ライフサイエンスコーパス: nuclear speckle

1 called DRS and MemA; a protein localized in nuclear speckles).

2 noticeably only after initial contact with a nuclear speckle.

3 fficient splicing of the IAV M transcript in nuclear speckles.

4 In addition, RCs coalesce at and reorganize nuclear speckles.

5 , the endogenous FRG1 is not associated with nuclear speckles.

6 on-human primate ISG15 from the cytoplasm to nuclear speckles.

7 olding protein for RNA processing factors in nuclear speckles.

8 ganization of pre-mRNA processing factors in nuclear speckles.

9 gulation by sequestering its constituents in nuclear speckles.

10 -3 reveals localization of these isoforms to nuclear speckles.

11 omatin that enables clustering around common nuclear speckles.

12 e and forms UBC26-RFA4-receptor complexes in nuclear speckles.

13 ein for proteosomal degradation, possibly in nuclear speckles.

14 - a property essential for its assembly into nuclear speckles.

15 oss and relocalizes to splicing antigen-rich nuclear speckles.

16 results in its subnuclear localization into nuclear speckles.

17 SR proteins do not immediately colocalize in nuclear speckles.

18 a rapid exchange rate of splicing factors in nuclear speckles.

19 with delayed localization of SR proteins to nuclear speckles.

20 issue, where they interact and colocalize in nuclear speckles.

21 tention of hypophosphorylated SR proteins in nuclear speckles.

22 nto subnuclear foci which are reminiscent of nuclear speckles.

23 full-length protein accumulates in distinct nuclear speckles.

24 in about 10% of the cells EVI1 localizes in nuclear speckles.

25 colocalizes with the splicing factor SC35 in nuclear speckles.

26 monstrated that ER81 and p300 colocalized to nuclear speckles.

27 tion of their signals are colocalized within nuclear speckles.

28 in coiled bodies and nucleoli, and later in nuclear speckles.

29 inositol signaling pathways are localized at nuclear speckles.

30 mDEAH9 and splicing factor SC35 in punctate nuclear speckles.

31 ecessary nor sufficient for targeting to the nuclear speckles.

32 population of Tax is tightly associated with nuclear speckles.

33 ncreased dephosphorylation of SR proteins in nuclear speckles.

34 it decreases in gene-rich regions located at nuclear speckles.

35 ] and 61 NHCCs are consistently found at the nuclear speckles.

36 els than genes that are located farther from nuclear speckles.

37 anscript populations of Polycomb domains and nuclear speckles.

38 15 from the nucleoplasm to the nucleolus and nuclear speckles.

39 R proteins phase separate and participate in nuclear speckles.

40 tional condensates, splicing condensates and nuclear speckles.

41 tion of the viral replication complexes with nuclear speckles.

42 odulate the size, stability, and dynamics of nuclear speckles.

43 nt of the speckle-type POZ protein (SPOP) to nuclear speckles.

44 ion between them, indicate they associate at nuclear speckles.

45 of phosphorylated SC35, which is retained in nuclear speckles.

46 into a compartment enriched in SC35-positive nuclear speckles.

47 and Malat1, a large ncRNA that localizes to nuclear speckles.

48 bserved for HSP70 transgenes associated with nuclear speckles.

49 ple genes and in a higher number of enlarged nuclear speckles.

50 a DNA- and RNA-binding protein localized in nuclear speckles.

51 aled costaining between PABP1 and markers of nuclear speckles.

52 s the assembly of mRNA processing factors in nuclear speckles.

53 oteins that we validated here as enriched in nuclear speckles.

54 ns and RNA components in the organization of nuclear speckles.

55 speckles and are visible as doughnuts around nuclear speckles.

56 antly nuclear and localized to SC35-positive nuclear speckles.

57 iquitinated, stabilized, and rerouted to the nuclear speckles.

58 promyelocytic leukemia nuclear bodies (38), nuclear speckles (27), paraspeckles (24), Cajal bodies (

59 Here we propose such a model for the nuclear speckle, a membraneless body implicated in RNA s

60 ed Ubc9 depletion effectively suppresses WT1 nuclear speckles, a SUMO-1-deficient WT1(+KTS)(K73, 177R

61 By contrast, nuclear speckles act as quality control checkpoints that

62 oval in response to stress is coordinated in nuclear speckles, adding a component of spatial regulati

63 ng motif protein 39 (RBM39) and localizes to nuclear speckles adjacent to spliceosomes.

64 pendent association of HSP70 transgenes with nuclear speckles after heat shock.

65 lear with specific enrichment of alphaCP1 in nuclear speckles, alphaCP3 and alphaCP4 are restricted t

66 The finding that FAST is concentrated at nuclear speckles also supports this contention.

67 AML1b and AML1b(Del179-242) are localized to nuclear speckles, AML1b(Del179-242) was observed to have

68 Rounding of nuclear speckles, an indication of transcriptional arres

69 Tax co-localized with phospho-DNA-PK into nuclear speckles and a nuclear excluded Tax mutant seque

70 t the (GGGGCC)n repeat RNA co-localizes with nuclear speckles and alters their phase separation prope

71 nerated from short transcripts accumulate in nuclear speckles and are bound to Nxf1.

72 ular protein kinase TAO2 as a constituent of nuclear speckles and as a factor required for the integr

73 rtially colocalizes with splicing factors in nuclear speckles and assembles into spliceosomal complex

74 Accumulation of HIPK2 in nuclear speckles and association with promyelocytic leuk

75 2 were co-expressed, CtBP1 was restricted to nuclear speckles and co-localized with Glis2.

76 homologous alpha-globin loci that occurs at nuclear speckles and correlates with transcription.

77 Cisplatin was preferentially enriched in nuclear speckles and excluded from closed-chromatin regi

78 with the nuclear matrix fail to localize to nuclear speckles and exhibit reduced transcriptional act

79 Although links between nuclear speckles and gene activation are emerging, the m

80 ghbourhoods, exposing a general link between nuclear speckles and gene expression dysregulation in hu

81 overexpressing either isoform displayed both nuclear speckles and GFP fluorescence throughout the nuc

82 mises the association of splicing factors to nuclear speckles and influences the levels and activity

83 he expression of Vpr excludes SAP49 from the nuclear speckles and inhibits the formation of the SAP14

84 Here we show that PIPKIalpha co-localizes at nuclear speckles and interacts with a newly identified n

85 The longer Ania-6 protein colocalizes with nuclear speckles and is associated with key elements of

86 at Malat1 with a SINE deletion forms diffuse nuclear speckles and is frequently translocated to the c

87 orylate SR domain-containing proteins in the nuclear speckles and mediate the pre-mRNA splicing.

88 osphorylate SR domain-containing proteins in nuclear speckles and mediate the pre-mRNA splicing.

89 tin loops and nuclear sub-structures such as nuclear speckles and nucleoli to the models' predictions

90 In cultured cells, HIPKs localize to nuclear speckles and potentiate the repressor activities

91 xf1 recruitment and may allow mRNAs to leave nuclear speckles and properly dock with the nuclear pore

92 est that SR proteins mediate the assembly of nuclear speckles and regulate gene expression by influen

93 ur results update older proteomic studies of nuclear speckles and should provide a useful reference d

94 n complexes traffic to and accumulate within nuclear speckles and that these steps precede the comple

95 Our results demonstrate that nuclear speckles and their surrounding regions are major

96 esicle stage, PARP-1 protein associates with nuclear speckles and upon meiotic resumption, undergoes

97 on of membrane-less organelles (specifically nuclear speckles) and of organelle heterogeneity on spli

98 ein BRM co-localizes with SYT and SYT-SSX in nuclear speckles, and also interacts with SYT and SYT-SS

99 nteraction with Pi04089, its localization to nuclear speckles, and its increased accumulation when co

100 fferent nuclear locales: the nuclear lamina, nuclear speckles, and nucleoli.

101 aining functional splice sites accumulate in nuclear speckles, and our data suggest that splicing occ

102 AD3 and PCBP1 to colocalize in SC35-positive nuclear speckles, and the two proteins interact in the v

103 N displayed close localization in and around nuclear speckles, and their physical association in prot

104 However, little is known about how nuclear speckles are assembled or regulated.

105 Nuclear speckles are dynamic nuclear bodies characterize

106 hysiological substrate Gli3, suggesting that nuclear speckles are hotspots of ubiquitination.

107 These changes in the nucleolus and nuclear speckles are reversible and dependent on both ti

108 Since nuclear speckles are storage sites for splicing factors,

109 Given that nuclear speckles are storage sites for splicing factors,

110 Nuclear speckles are subnuclear domains that contain pre

111 ibution, suggesting that CGBP accumulates at nuclear speckles as a result of protein/protein interact

112 uilding upon our prior research establishing nuclear speckles as pivotal membrane-less organelles for

113 cells, hPrp17 is highly concentrated in the nuclear speckles, as is SC35 and many other splicing fac

114 g the levels of several proteins involved in nuclear speckle assembly and splicing, including SC35 an

115 py reveals that CFP1 and Set1 co-localize to nuclear speckles associated with euchromatin.

116 Pnn/DRS (Pnn) is a "nuclear speckle"-associated protein involved in mRNA pro

117 nd SPOP (speckle-type POZ domain protein), a nuclear speckle-associated protein that recruits substra

118 Pinin (Pnn), a nuclear speckle-associated protein, has been shown to fu

119 accumulates in a hyperphosphorylated form in nuclear speckle-associated structures.

120 paper, we dissect cis-elements required for nuclear speckle association of the heat shock protein 70

121 ribonucleoprotein modifications, leading to nuclear speckle association.

122 ar compartment, where it resides in distinct nuclear speckles at or near sites of DNA replication.

123 rsisting for 15-20 min before dissipating as nuclear speckles began to form in G1.

124 e of NAPs in splicing factor trafficking and nuclear speckle biogenesis.

125 near or at intermediate distance (HSPH1) to nuclear speckles but shifting even closer with transcrip

126 n, we show that Par 6 localizes precisely to nuclear speckles, but not to other nuclear structures, a

127 Many active genes reproducibly position near nuclear speckles, but the functional significance of thi

128 major nuclear organelles including nucleoli, nuclear speckles, Cajal bodies, as well as in the cluste

129 s, including nucleoli, the nuclear envelope, nuclear speckles, centrosomes, mitochondria, the endopla

130 although only the C terminus accumulates as nuclear speckles characteristic of the intact protein.

131 Some CGBP-containing nuclear speckles co-localize with splicing factor SC-35

132 the nucleus acts as a scaffolding protein in nuclear speckle complexes, similar to its role in the cy

133 Moreover, several nuclear speckle components, including SRRM2, mislocalize

134 denosine analogue previously shown to affect nuclear speckle composition, we unexpectedly found that

135 ir highly looping partners are enriched near nuclear speckles - condensate bodies implicated in trans

136 ly disordered mixed-charge domains (MCDs) in nuclear speckle condensation.

137 cleotides, results in the mislocalization of nuclear speckle constituents in a transcription-dependen

138 Many of the nuclear speckle constituents work in concert to coordina

139 nucleoli, nucleoplasmic transcription sites, nuclear speckles, constitutive heterochromatin domains,

140 these sites overlap with a subset of larger nuclear speckles containing phosphorylated polymerase II

141 together with SUMO1 and SUMO2 into enlarged nuclear speckles containing polyadenylated RNA.

142 ive in transcription and DNA replication and nuclear speckles containing pre-mRNA splicing factors we

143 splicing efficiency and spatial proximity to nuclear speckles could explain this counterintuitive beh

144 ction leads to sequestration of PABP1 in the nuclear speckles, creating a state within the cell that

145 Here we show that genes localized near nuclear speckles display higher spliceosome concentratio

146 statistically significant shifts in relative nuclear speckle distances in pair-wise comparisons betwe

147 16, K562); however, these moderate shifts in nuclear speckle distances tightly correlate with changes

148 LL-ELL fusion gene delocalized EAF1 from its nuclear speckled distribution to a diffuse nucleoplasmic

149 and cyclin T1), at the splicing-factor-rich nuclear speckle domain.

150 nefficiently exported, do not associate with nuclear speckle domains but are instead distributed thro

151 l co-activator CREB-binding protein (CBP) in nuclear speckle domains in the developing brain and in n

152 complex colocalizes with splicing factors in nuclear speckle domains in vivo.

153 components, a portion of CIP29 localizes in nuclear speckle domains, and its efficient recruitment t

154 sibility that pre-mRNA undergoes splicing in nuclear speckle domains, before their release by TREX co

155 as well as total polyA+ RNA, accumulates in nuclear speckle domains.

156 ution of these and other splicing factors in nuclear speckle domains.

157 concentrated in 20-50 discrete foci known as nuclear speckle domains.

158 Ps, and colocalizes with splicing factors in nuclear speckle domains.

159 A subpopulation of pol IIo was localized to nuclear "speckle" domains enriched in splicing factors,

160 We demonstrate that HIPK2 localizes to nuclear speckles (dots) by means of a speckle-retention

161 by SUMO-1, which directs its localization to nuclear speckles (dots).

162 of HIPK2 correlates with its localization to nuclear speckles (dots).

163 se components are housed in splicing-related nuclear speckles during interphase.

164 we examined the formation and composition of nuclear speckles during stress induction with tubercidin

165 et-like nuclear bodies precedes formation of nuclear speckles during telophase.

166 patient postmortem tissues, exacerbating the nuclear speckle dysfunction.

167 %) were associated with splicing factor-rich nuclear speckles even though the speckles occupied <10%

168 induce this PIF3 phosphorylation, as well as nuclear speckle formation and degradation, by direct int

169 nuclear compartments-the nuclear lamina and nuclear speckles-from different regions of the developin

170 Moreover, the vast majority of nuclear speckles (>90%) had moderate to high levels of a

171 More recently, nuclear speckles have also been implicated in splicing a

172 such as the nucleolus, stress granules, and nuclear speckles have been designated as biomolecular co

173 ion stress induces the release of SF3B1 from nuclear speckles in a manner that depends on FANCI and o

174 Collectively, our data highlight a role of nuclear speckles in both co- and posttranscriptional spl

175 ues provide insights into the involvement of nuclear speckles in cancer progression.

176 nce assays revealed the emergence of H3K9me2 nuclear speckles in committed HSPCs, consistent with pro

177 transition, suggesting an important role of nuclear speckles in gene expression regulation.

178 cells, followed by increasing BRCA1-positive nuclear speckles in late S phase and G2/M phase cells.

179 KIIbeta and SPOP interact and co-localize at nuclear speckles in mammalian cells, and SPOP mediates t

180 d system, and is co-localized with U1-70K in nuclear speckles in mammalian cells.

181 The characteristic rounding up of nuclear speckles in response to inhibition of RNA polyme

182 in a direct path over long distances toward nuclear speckles in response to transcriptional activati

183 t regulates the formation and maintenance of nuclear speckles in the interphase nucleus is poorly und

184 anscript 1 RNA, can nucleate the assembly of nuclear speckles in the interphase nucleus.

185 pre-mRNA splicing factors are recruited from nuclear speckles, in which they are concentrated, to sit

186 early afternoon, generates diffuse and fluid nuclear speckles, increases their interactions with chro

187 Impaired nuclear speckle integrity induces global exon skipping a

188 sequence-dependent RNA positioning along the nuclear speckle interface coordinates RNA splicing.

189 boundaries are preferentially positioned at nuclear speckle interfaces.

190 HIV-1 transport to nuclear speckles is dependent on the interaction of the

191 Gene organization around nuclear speckles is dynamic between cell types, and chan

192 Significantly, however, the structure of nuclear speckles is lost when Par 6 levels are reduced b

193 A-seq mapping suggests that gene distance to nuclear speckles is more deterministic and predictive of

194 nally, directed recruitment of a pre-mRNA to nuclear speckles is sufficient to increase mRNA splicing

195 Hsp70 transgenes and their transcripts with nuclear speckles is transcription dependent, independent

196 olocalizes with pre-mRNA splicing factors in nuclear speckles, its depletion by RNAi leads to cell cy

197 mentalization states genome-wide relative to nuclear speckles, lamina, and putative associations with

198 e to trap TNNT3 pre-mRNA, driving it outside nuclear speckles, leading to an altered SC35-mediated sp

199 rease of splicing particle localization into nuclear speckles leads to a disproportionate enhancement

200 nomous mammalian 12-hour ultradian rhythm of nuclear speckle liquid-liquid phase separation (LLPS) dy

201 oth positive and negative regulators for the nuclear speckle localization of a long noncoding RNA, MA

202 HRAP3 by siRNA resulted in a decrease in the nuclear speckle localization of WTAP, whereas the nuclea

203 A protein and demonstrate that it exhibits a nuclear speckled localization and possesses the ability

204 rich (SR) splicing factors and appearance of nuclear speckle-localized HIN1 during low water potentia

205 n by sut-6 occurs independent of other known nuclear speckle-localized suppressors of tau such as sut

206 ng pathway that targets the viral M1 mRNA to nuclear speckles, mediates splicing at these nuclear bod

207 ng pathway that targets the viral M1 mRNA to nuclear speckles, mediates splicing at these nuclear bod

208 Aberrant nuclear speckle morphology, reduced protein quality cont

209 HIV-1 integration favors nuclear speckle (NS)-proximal chromatin and viral infect

210 Nuclear speckles (NS) are among the most prominent biomo

211 Current models posit that nuclear speckles (NSs) serve as reservoirs of splicing f

212 Here, we demonstrate that nuclear speckles (NSs), membraneless organelles enriched

213 ndent CPSF6 condensates that colocalize with nuclear speckles (NSs).

214 Many mammalian genes localize near nuclear speckles, nuclear bodies enriched in ribonucleic

215 REBP-2 heterodimer localize predominantly to nuclear speckles or foci, with some cells showing a diff

216 We have identified 7SK RNA to be enriched in nuclear speckles or interchromatin granule clusters (IGC

217 ions , association of some active genes with nuclear speckles or transcription "factories", and assoc

218 Nuclear speckles, or interchromatin granule clusters, ar

219 Altered splicing efficiency, nuclear speckles organisation, and PRPF8 interaction wit

220 HSP70 transgenes moving curvilinearly toward nuclear speckles over approximately 0.5-6 mum distances

221 hat endogenous EAF2 and ELL colocalized in a nuclear speckled pattern.

222 enous EAF1 and ELL colocalized in a distinct nuclear speckled pattern.

223 nti-RNAP I/III antibody-positive sera showed nuclear speckled patterns, but nucleolar staining was re

224 ear bodies including nucleoli, Cajal bodies, nuclear speckles, Polycomb bodies, and paraspeckles are

225 Aly is a nuclear speckle protein implicated in mRNA export.

226 Here, we demonstrate that the nuclear speckle protein SON is an essential m(6)A target

227 expression is tightly regulated by acinus, a nuclear speckle protein.

228 this issue of Neuron, Wu et al.(1) show that nuclear speckle proteins are sequestered by both nuclear

229 100 sorted proteins, respectively, are known nuclear speckle proteins, including proteins that we val

230 atio" approach successfully identified known nuclear speckle proteins.

231 Collectively, our results demonstrate that nuclear speckles provide an architectural basis for nucl

232 hough gene expression correlates mostly with nuclear speckle proximity, DNA replication timing correl

233 cogenesis to bring its chromatin target into nuclear speckle proximity.

234 of residual Ser-2-phosphorylated RNAP II to nuclear speckles reflects a host response to the inhibit

235 HIC colocalizes with cyclin T1 in nuclear speckle regions and with Tat in the nucleolus.

236 we aim to alleviate proteinopathies through nuclear speckle rehabilitation.

237 Instead, localization of CGBP to nuclear speckles requires signals within the acidic, bas

238 results suggest that the assembly of EVI1 in nuclear speckles requires the intact HAT activity of the

239 n of HDAC5 and co-localization with MEF2s in nuclear speckles requiring serine residues 259 and 498,

240 g but not Akt phosphorylation dictates Aly's nuclear speckle residency.

241 , we provide evidence for the involvement of nuclear speckle resident proteins and RNA components in

242 Formation of the SMRTe nuclear speckles results in recruitment of several class

243 Conversely, acute depletion of nuclear speckles revealed that they influence RNA abunda

244 Here, we show that the nuclear speckle RNA-binding protein (NSR) and the AS com

245 Moreover, the essential nuclear speckle scaffold protein SRRM2 is sequestered in

246 Higher expression of nuclear speckle scaffolding protein SON, observed at ear

247 While wild-type SPOP localizes to liquid nuclear speckles, self-association-deficient SPOP mutant

248 bers of splicing factors are concentrated in nuclear speckles, some of which occur at highly active t

249 nery complexes and splicing processes within nuclear speckles (specific type of non-membrane-bound or

250 ere ANA positive; 96% of ANA positives had a nuclear speckled staining pattern.

251 raneless organelles (MLOs) such as nucleoli, nuclear speckles, stress granules, or processing bodies.

252 t to guide future experimental dissection of nuclear speckle structure and function.

253 sed exclusively in the nucleus, and within a nuclear speckle structure that has recently been describ

254 r inhibition of its kinase activity disrupts nuclear speckle structure, decreasing the levels of seve

255 rated that Tax localizes to a multicomponent nuclear speckled structure (Tax speckled structure [TSS]

256 Monomeric actin probes concentrate in nuclear speckles, suggesting an interaction of monomers

257 tors including U2AF65B, U2A', and U2AF35A in nuclear speckles, suggesting SFPS might be involved in t

258 a largely non-overlapping set of euchromatic nuclear speckles, suggesting that Set1A and Set1B each b

259 re larger for loop apexes mapping closest to nuclear speckles, suggesting the possibility of conserva

260 ) polymerase, which we have termed Star-PAP (nuclear speckle targeted PIPKIalpha regulated-poly(A) po

261 copy, we show that phyB and cry2 interact in nuclear speckles that are formed in a light-dependent fa

262 orylation of Nrd1 and the formation of novel nuclear speckles that contain Nrd1 and Nab3.

263 Some structures are always present, such as nuclear speckles that contain RNA-binding proteins (RBPs

264 odified TEL localizes to cell-cycle-specific nuclear speckles that we named TEL bodies.

265 ingers three and four, localizes to discrete nuclear speckles, the function of which is unknown.

266 ough the long MALAT1 transcript localizes to nuclear speckles, the small RNA is found exclusively in

267 . elegans RRM proteins, localizes to dynamic nuclear speckles; this localization pattern supports a r

268 s PABII protein molecules to relocalize from nuclear speckles to a uniform distribution throughout th

269 SRRM1), resulting in its redistribution from nuclear speckles to cytoplasmic foci.

270 ridging of transcriptionally active RCs with nuclear speckles to form structures that enhance export

271 or efficient recruitment of SR proteins from nuclear speckles to nascent RNA.

272 We show that the influenza virus uses nuclear speckles to promote post-transcriptional splicin

273 We show that influenza virus utilizes nuclear speckles to promote post-transcriptional splicin

274 genes, we reveal a functional subversion of nuclear speckles to promote viral gene expression.

275 genes, we reveal a functional subversion of nuclear speckles to promote viral gene expression.

276 interaction prompts SPOP relocalization from nuclear speckles to the diffuse nucleoplasm.

277 RNA splicing, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin

278 nuclear condensates, including nucleoli and nuclear speckles, to deform and coalesce.

279 ate that transcripts at Polycomb domains and nuclear speckles undergo distinct RNA processing mechani

280 Finally, we find an increase in hnRNP K in nuclear speckles upon IAV infection, which may alter acc

281 ass spectrometry (MS) to compare proteins in nuclear speckles versus centromeres.

282 Specifically, lncRNA and RBP localization to nuclear speckles was disrupted, exon junction complex (E

283 Bovine BRCA1 was phosphorylated and nuclear speckling was enhanced in response to DNA-damagi

284 S105-ERbeta nuclear speckles were also seen in MCF-7 cells and marke

285 c-Myc nuclear speckles were distinct from SC-35 domains involv

286 ar speckle localization of WTAP, whereas the nuclear speckles were intact.

287 Distinct S105-ERbeta nuclear speckles were seen in some higher grade tumors.

288 d to direct this protein to the periphery of nuclear speckles, where coordinated transcription/RNA pr

289 here that T1L, but not T3D, mu2 localizes to nuclear speckles, where it forms a complex with the mRNA

290 express a protein variant that localizes to nuclear speckles, where it targets a cell mRNA splicing

291 itions PGC-1alpha is located within discrete nuclear speckles, whereas the expression of ERR-alpha re

292 RTe antibody reveal discrete cytoplasmic and nuclear speckles, which contain RARalpha in an RA-sensit

293 containing R-MCDs increases the cohesion of nuclear speckles, which induces selective capture of pur

294 distinct subnuclear domains, identified as "nuclear speckles," which also contained pre-mRNA process

295 nalysis demonstrated that Glis2 localized to nuclear speckles while in most cells CtBP1 was found dif

296 ession correlates inversely with distance to nuclear speckles, with chromosome regions of unusually h

297 70 transgenes associate with the exterior of nuclear speckles, with Hsp70 transcripts accumulating wi

298 gene loci already preposition very close to nuclear speckles, with the remaining positioned near or

299 d interactions with regulatory elements near nuclear speckles, yet CTCF looping is robust toward the

300 In the nucleus Pnn is concentrated in the "nuclear speckles," zones of accumulation of transcriptio