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1 that Gram-positive bacteria considered to be obligate aerobes may play previously unrecognized roles
2 trointestinal tract with this Gram-positive, obligate anaerobe can lead to potentially life-threateni
3 the molecular mechanisms underlying how this obligate anaerobe forms infectious spores and how these
4 teroides fragilis (ETBF) is a Gram-negative, obligate anaerobe member of the gut microbial community
5 e of facultative anaerobes and one confirmed obligate anaerobe, oxidase complexes (fox, sox, dox and
6 iotics was associated with lower richness of obligate anaerobes (adjusted risk ratio = 0.84[95% CI: 0
7 iotics was associated with lower richness of obligate anaerobes (adjusted risk ratio [aRR], 0.84; 95%
8 the class Armophorea, form a major clade of obligate anaerobes (APM ciliates) within the Spirotriche
9 e and duration of therapy on the richness of obligate anaerobes and known butyrate-producers in all i
12 prevalent in many species (even facultative/obligate anaerobes), suggesting a key role for oxygen am
13 e in facultative anaerobes at the expense of obligate anaerobes, as well as molecular disruptions in
14 obic blood cultures only recovered 2 (0.69%) obligate anaerobes, it did allow for recovery of clinica
18 methylation occurs in the cytosol of certain obligate anaerobic bacteria and archaea possessing the h
19 ering certain microbial populations, such as obligate anaerobic bacteria, is particularly critical if
21 from 11 different genera and an abundance of obligate anaerobic bacteria, with ratios of Firmicutes a
23 to the Lachnospiraceae family are abundant, obligate anaerobic members of the microbiota in healthy
24 micron was examined to determine whether its obligate anaerobiosis is imposed by endogenous reactive
25 vely antithetical to diversity, it is rarely obligate and actually provides a mechanism to recover an
29 his iconic marine predator as a true sea ice obligate and providing a firm basis for projection under
33 between irruptive (facultative) to regular (obligate), as a response to different predictability of
36 evolutionary events support the idea that co-obligate associations initiate in a predictable manner-t
37 the behaviour and geographic distribution of obligate avian brood parasites and their hosts to demons
41 pport a model in which iRhom2 and ADAM17 are obligate binding partners and indicate that iRhom2 stabi
43 ces cichoracearum), one of the most prolific obligate biotrophic fungal pathogens worldwide, infects
44 ractions at early stages of infection by the obligate biotrophic fungus Podosphaera pannosa, which ca
45 nity against infection by otherwise virulent obligate biotrophic powdery mildew fungi such as Golovin
47 nts related to increased encephalization and obligate bipedalism, resulting in relative enlargement o
50 associated RING domain protein 1 (BARD1)-the obligate BRCA1 binding partner(3)-as a reader of H4K20me
53 set most likely arises from formaldehyde, an obligate by-product of oxidative protein demethylation d
54 ected for for 244 individuals (132 proven or obligate C9orf72 carriers), of whom 147 were clinically
56 eased in abundance with elevated CO2 whereas obligate calcifying species, and non-calcareous macroalg
58 iplex families from Taiwan (205 affected, 21 obligate carriers, and 25 unaffected) using SeqCap EZ Hu
64 t has remained unclear why some proteins are obligate clients of the GroE system, whereas other close
65 es MSH4 and MSH5 (MutSgamma) to maintain the obligate CO/chiasma and accounts for ~85% of meiotic COs
66 n pathogen Candida albicans is considered an obligate commensal of animals, yet it is occasionally is
67 se functionally disparate proteins act as an obligate complex, we then systematically analyzed their
68 th SPPIDER, using an independent test set of obligate complexes enhanced performance (MCC=0.381) whil
70 action and trafficking identified CLN6 as an obligate component of a CLN6-CLN8 complex (herein referr
72 fy oncofetal fibronectin (FN) as a major and obligate component of the matrix assembled by stromal fi
73 ociated tripartite motif protein, TRIM27, as obligate components of the ZNF165-SMAD3 complex that als
75 alphaKG (also known as 2-oxoglutarate) as an obligate cosubstrate and are inhibited by succinate, fum
76 l characterization of evobrutinib, a potent, obligate covalent inhibitor with high kinase selectivity
77 uggest that the innate immune response to an obligate cytosolic bacterial pathogen lies at the inters
80 halpha-globin transcript, thus acting as an obligate determinant of halpha-globin gene expression.
85 Because the Gbeta and Ggamma proteins form obligate dimers, the phenotypes of plants lacking the so
86 chaeota species that have been described are obligate ectobionts, each with a different host species.
87 e screwworm fly and compared it with the non-obligate ectoparasitic secondary screwworm flies, C. mac
89 sion in GFI1B complexes depends upon GFI1B's obligate effector, lysine-specific demethylase 1 (LSD1).
91 mes are large and are not streamlined for an obligate endosymbiotic lifestyle, implying that they hav
95 V-1 with the membrane of its target cell, an obligate first step in virus infectivity, is mediated by
96 a Fox family transcription factor, Foxc1, is obligate for appreciable sweat duct activity in mice.
97 (PG), is entirely ineffective, indicating an obligate functional interaction between NPC2 and LBPA in
102 II through +1 nucleosomes genome-wide would obligate H2A.Z turnover, we propose that global transcri
105 or convergent gene losses associated with an obligate herbivorous or carnivorous diet in 31 placental
106 ults are consistent with the hypothesis that obligate hetero-oligomeric CSCs evolved independently in
107 ellulose synthesis complexes (CSCs) that are obligate hetero-oligomeric, comprising three non-interch
109 ver, GABA(B) is unique in its function as an obligate heterodimer in which agonist binding and G-prot
110 ere we identify the PAT complex, an abundant obligate heterodimer of the widely conserved ER-resident
112 tors, and its functional entity comprises an obligate heterodimer that is composed of the GB1 and GB2
113 chemical studies have established that as an obligate heterodimer with retinoid X receptor (RXR), PPA
114 g with vascular plant emergence, conditioned obligate heterodimerization and generated the critical f
117 es not apply to multicomponent systems where obligate heterotypic interactions drive phase transition
120 eterminants required for replication in such obligate hosts are under strong purifying selection duri
125 Pertussis, or whooping cough, caused by the obligate human pathogen Bordetella pertussis is undergoi
129 canivorax borkumensis SK2(T) is an important obligate hydrocarbonoclastic bacterium (OHCB) that can d
132 aerobic NH3 oxidation by AOB occurs via two obligate intermediates, NH2OH and NO, necessitating a me
135 mammalian epithelial cells infected with the obligate intracellular bacteria Chlamydia trachomatis.
149 d global stress response regulators, how the obligate intracellular bacterium Chlamydia trachomatis a
152 aring a deubiquitylase (DUB) domain from the obligate intracellular bacterium Orientia tsutsugamushi,
153 a neglected infectious disease caused by the obligate intracellular bacterium Orientia tsutsugamushi,
154 l RNA-seq to Orientia tsutsugamushi (Ot), an obligate intracellular bacterium that causes the vector-
157 a cholesterol-rich and cholesterol-dependent obligate intracellular bacterium, partially lacks genes
161 (HGA) is a tick-borne disease caused by the obligate intracellular Gram-negative bacterium Anaplasma
166 having a specialized infection apparatus, an obligate intracellular lifestyle(5), rudimentary mitocho
169 d transport proteins are key adaptations for obligate intracellular Microsporidia parasites, because
170 Coxiella burnetii is a zoonotic bacterial obligate intracellular parasite and the cause of query (
177 ents with varying nutrient availability, the obligate intracellular parasite Toxoplasma gondii reprog
183 he Plasmodium species that cause malaria are obligate intracellular parasites, and disease symptoms o
187 Many intracellular bacteria, including the obligate intracellular pathogen Chlamydia trachomatis, g
188 ant for the intracellular replication of the obligate intracellular pathogen Coxiella burnetii, as it
189 bacteria, we studied leprosy, caused by the obligate intracellular pathogen Mycobacterium leprae, as
194 Apicomplexa phylum includes a large group of obligate intracellular protozoan parasites responsible f
195 Ehrlichia chaffeensis, a tick-transmitted obligate intracellular rickettsial agent, causes human m
200 function in the immune response suggests an obligate link between inflammation and the comorbidities
201 be restricted to hepatocytes throughout this obligate liver stage of development, and how liver-stage
202 is one of the few canids considered to be an obligate meat-eater, possessing a robust dentition for t
204 The structure-function properties of these obligate MutSalpha-MutLalpha complexes remain mostly une
205 ecological role, the genetic basis of their obligate mutualism remains largely unknown, hindering ou
207 elial conditional loss of afadin (Afdn) - an obligate nectin- and actin-binding protein - induces a h
208 kground but blood feed in one region and are obligate nonbiters in the rest of their range: Wyeomyia
209 ng genes that distinguish blood feeding from obligate nonbiting is hampered by the fact that these di
210 omyia smithii Contemporary blood-feeding and obligate nonbiting populations represent end points of d
212 semiaquatic species (pinnipeds) compared to obligate ocean dwellers (cetaceans; chi(2) = 9.6, p = .0
214 ver, uridine phosphorylases are not found in obligate oomycete pathogens such as Hyaloperonospora ara
215 red substrates for human polymerases, and no obligate or non-obligate chain termination was observed.
216 first reported application of XP-GWAS for an obligate outcrossing and highly heterozygote plant genus
217 TEMENT Retinal ganglion cells (RGCs) are the obligate output neurons of the retina and are injured by
220 ibacteria strain coisolated as an ultrasmall obligate parasite with its bacterial host from the human
222 productive infection.IMPORTANCE Viruses are obligate parasites that depend on the host cell to provi
225 ation causes localized coevolution of hosts, obligate parasites, and pathogens which act as 'coevolut
227 anthropoid primates, where long-lasting and obligate parental care is required for successful recrui
233 that POC-RD have a greater potential against obligate pathogens than opportunistic pathogens already
234 ysis points to F. acidiphilum Y(T) having an obligate peptidolytic oligotrophic lifestyle alongside w
235 MSP production is not solely associated with obligate phototrophs, the process need not be confined t
236 elipanche aegyptiaca and Orobanche spp.) are obligate plant parasites that cause extreme damage to cr
237 of the genus Meloidogyne are highly adapted, obligate plant parasites, consisting of nearly one hundr
240 ely distributed in soils and in water bodies obligate predators of gram-negative bacteria that can af
241 us are Gram-negative proteobacteria that are obligate predators of other Gram-negative bacteria and a
246 efficient system for targeted mutagenesis in obligates remains a major impediment in understanding mi
247 of differentiation and that aging is not an obligate requirement for a CD19(neg) state to be establi
248 Testosterone activation of GPRC6A has the obligate requirement for calcium in the incubation media
249 Collectively, these findings suggest an obligate requirement for IL-11 signaling via constitutiv
250 a hitherto unknown transcriptional role and obligate requirement for pS-STAT3 in gastric cancer that
253 mblages, yet we know little about how extant obligate scavengers responded to this abrupt ecological
254 apex scavenger species, including nearly all obligate scavengers, are in a state of rapid decline and
255 in, due to elevated temperature and abundant obligate scavengers, may reduce the severity of the infe
259 butterfly Phengaris (=Maculinea) rebeli, an obligate social parasite of Myrmica ants and a model sys
260 n medium where extracellular albumin was the obligate source of the essential amino acid leucine.
261 geographically diverse interactions with the obligate specialized Greya moths and, in some species an
263 represented by dozens of endemic groundwater-obligate species with narrow, naturally fragmented distr
264 to describe adaptive divergence in an alpine-obligate species, the white-tailed ptarmigan (Lagopus le
265 , most work has focused on retroviruses with obligate ssDNA replication intermediates and it is uncle
266 quitin E3 ligase, the FA core complex, is an obligate step in activation of the FA pathway, and its a
267 associated with elevated erythropoiesis, an obligate step towards erythroid recovery in response to
268 tarate), a metabolite that also serves as an obligate substrate for a subset of chromatin-modifying e
270 yte-specific deletion of Sptlc1 Sptlc1 is an obligate subunit of serine palmitoyltransferase, the enz
271 ecting an archaeal species that is itself an obligate symbiont and dependent on a second host organis
278 as independently given rise to at least four obligate symbioses, one in nematodes and three in insect
280 Here we report the discovery of a nascent obligate symbiosis in Howardula aoronymphium, a well-stu
283 catalyzes neuronal SNARE assembly through an obligate template complex intermediate containing Munc18
284 the oldest, morphologically specialized, and obligate termitophiles from mid-Cretaceous Burmese amber
285 r interpretation that Cretotrichopsenius are obligate termitophiles, and Mesosymbion[3], a member of
286 ansplant waitlist and the organ shortage has obligated the transplant centers to consider suboptimal
287 ids in light-harvesting and photoprotection, obligating the need for high-resolution techniques capab
288 ft in the microbial community structure from obligate to facultative anaerobes such as Proteobacteria
289 e to positive) on plants and the dependence (obligate to facultative) of the plant-fungal interaction
291 the hemodialysis population, clinicians are obligated to explore whether factors related to dialytic
292 policy is disclosure, whereby landlords are obligated to notify potential tenants of current or prio
293 Research on trust suggests that people feel obligated to trust other people even at zero acquaintanc
295 the presence of cilia and on smoothened, the obligate transducer of Shh signaling, indicating that In
296 temperature-dependent sex determination and obligate use of beaches subject to sea level rise (SLR).
297 lia sochifolia and Datura stramonium, and an obligate vector in which it also replicates, western flo
298 expect these impacts to be most striking for obligate visitors of plants, like bees and other pollina
299 ng lactation and the birthing of live young (obligate viviparity), a vertebrate blood-specific diet b
300 ibosomes such that the tRNA is checked in an obligate way for integrity before reentry into the trans