ライフサイエンスコーパス: nucleophilic

1 a Mg(2+)-coordinated water deprotonates the nucleophilic 3'-OH, and this deprotonation is concerted

2 Less nucleophilic acceptors such as phenols were also glycosy

3 , thus demanding the participation of strong nucleophilic acetylenes.

4 xogenous boronic acid/ester (ArB(OR)(2)) and nucleophilic activator, representing a net defluorinativ

5 1,5]-H shift/cleavage of CS(2)/aromatization/nucleophilic acyl substitution reaction of 2-(4-oxo-2-th

6 g reagent at its N-side amide for undergoing nucleophilic acyl substitution with amines including a n

7 developed, which proceeds through sequential nucleophilic addition and electrophilic substitution fol

8 e-pot acid-mediated transannular cyclization/nucleophilic addition at C7 furnished the corresponding

9 e synthesized via solvent- and catalyst-free nucleophilic addition between PEG-diamine and vitamin E-

10 to activate the substrate toward a potential nucleophilic addition but also to subtly control the reg

11 the iminium precursor that was subjected to nucleophilic addition in a diastereoselective manner.

12 on related transformations where the initial nucleophilic addition involving the activated allenoate

13 The potential for dimer formation from the nucleophilic addition of 2-methyltetrol to trans-beta-IE

14 Nucleophilic addition of alkoxide to these N-arylquinazo

15 The reaction proceeds via the nucleophilic addition of an active methylene compound to

16 trile moiety, 5-exo cyclization, followed by nucleophilic addition of an alkanethiol to a 3-alkyliden

17 The reaction proceeds via nucleophilic addition of an alkanethiol to an isonitrile

18 The nucleophilic addition of organomagnesium and organolithi

19 al benzene photoreaction: the photoinitiated nucleophilic addition of solvent to benzene in acidic me

20 revealed an ~10(5)-fold rate enhancement for nucleophilic addition of sulfide into the trisulfide ver

21 Nucleophilic addition of thiolates to diethyl acetylened

22 BF(3).OEt(2)-catalyzed nucleophilic addition of vinyl azides to in situ generat

23 eps of synthesis were (i) diastereoselective nucleophilic addition of vinylmagnesium bromide to N-all

24 nd the competing mechanisms involving either nucleophilic addition or the formation of radical interm

25 and UV-vis-NIR experiments and isolated the nucleophilic addition product [(Me)(Ph)(CCHC){Au(IPr)}(2

26 f a single trans-beta-IEPOX + 2-methyltetrol nucleophilic addition product was obtained, but nucleoph

27 , metal-bound Cys can be easily labeled in a nucleophilic addition reaction after separation by rever

28 nstrated here in a tandem cycloisomerization/nucleophilic addition reaction, by attaining high enanti

29 l azide formation, Curtius rearrangement and nucleophilic addition reaction.

30 isobutylene-alt-maleic anhydride), PIMA, via nucleophilic addition reaction.

31 formation via a tandem cyclic N-acyliminium nucleophilic addition reaction.

32 rived chiral phosphoric acids for a range of nucleophilic addition reactions to imines and developed

33 This study establishes the feasibility of nucleophilic addition to an appended sulfoxide as a mean

34 tron-withdrawing and -donating groups on the nucleophilic addition to oxocarbenium ion intermediates.

35 ed from our group, whereby it was shown that nucleophilic addition to p-benzynes derived from unsymme

36 ment of new transformations involving direct nucleophilic addition to the amide bond as a key step.

37 products in excellent yields through direct nucleophilic addition to the amide bond.

38 luoroacetaldehyde also efficiently underwent nucleophilic addition with 2-arylindazoles.

39 fully taken through a second protonation and nucleophilic addition with a similar scope of nucleophil

40 ure, in turn, does not necessarily favor the nucleophilic addition, as shown for the reaction with fl

41 ne to benzvalene followed by protonation and nucleophilic addition.

42 enter, expanding the synthetic scope of this nucleophilic addition.

43 mechanism based on THIQ oxidation and R(3)In nucleophilic addition.

44 incorporation precedes cyclodehydration in a nucleophilic-addition-cyclodehydration (NAC) sequence.

45 Despite significant efforts, direct nucleophilic additions to heteroaromatics have remained

46 Thus, if present, both nucleophilic adducts and bound residues in organic matte

47 alpha-Alkylidene pyrazolinones act as N-nucleophilic agents which are distinguished from reporte

48 abilization and by reducing the pK(a) of the nucleophilic alcohol of a serine.

49 ss to N-carbamoyl-protected amino esters via nucleophilic allylation of readily accessible alpha-chlo

50 ion and replacement of an alkyl group by the nucleophilic alpha-C atom of the phosphaallene.

51 y in 2018 that the synthesis of a bottleable nucleophilic aluminyl anion is feasible, a handful of de

52 have been studied, and as expected, the more-nucleophilic amine generally results in faster primer ex

53 action is compatible with diverse amides and nucleophilic amines, affording the transamidation produc

54 t loading in approximately 20 min with these nucleophilic amines.

55 In the case of nucleophilic aminyl radicals direct N-arylation with ary

56 Directed nucleophilic and electrophilic chemistry was developed t

57 consistently reveal that competition between nucleophilic and electrophilic palladium difluorocarbene

58 to be considered as a reactant for both the nucleophilic and the radical reactions, and its dynamics

59 olvent, these solutions are used directly in nucleophilic aromatic and aliphatic (18)F-fluorination r

60 ion operating via cation radical-accelerated nucleophilic aromatic substitution (CRA-S(N)Ar) enables

61 Nucleophilic aromatic substitution (S(N)Ar) is a classic

62 Nucleophilic aromatic substitution (S(N)Ar) is routinely

63 selectively react with biological thiols via nucleophilic aromatic substitution (S(N)Ar).

64 nder basic conditions through the sequential nucleophilic aromatic substitution (S(N)Ar)/second-order

65 ss of 30 kcal mol(-1)), has the character of nucleophilic aromatic substitution and is thus accelerat

66 Nucleophilic aromatic substitution and metal-catalyzed (

67 ions suggest a mechanism with intramolecular nucleophilic aromatic substitution and replacement of an

68 The reaction rates for the nucleophilic aromatic substitution of 4,6-dichloro-5-nit

69 o acid is described using a highly efficient nucleophilic aromatic substitution of ortho-fluoronitrob

70 The PAE-COFs are synthesized through nucleophilic aromatic substitution reactions between ort

71 rocyclic tetrahydropentacene derivatives via nucleophilic aromatic substitution reactions of bidentat

72 The 2-sulfonylpyridine products undergo nucleophilic aromatic substitution reactions with oxygen

73 eroaromatic sulfones react with cysteine via nucleophilic aromatic substitution, providing a mechanis

74 JNJ-64413739 was radiolabeled via a one-step nucleophilic aromatic substitution.

75 es the C-2 position of benzoxazolones toward nucleophilic aromatic substitution.

76 arenes enabled by cation radical-accelerated nucleophilic aromatic substitution.

77 TPMA(PIP) ), and morpholine (TPMA(MOR) )) by nucleophilic aromatic substitution.

78 The text-book mechanism of bimolecular nucleophilic aromatic substitutions (S(N)Ar) reactions i

79 a nucleophile when the atom adjacent to the nucleophilic atom has high electron density.

80 ng junction (C5-C6) and trans at the site of nucleophilic attack (C6-C7) on the three contiguous ster

81 3) C-F bonds into C-Si bonds by two modes of nucleophilic attack (S(N) V or S(N) 2').

82 vel cycloisomerization based on ring-opening nucleophilic attack and rearrangement is observed.

83 0 promotes catalysis by activating water for nucleophilic attack at the 5'-phosphate group with respe

84 g the inward approach of indoles, leading to nucleophilic attack at the less substituted electrophili

85 (b) Nucleophilic attack by a carboxylate on the amide carbon

86 ramidimidoyl fluoride to a protein can allow nucleophilic attack by a specific amino acid side chain,

87 vinylglycine ketimine, which is subjected to nucleophilic attack by acetoacetate to form the new C(ga

88 imide activates a carboxyl group followed by nucleophilic attack by benzhydrazide forming a stable la

89 For CH(3)Br, nucleophilic attack by both H(2)O and Cl(-) caused signi

90 Subsequent nucleophilic attack by pyridyl nitrogen results in its c

91 romoted catalytic mechanism, invoking direct nucleophilic attack by the substrate alpha-amino group o

92 mulates a reaction intermediate of the first nucleophilic attack during catalysis of cysteine peptida

93 rates we find that at low pH the OH(-) anion nucleophilic attack is the rate-limiting step, which cha

94 ver mechanism, and the cyclization occurs by nucleophilic attack of a conveniently positioned phospho

95 culations suggest a mechanism proceeding via nucleophilic attack of a dicoordinate borylene intermedi

96 etic sequence (11 steps, 46% global) are the nucleophilic attack of a hindered tertiary alkoxide, a r

97 In an alternative outer-sphere process, nucleophilic attack of a metal-phosphido (M-PR(2)) group

98 This pathway involves the rate-limiting nucleophilic attack of a water molecule, leading to a sh

99 ring expansion of methylenecyclopropanes and nucleophilic attack of an enamine to realize the constru

100 tion of the amino group of glycine, enabling nucleophilic attack of CTQ, as well as the deprotonation

101 This transformation takes place via nucleophilic attack of enol ethers to electron-rich benz

102 a Ni-pai-allyl complex, and the outer-sphere nucleophilic attack of H-bonded amine aggregates is prop

103 Next, we propose a nucleophilic attack of molybdate onto the gamma-phosphat

104 However, the nucleophilic attack of the anion on carbonates induces a

105 This binding mode does not allow optimal nucleophilic attack of the peptidyl-tRNA by the reactive

106 e hydroalkynylation reaction takes place via nucleophilic attack of the terminal alkyne to the C2 car

107 compared to the gas phase and occurs through nucleophilic attack of water on the carbonyl carbon.

108 eptor residue, which subsequently performs a nucleophilic attack on FAD for flavin transfer.

109 can be used to enable highly stereoselective nucleophilic attack on intermediate tertiary carbocation

110 lation of biocatalytic activity for tyrosine nucleophilic attack on phosphorus.

111 The synthetic sequence merges well with the nucleophilic attack on the 2-amino group of pyridines/py

112 to a series of amide products through amine nucleophilic attack on the ketene intermediate.

113 ubstrate's carboxylated phenyl group makes a nucleophilic attack to form the pyrrole ring of the indo

114 nism for the O-O bond formation is the water nucleophilic attack to single Co(IV)-oxo or Co(III)-oxyl

115 rates, and control experiments revealed that nucleophilic attack to the pai-allylpalladium intermedia

116 oxyl, while the other carboxylate engages in nucleophilic attack upon the amide carbonyl; a substanti

117 tic equatorial ligands facilitates the water nucleophilic attack, as in the case of the highly effici

118 yclic double bond present in series I toward nucleophilic attack, compounds containing either an endo

119 ive site Pb2+ ion helps to stabilize in-line nucleophilic attack, provides direct electrostatic trans

120 ote electrophilic center to facilitate OH(-) nucleophilic attack.

121 onic substrate bias to influence the site of nucleophilic attack.

122 accounts for the feasibility of the initial nucleophilic attack.

123 is proposed to proceed through an S(N)2-like nucleophilic attack/ring-opening manifold.

124 tive site to activate the water molecule for nucleophilic attack?

125 formation of benzyl carbocation, followed by nucleophilic attacks.

126 Overall, the field of late-stage nucleophilic C-H fluorination has progressed much more s

127 Less nucleophilic C1 carbon was also alkylated when C3-substi

128 hese properties are consistent with those of nucleophilic carbenes.

129 ified glycoside bond stereochemistry using a nucleophilic carbohydrate residue and the synthetic equi

130 The reaction has been realized under nucleophilic catalysis conditions with dimeric cinchona

131 m their deprotonated anionic forms, or under nucleophilic catalysis.

132 y encodable surrogate of the widely employed nucleophilic catalyst dimethylaminopyridine(11), and its

133 cribed in which an amine acts as an internal nucleophilic catalyst to facilitate a novel cyclisation/

134 erases catalyze methylation reactions at non-nucleophilic centers in a wide range of substrates.

135 As an emblematic case, the nucleophilic character of a pai-extended enolate-type ch

136 ophiles (umpolung), vinylogation extends the nucleophilic character to "unnatural" beta, delta, ...

137 ts with boronic acids, which increases their nucleophilic character towards electrophiles.

138 f allyliridium complexes required to enforce nucleophilic character, which should inform the design o

139 Here we show that the nucleophilic characteristics of superoxides, generated g

140 in complex environments is a central goal in nucleophilic chemosensor development.

141 n this article, comprehensive studies on the nucleophilic chlorination and bromination of readily ava

142 se compounds are unexpectedly susceptible to nucleophilic cleavage under mildly basic conditions.

143 ight into the function of binary metal salen/nucleophilic cocatalyst systems at low concentrations, w

144 t the predominant binary Lewis acid catalyst/nucleophilic cocatalyst systems suffer lower polymerizat

145 e allows greater flexibility in choosing the nucleophilic coupling partner and expands the scope of t

146 ulfinates have recently emerged as effective nucleophilic coupling partners in palladium-catalyzed cr

147 e esters (RAEs), can be utilized as formally nucleophilic coupling partners with other carboxylic der

148 odium hydride or cesium carbonate, underwent nucleophilic cyclization to afford 4-methylene-3-[(4-nit

149 termediate in situ, which reacts with nearby nucleophilic cysteine residue from the DUB active site.

150 s (Pd-protein OACs), a process that converts nucleophilic cysteine residues into an electrophilic S-a

151 cleophilic serine, l,d-transpeptidases use a nucleophilic cysteine.

152 Herein, we present a method for the nucleophilic defluorination of unactivated fluoroarenes

153 A tentative mechanism is proposed involving nucleophilic displacement of S-F by the trifluoromethyl

154 Nucleophilic displacement of the chiral auxiliary with G

155 enzymatic cascade reactions: those involving nucleophilic, electrophilic, pericyclic, and radical rea

156 By harnessing the formation of a nucleophilic enamine intermediate, the C-C bond-forming

157 mply new possibilities for the inhibition of nucleophilic enzymes.

158 rophiles has been little explored outside of nucleophilic epoxidation.

159 he alpha effect correlated with the Bronsted nucleophilic factor, beta(nuc), for the reactions with t

160 alternatively, a proton transfer-independent nucleophilic ferric peroxo anion (compound 0, i.e. Fe(3)

161 entially representing an extensive molecular nucleophilic fingerprint of YDs.

162 n the presence of an iridium(I) catalyst and nucleophilic fluoride source (Et(3)N.3HF), allylic trich

163 rea adduct, formed in situ, allows effective nucleophilic fluoride transfer to a range of primary and

164 luorides, that are typically inaccessible by nucleophilic fluorination due to competing elimination.

165 distant hydroxyl groups, is able to catalyze nucleophilic fluorination in combination with 18-crown-6

166 The activation of potassium fluoride for nucleophilic fluorination of alkyl halides is an importa

167 We report a redox-neutral method for nucleophilic fluorination of N-hydroxyphthalimide esters

168 Recently, enantioselective nucleophilic fluorination with metal alkali fluoride has

169 angements impact the efficiency of catalytic nucleophilic fluorination.

170 alyst that controls the configuration at the nucleophilic fluorine-containing carbon.

171 3-triazole-fused analogues, using NH-Ts as a nucleophilic functional group allowed obtaining 10-membe

172 The method tolerates all other known nucleophilic functional groups of naturally occurring pr

173 ORX does not react with compounds containing nucleophilic functional groups other than thiols such as

174 The nature of both a heterocycle and a nucleophilic group affects the possibility of a 10-membe

175 focused on the effect of ortho'-substituted nucleophilic groups such as OH, NH(2), CH(2)OH, CH(2)NH(

176 in which the heteroatom, which is typically nucleophilic, has been rendered electrophilic by changes

177 ctional group orthogonality that complements nucleophilic imine allylation strategies for alpha-terti

178 lectron-rich species might be expected to be nucleophilic (in the same manner as I(-), for example),

179 erved under these conditions are a result of nucleophilic iodide ring opening of the aziridine to gen

180 rces of both electrophilic silylium ions and nucleophilic L(n)Pd(0).

181 ex shows substrate-induced ionization of the nucleophilic l-Tyr37, now H-bonded to l-Lys47, resulting

182 te covalent modification of a distal, poorly nucleophilic lysine on the surface of a protein target.

183 ally different from the more widely employed nucleophilic lysing of metal alkylcarboxylates for other

184 echin conjugate was captured in protic polar nucleophilic methanol alone or methanol-HCl extracts.

185 , include a solution to the problem of axial nucleophilic methylation of a late-stage cyclohexanone,

186 e exploited to enable both electrophilic and nucleophilic modes of activation in various organic reac

187 e also found that hydroxylamine and presumed nucleophilic moieties in model dissolved organic matter

188 ytes, including complex crosslinking between nucleophilic moieties.

189 mical oxidation conditions revealed that the nucleophilic molecular fingerprint of the YD was strongl

190 compared to reactions developed for the more nucleophilic N1 and N2 positions.

191 mechanism in which pai-participation by the nucleophilic olefin facilitates chloride ionization and

192 obu reaction, and regio- and stereoselective nucleophilic opening of an epoxide were used as the main

193 could be specifically tailored toward either nucleophilic or base-type reaction pathways.

194 ause it features several reaction sites with nucleophilic or electrophilic properties.

195 um intermediates enables the use of a mildly nucleophilic organoaluminium methylating reagent that pr

196 It functions by providing an intramolecular nucleophilic oxygen close to the oxo group to facilitate

197 er an electron-rich aryl or a pyrrole as the nucleophilic partner in the first cyclization.

198 ach using pyridine and diazine phosphines as nucleophilic partners and chloroazines where the heterob

199 m are found to be competent reagents for the nucleophilic pathway.

200 We demonstrate that a nucleophilic phosphine probe is able to modify Dhb-conta

201 ld Lewis acid (e.g., a Li or Na cation) or a nucleophilic promoter (e.g., an alkoxide).

202 t catalysis, which enables the generation of nucleophilic radicals through strain release.

203 alkyl iodides as precursors to unstabilized nucleophilic radicals.

204 y the reaction mechanism involving DMSO as a nucleophilic reactant is in harmony with the experimenta

205 strategies failed to achieve a ring-opening nucleophilic reaction with N-unprotected substrates.

206 ents which are distinguished from reported C-nucleophilic reactions.

207 lysine-targeted chemical probes, we asked if nucleophilic (reactive) catalytic lysines are common on

208 The nucleophilic reactivities of the title compounds correla

209 mmon reference electrophiles for quantifying nucleophilic reactivities, have been measured photometri

210 More interestingly, 1 shows a nucleophilic reactivity in aldehyde deformylation reacti

211 has furnished useful information on the high nucleophilic reactivity of benzofuroxan derivatives, whi

212 tion of an encounter complex with subsequent nucleophilic reactivity of the catalytic cysteine thiol

213 onal cross-coupling processes to alternative nucleophilic reagents and novel main group approaches.

214 lsilyl chloride and subsequent coupling with nucleophilic reagents including Grignard reagents and te

215 By choosing suitable nucleophilic reagents to selectively capture these inter

216 and MS analyses, we show that the conserved nucleophilic residue Cys-122 is S-sulfenylated after sub

217 -enzyme intermediate because it is neither a nucleophilic residue nor a substrate-interacting residue

218 nt inhibitors irreversibly modify a proximal nucleophilic residue on the protein via reaction with an

219 agent that can readily react with a range of nucleophilic residues in proteins.

220 de (PQM)-based crosslinkers that target nine nucleophilic residues through Michael addition, includin

221 A nucleophilic retro-Claisen ring-opening of donor-accepto

222 l-2,3-dihydroquinolin-4(1H)-one, followed by nucleophilic ring opening of the cyclopropyl ring to for

223 s of the transformation are the formation of nucleophilic ring-opening products from the D-A cyclopro

224 res electrophilic activation, and subsequent nucleophilic (S(N)2) attack on the less substituted carb

225 fundamental differences in the reactivity of nucleophilic serine and cysteine enzymes, and imply new

226 olysis products, the reaction of the class D nucleophilic serine beta-lactamases (SBLs) with carbapen

227 Replacement of the nucleophilic serine of serine beta-lactamases with cyste

228 dases (penicillin-binding proteins) employ a nucleophilic serine, l,d-transpeptidases use a nucleophi

229 Enzymes often use nucleophilic serine, threonine, and cysteine residues to

230 We find that in intact proteins weakly nucleophilic side chains (Ser, Thr, and Tyr) can be modi

231 to methylglyoxal (MGO)-induced glycation on nucleophilic side chains, particularly arginines, under

232 as well as N-acetylglucosamine residues and nucleophilic sites of an anomeric tag, yielding specific

233 te the possible competition between MGO with nucleophilic sites on proteins and polyphenols at concen

234 xic, due to their chemical reactivity toward nucleophilic sites present in biomacromolecules.

235 ve when carried out in classical organic non-nucleophilic solvents (such as MeCN or DME), leading to

236 et alpha-carbonyl carbene capture in aprotic nucleophilic solvents (with ylide bands at 1625 cm(-1) i

237 nsistently, the complex is found to act as a nucleophilic source of gold, reacting with diisopropylca

238 leophilic addition product was obtained, but nucleophilic strength calculations suggest that 2-methyl

239 cal shift trends, which were used along with nucleophilic strength calculations to interpret the resu

240 yzed the competition between the bimolecular nucleophilic substitution (S(N)2) and base-induced elimi

241 aromatic substitution (S(N)Ar)/second-order nucleophilic substitution (S(N)2) reaction to give spiro

242 The products are readily elaborated both by nucleophilic substitution and through transition-metal-c

243 The reaction is a formal stereoretentive nucleophilic substitution at an oxygenated tertiary carb

244 ion are restricted to coupling reactions and nucleophilic substitution at the meso position in the ch

245 vatives undergo a regio- and stereoselective nucleophilic substitution at the quaternary carbon cente

246 For CH(3)Cl only nucleophilic substitution by H(2)O was observed at signi

247 using amidation and intramolecular aromatic nucleophilic substitution chemistry.

248 An alternative approach based on nucleophilic substitution in 5-bromomethyl derivatives w

249 te), the reaction proceeds with the abnormal nucleophilic substitution irrespective of the base and w

250 re of cis and trans isomers and (2) a direct nucleophilic substitution leading to a stereoselective s

251 transformations in organic chemistry is the nucleophilic substitution of alcohols.

252 ioyl)oxy (oxa)helicenes in a flow reactor or nucleophilic substitution of dichloro (oxa)helicenes wit

253 Methodology of nucleophilic substitution of hydrogen (S(N)(H)) was firs

254 talyst components) for the enantioconvergent nucleophilic substitution of racemic secondary alkyl hal

255 ation of o-arylacetophenone, (ii) sequential nucleophilic substitution of the resulting alpha-bromo o

256 ggests that the forward reaction is mainly a nucleophilic substitution of type 2 (S(N)2) with a mix o

257 The nucleophilic substitution on 3-substituted 2-methoxytrop

258 We discovered that the nucleophilic substitution reaction between carboxylate a

259 3-nitro-1,2-diphenylcyclopropene undergoes a nucleophilic substitution reaction in alcohols and thiol

260 ined from alkyl bromides and tosylates via a nucleophilic substitution reaction or by hydrothiolation

261 were radiolabeled with (18)F using aromatic nucleophilic substitution reaction.

262 types of alkylating agents defined by their nucleophilic substitution reactions (SN1 and SN2) are st

263 are shown to be activated to stereospecific nucleophilic substitution reactions by precisely tailore

264 Nucleophilic substitution reactions of alcohols are amon

265 specially designed phosphine oxide promotes nucleophilic substitution reactions of primary and secon

266 e triazole as an effective LG for activating nucleophilic substitution reactions on tyrosine sites of

267 ups allows for further functionalization via nucleophilic substitution reactions to generate new full

268 as introduced by an NBS-mediated bromination-nucleophilic substitution sequence.

269 ng functional groups that are susceptible to nucleophilic substitution such as alkyl halides.

270 matic Heck cross-coupling and N-pyridin-2-yl nucleophilic substitution was described.

271 ransformation of Ugi four-component reaction/nucleophilic substitution was developed for the synthesi

272 anic diimide (MDI), that is shown to undergo nucleophilic substitution with a variety of ortho disubs

273 nium salts can be further functionalized via nucleophilic substitution, photoredox coupling, and elec

274 ative cycloetherification, and (iv) aromatic nucleophilic substitution.

275 n follows base-dependent normal and abnormal nucleophilic substitution.

276 r the insertion of more complex moieties via nucleophilic substitution.

277 eotide was assumed to be a classical in-line nucleophilic-substitution reaction in which the 3'-hydro

278 Its nucleophilic substitutions or cross-coupling reactions a

279 carbon-carbon bonds, allylic and propargylic nucleophilic substitutions, C-H activation reactions, cr

280 /- 0.04, respectively, which are typical for nucleophilic substitutions.

281 sm of catalysis consisting of two subsequent nucleophilic substitutions.

282 cids can act as cofactors for cage-catalyzed nucleophilic substitutions.

283 ion at position 6 through cross-couplings or nucleophilic substitutions.

284 emical shift of the alpha-proton in starting nucleophilic substrates was revealed which makes equilib

285 -allopyranose precursor by the corresponding nucleophilic suitable protected thioaldoses derived from

286 rotoxicity are the formation of adducts with nucleophilic sulfhydryl groups on cysteine residues of s

287 a key stereocontrol element and a furan as a nucleophilic terminator, the key structural features of

288 nthesise these materials using the efficient nucleophilic thiol-yne reaction between a dipropiolamide

289 a straightforward synthetic route to convert nucleophilic thiols into electrophilic, thiol-selective

290 blocking ion pair recombination by internal nucleophilic trapping.

291 leophile incorporation in a cyclodehydrative-nucleophilic-trapping (CNT) sequence, involving a reacti

292 es beyond the traditional cycloadditions and nucleophilic trappings previously reported, thus expandi

293 many reactions, including cycloadditions and nucleophilic trappings, often generating structurally co

294 g group and its subsequent activation of the nucleophilic trifluoromethyl group enabled the reaction.

295 g inexpensive and bench stable AgSCF(3) as a nucleophilic trifluoromethylthiolating (-SCF(3)) reagent

296 ough a halide-rebound mechanism in which the nucleophilic twisted amide is quaternized and subsequent

297 ed as a class of probes for the detection of nucleophilic two-electron oxidants.

298 ve site, a third Mn(2+) that coordinates the nucleophilic water appears necessary for product formati

299 ming its role in binding and addition of the nucleophilic water molecule.

300 spectively and prospectively predicted to be nucleophilic, when kinase is in the rare DFG-out/alphaC-