ライフサイエンスコーパス: olefinic

1 bromoetherification and desymmetrization of olefinic 1,3-diols has been developed using a C2-symmetr

2 The observation of a large beta olefinic (13)C isotope effect and small alpha carbon iso

3 ange of aldehydes (aromatic, heteroaromatic, olefinic, acetylenic, aliphatic).

4 Catalytic bromolactonization of long-chain olefinic acids resulting in the efficient synthesis of m

5 tic bromolactonizations of alkyl-substituted olefinic acids that proceed via 5-exo mode cyclizations

6 both the inverse vulcanization of S(8) with olefinic alcohols and dynamic covalent polymerizations w

7 yzed intramolecular carbonyl-ene reaction of olefinic aldehydes has been developed.

8 bertene by asymmetric cyclization of achiral olefinic alkyllithium precursors in the presence of (-)-

9 symmetric bromocyclization of trisubstituted olefinic amides that uses a C(2)-symmetric mannitol-deri

10 scribes the superacid-catalyzed chemistry of olefinic amines and related compounds.

11 A variety of olefinic amines are found to react with benzene in CF(3)

12 gs for the creation of diversely substituted olefinic amino acid systems.

13 shift of the resonances associated with the olefinic and allylic protons as a result of them residin

14 aintaining the activity for hydrogenation of olefinic and aromatic C=C bonds.

15 Low proportions of olefinic and aromatic relative to aliphatic and carboxyl

16 ast from the topological point of view, both olefinic and diene subunits; however, the stability of t

17 on works well with a wide range of aromatic, olefinic, and aliphatic aldehydes.

18 ructure, to include asymmetric substitution, olefinic, and cyclopropyl groups.

19 asymmetric intramolecular carbolithiation of olefinic aryllithiums.

20 aterials, we proved that the geometry of the olefinic axis of the interlocked struts determined the o

21 ourea-catalyzed Diels-Alder reaction between olefinic azlactones and alkylidene thiazolone derivative

22 vinylogous reactions with methyl-substituted olefinic azlactones and butyrolactones.

23 ivity is demonstrated for methyl-substituted olefinic azlactones and butyrolactones.

24 Monitoring of the olefinic band elicited seizure-induced lipid peroxidatio

25 e suggested that sulfate radical addition to olefinic biogenic volatile organic compounds (BVOCs) is

26 polymerization is employed to prepare living olefinic block copolymers and further synthesize novel p

27 Their olefinic bond affords relatively rapid reaction with hyd

28 )-based cuboctahedral MOP through orthogonal olefinic bond cleavage of the cavities of a 3D, Cu(II)-b

29 0BM-3 of a single oxidant species capable of olefinic bond epoxidation and sp3 carbon hydroxylation a

30 etathesis (RCM) strategy to form the C10-C11 olefinic bond failed.

31 al acid in the mechanism of reduction of the olefinic bond found in 2-cyclohexenone and codeinone.

32 midalyzing the nitrogen atoms, rendering the olefinic bond less electron rich and less polarized.

33 Due to a difference in olefinic bond location, the alpha- and beta- isomer exhi

34 While the 17,18-olefinic bond of eicosapentaenoic acid is epoxidized wit

35 Reactions involving the olefinic bond of the imide as well as its carbonyl group

36 rtion of the side chain including the C9-C10 olefinic bond, and the C10 methyl group.

37 Reduction of the 2,3-olefinic bond, as in (+/-)-dihydroquercetin, or glycosid

38 from the flavin to the beta-position of the olefinic bond, concomitant with or followed by uptake of

39 umor actions of n-3 PUFA may involve the n-3 olefinic bond.

40 ngle product with the Z configuration of the olefinic bond.

41 lude reduction and E-to-Z transitions of the olefinic bonds in the 14-carbon side chain of the molecu

42 catalyzed aerobic oxytrifluoromethylation of olefinic bonds of styrene derivatives using CF3SO2Na (La

43 ssymmetry, butterfly bending of the strained olefinic bonds was generally predicted.

44 ly by cleavable linkers (in this study, with olefinic bonds).

45 tastatin A-4 (1c) were focused mainly on the olefinic bridge to determine the effects on cancer cell

46 ess by proton abstraction from electron-rich olefinic C(9).

47 The olefinic C-C bond distances in 2 and 3, 1.328(4) and 1.3

48 to proceed via a directed activation of the olefinic C-H bond followed by two migratory insertions,

49 insertion of the "Si(I)2" unit of 2 into the olefinic C-H bond of the imidazole ring of 1 and four-me

50 um-catalyzed intramolecular alkylation of an olefinic C-H bond to set two stereocenters.

51 port a facile C-H borylation of aromatic and olefinic C-H bonds with 2-aminophenylboranes.

52 h addition of the C21-O-O* peroxyl adduct to olefinic C27 followed by HAT to the C26* from a Tyr.

53 talyzed Wolfe carboamination conditions with olefinic carbamate 7 to provide the racemic 2-(arylmethy

54 erse electronic and steric properties at the olefinic carbon alpha to the heteroatom of 1a-g and beta

55 (13)C isotope effect (1.024) at the terminal olefinic carbon and a smaller isotope effect (1.003-1.00

56 A normal (13)C KIE on the olefinic carbon that undergoes nucleophilic attack provi

57 oxylic acid moiety, nitration at the 9 or 10 olefinic carbon, and unsaturation is required for XOR in

58 s sizes are successfully installed on either olefinic carbon, furnishing a diverse array of products

59 ega-dienes as functionalization reagents for olefinic carbon-hydrogen bonds has been rarely studied.

60 vanced formation of the C-O bond to the beta olefinic carbon.

61 isotope effect (1.003-1.004) at the internal olefinic carbon.

62 n of 2,4-dimethyl-3-isopropyl-2-pentene, the olefinic carbons exhibit small and nearly equal (13)C is

63 The sequence of hydrogen transfer to the two olefinic carbons is calculated to change based on substr

64 carbons adjacent to the carbonyl and for the olefinic carbons of the pyran ring.

65 a nitrogen atom between the silyl enol ether olefinic carbons with the concomitant cleavage of the C=

66 ds or initial nitrene-addition to one of the olefinic carbons.

67 d 1,4-hydrogen elimination from the proximal olefinic carbons.

68 saturated lipid content was imaged using the olefinic =CH stretching mode at 3012 cm(-1).

69 rface and unperturbed by the presence of the olefinic chain on the solvent-exposed surface of the pep

70 ing alcohols, aldehydes or acetate esters of olefinic chains of 10-22 carbons.

71 r conditions to 1,2-diols bonded to terminal olefinic chains.

72 e remaining pyrrole ring retains substantial olefinic character.

73 The olefinic compound 4-phenyl-3-butenoic acid (PBA) is the

74 he species by MS/MS showed a wide variety of olefinic compounds allowing the IMS of different lipid c

75 reagent in biphasic media in the presence of olefinic compounds dissolved in the organic layer or eve

76 Meanwhile, synthetic efforts en route to olefinic compounds led to the discovery that 2-pyridylet

77 uttering to LDI-IMS of cholesterol and other olefinic compounds presents a novel approach to improve

78 icles (AgNPs) is shown to selectively ionize olefinic compounds, e.g., cholesterol, 1-palmitoyl-2-ole

79 Strikingly, the olefinic construct proved inert to attempted alpha-ketol

80 advance as it does not require stereodefined olefinic coupling partners (vinyl halide or vinyl organo

81 dition and Bi(OTf)3-catalyzed intramolecular olefinic cyclization has been developed.

82 egioselective, metal-free "Eliminative Azide-Olefinic Cycloaddition" of vinyl sulfones and organic az

83 a potent RAR gamma-selective retinoid, while olefinic derivative 11 was found to be comparable to ret

84 irst time application of hydroformylation on olefinic derivatives of isosorbide and isomannide is sho

85 cyclization between a cyclopentadiene and an olefinic dienophile to form norbornene, which is among t

86 nyl substituted orthoquinone monoketals with olefinic dienophiles furnished functionalized ortho-endo

87 Cycloaddition with olefinic dienophiles, under exceptionally mild condition

88 C-10 Olefinic dimers 7 and C-10 saturated dimers 8-13 all sho

89 s of these dipoles to typical acetylenic and olefinic dipolarophiles gave 4a-substituted 2a,2a(1)-dia

90 readily discernible with other less hindered olefinic donors.

91 up at C7 ("keto"-FPP), the relocation of the olefinic double bond into the methyl group ("iso"-FPP),

92 ds between the binding site and the reactive olefinic double bond.

93 of metathesis as an instrument to reorganize olefinic double bonds, substantial progress has been att

94 differing only in the number or location of olefinic double bonds.

95 The ammonium-directed olefinic epoxidations of a range of differentially N-sub

96 el glycosyl-beta-azido ester 3 from glycosyl olefinic ester 1 under mild conditions has been devised.

97 rmed by the conjugate addition of ammonia on olefinic ester, undergoes a metal-catalyzed diazotransfe

98 l to the success of this work was the use of olefinic-ester cyclization reactions and the utilization

99 Sciadonic acid (Scia) is a Delta5-olefinic fatty acid that is particularly abundant in edi

100 a stereochemical correlation between the two olefinic fragmentation products is preserved.

101 eophiles, higher 1,n-dienes are not, and the olefinic functional groups of the products remain intact

102 ted steric requirements for the insertion of olefinic functionalities into lanthanide-alkyl and -hete

103 regio- and stereoselective conversion of the olefinic functionality of a 5,6-dihydropyran-2-one to th

104 ion of beta-keto phosphonates that contained olefinic functionality proceeded more quickly than cyclo

105 etic elaboration through manipulation of the olefinic functionality.

106 on, and aerobic Wacker-type oxidation of the olefinic group of 6, followed by condensation of the res

107 Unexpectedly, the central olefinic group of this truncated product had a cis confi

108 cyclization by nucleophilic addition of the olefinic group to Cgamma of the ligand giving a boat-lik

109 ethylene units or inclusion of cis- or trans-olefinic groups greatly reduced antagonist potency at th

110 This process involves the cleavage of olefinic groups via ozonolysis, providing the resulting

111 ted hexahydroindolinones containing tethered olefinic groups were prepared and found to undergo effic

112 the 1-position with 2-phenylethyl (or alkyl/olefinic groups) and at N-3 with hydrogen or methyl favo

113 g those containing reactive moieties such as olefinic groups.

114 ctams 1 that have been doubly alkylated with olefinic halides gives good yields of alpha,alpha-disubs

115 ly diverse microbes that produce long chain, olefinic hydrocarbons have received much attention as po

116 ally 'pincer'-ligated iridium complexes--and olefinic hydrogen acceptors.

117 interchange of the platinum hydride with the olefinic hydrogens in 1 was determined to be 19.2 kcal/m

118 s thermophilus IDI-2, we discovered that the olefinic hydrogens of a vinyl thiomethyl analogue of iso

119 of site exchange between the hydride and the olefinic hydrogens yielded DeltaG(++) = 15.6 (6a-Ir), 16

120 As such, an olefinic intermediate formed after the addition of the f

121 internal proton transfer in a tightly bound olefinic intermediate.

122 a-4(20),11(12)-diene were tested as possible olefinic intermediates in taxa-4(5),11(12)-diene formati

123 The olefinic interproton two-bond coupling constants (2)JH,H

124 It was found that reduction of the olefinic isomers (E and Z geometries) produces chiral am

125 e frondosin ring-system, it also resulted in olefinic isomers that were easily isomerized in acidic c

126 ransition state, based on a smaller terminal olefinic isotope effect (1.012-1.015).

127 erties triggered by [2 + 2] cycloaddition of olefinic ligands, which is seldom observed in CPs.

128 The delta 7,8 olefinic linkages within (+)-calanolide A(1) and (-)-cal

129 lecular species contained exclusively Delta9 olefinic linkages.

130 egiospecificity and stereospecificity of its olefinic linkages; (2) the phospholipid subclass and ind

131 addition, while all the derivatives with an olefinic linker were antagonists, in quinpirole-stimulat

132 min analogs with a C7 linker bearing a C4-C5 olefinic linker with a single keto group at C3 (enone li

133 gen, the singlet oxygen produced cleaves the olefinic linkers in the complexes, resulting in precipit

134 We find that substituting acetylenic for olefinic linkers on the molecular cores significantly en

135 2]catenane copper complex, consisting of one olefinic macrocycle and one nonolefinic macrocycle, unde

136 Specifically, olefinic majority phases are selectively crosslinked thr

137 ,2,3,4-tetrahydro-beta-carbolines, while the olefinic mechanism had been ruled out by experiments car

138 tical, general process that involved a 12,13-olefinic methyl ketone as a starting material obtained b

139 ols, and simultaneous making and breaking of olefinic moieties.

140 zyme catalyzed oxygen atom insertion into an olefinic moiety in various natural products, but they ha

141 "expected" results, that is, cleavage of the olefinic moiety with generation of 1,4-dicarbonyl 1,2-di

142 ond, such as 20 (series II), or devoid of an olefinic moiety, such as 27 (series III), were designed

143 The primary products are toto-olefinic monocarboxylic acids with CO-derived COOH group

144 these polymerizations of nonpolar and polar olefinic monomers is prepared by in situ Zn reduction of

145 lling radical polymerizations to incorporate olefinic monomers, as well as combined approaches employ

146 to materials derived from abundant commodity olefinic monomers, which are the building blocks of ubiq

147 urn results from methyl group addition to an olefinic mycolate precursor.

148 ental evidence for the intermediacy of trans-olefinic mycolate precursors in trans-cyclopropane forma

149 The intramolecular reactions of olefinic N-heterocycles have been studied.

150 olate complexes via an unusual example of an olefinic Ni(I) complex, [Ni(COD)(OPh*)] (COD = 1,5-cyclo

151 The olefinic nitro group renders these derivatives electroph

152 converted to the spiranic compound 5 and an olefinic nucleoside 6 by the construction of the heteroc

153 rves as a hydrogenation catalyst for various olefinic or acetylenic substrates.

154 of a methylene group of 7 or inclusion of an olefinic or cyclopropyl group also reduced potency.

155 The ammonium-directed olefinic oxidation of a range of cyclic allylic and homo

156 After diastereoselective olefinic oxidation of the resultant enantiopure tetrahyd

157 have been prepared using diastereoselective olefinic oxidations of a range of enantiopure tetrahydro

158 Kraus annulation of sulfonylphthalide with 3-olefinic oxindole has been performed.

159 By the application of 3-olefinic oxindoles and benzofuranone, biologically relev

160 involves methylidyne radical addition to the olefinic pai electron system of 1,3,5-cycloheptatriene f

161 By simply changing the olefinic partner, the synthesis of a carnitine acetyltra

162 ecause of interaction between Ag(+) ions and olefinic pi electrons of fatty acids and lipids.

163 strength of cation-pi interactions involving olefinic pi-bonds.

164 Instead, flexible ligands that permit olefinic pi-electrons to be oriented more favorably towa

165 re also tolerated substitution at a terminal olefinic position and at the allylic position of the die

166 Specific mechanisms for each olefinic precursor were developed, as well as a generali

167 the reaction of sulfate radicals and several olefinic precursors, including allyl alcohol (AA), methy

168 vity as in earlier approaches involving 9,10-olefinic precursors.

169 ously supplied 3S-linalyl diphosphate to the olefinic product.

170 tandem decarboxylation-dehydration routes to olefinic products on Lewis acidic catalysts without the

171 These olefinic products were then transformed into phosphine o

172 ployed as well and, when used, produce trans-olefinic products.

173 rocycle is still distorted, but the external olefinic protons are shifted downfield compared to 9.

174 stic based on the chemical shifts of the two olefinic protons located at the macrocyclic double bond

175 of rAP enables chemoselective generation of olefinic radical anion intermediates and avoids undesire

176 icyclononyne to bypass the formation of this olefinic reaction intermediate, the reactions resulted e

177 turn controls the trajectory of the incoming olefinic reaction partner.

178 Transient structures of the olefinic-reaction intermediates such as the protonated c

179 considerable light on the diverse nature of olefinic reactions.

180 r undergo (1) hydrogen atom transfer to form olefinic repeat units or (2) beta-scission to deconstruc

181 rroles, pentasubstituted pyrroles bearing C2-olefinic side-chain and spiro-2-pyrrolinones and their c

182 rcaptan to an acrylate containing a tethered olefinic site followed by RCM (ring-closing metathesis)

183 ydroxylation of the arene renders a reactive olefinic site ready for further dihydroxylation.

184 hemical dominance by the remote ester on the olefinic site.

185 by the remote activating group bound to the olefinic site.

186 te, which results in cyclopropanation of the olefinic site.

187 ossible, even though the intermediates carry olefinic sites amenable to intramolecular cyclopropanati

188 ich a [Pd2]2+ unit is bound in pi-fashion to olefinic sites that are exocyclic to pyrrole rings of th

189 has enabled bond formation between aryl and olefinic (sp(2)) carbons in a selective and predictable

190 ne of these was also fully deuterated on the olefinic spacers.

191 agent in mass spectrometry (MS) for various olefinic species such as cholesterol and fatty acids.

192 on-interacting residues with a constraining, olefinic staple.

193 ere observed in CID, leading to formation of olefinic structures.

194 conjugate or Markovnikov-to the positions of olefinic substituents of the N-heterocycle.

195 ted skeletal rearrangement to synthesize exo-olefinic-substituted quinazolinone or oxazoloquinazolino

196 imethylsilane tolerated allylic and terminal olefinic substitution and a range of functional groups.

197 ort the proposal that rate inhibition by the olefinic substrate and product is caused by formation of

198 anism in which both molecular oxygen and the olefinic substrate coordinate to the iron center, leadin

199 tution of a phosphine ligand (PR(3)) with an olefinic substrate.

200 The olefinic substrates 4-fluorostyrene, vinylferrocene, and

201 acid/chiral HBD cocatalysis to weakly basic olefinic substrates and lays the foundation for further

202 tes that initiation mechanisms depend on the olefinic substrates and reveals the synergistic effect o

203 coupling reaction accommodates a variety of olefinic substrates and tolerates reducible groups, nice

204 ef2-TZVP/D3/cosmo) for the entire mechanism, olefinic substrates coordinate trans to the NHC of neutr

205 addition of DTPAs to alkenes and unsaturated olefinic substrates is a known reaction, but has not bee

206 ative reactions, including the conversion of olefinic substrates to epoxides by oxygen insertion.

207 s-coupling reactions between haloalkanes and olefinic substrates to generate functionalized alkenes.

208 h as the a-C-H bonds of tetrahydrofuran, and olefinic substrates, such as styrene, to afford aminated

209 addition of nitrenes (i.e., NR fragments) to olefinic substrates.

210 distributions of unsaturated compounds from olefinic substrates.

211 Modeling of an acyclic olefinic sulfonate ester substrate and the transition st

212 njugated linkage between the surface and the olefinic surface functionality, to allow for facile char

213 In both molecules, the chiral plane is an olefinic system, which is very rare among natural produc

214 ge of aryl, styrene, vinyl, and heterocyclic olefinic targets.

215 functionalized intermediates, such that the olefinic termini of the side chains could enter into int

216 he conjugate addition of hydride at the C(4) olefinic terminus using NADH to yield the cyclohexenol-c

217 cur when amido thioacetals possessing simple olefinic tethers were used.

218 three or four different substituents on the olefinic unit in a stereocontrolled fashion.

219 produced by selective transformation of the olefinic unit in the n-pentenyl glycoside to the four-ca

220 ol and the two terminal methyl groups on the olefinic unit shape the cyclization.

221 s via nucleophilic addition of the resulting olefinic unit to Calpha of 7.

222 ether enyne 3 with a cyclopentyl ring on the olefinic unit undergoes only single cyclization due to s