binding, nucleolar localizati

215 KBP51 expression ratio by favoring NF-kappaB nuclear retention, recruitment to the promoter regions o

216 s in the nuclei, and (iv) as a result of the nuclear retention, release of infectious virions is sign

217 se they lack an NES, but because they bear a nuclear retention sequence (NRS) that is capable of over

218 Here, we used genome editing to knock-in a nuclear retention signal (NRS) in Srsf1 to create a mous

219 function for the RRD repeat as a ribonucleic nuclear retention signal that is sufficient to retain an

220 ents indicates that p48 contains a bipartite nuclear retention signal within its amino-terminal DNA-b

221 Both subunits contained nuclear export and nuclear retention signals, whereas p54nrb was continuous

222 e thought to promote FoxO1 deacetylation and nuclear retention, thus increasing its activity.

223 in epidermal keratinocytes, which is due to nuclear retention, thus reducing the degradation of B-My

224 On the other hand, FKBP52 favors the nuclear retention time of RelA, its association to a DNA

225 ed by a dynamic combination of Wtm1-mediated nuclear retention to limit export and regulated nuclear

226 minant for the interaction with Crm1 and its nuclear retention upon TLR4 stimulation.

227 Hsp90 nuclear retention was coincident with glucose exhaustion

228 Nuclear retention was first monitored in tobacco using t

229 ermore, downregulating Kapbeta1 disrupts CAS nuclear retention, which highlights the balance between

230 mechanism by which PARP-1 promotes NF-kappaB nuclear retention, which ultimately can influence NF-kap

231 ine phosphatase, Ptp2, showed decreased Hog1 nuclear retention, while a strain lacking the cytoplasmi

232 helix assembly, phase separation, and TDP-43 nuclear retention, while polar residues down regulate th