ライフサイエンスコーパス: nucleophile

1 onor species) and the glycosyl acceptor (the nucleophile).

2 rained thioester bond to attack by substrate nucleophile.

3 + cation, which coordinates another reactive nucleophile.

4 rate scope as well as the terminating oxygen nucleophile.

5 all react with high efficiency as the second nucleophile.

6 rophilic probes, the current probe acts as a nucleophile.

7 ic Ras mutants that are devoid of a cysteine nucleophile.

8 to a rapid S(N)2 reaction with the enzymatic nucleophile.

9 tomic electrophile with an in situ generated nucleophile.

10 oselective acylation of an indole or pyrrole nucleophile.

11 rboxylic acid, based on the selection of the nucleophile.

12 alkenes initiated by an unstabilized enolate nucleophile.

13 ations suggest that 2-methyltetrol is a poor nucleophile.

14 tion using the side-chain thiol group as the nucleophile.

15 ryl-2-carboxypropenone and the nature of the nucleophile.

16 d show how it is important in generating the nucleophile.

17 cemic chain mechanism mediated by a thiolate nucleophile.

18 ave been carried out in the presence of weak nucleophiles.

19 even very large alpha-tertiary primary amine nucleophiles.

20 phonium salts and then displaced with halide nucleophiles.

21 a sulfur dioxide reagent, and nitrogen based-nucleophiles.

22 s such as amines, alcohols, and carbon-based nucleophiles.

23 st-order in both the cation radicals and the nucleophiles.

24 nzylic C-H bonds with a wide range of oxygen nucleophiles.

25 erivatives as nonstabilized photogenerated C-nucleophiles.

26 alkyne-containing comonomers and heteroarene nucleophiles.

27 cular reactions such as ylide formation with nucleophiles.

28 itution of the halide atom for C-, S-, and N-nucleophiles.

29 cription: these reagents behave as aluminium nucleophiles.

30 s on exposure of the oxonium ions to various nucleophiles.

31 palladations with different Pd catalysts and nucleophiles.

32 ility to undergo near-perfect reactions with nucleophiles.

33 ospecifity (es) using a variety of amines as nucleophiles.

34 ble olefins as surrogates for organometallic nucleophiles.

35 the incorporation of a variety of heteroatom nucleophiles.

36 ted conjugated diene and nitrogen-containing nucleophiles.

37 in catalysis for these two classes of alkyl nucleophiles.

38 rom l-serine and indole derivatives or other nucleophiles.

39 ptidase, OaAEP1, is promiscuous for incoming nucleophiles.

40 ciations releasing C-centered and O-centered nucleophiles.

41 onditions without using any strong bases and nucleophiles.

42 dride, azide, and electron-rich aromatics as nucleophiles.

43 eactive toward addition of thiolate or amine nucleophiles.

44 found to possess ambident reactivity towards nucleophiles.

45 lates of alpha-bromo esters were employed as nucleophiles.

46 H-pyrrolo[3,4-b]quinolines using alcohols as nucleophiles.

47 and subsequent intramolecular reaction with nucleophiles.

48 shown to be alkylating agents to a range of nucleophiles.

49 protection is achieved with strong bases and nucleophiles.

50 which can themselves be further modified by nucleophiles.

51 ty scale, which compares n-, pai-, and sigma-nucleophiles.

52 ubstitution reactions with suitably reactive nucleophiles.

53 l(4) and TiCl(4) as Lewis acids and chloride nucleophiles.

54 pha-amino carbanion equivalents which act as nucleophiles.

55 n, alkyltin, alkylgermanium and alkylsilicon nucleophiles.

56 interactions of most stable conformers with nucleophiles.

57 n subjection to a range of C-, N-, O-, and S-nucleophiles, (13)C-labeled beta-amino acids and derivat

58 e addition of either radicals or metal-based nucleophiles(3-13).

59 ucleophilic addition with a similar scope of nucleophiles (54-80%).

60 use of a chiral ligand and imides as carbon nucleophiles, a 3,4-addition protocol was developed, ena

61 amides are employed as unstabilized C(sp(3)) nucleophiles, a highly regioselective 1,4-addition proce

62 mitant borane activation of glycal donor and nucleophile acceptor.

63 ovalent interaction (Lys131-Tyr154) triggers nucleophile activation for nucleotide excision.

64 ors the general base guanine in position for nucleophile activation.

65 According to the BBAH, nucleophiles add to oxocarbenium intermediates by S(N)2-

66 le, only one isomer is required-the order of nucleophile addition controls the absolute stereochemist

67 Most nucleophile addition products [i.e., formed via (photo)r

68 The formation of such nucleophile adducts limits formation of photohydrates, s

69 -pot converting of methoxy groups into other nucleophiles allowed achieving alkene difunctionalizatio

70 rminating the polymerization with functional nucleophiles allows for chain-end functionalization in h

71 ropones to form azulenes is dependent on the nucleophile and base employed.

72 n states, with minimal bond formation to the nucleophile and bond cleavage to the leaving group alrea

73 es, enabling simultaneous activation of both nucleophile and electrophile in the same chiral environm

74 olves an unusual reversal of the role of the nucleophile and electrophile to form C-N, C-O, C-S and C

75 Promoting selective interactions between a nucleophile and electrophilic dye in complex environment

76 ith a N,N'-bistosyl urea as the bifunctional nucleophile and N-fluorocollidinium tetrafluoroborate as

77 s and relies on the dual role of peroxide as nucleophile and oxidant through an orchestrated reaction

78 Because the interactions between the nucleophile and the alkene substrate are influenced by a

79 ene radical cation that gets trapped by an N-nucleophile and the cascade is terminated by radical C-C

80 ated C-H activation barriers to the external nucleophile and to continuum solvent polarity.

81 hydrates, suggesting competition between the nucleophile and water for photochemical addition into th

82 A diverse array of nucleophiles and amine directing groups are demonstrated

83 tolerates electronically diverse benzylzinc nucleophiles and an array of functionalized and/or chall

84 With B(2) pin(2) or PhMe(2) Si-Bpin as nucleophiles and aryl/alkenyl triflates as electrophiles

85 ing from widely available heterocyclic amine nucleophiles and carbonyl electrophiles.

86 ed the Chan-Lam coupling to include C(sp(3)) nucleophiles and converted them into corresponding aceta

87 aromatic derivatives as aromatic C(sp(2))-H nucleophiles and DDs as acceptors.

88 Examples of trapping with O- and C-centered nucleophiles and deoxyfluorination via N-hydroxyphthalim

89 er weak interactions to activate various pro-nucleophiles and electrophiles.

90 issociation of oxygen but reacts with simple nucleophiles and electrophiles.

91 This species is unreactive toward nucleophiles and reactive toward strong electron donors,

92 aromatic substitution reactions of bidentate nucleophiles and tetrafluoroterephthalonitrile was devel

93 ergoing two addition reactions with thiolate nucleophiles and the (Z)-enamine being much less reactiv

94 nitrogen-, oxygen-, sulfur-, or carbon-based nucleophiles and unactivated alkyl bromides (>130 exampl

95 tosulfones with an o-hydroxyaryl group (dual nucleophile) and arylaldehydes (dual electrophile) in re

96 acids from H-phosphinates, an organometallic nucleophile, and quenching with elemental sulfur.

97 ve site ensures an in-line attack of the O2' nucleophile, and the conformation at the scissile phosph

98 lic intermediates, radical species as formal nucleophiles, and activated transition metals as well as

99 h hydrophobic active sites, available strong nucleophiles, and hydrogen bond donors as attractive tar

100 st examination of the alpha effect in sulfur nucleophiles, and sheds light on the chemical basis of t

101 This substrate reacts with organolithium nucleophiles, and the resulting anionic intermediates ma

102 ls, and amino acid derivatives are effective nucleophiles, and their products are formed in very high

103 s are characterized by one parameter (E) and nucleophiles are characterized by the two solvent-depend

104 Both alpha,beta- and beta,gamma-butenolide nucleophiles are compatible with the Zn-ProPhenol cataly

105 that influence the reactivity of alkylmetal nucleophiles are described and presented in the context

106 For this purpose, N-nucleophiles are explored according to their positions i

107 A wide variety of external nucleophiles are introduced with high regioselectivity a

108 While various nucleophiles are used in such transformation, organotita

109 n-, oxygen-, and other heteroatom-containing nucleophiles, as well as radicals.

110 ved from rivaroxaban and hundreds of diverse nucleophiles, as well as the late-stage derivatization o

111 nucleophiles, resulting in aryl-Ge or Me-Ge nucleophile-assisted fragmentations.

112 lectron-withdrawing groups, which react with nucleophiles at the beta-position, BCB-Bpin reacts with

113 uct to valuable allylic building blocks upon nucleophile attack.

114 ng in diffusion of a highly reactive carbene nucleophile away from the POI.

115 trophiles (propargylic halides) with racemic nucleophiles (beta-zincated amides) to form carbon-carbo

116 has centered on exposed cysteine residues as nucleophiles but the low abundance of cysteine in the pr

117 ization of unactivated pyridines with carbon nucleophiles, but the mechanistic basis for this result

118 Because the configuration of the nucleophile can be precisely controlled, both alpha- and

119 ilable oxygen, nitrogen, sulfur, and halogen nucleophiles can be used to generate alpha-functionalize

120 ory and ab initio calculations indicate that nucleophiles can significantly reduce enthalpic barriers

121 tion, and termination through intermolecular nucleophile capture have tremendous utility.

122 range of conventional heteroatom and carbon nucleophiles catalysed by a metallacyclic iridium cataly

123 In this report, we describe a nucleophile-catalyzed innovation on this condensation th

124 to one hour) across multiple (more than ten) nucleophile classes and can accommodate a diverse array

125 r mild conditions and is amenable to various nucleophile classes, including azoles, amines, and carbo

126 The proposed strategy shows that nucleophiles co-accumulated with GSH during the enrichme

127 ct signals, regioselectivity for various dye/nucleophile combinations, and suggests use of the Btz ac

128 e on both the alpha-chloro glycinate and the nucleophile, consistent with rate-limiting C-C bond form

129 pha-functionalization of ketones by external nucleophiles constitute such an example.

130 nic dissociations for both O- and C-centered nucleophiles could be achieved with fluorenylmethyl- and

131 nt, activated as an electrophile, onto which nucleophile coupling results in the formation of a carbo

132 For weaker nucleophiles, cyclodehydration precedes nucleophile inco

133 chlorides in situ with a variety of nitrogen nucleophiles delivers sulfinamides in 32-83% yields.

134 roperty of the cage promotes spontaneous pro-nucleophile deprotonation, suggesting acidity enhancemen

135 ng advantage of the amide functionality as a nucleophile, directing group, and amide coupling partner

136 According to the BBAH, incoming nucleophiles displace one of the two bent bonds of bicyc

137 enantioselective addition of a carbon-based nucleophile (e.g., one enzyme-catalyzed aldol addition i

138 liant bases (e.g., deprotonating C-H bonds), nucleophiles (e.g., adding to unsaturated molecules), an

139 ous nitrogen-, sulfur-, or oxygen-containing nucleophiles (e.g., azide, ammonia, or thiosulfate, resp

140 lectron bond as the origin for the catalytic nucleophile effect.

141 tions will be categorized around the type of nucleophile employed for sulfenofunctionalization.

142 e our attempts to extend the range of useful nucleophiles employed in this oxidative deamination proc

143 ed azulenes based on the nature of bases and nucleophiles employed.

144 g sulfinyl nitrenes with carbon and nitrogen nucleophiles enables the synthesis of sulfoximines and s

145 the electrophile and light activation of the nucleophile, enables the stereoselective installation of

146 The better binding ability of alkenes over O nucleophiles ensured the success of intermolecular oxyar

147 With bulkier nucleophiles (ethyl/methyl cyanoacetate), the reaction p

148 diverse set of heteroatom (O, S, N)-centred nucleophiles exclusively at the alpha-position.

149 s assessed through a series of model epoxide-nucleophile experiments using nuclear magnetic resonance

150 Using other N,N'-nucleophiles failed to either generate chlorins containi

151 natural substrate undergoes which align the nucleophile for efficient catalysis.

152 he precursor mRNA branch-site adenosine, the nucleophile for the first step of splicing(1).

153 stic possibilities by which it generates the nucleophile for the synthesis reaction.

154 esters were established as excellent partner nucleophiles for enantioselective cooperative isothioure

155 odels for S(N)1-type glycosylation with weak nucleophiles for the explanation of O-glycosylation.

156 a folded structure, displacing the phosphate nucleophile from the catalytic site.

157 try of its imidazole group that can serve as nucleophile, general acid or base depending on its proto

158 ficity and catalysis including the catalytic nucleophile (Glu-297) and acid/base residue (Glu-160).

159 ]butyl pinacol boronic ester (BCB-Bpin) with nucleophiles has been studied.

160 the oxyallyl cation with a diverse range of nucleophiles has been used to generate over 50 novel ami

161 pling of N-aryl tetrahydroisoquinolines with nucleophiles has inspired the development of novel C-H f

162 l process is general for a broad spectrum of nucleophiles, has a high degree of electronic and steric

163 oxide with carbanions or enamines (reference nucleophiles) have been measured photometrically in acet

164 ous conditions with an alkylamine base and a nucleophile (HNuc(1)), such as an alcohol (neopentanol,

165 tionalized tetrametaphosphates with a second nucleophile (HNuc(2)), such as hydroxide, a phenol (4-me

166 Here we used an MS-compatible inorganic nucleophile, hydroxylamine hydrochloride, to chemically

167 Accordingly, 3 reacts with an NHC nucleophile (IMe(4)) to yield the Lewis adduct [{(NHC)C(

168 catalyst, electrophile (halenium donor), and nucleophile in determining rates and stereopreferences.

169 g primary alcohols can supplant water as the nucleophile in the PLD active site in a transphosphatidy

170 -magnesium centre that positions a hydroxide nucleophile in-line with the P(alpha)-O(5') bond to cata

171 n that employs phosphinic acids as prochiral nucleophiles in a Pd-catalyzed asymmetric allylic alkyla

172 tes are susceptible to attack by a myriad of nucleophiles in a stereospecific ring-opening event to a

173 lycolysis that reacts non-enzymatically with nucleophiles in cells, including basic amino acids, and

174 long-standing challenge when using canonical nucleophiles in enzyme design(6-10).

175 onor ligands in coordination chemistry or as nucleophiles in organic chemistry.

176 thylgermane cation radicals react with added nucleophiles in reactions that are first-order in both t

177 ts were prepared and shown to be outstanding nucleophiles in reactions with industrially relevant flu

178 by years while maintaining reactivity toward nucleophiles in S(N)Ar reactions.

179 be the use of enantioenriched organometallic nucleophiles in stereospecific, Pd-catalysed cross-coupl

180 cids and some of their derivatives as carbon-nucleophiles in the absence of transition-metals.

181 cations may react with (hetero)aromatic pai-nucleophiles in various directions, depending on their s

182 ving well-defined, isolable, enantioenriched nucleophiles in which a clear stereochemical course of t

183 successfully employed a range of traditional nucleophiles including carbon, nitrogen, and sulfur cont

184 the use of various unstable and/or volatile nucleophiles including hydrazines, methylamine, t-butyl

185 o be crucial to accommodate a broad range of nucleophiles including lithium acetylides, Grignard reag

186 enzenium complex reacts with a wide range of nucleophiles including protected enolates, cyanide, amin

187 allows for the coupling of a range of amine nucleophiles, including (1) unhindered, (2) five-membere

188 A wide variety of alcohol nucleophiles, including complex natural products, glycos

189 ons of alkyl electrophiles by organometallic nucleophiles, including enantioconvergent processes, hav

190 f-lives ~20-60 min), photochemically induced nucleophile incorporation across the parent steroid's tr

191 aker nucleophiles, cyclodehydration precedes nucleophile incorporation in a cyclodehydrative-nucleoph

192 undergo acid promoted cyclodehydration with nucleophile incorporation to form highly substituted ind

193 wn that the nature and the reactivity of the nucleophile influence the outcome of a glycosylation, th

194 ar Mg complex in which the substrate and the nucleophile initially bind to different Mg centers and t

195 verse heterolytic dissociations that release nucleophiles instead of electrophiles could also be stim

196 s between an alkyl electrophile and an alkyl nucleophile is a persistent challenge in organic synthes

197 pentanone intermediate by an aryl or N-based nucleophile is followed by C-C or C-N bond-forming "coll

198 embered N,N'-heterocyclic potassium alumanyl nucleophile is introduced and utilised in the metathetic

199 atization of 3-nitroindoles with propargylic nucleophiles is described.

200 s, anilines, activated alkynes, and aromatic nucleophiles is developed to synthesize a diverse range

201 Although their coupling with carbon nucleophiles is well developed, the cross-electrophile c

202 o find use with many other electrophiles and nucleophiles leading to new cross-coupling processes.

203 ynes may also react with arenes, as external nucleophiles, leading to CF(3)-indenes.

204 sed equivalents of base or the use of softer nucleophiles, less polar solvents, and larger halogens o

205 the rate of the reaction, and the impact of nucleophile, Lewis acid, and silyl substituent are evalu

206 as observed directly adjacent to the epoxide-nucleophile linkage, with smaller decreases in chemical

207 xture by ring opening with primary phosphido nucleophiles LiPHR (R = ferrocenyl, Ph, Cy, t-Bu, Mes* (

208 on irrespective of the base and with smaller nucleophiles (malononitrile), the reaction follows base-

209 A mechanistic study of the nucleophile-mediated reductive elimination was conducted

210 between ring cleavage products and the model nucleophile N-alpha-acetyl-lysine, we identified the alp

211 the active site was believed to generate the nucleophile necessary to accomplish the reaction.

212 d just 2.02 angstrom away from the catalytic nucleophile of Kgp, C(477)Sgamma.

213 ere shown to efficiently label the catalytic nucleophiles of retaining GH51 and GH54 alpha-l-arabinof

214 pening to linear tetraphosphates bearing one nucleophile on each end ([Nuc(1)(PO(3))(3)PO(2)Nuc(2)](4

215 ophilic 'warhead' to covalently react with a nucleophile on the target.

216 blished that the ribosome can accept various nucleophiles on the Xacyl-tRNA in the A site during elon

217 can be easily substituted with S-, N-, and P-nucleophiles, opening access to various monofunctionaliz

218 o-Quinone methide interception by a nucleophile or a dienophile allows for one-pot conversio

219 ied: the use of increased equivalents of the nucleophile or decreased equivalents of base or the use

220 nalization of allenes with N-H, C-H, and O-H nucleophiles or electrophiles.

221 nt to a one-step concerted process, with the nucleophile playing a critical role in activating the ol

222 Q-ToF MS analyses specifically identified 52 nucleophiles potentially representing an extensive molec

223 deprotonation pathway is reversible and the nucleophile prefers to attack at the more electrophilic

224 triphosphate can be opened with a variety of nucleophiles providing ready access to diverse functiona

225 arbonyls as the environmentally benign alkyl nucleophiles, providing an efficient and selective catal

226 and sulfonamides were found to be competent nucleophiles, providing ready access to alpha-heteroatom

227 Addition of nucleophiles R'C=C-Li (R' = aryl, silyl) and Ph-Li to [C

228 The scope of N-nucleophiles ranges from primary and secondary alkyl and

229 ically hindered bis-sulfonamides and related nucleophiles reacted with BCB-Bpin at the beta'-position

230 ines, although the use of aromatic amines as nucleophiles requires microwave heating.

231 4 and Glu-361 as the catalytic acid/base and nucleophile, respectively, and we observed a chloride io

232 and strongly electron-donating outer sphere nucleophile, result in the lowest reaction barriers.

233 ric salts and beta-hydrogen-containing alkyl nucleophiles, result in the formation of [FeEt(3) ](-) .

234 the intermediate cation radicals react with nucleophiles, resulting in aryl-Ge or Me-Ge nucleophile-

235 partners, as well as those bearing base- and nucleophile-sensitive functional groups.

236 e in Pd-AAA for setting point chirality on a nucleophile simultaneous to stereoinduction on an axial

237 However, when nitroethane was used as a nucleophile source in lieu of nitromethane, a mixture of

238 of gluten proteins using ethylamine as amine nucleophile, substantial amounts of glutamine residues w

239 methylidene triphenylphosphorane, results in nucleophile substituted tetrametaphosphates ([P(4)O(11)N

240 heme is established to identify the dominant nucleophile-substrate interaction affecting the regiosel

241 antitatively separate the different types of nucleophile-substrate interactions, including steric, el

242 on of ketenimine intermediates with nitrogen nucleophiles such as amines, hydrazines, and TMSN(3) aff

243 formed) with activated alkynes and aromatic nucleophiles such as indoles, pyrroles, and naphthols at

244 y of the intermediate cationic species, weak nucleophiles such as NH-oxazolidinone participated effic

245 Many types of carbon nucleophiles such as silyl ketene acetals, silyl ketene

246 activities toward a wide range of biological nucleophiles, such as amines, alcohols, and thiols.

247 it a range of arenes, as well as different O-nucleophiles, such as oximes and benzyl alcohols.

248 s shown herein to be a versatile reagent for nucleophile tetraphosphorylation.

249 enerates a delocalized 2-azaallyl anion-type nucleophile that engages in dearomative C-C bond-forming

250 Based on the use of alkoxyamine nucleophiles, this sequence not only highlights a rare e

251 highly unfavorable for a negatively charged nucleophile, thus hindering autoacylation.

252 omative rearrangement of the phenethylcopper nucleophile to a Cpara-metalated form prior to reaction

253 nce the Cys-quinonoid PLP intermediate, as a nucleophile to form an NFS1 persulfide, and as a sulfur

254 lefin (NHO) catalytic species that acts as a nucleophile to promote the cyclic amidine ring opening.

255 Reversible conjugate addition of the nucleophile to the 4-position then initiates the reactio

256 inal aliphatic alkenes typically deliver the nucleophile to the more substituted sp(2) carbon to form

257 trolling the accessibility of water or amine nucleophile to the S-ester intermediate.

258 y the addition of a second equivalent of the nucleophile to this and, finally, a retro Michael reacti

259 Addition of heteroaryl nucleophiles to a simple, readily-accessible alkyl sulfi

260 complexes reacted efficiently with O- and N-nucleophiles to afford gamma-functionalized alkylamine p

261 actions use a single enantiomer from racemic nucleophiles to afford stereopure quaternary carbons.

262 njugate addition of boron-stabilized allylic nucleophiles to alpha,beta-unsaturated ketones is disclo

263 tituted imidazole functionalities, by adding nucleophiles to an iron(III) pai-dication species formed

264 1,4-conjugate additions of several nitrogen nucleophiles to chiral bicyclic dehydroalanines have bee

265 he scope of the process tolerates a range of nucleophiles to construct C-N, C-O, C-S, and C-C bonds.

266 es, cyanide, amines, methoxide, and aromatic nucleophiles to form 5-substituted 3,4-eta(2)-1,3-cycloh

267 , enantioenriched, main-group organometallic nucleophiles to form C(sp (3))-C(sp (2)) bonds.

268 uct of C-H cleavage reacts with a variety of nucleophiles to form C(sp(3))-X bonds (X = halide, oxyge

269 rgo reactions with a range of organometallic nucleophiles to generate alpha-functionalized amines in

270 ariety of imine substrates as unconventional nucleophiles to mediate highly chemo-, regio-, diastereo

271 Addition of three carbon nucleophiles to Pai, followed by stereospecific reductio

272 affold enables sequential addition of carbon nucleophiles to produce a variety of enantiopure C-P bui

273 ubstitution reactions with oxygen and carbon nucleophiles to provide access to a variety of highly su

274 using InI(3) and organosilicon or -stannane nucleophiles to synthesize (Z)-beta-alkoxyalkenylindiums

275 ans to achieve the addition of two disparate nucleophiles to the amide carbonyl carbon in a single op

276 y anilines, secondary amines, and amide type nucleophiles together with tolerance for a range of base

277 Employment of O- and C-nucleophiles toward oxyalkylation and dialkylation produ

278 atural" carbonyl ipso-sites are activated as nucleophiles (umpolung), vinylogation extends the nucleo

279 recalcitrant to reaction with thiol or amine nucleophiles under mild aqueous conditions.

280 rgoes formal allylic substitution with amine nucleophiles under Pd-catalysis.

281 hosphates in combination with alkylzirconium nucleophiles undergo highly regio-, diastereo- and enant

282 d styrenes with internal oxygen and nitrogen nucleophiles undergo oxidative fluorocyclization reactio

283 the deprotonation of a weakly acidic C-H pro-nucleophile using a strong Bronsted base are central to

284 ng various radical precursors and heteroatom nucleophiles via a metallaphotoredox catalysis protocol.

285 ng para-cycloadducts are treated with oxygen nucleophiles via formal allylic substitution, providing

286 ical oxabenzonorbornadienes (OBD) with oxime nucleophiles was investigated.

287 A preference for less sterically hindered nucleophiles was observed in all model systems.

288 the reaction of silyl ketenes with different nucleophiles was studied.

289 ivity parameters N and s(N) of the reference nucleophiles were substituted into the correlation log k

290 a effect, i.e. the increased reactivity of a nucleophile when the atom adjacent to the nucleophilic a

291 bicyclo[3.1.0]hexenium cation, trapped by a nucleophile, while the second involves photorearrangemen

292 r bond from wayward reactivity toward errant nucleophiles, while Atg8 lipidation cascade enzymes indu

293 ted as a borylated Horner P(=O)CH(2)B carbon nucleophile with carbon dioxide to give a bicyclic produ

294 d for the challenging coupling of 2-pyridine nucleophiles with (hetero)aryl electrophiles, and ranges

295 ctive N-allylation of N-silyl pyrrole latent nucleophiles with allylic fluorides followed by hydrogen

296 atalyzed cross-coupling of these fluoroalkyl nucleophiles with aryl and alkyl bromides to produce a d

297 eutral and anionic Pd catalysts and N- and O-nucleophiles with different steric and electronic proper

298 quent interaction of arenes and nitriles, as nucleophiles, with intermediate cationic species derived

299 and optimized orientation of the antidotes' nucleophile within the AChE active-center gorge.

300 malonates and a wide range of soft anionic C-nucleophiles without using any catalyst or additive.