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1 o chromatin and SCML2B that is predominantly nucleoplasmic.
3 eling, we previously observed a depletion of nucleoplasmic A-type lamins in mouse cells lacking LAP2a
8 relocalized from the nuclear periphery into nucleoplasmic aggregates and produced no nuclear blebbin
9 localize lamin A/C from the nuclear rim into nucleoplasmic aggregates, (ii) overexpression of U(L)34
11 obic cluster analysis also predicts that the nucleoplasmic amino-terminal portion of LBR contains two
12 R from four patients with PBC recognized the nucleoplasmic, amino-terminal domain but not the carboxy
15 hat is phosphorylated on serine 366 (pLa) is nucleoplasmic and associated with precursor tRNAs and ot
16 lls that incorporates a method for obtaining nucleoplasmic and chromatin fractions and removing cytop
21 nation iCLIP (Fr-iCLIP), in which chromatin, nucleoplasmic and cytoplasmic fractions are prepared fro
26 CHD7 dually functions as a regulator of both nucleoplasmic and nucleolar genes and provide a novel av
30 apping subcellular distribution of cytosolic/nucleoplasmic and topogenic signal-encoding mRNAs, with
31 s of RNA enrichment between the cytoplasmic, nucleoplasmic, and chromatin fractions, with some genes
34 s the CB marker protein, coilin is primarily nucleoplasmic, and the function of this fraction is not
36 lamins comprise the lamina and a variety of nucleoplasmic assemblies that together are major structu
37 s and Rac GTPases mediate the recruitment of nucleoplasmic Aux/IAAs into proteolytically active nucle
38 ve, eight-fold symmetric channel capped by a nucleoplasmic basket and structurally unique, cytoplasmi
41 ne patient showed increased micronucleus and nucleoplasmic bridge formation, delayed recovery of DNA
42 -) cells is associated with the formation of nucleoplasmic bridges and increased chromosomal instabil
43 of cases (and no controls) had >or=6 induced nucleoplasmic bridges, and 23% of cases (versus 2% of co
44 ases (and no controls) had >or=4 spontaneous nucleoplasmic bridges, and 25% of cases (versus 5% of co
45 er risk based on the numbers of micronuclei, nucleoplasmic bridges, and nuclear buds defined by perce
46 a continuous scale, spontaneous micronuclei, nucleoplasmic bridges, and nuclear buds were associated
47 d chromosomal damage endpoints (micronuclei, nucleoplasmic bridges, and nuclear buds) per 1,000 binuc
48 of spontaneous and NNK-induced micronuclei, nucleoplasmic bridges, and nuclear buds, respectively.
53 independently in raising levels of cytosolic/nucleoplasmic Ca(2+) as a source of Ca(2+) for Ca(2+)-de
54 channels) induces NE-derived Ca(2+) release, nucleoplasmic Ca(2+) elevation and cyclic AMP response e
55 These changes were associated with altered nucleoplasmic Ca(2+) handling in cardiomyocytes from hyp
58 al and potential pathophysiological role for nucleoplasmic Ca(2+) signals and suggest that this infor
59 to GM1 ganglioside that mediates transfer of nucleoplasmic Ca(2+) to the NE lumen and constitutes a c
65 d Mre11 in fractionated lysates (cytoplasmic/nucleoplasmic, chromatin-bound, and nuclear matrix fract
67 nto cohesive structures behind them, or from nucleoplasmic cohesin that is loaded de novo onto nascen
73 on, quantitative study of the changes in the nucleoplasmic concentration and distribution of these nu
74 est a dynamic interaction, controlled by the nucleoplasmic concentration of Gsp1p-GTP, between Nup60p
75 leus is dynamically regulated, and may alter nucleoplasmic concentrations and/or assembly of multimol
76 inated state in the nucleolus, requiring the nucleoplasmic deubiquitinase (DUB) USP1 and the nucleola
77 hromosomes, its deletion subtly affected the nucleoplasmic distribution of the protein during interph
78 ates from these stress granules to a diffuse nucleoplasmic distribution, typical of unstressed cells.
79 romatin immunoprecipitation reveal a diffuse nucleoplasmic distribution, weak association with chroma
85 ed a functional link between Gcn5 and acidic nucleoplasmic DNA-binding protein 1 (And-1) that is elev
86 t residues 72-98 adjacent to the membrane in nucleoplasmic domain are important for the interaction w
87 uses with large deletions in the cytoplasmic-nucleoplasmic domain of ADP retain much of their ability
88 iruses with mutations within the cytoplasmic-nucleoplasmic domain of ADP showed normal glycosylation
90 of a recombinant polypeptide comprising the nucleoplasmic domain of rat LAP2 (residues 1-398) into m
91 hanges and HIV inhibition both mapped to the nucleoplasmic domain of SUN2 that interacts with the nuc
92 lipid-binding amphipathic helix (AH) in the nucleoplasmic domain of Sun2 that prefers membrane packi
98 d at the nuclear periphery during G1, became nucleoplasmic during S-phase, and then returned to the n
99 TP was elevated in the extracts to mimic the nucleoplasmic environment, the patterns of interacting p
101 nalyzing the role of the nuclear basket, the nucleoplasmic extension of the NPC, we reveal that the a
104 We find that cdc7 is greatly enriched in nucleoplasmic extract and that this high concentration i
109 pproach to investigate DNA end processing in nucleoplasmic extracts derived from the unfertilized egg
110 his activity can be provided by cytosolic or nucleoplasmic extracts in a subsequent export step.
111 cleus, with import cargo accumulating at the nucleoplasmic face of nuclear pore complexes, as when Ra
113 lear lamina is a protein meshwork lining the nucleoplasmic face of the inner nuclear membrane and rep
114 o filamentous structures stretching from the nucleoplasmic face of the NE into the nucleoplasm, simil
126 mutations in human cells and found that the nucleoplasmic Fbw7alpha isoform accounts for almost all
127 t occupy distinct compartments: Fbw7alpha is nucleoplasmic, Fbw7beta is cytoplasmic, and Fbw7gamma is
130 three characteristic morphologies: (i) long, nucleoplasmic filaments; (ii) short, nucleolus-associate
131 g showed colocalization in both nucleoli and nucleoplasmic foci in breast tumor cells and asynchronou
132 s, BRCA1 protein dispersed from nucleoli and nucleoplasmic foci to other nucleoplasmic sites, which d
134 PML tumor suppressor protein into a diffuse nucleoplasmic form and its association with metaphase ch
137 These results bear on the structure of the nucleoplasmic ground substance-an extremely controversia
138 PLK-2 docking to the SC is prevented by the nucleoplasmic HAL-2/3 complex until crossover designatio
139 ether, our data support a model in which the nucleoplasmic HAL-2/HAL-3 protein complex constrains bot
141 ions give rise to a strong dependence of the nucleoplasmic HP1 density on HP1-H3K9me2/3 stoichiometry
143 This reactivated geminin provides the major nucleoplasmic inhibitor of origin relicensing during lat
149 ormation of higher order structures, keeping nucleoplasmic lamin A/C in a mobile state independent of
150 we show here leads to loss of LAP2alpha and nucleoplasmic lamins A/C, impaired proliferation, and do
152 restingly, large forces were also present on nucleoplasmic lamins, indicating that these lamins may a
154 r globules that are percolated with the same nucleoplasmic liquid as the surrounding euchromatin, whi
155 1 transcriptional memory is lost, leading to nucleoplasmic localization after repression and slower r
156 9 functions, it did result in increased DDX1 nucleoplasmic localization and decreased DDX1 interactio
157 croscopy confirmed mrnp 41's cytoplasmic and nucleoplasmic localization and revealed a striking label
162 -GFP predicted to ablate N-acetylation cause nucleoplasmic location, whereas a variant with an N-term
163 speculate that SNIP is part of an organized nucleoplasmic machinery responsible for processing of SL
170 phy and demonstrated for the first time that nucleoplasmic NF7 exists primarily as free homotrimers.
171 d Mlp1, baskets assemble only on a subset of nucleoplasmic NPCs, and these basket-containing NPCs ass
173 p interact at the cytoplasmic NPC face, with nucleoplasmic Nup116p localization utilizing novel bindi
174 tead, sPom121 colocalizes and interacts with nucleoplasmic Nup98, a previously identified transcripti
175 of the cytoplasm, nuclear invaginations, and nucleoplasmic opacity, as well as aggregations of juncti
177 -231 cells with adenoviral RXR alpha induced nucleoplasmic overexpression of RXR alpha and resulted i
178 a substantial increase in both nucleolar and nucleoplasmic p19(ARF), Mdm2 did not relocalize to the n
179 ramatically altered, from its normal diffuse nucleoplasmic pattern to accumulation in dense nuclease-
181 a cells without affecting migration and with nucleoplasmic patterns of damage similar to constricted
182 ecruitment to the pre-60S near the nucleolar/nucleoplasmic phase boundary, forming a kinetic checkpoi
184 by dim light, which enhanced PB dynamics and nucleoplasmic PHYB and PIF5, switched the balance toward
186 ctories exchange components with the soluble nucleoplasmic pool over time as gene expression programs
188 e obtained direct physical evidence that the nucleoplasmic PRC1 is monomeric, whereas PRC2 can dimeri
189 previously been shown to associate with the nucleoplasmic pre-60S in a region containing the "foot"
190 copy to characterize the structures of yeast nucleoplasmic pre-60S particles affinity-purified using
191 g2 binds the inter-subunit face of maturing, nucleoplasmic pre-60S particles, and the location clashe
196 nsists of nuclear membrane protein UL50, and nucleoplasmic protein UL53, which is recruited to the nu
199 y binary selection; mRNAs encoding cytosolic/nucleoplasmic proteins are translated on free ribosomes,
204 NA export involves association of mRNAs with nucleoplasmic proteins, delivery to the nuclear pore com
207 questering or mobilizing a small fraction of nucleoplasmic Rad51 and suggest a mechanism for the dyna
211 this protein, we have examined in detail its nucleoplasmic region, which is predicted to harbor a Tud
213 erous punctate foci dispersed throughout the nucleoplasmic regions of the nucleus and was also presen
214 Eukaryotic cells begin to assemble discrete, nucleoplasmic repair foci within seconds after the onset
216 des may be taking place, particularly at the nucleoplasmic reticula that reach deep within the nucleo
218 nucleus, leading to Ca(2+) release from the nucleoplasmic reticulum by inositol 1,4,5-trisphosphate
219 e presence of nuclear LDs attached to type I nucleoplasmic reticulum in triple seipin mutant embryos,
223 in substructures (the inner, cytoplasmic and nucleoplasmic rings) around the central transport channe
224 scaffold nucleoporin of the cytoplasmic and nucleoplasmic rings, we observe the interdependence of e
228 plasmic sequences, 0.80% for randomly chosen nucleoplasmic sequences and 12% for nuclear localization
230 P3-gated Ca(2+) as a key regulator of TDP-43 nucleoplasmic shuttling and proteostasis and suggest pha
232 on between TET2 and p53 that facilitated the nucleoplasmic shuttling of TET2, as well as its recruitm
233 primarily interact with the periphery on the nucleoplasmic side and in the centre of the NPC, without
234 AFM images further show polyplexes on the nucleoplasmic side of the envelope, presumably indicatin
236 t substrate is released from Kapbeta2 at the nucleoplasmic side of the NPC by competition with the Nu
237 ect targeting of both Nup96 and Nup98 to the nucleoplasmic side of the NPC was found to be dependent
238 alpha/cargo complexes are dissociated on the nucleoplasmic side of the NPC, and this dissociation req
239 ctron microscopy, Nup96 was localized to the nucleoplasmic side of the NPC, at or near the nucleoplas
240 Nup214 on the cytoplasmic, and Nup153 on the nucleoplasmic side of the NPC, failed to assemble into N
241 that among the nucleoporins localized at the nucleoplasmic side of the NPC, TPR is the key nucleopori
243 lamina, a filamentous network underlying the nucleoplasmic side of the nuclear membrane, whereas lami
244 lp1 and Mlp2) form filaments attached to the nucleoplasmic side of the nuclear pore complexes via int
247 te of movement away from either a speckle or nucleoplasmic site was monitored using digital imaging m
250 he nucleoplasm, largely to specific discrete nucleoplasmic sites or speckles; this pattern was stable
251 rom nucleoli and nucleoplasmic foci to other nucleoplasmic sites, which did not colocalize with nucle
253 ays at both the nucleolar Sm-independent and nucleoplasmic Sm-dependent stages of SL RNA maturation c
257 nt assembly of membrane-less cytoplasmic and nucleoplasmic structures, including ribonucleoprotein (R
258 of the presenilins with kinetochores on the nucleoplasmic surface of the inner nuclear membrane, tog
261 be caused by inappropriate desumoylation of nucleoplasmic targets that are normally spatially protec
263 RNA, and lipids were determined in nucleoli, nucleoplasmic transcription sites, nuclear speckles, con
265 a (TNFalpha) induced rapid and complete sNix nucleoplasmic translocation concomitant with nuclear tra
266 ow that both the precursor and mature length nucleoplasmic U3 snoRNAs are present in larger multiprot
269 in the rapid (within minutes) recruitment of nucleoplasmic YFP-SRC-1, while antagonist additions dimi