ライフサイエンスコーパス: oestradiol

1 , but not with chronic progesterone or acute oestradiol.

2 locked by 17beta-oestradiol, but not 17alpha-oestradiol.

3 observed for ER's endogenous hormone, 17beta-oestradiol.

4 P gamma S(in) occluded the effect of 17 beta-oestradiol.

5 th and without concurrent infusion of 17beta-oestradiol.

6 a significant relationship between JTpc and oestradiol.

7 on complexes for riboflavin, L-thyroxine and oestradiol.

8 HT), a form of testosterone not converted to oestradiol.

9 HT), a form of testosterone not converted to oestradiol.

10 olume was significantly influenced by 17beta-oestradiol.

11 secretion, responses that were augmented by oestradiol.

12 nistration of physiological levels of 17beta-oestradiol (0.08 mg/kg/day) in vivo.

13 Dawley rats were ovariectomised and a 17beta-oestradiol (0.25 mg, 21 day release) or placebo pellet i

14 trations similar to those achieved with oral oestradiol 1-2 mg, with lower intra-patient and inter-pa

15 17beta-Oestradiol (1 microM), reported to potentiate BKCa curre

16 reatment of primary human keratinocytes with oestradiol (10 nM) increased production of CER[NS] and C

17 increased (118%) with oestradiol treatment (oestradiol=124+/-84.5, placebo=57+/-46.4 mm3, mean+/-SD,

18 cultured for 2-4 days with or without 0.2 nM oestradiol-17 beta (E2) before use.

19 four of them being natural (oestriol, 17beta-oestradiol, 17alpha-oestradiol and oestrone), four being

20 Treatment with oestradiol-17beta (E2beta), but not progesterone or thei

21 an ER antagonist on exogenous and endogenous oestradiol-17beta (E2beta)-mediated elevations in UBF.

22 Treatment of monolayers with 20 nm oestradiol-17beta produced a 2-fold increase in SK3 mRNA

23 he biologically active metabolites of 17beta-oestradiol, 2-hydroxyoestradiol (2-OHE2 ) and 4-hydroxyo

24 tment (n=34; 3 months of transdermal 17 beta-oestradiol 200 micrograms daily alone, then 3 months wit

25 Administration of oestradiol, a hormone produced mainly in the ovaries, in

26 of gonadotropin-releasing hormone (GnRH) or oestradiol (administered as patches or implants), effect

27 .6 ng (100 ml tissue)-1 min-1) acute 17 beta-oestradiol administration.

28 tective benefits previously seen with 17beta-oestradiol after spinal cord injury may be in part due t

29 th HFD female and HFD male mice treated with oestradiol also displayed striking reductions in WAT inf

30 Serum oestradiol analyses were performed with radioimmunoassay

31 led via capillary bursting valves, real-time oestradiol analysis and calibration with simultaneously

32 h or without hormonal add-back therapy (1 mg oestradiol and 0.5 mg norethisterone acetate) compared w

33 once-per-day hormonal add-back therapy (1 mg oestradiol and 0.5 mg norethisterone acetate), (4) 200 m

34 once-per-day hormonal add-back therapy (1 mg oestradiol and 0.5 mg norethisterone acetate).

35 lpha-hydroxytestosterone to oestrone, 17beta-oestradiol and 17beta,16alpha-oestriol, respectively.

36 ns, and that there is an interaction between oestradiol and BCO in the control of PGHS-2 expression i

37 ance of PGHS-2 protein was increased by both oestradiol and BCO in the hippocampus.

38 anisms of the catecholoestradiols, to 17beta-oestradiol and catecholamines, we observed that converge

39 iation between serum concentrations of total oestradiol and cognitive function, but these measurement

40 sence of hormone, most synergize with 17beta-oestradiol and dafachronic acid respectively to increase

41 tocin precursor gene as biomarker for 17beta oestradiol and dexamethasone treatment in beef cattle, a

42 and 13.3-fold in cattle treated with 17beta oestradiol and dexamethasone, respectively, in compariso

43 en in the high tertile for non-protein-bound oestradiol and in 17 (16%) of 106 in the low tertile (od

44 nNOS correlated directly with plasma 17beta-oestradiol and inversely with the magnitude of sympathet

45 nopausal symptoms is similar to that of oral oestradiol and is also well-tolerated.

46 The predominance of females in studies of oestradiol and memory and the general (but erroneous) pe

47 ast cancer risk with obesity, data on 17beta-oestradiol and oestrone levels in the breast and circula

48 atural (oestriol, 17beta-oestradiol, 17alpha-oestradiol and oestrone), four being synthetic (17alpha-

49 Plasma 17beta-oestradiol in oestradiol and placebo groups was 72.6+/-38.0 and 9.3+/-

50 Follicular and luteal oestradiol and progesterone serum titres were grouped in

51 We then compared serum oestradiol and progesterone titres during these days of

52 A2 mutations are exposed to higher titres of oestradiol and progesterone-known risk-factors for breas

53 nction is mediated by an interaction between oestradiol and prostaglandin biosynthesis in the fetal b

54 We aimed to assess the effects of serum oestradiol and testosterone concentrations on the effica

55 associated with high serum concentrations of oestradiol and testosterone in postmenopausal women, but

56 ations of non-protein-bound and bioavailable oestradiol and total and non-protein-bound testosterone

57 valid marker for detection of illicit 17beta oestradiol and/or dexamethasone use in beef cattle.

58 ven ability to impart the health benefits of oestradiol, and also provides a mechanistic insight into

59 omplex with the endogenous oestrogen, 17beta-oestradiol, and the selective antagonist raloxifene, at

60 teroids digitoxigenin, progesterone and beta-oestradiol, and this steroid binding preference can be r

61 APKs involved in catecholoestradiol-, 17beta-oestradiol- and catecholamine-induced endothelial cell p

62 In postmenopausal women, treatment with oestradiol appears to restore the ability of aerobic exe

63 shown that high concentrations of endogenous oestradiol are associated with an increase in risk.

64 Both female and male mice treated with oestradiol are protected against obesity-induced insulin

65 We tested the hypothesis that oestradiol attenuates peripheral cutaneous adrenergic re

66 Local infusion of exogenous 17beta-oestradiol augmented endothelial and smooth muscle micro

67 study shows that local infusion of exogenous oestradiol augmented microvascular vasodilatation in pre

68 We conclude that oestradiol augments the activity of the central barorece

69 es the expression of PGHS isoforms, and that oestradiol augments the PGHS response to cerebral hypope

70 ction between peptides and PDIp, with 17beta-oestradiol being the most potent inhibitor.

71 heifers (n = 5), steers (n = 5) treated with oestradiol benzoate (0.15 mg/kg body weight) and untreat

72 I, in ovariectomized (OVX) rats treated with oestradiol benzoate (EB).

73 utaneous injections of PPT (10 mg kg(-)(1)), oestradiol benzoate (EB; 20 mug kg(-)(1)), the ERbeta ag

74 d not differ by tertile of non-protein-bound oestradiol, bioavailable oestradiol, or testosterone.

75 d by ATP and tamoxifen was blocked by 17beta-oestradiol, but not 17alpha-oestradiol.

76 this nonapeptide only in cattle after 17beta oestradiol, but not after dexamethasone or placebo treat

77 ations of non-protein-bound and bioavailable oestradiol, but not testosterone, were less likely to de

78 by chronic treatment of OVX rats with 17beta-oestradiol, but not with chronic progesterone or acute o

79 pendent on the conversion of testosterone to oestradiol by aromatase.

80 Oestradiol, by itself, increased the abundance of PGHS-2

81 study examines whether the steroid hormone, oestradiol, can modulate inflammatory responses in an in

82 During the menopausal transition, endogenous oestradiol concentrations diminish.

83 la were 13000-22000 times higher than plasma oestradiol concentrations in early life, and may be suff

84 ve effects, the menopause-associated drop in oestradiol concentrations is hypothesized to contribute

85 The rise in fetal PGE(2) and maternal oestradiol concentrations post-Dex occurred earlier in t

86 Serum oestradiol concentrations were also significantly reduce

87 their serum follicle-stimulating hormone and oestradiol concentrations were within postmenopausal ran

88 to changes in total or free testosterone, or oestradiol concentrations.

89 Serum oestradiol correlated with ceramide abundance and length

90 We also found that the 17beta-oestradiol decreased Ca(2+) retention in brain mitochond

91 ere measured in beef cattle receiving 17beta oestradiol, dexamethasone or placebo over a period of 40

92 th HFD female and HFD male mice treated with oestradiol displayed increased whole-body insulin sensit

93 ata indicate a cyclical fluctuation in sweat oestradiol during menstrual cycles, and a high correlati

94 Oestradiol (E(2) ) markedly attenuated the N/OFQ-induced

95 We have investigated rapid effects of 17beta-oestradiol (E) on prolactin (PRL) release in vitro.

96 Myocytes were incubated +/-17beta-oestradiol (E2 = 1 nm) and INCX was measured on days 0,

97 Y POINTS: The catechol metabolites of 17beta-oestradiol (E2 beta), 2-hydroxyoestradiol (2-OHE2 ) and

98 tudies have demonstrated protection of serum oestradiol (E2) against oxidative stress through upregul

99 These led us to examine whether oestradiol (E2) and progesterone (P) affect intestinal a

100 17 beta-Oestradiol (E2) at 0.1-10 microM directly inhibited vari

101 The impact of 17beta-oestradiol (E2) exposure on autonomic control of orthost

102 In rodents, the preovulatory surge in 17B-oestradiol (E2) temporarily increases energy expenditure

103 ort that in human breast cancer cells 17beta-oestradiol (E2)-bound oestrogen receptor alpha (ER-alpha

104 Oestradiol (E2, 0.2 mg day-1, patch; days 4-16), and pro

105 endothelial dysfunction in AE-PCOS women and oestradiol (EE) administration reverses these effects.

106 ng pregnant rats a high-fat (HF)- or ethinyl-oestradiol (EE2)-supplemented diet affects carcinogen-in

107 17beta-oestradiol establishes an anti-ferroptotic state through

108 Oestradiol establishes neural sex differences in many ve

109 In the canonical pathway, oestradiol exerts its effects through the transcription

110 S21400 increased serum oestradiol exposure dose-dependently, to concentrations

111 The results were similar for bioavailable oestradiol (five [5%] vs 15 [15%]; adjusted odds ratio 0

112 Cells were pre-treated with oestradiol for 24- and 48-hours during proliferation, fo

113 re 'female' hormones have probably prevented oestradiol from being more widely considered as a key me

114 s between the S21400 and the placebo or oral oestradiol groups, except for a greater incidence of sne

115 In contrast, oestradiol had no significant effect on the abundance of

116 Because oestradiol has vasoprotective effects, the menopause-ass

117 increases in fetal plasma concentrations of oestradiol have a neuroendocrine effect to increase both

118 hormones such as the potent oestrogen 17beta-oestradiol have been less well recognized by the scienti

119 ves were repeated in the presence of 17 beta-oestradiol in 20 of the 31 non-users.

120 Higher titres of oestradiol in carriers are compatible with this hormone

121 ta also do not support the administration of oestradiol in COVID-19.

122 Plasma 17beta-oestradiol in oestradiol and placebo groups was 72.6+/-3

123 derable evidence supports a crucial role for oestradiol in regulating learning and memory in females,

124 te testis fluids, which is higher than serum oestradiol in the female.

125 he positive and negative feedback effects of oestradiol in the hypothalamic anteroventral periventric

126 uman Msx-2 homologue was regulated by 17beta-oestradiol in the MCF-7 breast cancer cell line.

127 ggest that the non-genomic action of 17 beta-oestradiol in the potentiation of kainate-induced curren

128 p53 (p53 is induced upon binding of p53ER to oestradiol) in a p53-deficient cell line, we found that

129 We found that oestradiol increased Fos abundance in nucleus tractus so

130 ent with a high physiological dose of 17beta-oestradiol increased infarct volume after permanent MCAO

131 ts were designed to test the hypothesis that oestradiol increases the expression of PGHS isoforms, an

132 We conclude that oestradiol increases the expression of PGHS-2 in specifi

133 Progesterone can block the oestradiol-induced GnRH/LH surge and inhibit LH pulse fr

134 sfer to the cognate promoters permitting 17B-oestradiol-induced pause release and activation of the t

135 Concurrent oestradiol infusion augmented the vasodilatory response

136 rogen action enhancing torsadogenic effects: oestradiol interaction with hERG mutations in the pore l

137 which, on binding the steroid hormone 17beta-oestradiol, interacts with co-activator proteins and sti

138 Intranasally administered 17beta-oestradiol is significantly better than placebo; its eff

139 Oestradiol is vasoprotective because it has direct and i

140 monitoring of female hormones (for example, oestradiol) is of great interest in fertility and women'

141 h hormonal changes characterised by elevated oestradiol levels and reduced progesterone levels.

142 or the inverse relationship between FVII and oestradiol levels observed during the menstrual cycle.

143 follicle stimulating hormone >30 mIU/mL and oestradiol <17 pg/mL) and medical chart or questionnaire

144 administration, and serum gonadotropins and oestradiol measured.

145 ogical deficits were similar between groups (oestradiol median=13, placebo=14, max score=33).

146 om obesity-induced insulin resistance due to oestradiol-mediated reductions in WAT inflammation, lead

147 The dominance of oestrone and loss of 17beta-oestradiol might underlie the increased prevalence of ho

148 clude that the conversion of testosterone to oestradiol modulates phrenic and XII LTF in male F344 ra

149 we test whether levels of prenatal oestriol, oestradiol, oestrone and oestrone sulphate in amniotic f

150 ison of standardised odds ratios showed that oestradiol, oestrone and progesterone had the largest ef

151 Oestradiol, oestrone, oestriol and progesterone each rel

152 n concert with an internal action of 17 beta-oestradiol on a cAMP-dependent phosphorylation.

153 gets we identify may underlie the effects of oestradiol on brain development, behaviour and disease.

154 d to determine the effect of acute exogenous oestradiol on endothelium-dependent, endothelium indepen

155 culate that at least a part of the effect of oestradiol on fetal HPA axis function is mediated by an

156 is on data collected in females, effects of oestradiol on memory in males will be discussed, as will

157 of allopregnanolone, progesterone and 17beta-oestradiol on oxytocin and vasopressin release from inta

158 g and provides an overview of the effects of oestradiol on spatial, object recognition, social and fe

159 nt study was performed to test the effect of oestradiol on the central baroreceptor and chemoreceptor

160 We also studied HFD male mice treated with oestradiol or vehicle.

161 f non-protein-bound oestradiol, bioavailable oestradiol, or testosterone.

162 Conversely, in male HIP-009 cells, oestradiol pre-treatment did not prevent IL-1beta-induce

163 Notably, oestradiol pre-treatment in both lines reduced neuronal

164 In female HPC0A07/03C cells, oestradiol pre-treatment prevented IL-1beta-induced prol

165 Furthermore, 17beta-oestradiol protected G93A cortical neurons and spinal co

166 l CA1 neurones, we demonstrated that 17 beta-oestradiol rapidly potentiates kainate-induced currents

167 ons detecting changes in the progesterone to oestradiol ratio across the oestrous cycle.

168 t group's reduced levels of testosterone and oestradiol relative to the MSG-induced fibrotic group de

169 s implantation of a pellet containing 17beta-oestradiol (release rate 5 mg (21 days)-1).

170 Half of the Ovx rats received 17B-oestradiol replacement (Ovx + E2).

171 were either ovariectomized and given 17beta-oestradiol replacement (OVXE2) or sham ovariectomized wi

172 In addition, while 17beta-oestradiol replacement at the end of the long-term oestr

173 After 1 month of transdermal oestradiol replacement in these women, the normal effect

174 provide increased support that early 17beta-oestradiol replacement is critical in preventing the neg

175 iectomy-induced menopause, and the effect of oestradiol replacement.

176 otent suppressor of follicle development and oestradiol secretion in women.

177 ncreasing breast cancer risk with increasing oestradiol-SHBG ratio was found in the placebo group (tr

178 o sex hormone binding globulin (SHBG) ratio (oestradiol-SHBG ratio) on the development of all breast

179 74], and quartile 4 (0.56 [0.23 to 0.76]) of oestradiol-SHBG ratio, but not in quartile 1 (0.18 [-0.6

180 This Review discusses the mechanisms of oestradiol signalling and provides an overview of the ef

181 Intra-arterial infusion of 17 beta-oestradiol significantly potentiated bradykinin-induced

182 An intranasal 17beta-oestradiol spray, S21400, which bypasses such drawbacks,

183 In separate experiments, we have found that oestradiol stimulates fetal HPA axis activity.

184 Transdermal administration of oestradiol (tE2) circumvents first-pass hepatic metaboli

185 dotropin-releasing hormone analogues, 17beta-oestradiol, testosterone, steroidal antiandrogens and pr

186 xyoestradiol (2-ME), a natural metabolite of oestradiol that is elevated during the third trimester o

187 lammatory properties of premenopausal 17beta-oestradiol, the dominant postmenopausal oestrogen, oestr

188 mary analysis was the effect of the baseline oestradiol to sex hormone binding globulin (SHBG) ratio

189 ro culture system we demonstrate that 17beta-oestradiol treatment (50 nM) is sufficient to increase g

190 lume was significantly increased (118%) with oestradiol treatment (oestradiol=124+/-84.5, placebo=57+

191 d (2) that the conversion of testosterone to oestradiol (under the influence of aromatase) is require

192 In artificial cycles, oral oestradiol valerate (8 mg/day from day 2-4 of menstruati

193 0 microg, 300 microg, or 400 microg, or oral oestradiol valerate in doses of 1 mg or 2 mg, daily for

194 for automatic and non-invasive monitoring of oestradiol via in situ sweat analysis.

195 Oestradiol was associated inversely with ABSI in obese p

196 tion of hot flashes and, for the first time, oestradiol was detected in the serum.

197 d a high correlation between sweat and blood oestradiol was identified.

198 ersensitivity and amyloidogenesis, if 17beta-oestradiol was initiated at the time of ovariectomy and

199 24% of male multiple sclerosis patients and oestradiol was low in 25% of pre-menopausal female multi

200 At the 24 h end point, plasma oestradiol was measured and brain sections stained with

201 ation of kainate-induced currents by 17 beta-oestradiol was occluded by cholera toxin pretreatment an

202 in women negative for the mutations, and for oestradiol were 33% higher (p=0.007)-ie, 59% of carriers

203 However, unlike 17beta-oestradiol, which induces proliferation via oestrogen re