ライフサイエンスコーパス: nuclear transport

1 ociated with essential recognition events in nuclear transport.

2 e when SHMT1 undergoes SUMO modification and nuclear transport.

3 ggesting this amino acid plays a key role in nuclear transport.

4 substrate specificity and rapid evolution in nuclear transport.

5 e replication proteins that are regulated by nuclear transport.

6 he requirements for FG repeat domains in Ty3 nuclear transport.

7 s neither NLSII nor NLSIII have roles in p53 nuclear transport.

8 -translational modification shown to control nuclear transport.

9 Hsp40/DnaJB6 in the regulation of HIV-2 PIC nuclear transport.

10 scription 1 (STAT1) and be involved in STAT1 nuclear transport.

11 led us to analyze the role of acetylation in nuclear transport.

12 rgeting of integral INM proteins and soluble nuclear transport.

13 lization, consistent with a role for SAD2 in nuclear transport.

14 main family protein likely to be involved in nuclear transport.

15 suggesting that glycosylation may influence nuclear transport.

16 ritical for its proteolysis beyond a role in nuclear transport.

17 lar receptors, disrupt membranes, or enhance nuclear transport.

18 NUP214, NUP358, NUP153, and p62, involved in nuclear transport.

19 entical to that used in classical NLS-driven nuclear transport.

20 functional classes, including olfaction and nuclear transport.

21 PIC may proceed concurrently with the normal nuclear transport.

22 suppressing tumor growth by regulating NICD nuclear transport.

23 ar patterns by inhibiting IRF3 and NF-kappaB nuclear transport.

24 ignals into the central channel for directed nuclear transport.

25 odified nucleoporins to proteins involved in nuclear transport.

26 ession besides their established function in nuclear transport.

27 ffectively compete with and inhibit PY-STAT1 nuclear transport.

28 l (Tl) signaling pathway, which regulates Dl nuclear transport.

29 NA5 that is necessary for efficient PY-STAT1 nuclear transport.

30 Cs), membrane-embedded channels that mediate nuclear transport across the nuclear envelope.

31 STAT1, in a reaction that is competed by the nuclear transport adapter importin alpha5.

32 s studies have described a role for importin nuclear transport adaptors in mediating the retrograde t

33 This novel mechanism of inhibiting nuclear transport also shows that the nuclear pore compl

34 ominant negative importin beta that inhibits nuclear transport, also prevents pronucleus formation an

35 We show that WNT10B causes nuclear transport and binding of RAC1 and beta-catenin i

36 a small G protein best known for its role in nuclear transport and can be found at the nuclear pore t

37 rongly suggesting a mechanistic link between nuclear transport and cell-to-cell movement.

38 ate motor activity to achieve unidirectional nuclear transport and demonstrate a direct link between

39 F-M, GAP-43) by compromising their efficient nuclear transport and disrupting their loading onto poly

40 A library to silence 82 proteins involved in nuclear transport and found that knockdowns of karyopher

41 tates the re-evaluation of current models of nuclear transport and how this process is regulated.

42 iferating cells, formin inhibition abolishes nuclear transport and initiation of DNA replication, as

43 regulated by mechanisms similar to those of nuclear transport and is dependent on nucleoporins (NUPs

44 ical eukaryotic cellular functions including nuclear transport and mitosis through the creation of a

45 d form (RanGTP) and plays important roles in nuclear transport and mitosis.

46 s risks of failure that can cause defects in nuclear transport and nuclear envelope (NE) morphology;

47 otein (eVP24) binds KPNA to inhibit PY-STAT1 nuclear transport and render cells refractory to IFNs.

48 C patients at least in part by inhibiting AR nuclear transport and signaling.

49 hosphorylation within a domain that controls nuclear transport and stability and that is mutated in h

50 In this work, we have investigated SLBP nuclear transport and subcellular localization during th

51 nk between two major cell-fate determinants: nuclear transport and the Ras/ERK/RSK and PI3K/Akt signa

52 The intrinsic signals directing mTOR nuclear transport and the underlying mechanisms are unkn

53 orresponding chromosomes to ensure efficient nuclear transport and thereby overcome the need for a st

54 roteins involved in numerous roles including nuclear transport and transcriptional regulation.

55 IP30), a proapoptotic factor, which inhibits nuclear transport and, consequently, Notch1-mediated oli

56 TCL1 family proteins regulate nuclear transport and/or activation of AKT.

57 nvolved in translation, ribosome biogenesis, nuclear transport, and amino acid metabolism are more li

58 processes, including cell cycle progression, nuclear transport, and autophagy.

59 asmic RNA processing, vesicular trafficking, nuclear transport, and DNA maintenance.

60 protein degradation, translation, splicing, nuclear transport, and mRNA homeostasis converge on P-gr

61 l signaling, cytoskeletal self-organization, nuclear transport, and the cell cycle.

62 critical for the stabilization, processing, nuclear transport, and translation of the transcript.

63 , the determinants and regulation of NAMPT's nuclear transport are not known.

64 olding, proteolysis, nucleolar function, and nuclear transport as well as several other cellular proc

65 elaborate mechanism that involves regulated nuclear transport as well as SUMOylation and ubiquitinat

66 In a nuclear transport assay, we have determined that Maelstr

67 Nuclear transport assays exhibited defects in the classi

68 Nuclear transport assays showed that this IBB mutant is

69 We found that in in vitro nuclear transport assays tyrosine-phosphorylated STAT1al

70 PSF6 recruitment) have reduced dependency on nuclear transport associated cofactors, altered integrat

71 Spindle assembly and nuclear transport both utilize the same simple device: R

72 e addition of Nup210 to NPCs does not affect nuclear transport but is required for the induction of g

73 y, NUP88 overexpression did not alter global nuclear transport, but was a potent inducer of aneuploid

74 respectively, modulate the Ran gradient and nuclear transport by interacting with, phosphorylating,

75 Importin alpha's mediate nuclear transport by linking nuclear localization signal

76 contribute to the anomalously high rates of nuclear transport by, e.g., stirring of molecules next t

77 We show that the requirements for nuclear transport can be recapitulated by a simple two-p

78 is important for the correct localization of nuclear transport cargoes and of components of the NPC.

79 Nuclear transport carriers interact with proteins of the

80 ay, soluble cargo proteins are recognized by nuclear transport carriers, called importins, which medi

81 lps are multifunctional proteins linking the nuclear transport channel to multiple macromolecular com

82 Nuclear pore complexes (NPCs) emerged as nuclear transport channels in eukaryotic cells approxima

83 We tested the nuclear transport characteristics of full-length phyB as

84 hey fall into four major functional classes: nuclear transport, chromatin binding/structure, transcri

85 t by controlling assembly and disassembly of nuclear transport complexes.

86 -containing nucleoporin that, in addition to nuclear transport, contributes to multiple aspects of ge

87 This adds nuclear transport control to the mitotic roles of Mad1.

88 ocorticoid responsiveness, changes in GRbeta nuclear transport could influence subsequent responses t

89 a dominant-negative mutant of Ran, causes a nuclear transport defect of ErbB-2.

90 The nuclear transport domain (NTD) of RHA is known to be nec

91 ther, these studies reveal that specific NPC nuclear transport events directly influence aging.

92 ally, genes involved in stress responses and nuclear transport exhibited mostly changes in alternativ

93 ting that at least two different pathways of nuclear transport exist for cell surface receptors.

94 One such carrier is nuclear transport factor 2 (NTF2), whose import cargo is

95 an relies on a small RanGDP-binding protein, Nuclear Transport Factor 2 (NTF2).

96 for the nuclear import of RanGDP mediated by nuclear transport factor 2 (NTF2).

97 is applied to study the stoichiometry of the nuclear transport factor 2 in a cell-free system over a

98 ), density-regulated protein 1, P150(glued), nuclear transport factor 2, binder of ARL 2, Paxillin, a

99 eceptor complex, nuclear RNA export factor 1-nuclear transport factor 2-related export protein 1 (NXF

100 determine the oligomerization of cytoplasmic nuclear transport factor 2.

101 Ets 2, and the Ras nuclear transport factor, nuclear transport factor 2.

102 ly assays, we have identified a role for the nuclear transport factor importin alpha in the regulatio

103 s overlapping binding sites for Acl4 and the nuclear transport factor Kap104, facilitating its contin

104 nslocation of pSTAT1 by interacting with the nuclear transport factor karyopherin alpha1 through its

105 m cell-derived cardiac cells distributed the nuclear transport factor Ran in the nucleus, decreased t

106 This suggests that G3BP is a nuclear transport factor, as hypothesized previously, an

107 ctor Hox C6, the oncogene Ets 2, and the Ras nuclear transport factor, nuclear transport factor 2.

108 The CTD is a member of the ubiquitous Nuclear Transport Factor-2 (NTF2) superfamily (pfam02136

109 complex proteins (nucleoporins) and soluble nuclear transport factors (karyopherins, importins, and

110 ed, we find that overexpression of different nuclear transport factors can suppress the temperature-s

111 enes with the nuclear pore complex (NPC) and nuclear transport factors has been implicated in transcr

112 We determined that NUP88 and the nuclear transport factors NUP98 and RAE1 comprise a regu

113 Nuclear transport factors recognize nuclear targeting si

114 ins termed nucleoporins (or "Nups"), and (2) nuclear transport factors that recognize the cargoes to

115 fect nondividing cells by commandeering host nuclear transport factors to facilitate the passage of t

116 proteins, cytoskeleton-associated proteins, nuclear transport factors, lipid metabolism regulators,

117 sslinking between FG-repeat nucleoporins and nuclear transport factors, suggesting that O-GlcNAc resi

118 tions for various NE-associated proteins and nuclear transport factors.

119 t also may serve as storage compartments for nuclear transport factors.

120 have a novel mitotic role in addition to its nuclear transport functions.

121 particular instance in Drosophila, X-linked nuclear transport genes (Ntf-2 and ran) have given rise

122 ans closed mitosis, a systematic analysis of nuclear transport genes has been completed.

123 Factors involved in nuclear transport have been well studied, but systems an

124 mainly with PER proteins and directs PER/CRY nuclear transport in a circadian fashion.

125 The results suggest a role for nuclear transport in ABA signal transduction, and the po

126 a hindrance in importin-mediated cytoplasmic-nuclear transport in AD.

127 explain the alterations in permeability and nuclear transport in enterovirus-infected cells and how

128 he mechanisms responsible for alterations in nuclear transport in enterovirus-infected cells that lea

129 To gain insight into the role of nuclear transport in replication, we investigated whethe

130 a qualitative insight and interpretation of nuclear transport in the cellular context.

131 tional factors might be responsible for phyB nuclear transport in the plant.

132 chain uPA, but not uPA variants incapable of nuclear transport, increases the expression of cell surf

133 iation in concentrations of freely diffusing nuclear transport intermediates among cells indicates th

134 s suggest that formation of freely diffusing nuclear transport intermediates is in competition with b

135 These findings suggest that the rate of nuclear transport is a critical factor affecting growth

136 Nuclear transport is facilitated by the Nuclear Pore Com

137 When nuclear transport is inhibited, reverse transcription is

138 fate; however, little is known regarding how nuclear transport is regulated by or regulates these pat

139 lpha1, an essential component of cytoplasmic-nuclear transport, is abnormally accumulated in Hirano b

140 We discuss nuclear transport issues recently addressed by single-mo

141 e additional insight on how AdV exploits the nuclear transport machinery for infection.

142 ted that there is failure of the cytoplasmic-nuclear transport machinery in AD.

143 xamined the association of components of the nuclear transport machinery including karyopherins, nucl

144 retroviruses like HIV, may utilize cellular nuclear transport machinery to import their essential nu

145 Nuclear transport machinery was the sole process-level d

146 le formation system that uses the Ran-GTPase nuclear transport machinery, but no targets of Ran for s

147 the transport receptor TAP of the host cell nuclear transport machinery, several aspects of ICP27 tr

148 rtin beta and importin alpha, members of the nuclear transport machinery.

149 is coupled via transcriptional state to the nuclear transport machinery.

150 ns destined for active nuclear import to the nuclear transport machinery.

151 relationship between the NPC and the soluble nuclear transport machinery.

152 esses, including transcriptional regulation, nuclear transport, maintenance of genome integrity, and

153 susceptibility protein associated defective nuclear transport may play a mechanistic role in the pat

154 y of IAV structural components, regulated by nuclear transport mechanisms and host factor binding.

155 Thus, nuclear transport mechanisms are physiological regulator

156 sion coefficients provides new insights into nuclear transport mechanisms.

157 ested that ciliary transport is analogous to nuclear transport mechanisms.

158 ate into living mammalian cells triggers the nuclear transport of a Gal4 DNA binding domain-glucocort

159 us nuclear localization signal to facilitate nuclear transport of a heterologous protein.

160 translocation of caspase-3, indicating that nuclear transport of active caspase-3 required proteolyt

161 We also found that TRIM3 suppressed nuclear transport of active NOTCH1 (NICD) in glioblastom

162 Blocking nuclear transport of ANG inhibited latent ORF73 gene exp

163 osphorylation by PKD1 and is associated with nuclear transport of AR resulting in increased AR transc

164 nuclear GTPases, Rap1a/b, to facilitate the nuclear transport of beta-catenin, defining a parallel n

165 FKBP51 was involved in constitutive nuclear transport of both GRalpha and -beta in the absen

166 is and endosomal sorting are involved in the nuclear transport of cell surface RTKs.

167 The nuclear transport of classical nuclear localization sign

168 gether, our results indicate that synapse-to-nuclear transport of CRTC1 dynamically informs the nucle

169 The purpose of this study was to compare the nuclear transport of EGFR family proteins with that of F

170 the cytoplasm and has been shown to inhibit nuclear transport of FGFR-1, had no effects on EGFR nucl

171 estigated the process mediated by the active nuclear transport of Gal-3 and have identified a nuclear

172 he present study, the roles of FKBP51 in the nuclear transport of GRbeta and glucocorticoid responsiv

173 Nuclear transport of GRbeta represents a novel mechanism

174 In this study, the roles of Hsp90 in the nuclear transport of GRbeta were investigated.

175 is an essential molecular chaperone for the nuclear transport of GRbeta.

176 contribute to the model whereby the induced nuclear transport of HCF-1 in sensory neurons may be cri

177 a novel role for importin-4 in governing the nuclear transport of HE4.

178 d C-terminal cleavage was also necessary for nuclear transport of HO-1.

179 We show that the mimetic mediates the nuclear transport of IFNGR-1 through its interaction wit

180 Nuclear transport of immune receptors, signal transducer

181 xts, proteolysis controls the cytoplasmic-to-nuclear transport of important transcription factors or

182 Nuclear transport of KAP-GFP could be due to a putative

183 52 appeared to be solely responsible for the nuclear transport of ligand-activated GRalpha.

184 e initiated in the nucleus, we asked whether nuclear transport of MLH1 and PMS2 is limiting for the n

185 sociated proteins with roles in assembly and nuclear transport of multisubunit eukaryotic RNA polymer

186 e been elucidated, mechanisms regulating the nuclear transport of NF-kappaB remain elusive.

187 Because calcineurin induces nuclear transport of NFATc proteins, whose expression pa

188 epression of CYP7A1 by cholate, and blocking nuclear transport of nitrosylated GAPDH reduced cholate-

189 increasing protein expression and enhancing nuclear transport of Notch intracellular domain (NICD).

190 ent of head and neck cancer cells results in nuclear transport of p16 leading to a molecular modifica

191 versatile to elucidate the mechanism of the nuclear transport of phyB.

192 epeat circles implies that the impairment of nuclear transport of preintegration complexes is respons

193 Excessive ROS production also facilitates nuclear transport of proatherogenic transcription factor

194 Several studies suggest that the nuclear transport of proteins from synapses is involved

195 This location would provide nuclear transport of putative truncated proteins encoded

196 hat extent DNA damage-induced cytoplasmic to nuclear transport of Rad51 may contribute to this proces

197 Mechanistically, KPNA4-mediated nuclear transport of Ras-responsive element-binding prot

198 rolyze it are inviable and unable to support nuclear transport of RNAPII.

199 Blocking of sumoylation and nuclear transport of S100A4 inhibited the IL-1beta-induc

200 monstrate that nucleolin is required for the nuclear transport of scuPA.

201 SUMO2 modification at K68, which facilitates nuclear transport of SHP and its interaction with repres

202 lear import of Smad3 and Smad4 suggests that nuclear transport of Smad3 and Smad4 is subject to contr

203 uclear morphology, chromatin remodeling, and nuclear transport of soluble signaling intermediates usi

204 , is directly involved as a chaperone in the nuclear transport of STAT1alpha and shares this mechanis

205 whether differentiated cells facilitate the nuclear transport of tegument-delivered pp71.

206 t endocytosis plays an essential role in the nuclear transport of the ErbB family members, such as ep

207 gest a model of VZV capsid assembly in which nuclear transport of the major capsid protein and associ

208 cycle arrest resulted from inhibition of the nuclear transport of the mitotic inducer Cdc25 by target

209 The nuclear transport of the non-ligand-binding GRbeta is st

210 The nuclear transport of the phytochromes upon light activat

211 , indicating that this deletion affected the nuclear transport of the portal protein.

212 activities during viral infection, including nuclear transport of the proviral integration complex, i

213 y structures.Importin alpha3 facilitates the nuclear transport of the Ran guanine nucleotide exchange

214 We previously reported that nuclear transport of the Rous sarcoma virus (RSV) Gag pr

215 receptor-1 (PAR1) and PAR3, which inhibited nuclear transport of the Sp1 transcription factor.

216 Nuclear transport of the vector was evident by transgene

217 ts transduction by AAV2 vectors by impairing nuclear transport of the vectors.

218 Nuclear transport of the viral tegument protein VP16, tr

219 ed by cAMP, calcium, or GPCR activation, and nuclear transport of TORC1 was sufficient to activate CR

220 gous deletion strain are devoid of O-GlcNAc, nuclear transport of transcription factors appears norma

221 defense, interferon (IFN) signaling triggers nuclear transport of tyrosine-phosphorylated STAT1 (PY-S

222 l adhesion kinase phosphorylation and led to nuclear transport of viral capsids and viral gene expres

223 new structures shed additional light on the nuclear transport of viral transcripts.

224 ported protein, which determines both active nuclear transport of YAP and passive transport of small

225 nucleoporin mobility makes to the process of nuclear transport or how such mobility is regulated.

226 ing this modification had no consequences on nuclear transport or NPC organization but strongly affec

227 ied a nuclear pool of CXCR4 and we defined a nuclear transport pathway for CXCR4.

228 1 mutant and highlight the importance of the nuclear transport pathway for virulence of eukaryotic pa

229 lity barrier properties of the physiological nuclear transport pathway in intact NPCs in cells: that

230 sis of a number of features of the classical nuclear transport pathway specific to plants.

231 ansport of beta-catenin, defining a parallel nuclear transport pathway to Ran.

232 to nucleocytoplasmic shuttling via the CRM1 nuclear transport pathway.

233 ing infection, leading to disruption of host nuclear transport pathways and alterations in nuclear pe

234 Although the nuclear transport pathways are just beginning to be unra

235 his contributes to the disruption of certain nuclear transport pathways.

236 ate additional levels of complexity in these nuclear transport pathways.

237 , and disruption of actin dynamics abrogates nuclear transport, preventing NLS (nuclear localisation

238 Nuclear transport processes can have a major impact on t

239 ear transporters, pointing to disruptions in nuclear transport processes in the presence of elevated

240 uired for nuclear translocation and that the nuclear transport properties of the mimetic correlated w

241 ins with diverse functional roles, including nuclear transport, prostaglandin synthesis, ubiquitinati

242 sensus site and by association with Kpna6/1, nuclear transport proteins that did not co-purify with o

243 Nuclear transport requires freely diffusing nuclear transport proteins to facilitate movement of car

244 5 (IPO5), a member of the importin family of nuclear transport proteins, as an intracellular binding

245 n (C) by the host importin (IMP) alpha/beta1 nuclear transport proteins.

246 etween DENV nonstructural protein 5 and host nuclear transport proteins.

247 diverse set of cellular processes, including nuclear transport, proteolysis, translation, autophagy,

248 transport of FGFR-1, had no effects on EGFR nuclear transport, raising the possibility that EGFR and

249 Thus, Pdr6 is a bidirectional nuclear transport receptor (i.e., a biportin) that shutt

250 e to selectively facilitate translocation of nuclear transport receptor (NTR)-bearing macromolecules.

251 We show that the nuclear transport receptor importin alpha is modified by

252 and revealed age-associated decreases in the nuclear transport receptor RanBP17.

253 We found that it interacts with the nuclear transport receptor XPO1 and is exported by XPO1

254 he interaction of the cargo with the classic nuclear transport receptor, importin alpha.

255 ortin beta, once thought to be exclusively a nuclear transport receptor, is emerging as a global regu

256 eptide is chaperoned through the nanopore by nuclear transport receptors (e.g., importins) owing to t

257 Nuclear transport receptors (NTRs) carry cargos through

258 Nuclear transport receptors (NTRs) mediate nucleocytopla

259 o nuclear pore complex (NPC) function, where nuclear transport receptors (NTRs) move through the NPC

260 tively analyzed the binding of two different nuclear transport receptors (NTRs), NTF2 and Importin be

261 FG Nups interact promiscuously with various nuclear transport receptors (NTRs), such as karyopherins

262 duct massive transport mediated by shuttling nuclear transport receptors (NTRs), while keeping nuclea

263 as distant similarity with flexible S-shaped nuclear transport receptors (NTRs).

264 Added nuclear transport receptors accumulate on the intact tra

265 rogel that allows highly selective access of nuclear transport receptors and their cargos, but reject

266 Here, we report the involvement of nuclear transport receptors belonging to the importin-al

267 Soluble nuclear transport receptors bind signal-dependent cargos

268 t 1-microm-sized colloidal particles bearing nuclear transport receptors called karyopherins can exhi

269 omain self-assembly and selective binding of nuclear transport receptors is largely unexplored.

270 ore protein and are associated with cellular nuclear transport receptors karyopherin-alpha and -beta.

271 regulating interactions between cargoes and nuclear transport receptors of the importin-beta family.

272 macromolecules is mainly mediated by soluble nuclear transport receptors of the karyopherin-beta supe

273 barrier, which is selectively permeable for nuclear transport receptors that interact with these rep

274 larger than approximately 5 nm must bind to nuclear transport receptors to overcome a selective barr

275 l for cell viability and which interact with nuclear transport receptors.

276 phenylalanine-glycine (FG) binding sites for nuclear transport receptors.

277 to what extent cargos compete for binding to nuclear transport receptors.

278 ow that RanGTP, a small GTPase that dictates nuclear transport, regulates ciliary trafficking of KAP3

279 Mediator complex; E3 ubiquitin ligase Nedd4; nuclear transport regulator RanGap1; and several protein

280 tion, the mechanisms regulating beta-catenin nuclear transport remain undefined.

281 f p53 cytoplasmic sequestration that impairs nuclear transport rendering cells functionally deficient

282 NPC proteins and promotes accumulation of a nuclear transport reporter, suggesting conserved NPC reg

283 Nuclear transport requires freely diffusing nuclear tran

284 Although major nuclear transport routes are not regulated by Nup60 modi

285 eath, strongly indicating that inhibition of nuclear transport serves as a potent apoptotic signal.

286 To address this question, we analyzed the nuclear transport signals in Exd, including a divergent

287 eat germ agglutinin and thus required active nuclear transport, similarly to the assembly of full-siz

288 iphosphatase and performs essential roles in nuclear transport, spindle organization, and nuclear env

289 intermediates among cells indicates that the nuclear transport system is sufficiently robust to funct

290 function provides an alternative pathway for nuclear transport that can be utilized by membrane-embed

291 and how enteroviruses exert these effects on nuclear transport, the mechanisms and consequences of Nu

292 rther find that importin beta regulates EGFR nuclear transport to the INM in addition to the nucleus/

293 dent and -independent mechanisms of RelA/p65 nuclear transport using the proinflammatory mediators, t

294 oice for studying dynamic processes, such as nuclear transport, vesicular trafficking, and virus entr

295 S, these data suggest that progerin inhibits nuclear transport via oxidative stress.

296 owing viral attachment, internalization, and nuclear transport was assayed by detecting newly synthes

297 gered an intracellular calcium response, but nuclear transport was inhibited.

298 ssible Brca2-independent mechanism for Rad51 nuclear transport, we analyzed subcellular fractions for

299 NA picornaviruses, encode factors that alter nuclear transport with the aim of suppressing synthesis

300 NM) protein Heh1 are spatially segregated by nuclear transport, with Chm7 being actively exported by