ライフサイエンスコーパス: nucleus pulposus

1 course of sciatica secondary to a herniated nucleus pulposus.

2 k pain who are suspected of having herniated nucleus pulposus.

3 expression and reduced Bgm1 in degenerating nucleus pulposus.

4 cal stress and the resulting prolapse of the nucleus pulposus.

5 n the intervertebral disc, especially in the nucleus pulposus.

6 were used to measure CCN3 expression in the nucleus pulposus.

7 part of the intervertebral disc, called the nucleus pulposus.

8 differentiation and function of cells of the nucleus pulposus.

9 were used to measure CTGF expression in the nucleus pulposus.

10 positive regulator of CTGF expression in the nucleus pulposus.

11 -regulatory protein, TonEBP, in cells of the nucleus pulposus.

12 There was a significant increase in both nucleus pulposus and annulus fibrosus MR elastography-de

13 Cells of the nucleus pulposus and annulus fibrosus of rat disc tissue

14 elastography-derived shear stiffness of the nucleus pulposus and annulus fibrosus regions of all lum

15 hat of the other Notch receptors in both the nucleus pulposus and annulus fibrosus.

16 ort and long forms of alpha1(IX) from bovine nucleus pulposus and articular cartilage.

17 bolic and pro-angiogenic phenotype in bovine nucleus pulposus and cartilage endplate cells at the gen

18 recan extracted from the anulus fibrosus and nucleus pulposus, and of these aggrecan preparations fol

19 lly fixed yet unstained samples resolved the nucleus pulposus, annulus fibrosus and constituent lamel

20 ury caused significant deteriorations in the nucleus pulposus, annulus fibrous and at the interfaces

21 more inhibitory than that isolated from the nucleus pulposus, but enzymic pretreatments to reduce th

22 ssing cells inactivated Wnt signaling in the nucleus pulposus by 95%, degenerated the IVD to levels s

23 tebral disk structures (annulus fibrosus and nucleus pulposus) by cartilage and bone tissues, with ce

24 disc disease may restore NOTCH signaling and nucleus pulposus cell function.

25 nal coactivators MRTF-A and YAP/TAZ regulate nucleus pulposus cell phenotype through cell shape.

26 entified a subtype of locally residing human nucleus pulposus cells (NPCs), generated by certain cond

27 on and promoter activity was observed in rat nucleus pulposus cells after TGFbeta treatment.

28 crease in promoter activity was seen both in nucleus pulposus cells and in N1511 chondrocytes.

29 s biology to mimic the cellular behaviour of Nucleus Pulposus cells exposed to a 3D multifactorial bi

30 lyses were used to measure ANK expression in nucleus pulposus cells from rats and humans.

31 ssion and the suppression of CCN2 by CCN3 in nucleus pulposus cells further the paradigm that these C

32 transcriptional coactivator of HIF-1alpha in nucleus pulposus cells independent of the PKM2-JMJD5 axi

33 Adenovirus-mediated gene transfer to nucleus pulposus cells may be the initial stage of a new

34 Adaptive response to hypoxia in nucleus pulposus cells of the intervertebral disc is reg

35 ation through controlling ADAMTS activity in nucleus pulposus cells of the intervertebral disc.

36 histochemical staining, annulus fibrosus and nucleus pulposus cells of young-adult IVD expressed oste

37 ss of all the PHDs is maintained in isolated nucleus pulposus cells regardless of the disease state.

38 Since nucleus pulposus cells reside under conditions of hypoxi

39 erexpression of HIF-1alpha and HIF-2alpha in nucleus pulposus cells resulted in a significant suppres

40 stochemically in disc tissue, and numbers of nucleus pulposus cells staining positive for ADAMTS 4, 5

41 ng CCN3 expression in Smad3-null mice and in nucleus pulposus cells transduced with lentiviral short

42 Above 330 mosmol/kg, cultured nucleus pulposus cells up-regulated target genes TauT, B

43 xygen-dependent changes in ANK expression in nucleus pulposus cells were minimal.

44 reducing cellular aging and inflammation in nucleus pulposus cells while increasing collagen type II

45 pathologies include loss of reticular-shaped nucleus pulposus cells, disorganization of annulus fibro

46 Results of this study indicate that in nucleus pulposus cells, HIF-2 and HIF-1 modulate their o

47 Here, we show that in nucleus pulposus cells, hypoxia robustly induces PHD3 ex

48 suppressed GlcAT-1 promoter activity only in nucleus pulposus cells, suggesting a cell type-specific

49 T-1 promoter activity and expression only in nucleus pulposus cells.

50 CCN3 and suppressed its promoter activity in nucleus pulposus cells.

51 e-dependent decrease in the proliferation of nucleus pulposus cells.

52 cules, and that this regulation is unique to nucleus pulposus cells.

53 fect of HIFs on GlcAT-1 promoter function in nucleus pulposus cells.

54 umber of human studies focusing primarily on nucleus pulposus cells.

55 ommon target gene for HIF-1 and HIF-2 in the nucleus pulposus cells.

56 findings indicate that the matrix of bovine nucleus pulposus contains only the short form of alpha1(

57 inate the notochord from the surrounding the nucleus pulposus, especially in murine models.

58 e alpha1(IX)COL3 domain purified from bovine nucleus pulposus gave a different sequence to that of th

59 ith increasing Pfirrmann degeneration grade (nucleus pulposus grade 1, 12.5 kPa +/- 1.3; grade 5, 16.

60 lls such as human annulus fibrosus (hAF) and nucleus pulposus (hNP).

61 r third of the annulus fibrosus and into the nucleus pulposus in 21 (46%) and ten (22%) samples, resp

62 tabolism, function, and fate of cells of the nucleus pulposus in the intervertebral disk.

63 re was a robust expression of GlcAT-I in the nucleus pulposus in vivo.

64 The nucleus pulposus is an aggrecan-rich hydrated tissue tha

65 The cells of the nucleus pulposus (NP cells) have adapted to this environ

66 works that govern the maintenance of healthy nucleus pulposus (NP) and annulus fibrosus (AF) have not

67 progenitors of cells that populate the adult nucleus pulposus (NP) and are an important source of sec

68 o production of proinflammatory molecules by nucleus pulposus (NP) and other disc cells.

69 Cells of the adult nucleus pulposus (NP) are critically important in mainta

70 of stem cell therapies for regenerating the nucleus pulposus (NP) are hindered by the lack of specif

71 Here, bovine nucleus pulposus (NP) CD44 cells were sorted and compare

72 The nucleus pulposus (NP) cells adapt to their physiological

73 L-1beta regulation of ADAMTS-4 expression in nucleus pulposus (NP) cells and its role in aggrecan deg

74 of FIH-1 in regulating HIF-1 activity in the nucleus pulposus (NP) cells and the control of this regu

75 ic mediator LPS and IL-1 in bovine and human nucleus pulposus (NP) cells by assessing matrix-degradin

76 al treatments and combined therapy on bovine nucleus pulposus (NP) cells by assessing proteoglycan (P

77 Nucleus pulposus (NP) cells cultured with UCNPs are viab

78 Human nucleus pulposus (NP) cells derived from nondegenerated

79 We show that TonEBP deletion in nucleus pulposus (NP) cells does not affect their surviv

80 Monolayer cultures of nucleus pulposus (NP) cells from the intervertebral disc

81 tion and extracellular matrix homeostasis of nucleus pulposus (NP) cells in their hypertonic tissue n

82 However, in nucleus pulposus (NP) cells of the healthy intervertebra

83 Nucleus pulposus (NP) cells of the intervertebral disc a

84 Nucleus pulposus (NP) cells reside in a physiologically

85 3 controls HIF-1 transcriptional activity in nucleus pulposus (NP) cells through the pyruvate kinase

86 Bovine nucleus pulposus (NP) cells were treated with BMP-7 and

87 ite for SOX9 binding to the Ctgf promoter in nucleus pulposus (NP) cells.

88 1beta-dependent catabolic gene expression in nucleus pulposus (NP) cells.

89 NF-alpha control NOTCH signaling activity in nucleus pulposus (NP) cells.

90 y a new set of genes characterizing immature nucleus pulposus (NP) cells.

91 (CCN2) form a regulatory network in hypoxic nucleus pulposus (NP) cells.

92 ctor (HIF)-alpha degradation and activity in nucleus pulposus (NP) cells.

93 nditional knockout of PTH 1 receptors in the nucleus pulposus (NP) did not abolish the treatment effe

94 Spontaneous mineralization of the nucleus pulposus (NP) has been observed in cases of inte

95 isc degeneration by regenerating the central nucleus pulposus (NP) hold significant promise, but key

96 Degeneration of nucleus pulposus (NP) is irreversible in most of spine d

97 The nucleus pulposus (NP) of the intervertebral disc (IVD) d

98 The nucleus pulposus (NP) of the intervertebral disc develop

99 Each IVD consists of a central semi-liquid nucleus pulposus (NP) surrounded by a multi-layered fibr

100 age endplate (EP) annulus fibrosus (AF), and nucleus pulposus (NP) with varying ciliary length.

101 ped into the following annotated partitions: nucleus pulposus (NP), outer annulus fibrosus (oAF), inn

102 lus fibrosus (AF), transition zone (TZ), and nucleus pulposus (NP), respond to osmotic stress with al

103 drugs to reach their target cells inside the nucleus pulposus (NP), the central gelatinous region of

104 oss of proteoglycan and water content in the nucleus pulposus of intervertebral discs.

105 differentiation; and directly by forming the nucleus pulposus of intervertebral discs.

106 abolic proteins (MMP-13 and ADAMTS-5) in the nucleus pulposus of the disc.

107 From nucleus pulposus of the intervertebral disc (in which th

108 elopment, and it becomes embedded within the nucleus pulposus of the intervertebral disc (IVD) during

109 , internal swelling pressures in the central nucleus pulposus of the intervertebral disc generate pre

110 Their pre-diagnoses were 'herniated nucleus pulposus' or 'lumbar disc herniation' or 'back p

111 the inner third of the annulus fibrosus, the nucleus pulposus, or both was seen in four (25%) of 16 b

112 r with an unconfirmed diagnosis of herniated nucleus pulposus, outcome at 2-year follow-up was no bet

113 rning and afternoon imaging results for both nucleus pulposus (R = 0.92) and annulus fibrosus (R = 0.

114 y in anulus fibrosus regions and modestly in nucleus pulposus regions.

115 btained (n = 8) from the anulus fibrosus and nucleus pulposus regions.

116 shear strains located in the posterior disc (nucleus pulposus) regions.

117 Analysis of human nucleus pulposus samples indicated a trend toward increa

118 king sites occupied in type IX collagen from nucleus pulposus showed that usage of the short alpha1(I

119 Additionally, nucleus pulposus structures, heretofore unknown in birds

120 ssue-engineered IVD composed of a gelatinous nucleus pulposus surrounded by an aligned collagenous an

121 e intervertebral discs, normally composed by nucleus pulposus surrounded by the annulus fibrosus, wer

122 saminoglycans and increased hydration in the nucleus pulposus that culminated in higher stiffness of

123 Nucleus pulposus, the central zone of the intervertebral

124 regulates GlcAT-I expression in cells of the nucleus pulposus through a signaling network comprising

125 Finally, analysis of human nucleus pulposus tissue showed that while ANK was expres

126 We conclude that in nucleus pulposus, TNF-alpha and IL-1beta regulate SDC4 e

127 As in cartilage, type IX collagen of nucleus pulposus was heavily cross-linked to type II col

128 ntibody, we detected Bgm1 in human and mouse nucleus pulposus, with prominent intracellular expressio