ライフサイエンスコーパス: ocular

1 rs than those of comparable size hung by the oculars.

2 The frequency of ocular abnormalities in our patients was lower than the

3 Mild-to-moderate changes in the ocular adnexa can develop in children and young adults w

4 nd/or adnexa, open globes and open wounds of ocular adnexa, diplopia, superficial corneal and/or conj

5 in various tumors, including those involving ocular adnexa, has led to a deeper insight into the mole

6 ds in lacrimal gland and primary orbital and ocular adnexal soft tissue tumors; reappraisal of diagno

7 tic, prognostic, and therapeutic approach to ocular adnexal tumors in light of emerging molecular gen

8 erpretation of PD-L1 and PD-L2 expression in ocular adnexal tumors.

9 All ocular AEs resolved quickly under appropriate treatment.

10 ly misdiagnosed as PAX6-related phenotype or ocular albinism prior to NGS.

11 ody height (OR: 1.02, 95% CI: 1.01-1.04) and ocular alignment (heterophoria vs. orthophoria, OR: 2.20

12 ass index (OR: 0.98, 95% CI: 0.96-1.00), and ocular alignment (horizontal heterophoria vs. orthophori

13 Current treatments for strabismus involve ocular alignment through surgical or optical methods and

14 are observed post-flight in astronauts with ocular alterations, arguing against a primary causal rel

15 basis of ZIKV and host interactions inducing ocular and neuronal pathogenesis are unclear.

16 study was to determine bacterial etiology of ocular and periocular infections, antimicrobial suscepti

17 the study eye had significant differences in ocular and systemic characteristics.

18 nts with medication-related risk factors and ocular and systemic comorbidities because they are likel

19 roid and antiglaucoma agents, and those with ocular and systemic diseases were susceptible to further

20 of these choroidal parameters in a myriad of ocular and systemic diseases.

21 Associations of ocular and systemic factors with GCIPL thickness paramet

22 tion, leading to altered elastin matrices in ocular and systemic tissues.

23 of unknown function recently associated with ocular anterior segment dysgenesis, myopia, and ectopia

24 ns were found in 6 of 62 patients (9.7%) and ocular associations in 77 of 116 eyes (66.3%); 68 of 116

25 vere, untreatable condition characterized by ocular, auditory, and cutaneous abnormalities, with majo

26 dose-dependent impairment in oculomotor and ocular behaviours across a range of ultra-low BACs (<0.0

27 pendence of the impairment in oculomotor and ocular behaviours caused by EtOH administration across a

28 While there are ocular benefits from this diet trend, the potential for

29 Nevertheless, low ocular bioavailability of topically applied drug molecul

30 cells, leading to a significant increase in ocular bioluminescence in the T cell reporter line.

31 c mechanisms of angle narrowing by assessing ocular biometric determinants of anterior chamber angle

32 t, weight, and BMI with refractive error and ocular biometric measures at age 15 years from 1613child

33 ns increased by 43% within the 90 days after ocular biometry (1.0% vs. 0.7%; P < 0.0001).

34 ere examined, who underwent retinal imaging, ocular biometry assessment, and clinical ascertainment o

35 An anonymous survey on vision and ocular care in the PA profession was administered to PAs

36 the regulation of global gene expression in ocular cells, making LOXL1-AS1 a prime target for invest

37 tionary phase bacteria and used to challenge ocular cells.

38 The SANS has blurred vision and ocular changes as typical features.

39 eflights, some astronauts develop structural ocular changes including optic disc oedema that resemble

40 The NEI-VFQ-25 was more sensitive to ocular changes than the general QoL metrics but less sen

41 Patients may be identified based on specific ocular changes, whereas skin and cardiovascular changes

42 ffer with respect to baseline demographic or ocular characteristics.

43 azithromycin distribution leads to decreased ocular chlamydia prevalence over a short-term period.

44 led to a significantly greater reduction in ocular chlamydia prevalence than the World Health Organi

45 Ocular chlamydia prevalence was significantly different

46 In some regions with high levels of ocular chlamydia prevalence, additional azithromycin dis

47 ed frequency of azithromycin distribution on ocular chlamydia prevalence.

48 in conjunctival epithelium of patients with ocular cicatricial pemphigoid and increased levels of Bi

49 ne could be implicated in the development of ocular coloboma.

50 ected on baseline demographics, systemic and ocular comorbidities, ocular surgical history, best-corr

51 Despite substantial ocular comorbidities, PPV can result in retinal reattach

52 dence, systemic health (Charlson Index), and ocular comorbidities.

53 X) (aOR, 1.53; P < 0.001); sight-threatening ocular comorbidity other than age-related macular degene

54 ty and pharmacological inhibition within the ocular compartment.

55 mmune-related AEs are elevated compared with ocular complication rates in the entire registry populat

56 Despite well-known ocular complications of HIV-related immune suppression,

57 better corneal integrity and reduced risk of ocular complications.

58 ar disease are at high risk of recurrence of ocular complications.

59 Though presbyopia is a common ocular condition, there is limited evidence regarding th

60 The ocular consequences of AHT are controversial, and the pa

61 ition and 32 eyes with poorly defined fovea, ocular cycloposition was assessed by 2 observers using 5

62 alence of parenchymal neurocysticercosis and ocular cysticercosis in some countries (which have a sta

63 ng, culture analysis, or both at the time of ocular diagnosis.

64 Refractive states and ocular dimensions were compared at 4, 6, 8, and 10 weeks

65 3, and the association between the extent of ocular disease and neurological function and age was ass

66 patients with a history of prior autoimmune ocular disease are at high risk of recurrence of ocular

67 cular examination findings, retinal imaging, ocular disease course, and laboratory findings in 4 pati

68 s report implicates a distinct microbiome in ocular disease development.

69 Patients with other ocular disease, history of ocular surgery or trauma, and

70 omplete in all patients except in those with ocular disease.

71 tions have been researched and used to treat ocular diseases as far back as the 18th century.

72 tion of autophagy is associated with several ocular diseases including keratoconus and macular degene

73 patients with corneal diseases without other ocular diseases were included.

74 -care settings can enable early diagnosis of ocular diseases.

75 perfused neovascular tufts that mimic human ocular diseases.

76 in choroidal angioarchitecture in a range of ocular diseases.

77 adapted for driving neovessel regression in ocular diseases.

78 epresenting the treatment of choice for many ocular diseases.

79 Bacterial keratitis (BK) is an ocular disorder associated with poor visual prognosis.

80 d, diabetic, and inherited neuropathies, and ocular disorders, such as glaucoma.

81 rons classified as monocular by conventional ocular dominance (OD) measurements.

82 ns rats is a consequence of the existence of ocular dominance columns (ODCs), and of callosal patches

83 find a relationship between speed tuning and ocular dominance in all three areas that MD preferential

84 ed critical period [a process referred to as ocular dominance plasticity (ODP)].

85 t, differences in inhibitory innervation and ocular dominance plasticity between NF1 mice and WT litt

86 adulthood can, like the critical period for ocular dominance plasticity in mammals, be extended by b

87 nous nicotinic signaling modulator, enhances ocular dominance plasticity in the adult primary visual

88 We found that reactivation of ocular dominance plasticity in the adult visual cortex i

89 ortical development, the critical period for ocular dominance plasticity is shortened in NF1 mice due

90 r the termination of the critical period for ocular dominance plasticity, and can rescue deficits ind

91 Since the discovery of ocular dominance plasticity, neuroscientists have unders

92 Plasticity extends to visual features beyond ocular dominance, involving subcortical and cortical reg

93 achieved by adapting both microsaccades and ocular drifts to precisely position the image on the ret

94 remains the most common and easiest route of ocular drug administration, representing the treatment o

95 n the recent advances for the development of ocular drug delivery systems.

96 is perspective focuses on various aspects of ocular drug discovery and the recent advances therein.

97 The ocular drug discovery field has evidenced significant ad

98 ction of Sunb-malate MS provided a prolonged ocular drug retention and did not cause ocular toxicity

99 associated with variable degrees of limited ocular duction.

100 The impact of ocular (e.g., changes in visual acuity [VA], activity st

101 r documentation of senolytic-related adverse ocular effects by treating ophthalmologists.

102 oncentration of soluble drug in contact with ocular epithelium for as long as possible.

103 est a MEWDS-like reaction may be elicited by ocular events in a subset of susceptible patients.

104 y reviewed the medical and ocular histories, ocular examination findings, retinal imaging, ocular dis

105 Each subject underwent a complete ocular examination including gonioscopy and AS-OCT imagi

106 American Eye Study underwent a comprehensive ocular examination, including anterior segment optical c

107 After all ocular examinations adult's aged >=18 years with present

108 icipants underwent standardized systemic and ocular examinations and interviewer-administered questio

109 Both anterior and posterior segment ocular examinations were done by Optometrists and Ophtha

110 tributors, recommendations were proposed for ocular examinations, imaging modalities, and treatment s

111 jury was thought to be caused by inadvertent ocular exposure to EMLA cream, which was used in prepara

112 ture, brachydactyly and joint stiffness, and ocular features including microspherophakia and ectopia

113 depletion syndromes (MDSs), which associate ocular features with severe neurological syndromes.

114 The ocular features, comorbidity, and abnormalities in diagn

115 aimed to evaluate the frequency of abnormal ocular findings and their relationship with hematologic

116 Evaluation of ocular findings at RP diagnosis and at time of presentat

117 ologists should be aware of the systemic and ocular findings of this rare life-threatening disease.

118 ifestations, but only 3% presented with only ocular findings.

119 mal depigmentation, without other pathologic ocular findings.

120 esponse that stiffens the tissue and impairs ocular function.

121 the finding of a macular cherry-red spot on ocular fundus examination.

122 lthough the gross mechanism signaling myopic ocular growth and its recovery in the young mammalian ey

123 gest a potential association between chronic ocular GVHD pathogenesis and stress-induced cellular sen

124 o elucidate an additional pathway of chronic ocular GVHD.

125 gical treatments include oral, intranasal or ocular H(1)-antihistamines, intranasal corticosteroids o

126 associated with protective immunity against ocular herpes infection and disease.IMPORTANCE We report

127 eting immune checkpoints to combat recurrent ocular herpes.

128 associated with protective immunity against ocular herpes.

129 cell-based immunotherapy to combat recurrent ocular herpes.

130 t iNKT cell subsets using the mouse model of ocular herpesvirus infection and disease.

131 nd coma root mean square (RMS) postoperative ocular higher-order aberrations were 1.07 +/- 0.34, 0.67

132 We retrospectively reviewed the medical and ocular histories, ocular examination findings, retinal i

133 ing factors related to patient demographics, ocular history, and comorbidity.

134 nd reviewed for etiology of endophthalmitis, ocular history, interventions, visual outcomes, complica

135 Patient demographics, ocular history, type of drops used, duration of therapy,

136 3 categories based on multimodal imaging and ocular history: retinal pigment epithelium (RPE) atrophy

137 HSV-1 0DeltaNLS vaccine is effective against ocular HSV-1 challenge, reducing ocular neovascularizati

138 For eyes with ocular hypertension (n = 45) at baseline, the incidence

139 intraocular pressure (IOP) in patients with ocular hypertension (OHT) or glaucoma.

140 mic fibrillopathy, which often presents with ocular hypertension and exfoliation glaucoma (XFG).

141 ion in Tlr4, in our inducible mouse model of ocular hypertension by injection of Ad5.TGFbeta2.

142 ibronectin-EDA (FN-EDA), in TGFbeta2-induced ocular hypertension in mice.

143 Ad5.TGFbeta2 induced ocular hypertension in wildtype C57BL/6J mice and furthe

144 GCs and preserved visual function in a mouse ocular hypertension model.

145 central corneal thickness of subjects in the Ocular Hypertension Treatment Study (OHTS) and determine

146 profile of DH from fundus photographs in the Ocular Hypertension Treatment Study (OHTS).

147 Fisher exact test); however, development of ocular hypertension was associated with worse final BCVA

148 with a diagnosis of any kind of glaucoma or ocular hypertension who were aged >=40 years, were takin

149 ar pressure (IOP) in patients with glaucoma, ocular hypertension, anatomic narrow angles, and in glau

150 phenotypes in human TM (hTM) cells to cause ocular hypertension, via a yet unknown mechanism.

151 R4 and FN-EDA contribute to TGFbeta2 induced ocular hypertension.

152 f the ciliary body had the largest impact on ocular hypertension.

153 y contribute to disc hemorrhage formation in ocular hypertension.

154 ry assessment, and clinical ascertainment of ocular hypertensive or glaucoma status (including glauco

155 k (TM) extracellular matrix (ECM) may induce ocular hypertensive phenotypes in human TM (hTM) cells t

156 Despite advances in quantitative ocular imaging and perimetry, the transition among healt

157 In this report, high-resolution ocular imaging reveals unexpected findings that reject p

158 nternational Uveitis Study Group, and Foster Ocular Immunological Society, set up an international, e

159 and disease progression in a murine model of ocular infection.

160 ease in HSV-1-infected mice.IMPORTANCE HSV-1 ocular infections are the leading cause of corneal blind

161 e overlapping functions.IMPORTANCE Recurring ocular infections caused by HSV-1 can cause corneal scar

162 There have been 5 cases of M. haemophilum ocular infections reported in the literature.

163 Patients with noninfectious ocular inflammation had been followed longitudinally bet

164 s Study (COTS), along with the International Ocular Inflammation Society and the International Uveiti

165 Study (COTS), supported by the International Ocular Inflammation Society, International Uveitis Study

166 g dexamethasone intracanalicular insert) for ocular inflammation, ReSure sealant to seal corneal inci

167 Patients with a history of uveitis or other ocular inflammatory condition demonstrated high recurren

168 Other ocular inflammatory conditions in addition to VKH syndro

169 rading processes in idiopathic melting or in ocular inflammatory diseases of the sclera.

170 rs for exudative retinal detachment (ERD) in ocular inflammatory diseases.

171 tent management approach of this spectrum of ocular inflammatory events should they arise in nAMD aft

172 sked to all other clinical, demographic, and ocular information independently graded the OCT scans fo

173 p orbitary cavity, in absence of significant ocular injury and with visual prognosis preservation.

174 After ocular injury or retinal detachment, misplaced retinal c

175 at support a MEWDS-like reaction to previous ocular insults.

176 Ocular intracameral injection of Mgp.floxed mice with a

177 3 [31.8%]) had either ocular-only disease or ocular involvement in multisite disease.

178 rated, it can be associated with significant ocular irritation.

179 between 21 and 75 years of age and showed no ocular issues at presentation.

180 e groups and no relationship with peripheral ocular length.

181 n RA and measures of co-localised peripheral ocular length.

182 The transparent ocular lens plays a crucial role in vision by focusing l

183 immunocompromised individuals and recurrent ocular lesions in the immunocompetent.

184 To control ocular magnification effects, the true scanning radius w

185 represents one of the most common congenital ocular malformations accounting for up to 10% of childho

186 glion cell (RGC) degeneration is a prominent ocular manifestation of mitochondrial dysfunction.

187 Ocular manifestations associated with TTP are uncommon.

188 files, systemic symptoms, comorbidities, and ocular manifestations were noted.

189 It has known ocular manifestations, but has not previously been shown

190 ately 1 in 6 patients with neuroblastoma had ocular manifestations, but only 3% presented with only o

191 after adjusting for age, sex, ethnicity, and ocular measures.

192 ion of spectral density and transmittance of ocular media (the mainly crystalline lens) in visible li

193 (VA), refraction, stereoacuity, strabismus, ocular media, and fundus were investigated.

194 oured eyes, congenital ocular melanocytosis, ocular melanocytoma and the BAP1-tumour predisposition s

195 e fair skin, light-coloured eyes, congenital ocular melanocytosis, ocular melanocytoma and the BAP1-t

196 mittee on Cancer (AJCC) stage, Collaborative Ocular Melanoma Study (COMS) size, tumor largest basal d

197 The ocular microbiome was described only recently, and this

198 The ocular microbiota alters ocular surface inflammation and

199 ovides precise detection and measurements of ocular misalignment and differentiated between phorias a

200 apse at any site (HR = 0.17, P = .02) and of ocular MMP (HR = 0.11, P = .007) were significantly lowe

201 s but showed limited value in DIF- multisite ocular MMP patients.

202 inephrine-induced reactivation in the rabbit ocular model.

203 ttern of cranial fusion and an autapomorphic ocular morphology(9) that resembles the eyes of lizards.

204 ted adhesion in the development of zebrafish ocular motor (sub)nuclei.

205 Vision therapy in the form of ocular motor training is increasingly used to treat visu

206 were due to inadequate pain control (n = 2), ocular movement resulting in capsular rupture (n = 2), o

207 ive against ocular HSV-1 challenge, reducing ocular neovascularization and suppressing peripheral ner

208 As a result, attenuation of ocular neuropathic pain and dry eye will take place.

209 All DIF- patients (24/73 [31.8%]) had either ocular-only disease or ocular involvement in multisite d

210 Alternative diagnostic criteria for ocular-only MMP are required to exclude the other causes

211 provide immunopathologic evidence of MMP in ocular-only MMP patients but showed limited value in DIF

212 The exact nature of the correlation between ocular optics and eye development is not known because o

213 isturbance (4.3%; n = 42), and postoperative ocular pain (3.4%; n = 34).

214 responses to all three question sets except ocular pain were consistent with significant improvement

215 ale mice appear more susceptible to signs of ocular pain, irritation, and anxiety in response to aque

216 ious LASIK or who have radial keratotomy and ocular pathologic features, including glaucoma, age-rela

217 mes were better in eyes with no pre-existing ocular pathologies, but both groups showed a statistical

218 isional glaucoma surgery, or any significant ocular pathology other than glaucoma were excluded.

219 e vision in eyes with or without concomitant ocular pathology such as macular degeneration, glaucoma,

220 al features of the human disorder, including ocular pathology, and show a response to established tre

221 We took repeated measures of oculomotor and ocular performance from sixteen participants, both pre-

222 U, TIU, TPU, and TRV were obtained, based on ocular phenotypes suggestive of TBU and corroborative ev

223 When microsaccades are not occurring, ocular position exhibits continuous slow changes, often

224 ndex questionnaire, Tear film break-up time, Ocular Protection Index, Ocular Surface Staining, Schirm

225 epresentatives-from an ancestral pair of pre-ocular (protocerebral) appendages [3-5].

226 + channel SK2 (L7-SK2) show intact vestibulo-ocular reflex (VOR) gain adaptation but impaired eyeblin

227 instability or maladaption of the vestibulo-ocular reflex.

228 ormal vestibular input, but normal vestibulo-ocular reflexes and apparently normal motor performance

229 main outcome measures were the incidence of ocular remission, incidence rate of disease relapse afte

230 of the cornea were investigated by using the Ocular Response Analyzer (ORA) (Reichert Instruments) fo

231 line CH measurements were obtained using the Ocular Response Analyzer (ORA; Reichert Ophthalmic Instr

232 The ocular response analyzer was used to measure corneal bio

233 6x magnification through dilated pupils with ocular saccades before an injection.

234 Further, there were no ocular serious AEs (SAEs) and no cases of endophthalmiti

235 The described cerebrovascular and ocular signs are consistent with predicted effects of th

236 Worse ocular symptoms and ocular staining were also found in low-delivery MGD grou

237 Further research into the growth pattern of ocular structures and the development of refractive erro

238 ding higher drug concentrations to posterior ocular structures compared with other intraocular and pe

239 significant improvement in not touching the ocular surface (P = 0.046), the eyelashes (P = 0.020), o

240 al povidone-iodine (PI) is widely used as an ocular surface antiseptic for intravitreal injections (I

241 portance of formulations that conform to the ocular surface before viscosity enhancement for increase

242 We compared patient pain scores, ocular surface characteristics, and antimicrobial effica

243 sity enhancement for increased and prolonged ocular surface contact and drug absorption.

244 An interviewer-assisted Ocular Surface Disease Index (OSDI) questionnaire was us

245 bum quality, meibomian gland expressability, ocular surface disease index (OSDI), and standard patien

246 t months 4, 8, 12, 18 patients underwent the Ocular Surface Disease Index questionnaire (OSDI), tear

247 smometer, along with other diagnostic tests (Ocular Surface Disease Index questionnaire, Tear film br

248 Tear film stability is the key event in ocular surface diseases.

249 We built a tool to assess ocular surface frailty.

250 ting the pivotal role of meibum secretion in ocular surface health that should be targeted in MGD the

251 Secondary outcomes included tolerability, ocular surface health, quality of life, disease progress

252 The ocular microbiota alters ocular surface inflammation and may influence dry eye di

253 However, the ocular surface is one of the more complex biological bar

254 al acuity (CDVA), severity scores of various ocular surface parameters, and the occurrence of complic

255 termed meibogenesis-plays a critical role in ocular surface physiology.

256 associated with chronic inflammation of the ocular surface remain unclear.

257 ); using the LogMAR scale, a multiparametric ocular surface score (OSS), and the Schirmer's test.

258 ocular surface, as assessed by change in the ocular surface severity scores was the primary outcome m

259 film break-up time, Ocular Protection Index, Ocular Surface Staining, Schirmer I test, Meibomian glan

260 y preoperative sign) was a good predictor of ocular surface symptom onset (odds ratio, 9.45; 95% conf

261 The percentage of patients with postsurgical ocular surface symptoms was 17%.

262 ession of her LSCD, and stabilization of her ocular surface was achieved.

263 requent blinking limit drug retention on the ocular surface, and gelling drops typically form clumps

264 Attainment and maintenance of a stable ocular surface, as assessed by change in the ocular surf

265 microbial commensals and inflammation on the ocular surface.

266 otal role in sustaining the integrity of the ocular surface.

267 baseline) and on postoperative day 90: MRD1, Ocular-Surface-Disease-Index (OSDI), Schirmer test 2, te

268 order to improve drug bioavailability on the ocular surfaces.

269 Previous ocular surgeries were associated with decreased probabil

270 prevalent risk factors included a history of ocular surgery (62.5%), topical corticosteroid use (35.4

271 tients with other ocular disease, history of ocular surgery or trauma, and contact lens wear within 2

272 graphics, systemic and ocular comorbidities, ocular surgical history, best-corrected visual acuity (B

273 Worse ocular symptoms and ocular staining were also found in l

274 elivery MGD had worse dry eye parameters and ocular symptoms than those with high meibum delivery, in

275 rglycemia and ketosis, neurologic illnesses, ocular symptoms, and dermatologic complications.

276 The spaceflight-associated neuro-ocular syndrome (SANS) affects astronauts on missions to

277 This case-control study compared ocular syphilis cases, matched (1:4) to syphilis control

278 Ocular syphilis increased over the study period, both in

279 Of ocular syphilis patients, 48.5% were living with HIV at

280 of syphilis-related complications, including ocular syphilis.

281 By day 7, the ocular T cell population increases to 50% of CD45 + cell

282 me of the major developments in the field of ocular therapeutics.

283 ficiency leads to apoptotic defects in mouse ocular tissue and downregulation of eye development mark

284 The trabecular meshwork (TM) is an ocular tissue that maintains intraocular pressure (IOP)

285 a normally avascular and densely innervated ocular tissue, as a model.

286 Viral transmission through ocular tissues has not been substantiated.

287 d to explore the role of the conjunctiva and ocular tissues in the transmission of disease.

288 noprost, at every time point assessed and an ocular tolerability profile similar to that of netarsudi

289 hemotherapy agents to consider the potential ocular toxicities that may result in their use.

290 hat senolytic drugs do not carry significant ocular toxicity and provide further support for addition

291 nged ocular drug retention and did not cause ocular toxicity at a dose of 150 mug of active agent.

292 Ocular toxicity studies revealed that intravitreal injec

293 ascular repair upon FECH inhibition, without ocular toxicity.

294 ere women, and 25% had a history of previous ocular trauma.

295 us initiative organized by the Collaborative Ocular Tuberculosis Study (COTS), along with the Interna

296 The Collaborative Ocular Tuberculosis Study (COTS), supported by the Inter

297 Demographic and ocular variables related to greater PD loss compared wit

298 ses to extract features based on cardiac and ocular variables.

299 ant to consider the expected outcomes (e.g., ocular vs. systemic) to ensure that the selected measure

300 Ocular WD in the form of uveitis may occur in the absenc